DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10505 and pgp-11

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_001364583.1	Gene:	pgp-11 / 183971	WormBaseID:	WBGene00004005	Length:	1241	Species:	Caenorhabditis elegans

Alignment Length:	1401	Identity:	333/1401 - (23%)
Similarity:	539/1401 - (38%)	Gaps:	338/1401 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 KLYEHLPSFDSESLTRNLQPHWEKESKKKNPSLMRLIFKVYGWQFVPVCILYSLLEMAIHSFQP- 109
            ||...:.:|..||...::.|     |.:::.:||....|.....|:...::.:||...|   ||
Worm     6 KLCRPVSAFGDESKVSDVTP-----SIRQSLNLMINFAKKSDLIFIITALICALLGGTI---QPV 62

  Fly   110 -LLLGGLIS--YFAYGQTTVTKESAY-----LYA-MGIVLCSLVTSLVFHPFMFYVFAVGT---- 161
             ||:||.|:  |...|.|....|..|     :|| :|..:..||.:|:    .......||
Worm    63 VLLIGGWITDLYLTNGNTAGNDEFLYSVLTLIYAGLGFGVIILVLALI----QGVCIQRGTSRIL 123

  Fly   162 -RVRLACAGLVYRKCLRASA------SSG--------------EGLGGQAI-----------SVM 194
             .:|....|.|    ||..|      |||              :|||.:..           |::
Worm   124 DSIRKEFLGAV----LRQDANWLDKHSSGSITCQLNENIEVISDGLGNKCCMLVRGFAMFTSSII 184

  Fly   195 SIDLSQFDLTFYFFHDLWKGPVEACIFGYLMTR--QVGWTSLIGIAFIVILIPLQAWAAKASASF 257
            :.....:.|||..|   ..|||.|.:. :|:|:  :|....|:.::       .|:.|....:..
Worm   185 ACAFINWQLTFITF---TMGPVSAFVL-HLLTKVNEVSNEELMSLS-------AQSHAIIEESIL 238

  Fly   258 GTR---SAKHRDARVKLMNEIIGAIQVIKMY----AWEKSFGRLIAAVRQSEVKAIRGSMSIYAA 315
            ..|   |...::..:..:|::...|:  |.|    .|...|..|...|             ||
Worm   239 NVRTVQSCNGQNFMITKLNQVNEKIK--KFYNKSTFWAGFFDGLALFV-------------IY-- 286

  Fly   316 LQCTNMISKISLFLSLVAYV-----YVGDLVTAKKVFILSSYY-GLLNDSLLHYWPMAITTWAQT 374
                 .|:.||||.....|.     ..||::.......::.|: |||...:            .:
Worm   287 -----FITGISLFFGCRLYFNQEIGKAGDVILIVNTICVTGYFLGLLGPHM------------SS 334

  Fly   375 LVSARRVVEFLLQVEKPTEESCCRDNPGLELDAEKPK-PAQSGRLHCVQSETKCLSFRKVSASW- 437
            |..|  ...|||..:  |.||.             || ..:.|.:. :.|....:.||.|...:
Worm   335 LQQA--ATSFLLLYK--TIESA-------------PKSEGKEGEIK-ISSTRGNIEFRDVRFKYF 381

  Fly   438 --DKPSIKQPRKPHIEGISFHINAGQFVGIVGNVGSGKST-------LLHAILGEIELMQGR--- 490
              |...        ::|:|..:..||.|.:||..|.||||       |..|..||| |:.|:
Worm   382 TRDNEV--------LQGLSLQVLPGQTVALVGTSGCGKSTSIGLLTKLYRASEGEI-LIDGKNID 437

  Fly   491 ----VEVHGRISYAAQQPWVFQGSIRENILFVEQYEEKRYRAVVHACQLDRDLELLPRGDATVVG 551
                ..:..:|....|:|.:|.|:|.|||......:|:..:...........:|.|..|..|.:|
Worm   438 MLDAKSLRQQIGIVQQEPKLFDGTIMENIKLGRNVDEETIKTAADIANASSFIEKLENGYETRLG 502

  Fly   552 ERGISLSGGQKARIALARAVYRQADIYLFDDPLAAVDAQVGKLLMDKCFHRLLDGKMRILVTHHV 616
            ..|:.||||||.||.:|||:.....|.|.|:..:|:|:. .:.:::|...:..:|:..|::.|.:
Worm   503 PGGVQLSGGQKQRICIARALVTSPSILLLDEATSALDSH-NEHIVNKALTKASEGRTTIIIAHRL 566

  Fly   617 QLLKSVDQLLLLEGGKLTQQGSYEE--LKDVITHHAALDLEAIEADKQQVKRVLSQVDRTSKQLS 679
            ..|||||::.:|:.||..:.|:::|  |...|....|...|..::.|:..:|  .::.|..|...
Worm   567 SSLKSVDRIYVLDQGKTKEIGTHDELILLGGIYARLAKSQEVEQSSKKDWER--EELRRAEKMKK 629

  Fly   680 KGE-----EKDPATIQDENGN------AEQQLQGAVSYDTYKAYFRALGAPFLVCLVLSMFVLAR 733
            ||.     |.:...:|:...|      .|.:.| .:|:......|..|.......:::...::.|
Worm   630 KGRTVEIIEPNSTILQEHEHNFVGSVITENEEQ-KISFSGISKLFNYLPKHRKTLILIIALLIPR 693

  Fly   734 G---CQAVMDIFISRWATWEEDRGYDSVDDYEATRTKMVIW-YTVLLLLTLALFLLRTFGFFFMC 794
            .   |...:.:..: :.|.:.     |.|||       :.| |..|...|||       |..|..
Worm   694 AIELCSYGIGMSFA-FKTLQR-----SKDDY-------MTWNYITLAQQTLA-------GITFWI 738

  Fly   795 LRISLTLHDQLYHGIIRAWMYFFNANPSGRVLNRFSSDIQNVDVNLPQAMMDS------------ 847
            |..||     :|   :..|:       :..|:|....::.:..:|.|....|:
Worm   739 LHTSL-----MY---LCGWL-------ANEVMNEVKQEMLSEVLNKPIPYFDNPETSPSACVSRI 788

  Fly   848 LQFLVDVVAVLVIVAIANYWLLIPAAIMVILLYF-----CRALYIGASRSLKRIESLTRSPIYS- 906
            :....:..|.|...||...| .|...|..:||.|     ...|.:|.:..|         .|:|
Worm   789 ISHAHNCYACLDHRAIRFVW-FIAGTIFSLLLAFPFVWELGVLGLGITILL---------TIFSL 843

  Fly   907 HTNQTFH-GHSTIRSMDAMPQLEQTFHGHQNTNSSALFLYVSANRAFSFWTDLICVIYILAV--- 967
            |.....| .||....||...:.......|                        |..|.:|||
Worm   844 HFVSVAHRAHSEKSVMDKSGEFAVEIVEH------------------------IRAIKLLAVEGY 884

  Fly   968 ---TFSFLVINQSFYSGDVG------LAITQSM------------TLVI---------------- 995
               .||..:.....|...:|      .|||||.            ||:|
Worm   885 FENKFSEYLKTSEIYENKIGFVSSLNFAITQSYVFACDMLLFFVGTLLIYHGRYSPDKVFLAFNG 949

  Fly   996 --MCQWGMRQTA----EMENNMTSVERVLEY---AQTPSEPPLESPKSVNLAAEWPQAGHLRFQD 1051
              |..||:...:    |:.....|..::..:   .:|.|...|..|: :|        |.:...|
Worm   950 AQMSAWGVMYFSPWFPEIVRGSASANQIFSFFDKNRTNSTSGLSKPE-IN--------GKVEVSD 1005

  Fly  1052 LRMRY-SPGDEDILRGLNFESQPMEKIGIVGRTGAGKSSIIQALFRL-ALNEGTIEIDGLDIGKL 1114
            :...| |....::..|.:........|.:||.:|.|||:||..|.|. :...|.|.:|..||..:
Worm  1006 VTFAYPSTPHRNVCEGFSLNIPKGHSIALVGASGCGKSTIISMLERFYSAKAGRISVDDNDIDGI 1070

  Fly  1115 GLHDLRSRISIIPQDPVLFSGTLRFNLD-PFDEKSDESLWSALDDVKLKKHVASLEGGLSCRMQD 1178
            .::.||:.||::.|:||||:.|:|.|:. ..||.|.|.:..|.........:.|...|....:.:
Worm  1071 DVNHLRNNISVVGQEPVLFNATIRENITIGIDEVSVEEVQKACKAANAAGFIESFPLGYDTIVGE 1135

  Fly  1179 GGSNFSMGQRQLVCLARAILRQNRVLVMDEATANVDTETDILIQETIQTKFAECTVLTIAHRLHT 1243
            ||::.|.||:|.:.:||||:|:.::|::||||:.:||:::.::|:.:::.....|.:.:||||.|
Worm  1136 GGASLSGGQKQRIAIARAIIRKPKILLLDEATSALDTQSEEIVQKALRSATTGRTSIIVAHRLST 1200

  Fly  1244 VMDNDSVLVMDAGQIVEFGAPHKLLQRKDGALLKLV 1279
            |...|::..:..|.:.|:|. |..|...|....:||
Worm  1201 VQHCDTIYYISRGAVAEYGT-HAELVAMDSKYARLV 1235

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	329/1388 (24%)
		ABC_membrane	95..360	CDD:294371	74/325 (23%)
		ABCC_MRP_domain1	428..632	CDD:213217	65/220 (30%)
		ABC_membrane	728..994	CDD:294371	62/312 (20%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	70/221 (32%)
pgp-11	NP_001364583.1	PTZ00265	38..1235	CDD:240339	322/1362 (24%)
pgp-11	NP_001364583.1	MdlB	46..607	CDD:224055	158/644 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000