DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10505 and mrp-3

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_001359552.1	Gene:	mrp-3 / 181677	WormBaseID:	WBGene00003409	Length:	1505	Species:	Caenorhabditis elegans

Alignment Length:	1380	Identity:	437/1380 - (31%)
Similarity:	691/1380 - (50%)	Gaps:	182/1380 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PFIKANIISKWLFLWMHSVFRKGRREELDASKLYEHLPSFDSESLTRNLQPHWEKESKKKNPSLM 79
            |...||.||:.|.||...:...|....|.|..::|.....|.|.|....:..|.|:::|.....:
Worm   194 PEENANFISRQLLLWFTQIISLGYERTLVADDVFEMDSQMDQEYLKARWKTEWLKQTEKAREKQV 258

  Fly    80 RL------------------IFKVYG--------------------WQFVP--------VCILYS 98
            :|                  .|..||                    ||.:.        :..|..
Worm   259 KLDDKRERARTGSEKAPLLGTFNNYGAVNLDDKDRVIVQPSVIVTLWQIMKWEILGGSFIKFLSD 323

  Fly    99 LLEMAIHSFQPLLLGGLISYFAYGQTTVTKESAYL-----YAMGIVLCSLVTSLVFHPFMFYVFA 158
            ||:.|    .|..|..||.:       :...:|.|     .|:|:.|...:.||..:.:...:..
Worm   324 LLQFA----NPTFLNYLILF-------IETPNAPLINGIGLAVGLFLAGQIKSLFMNTYFIAMTR 377

  Fly   159 VGTRVR--LACAGLVYRKCLRAS-ASSGEGLGGQAISVMSIDLSQFDLTFYFFHDLWKGPVEACI 220
            ||.:::  |:||  ||.|.|..| .:..|...|:.::::|||:.:|.:........|..|.:..|
Worm   378 VGAKIQTMLSCA--VYEKSLLLSNTARRERTVGEMVNILSIDVDRFRMITPQIQQYWSSPFQIII 440

  Fly   221 FGYLMTRQVGWTSLIGIAFIVILIPLQAWAAKASASFGTRSAKHRDARVKLMNEIIGAIQVIKMY 285
            ...|:::.:|.....||..::.::|:....:..:..:..|..|::|.|::|:||::..|:|:|:.
Worm   441 CMVLLSQTIGVAVWAGIVVMISIVPINICVSMITKRWQLRLMKYKDERIRLINEVLNGIKVVKLS 505

  Fly   286 AWEKSFGRLIAAVRQSEVKAIRGSMSIYAALQCTNMISKISLFL-SLVAYVYVG--DLVTAKKVF 347
            |||.:....|..||..|:|.|:.|..:.....|.|:.:.:.:.| |...:|.:.  :::|....|
Worm   506 AWETAMEETIERVRDKELKMIKQSALLKTFADCLNVGAPVFVALSSFTVFVLIDPKNVLTPNIAF 570

  Fly   348 ILSSYYGLLNDSLLHYWPMAITTWAQT---LVSARRVVEFLLQVEKPTEESCCRDNPGLELDAEK 409
            :..|.:.||...|:    ||....|||   :||.:||..||.:.|..|          ..:|.|
Worm   571 VSLSLFNLLRGPLM----MAAELVAQTVQLVVSNKRVRTFLCEKEVDT----------AAIDKE- 620

  Fly   410 PKPAQSGRLHCVQSETKCLSFRKVSASWDKPSIKQPRKPHIEGISFHINAGQFVGIVGNVGSGKS 474
                ..|.|:     |..:.....|.:||....:     .:..|.|...:.:.|.:||:||||||
Worm   621 ----IRGELY-----TNTVEIHSGSFAWDSAEAR-----ILSDIEFLAGSKELVTVVGSVGSGKS 671

  Fly   475 TLLHAILGEIELMQGRVEVHGRISYAAQQPWVFQGSIRENILFVEQYEEKRYRAVVHACQLDRDL 539
            :||.|.|||:|.:.|.|.|.|.::|.:||||:...|:::|:|......:..|:.|:.:|.|..||
Worm   672 SLLLAALGEMEKVCGYVGVRGSVAYLSQQPWILNQSLKKNVLMQADLNDVLYKKVIESCALKEDL 736

  Fly   540 ELLPRGDATVVGERGISLSGGQKARIALARAVYRQADIYLFDDPLAAVDAQVGKLLMDKCF--HR 602
            :.||.||.|.:||:||:||||||||||||||||:..|:|..||||:||||.|||.:.|...  :.
Worm   737 KQLPDGDDTEIGEKGINLSGGQKARIALARAVYQSKDVYFLDDPLSAVDAHVGKHIFDNVIGPNG 801

  Fly   603 LLDGKMRILVTHHVQLLKSVDQLLLLEGGKLTQQGSYEELKDVITHHAALDLEAIEADKQQVKRV 667
            :|....|||||:....|:...::::::.|::...|:|.||        ..|:||.|. .|:|...
Worm   802 MLSHTTRILVTNCTSFLQESGKIIVMKDGRIKHCGTYNEL--------LTDVEAREY-LQEVDNE 857

  Fly   668 LSQVDRTSKQLSKGEEKD---PATI-----------------------------QDENGNAEQQL 700
            .:|...:|.:.|.|||..   |.:|                             .|.....|:..
Worm   858 YAQAQESSGEESGGEENSDILPGSIASGSRMSRLSRLSKISRKKSKSSIVEKKKPDALITKEEAA 922

  Fly   701 QGAVSYDTYKAYFRALG-----APFLVCLVLSM-FVLARGCQAVMDIFISRWATWEEDRGYD-SV 758
            .|.|:...|..||:|:|     .|:.:.:||:: |.|.|          |.|.|...|...| :.
Worm   923 IGRVNPGVYLLYFKAMGIVTYVLPYAIAVVLNVSFALGR----------SLWLTAWSDANIDINH 977

  Fly   759 DDYEATRTKMVIW----YTVLLLLTLALFLLRTFGFFFMCLRISLTLHDQLYHGIIRAWMYFFNA 819
            .|..:...::.::    .|.::.|..:|.||...|     :..|..||..|.|.::|..:.:|:.
Worm   978 PDTMSVGARLGVYAGFGITEVIFLFFSLVLLLIGG-----VAASKNLHKPLLHNVLRNPLSYFDI 1037

  Fly   820 NPSGRVLNRFSSDIQNVDVNLPQAMMDSLQFLVDVVAVLVIVAIANYWLLIPAAIMVILLYFCRA 884
            .|.||::||.:.|::.||:.|..:....:..|:::|..::||:.... |.|...|.|.::||...
Worm  1038 TPIGRIINRLAKDMEVVDLRLSSSFRFLVMALINMVQTVLIVSYTTP-LFIAIIIPVFIIYFFVL 1101

  Fly   885 LY-IGASRSLKRIESLTRSPIYSHTNQTFHGHSTIRSMDAMPQLEQTFHGHQNTNSSALFLYVSA 948
            .| |.::|.|:||.|||||||:|:.::|..|.||:|:.....:..:....|.||:....:....|
Worm  1102 KYSIKSTRQLQRIASLTRSPIFSNFSETLQGISTVRAFQWSDEFVRRNDEHLNTHVKCSYYSQMA 1166

  Fly   949 NRAFSFWTDLICVIYILAVTFSFLVINQS-FYSGDVGLAITQSMTLVIMCQWGMRQTAEMENNMT 1012
            ||..|...:|:..|.|.:.....::..:| ..:|.:||:::.|:.:..|....:||..|:|.|:.
Worm  1167 NRWLSIRLELLGNIVIFSAAILAIIGKESGITAGMLGLSVSYSLNITFMLNMFVRQINEVETNVV 1231

  Fly  1013 SVERVLEYAQTPSEPPLESPKSVNLAAEWPQAGHLRFQDLRMRYSPGDEDILRGLNFESQPMEKI 1077
            ||||:.||::|.||.......: ||.:.||..|.:..:|...||....:.:|:.::....|.:|:
Worm  1232 SVERIDEYSKTKSEAEWRLDNN-NLPSNWPTGGAVNIEDYSCRYRDELDLVLKQISLNILPGQKV 1295

  Fly  1078 GIVGRTGAGKSSIIQALFRLA-LNEGTIEIDGLDIGKLGLHDLRSRISIIPQDPVLFSGTLRFNL 1141
            |:.|||||||||:..||||:. ..:|.|.||......:||||||.:::||||:.|||:.|||||:
Worm  1296 GVCGRTGAGKSSLALALFRIVEAADGNISIDQTITSHIGLHDLREKLTIIPQENVLFANTLRFNI 1360

  Fly  1142 DPFDEKSDESLWSALDDVKLKKHVASLEGGLSCRMQDGGSNFSMGQRQLVCLARAILRQNRVLVM 1206
            ||..:.:|:.||.||::..||.||..|...|...:.:||.|||:|||||:||.||:||:::|||:
Worm  1361 DPKGQFTDQQLWLALENSNLKAHVELLPHKLESPVAEGGENFSVGQRQLLCLTRALLRKSKVLVL 1425

  Fly  1207 DEATANVDTETDILIQETIQTKFAECTVLTIAHRLHTVMDNDSVLVMDAGQIVEFGAPHKLLQRK 1271
            |||||.:|..||.::|.||:.|||:.|::||||||||::|.|.::|||||:|||.|.|.:||:.:
Worm  1426 DEATAGIDNRTDTMVQATIREKFADSTIITIAHRLHTIIDYDRIIVMDAGRIVEDGIPGELLKNR 1490

  Fly  1272 DGAL------LKLVN 1280
            :...      .|:||
Worm  1491 NSQFYGLAKSAKIVN 1505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	432/1360 (32%)
		ABC_membrane	95..360	CDD:294371	69/275 (25%)
		ABCC_MRP_domain1	428..632	CDD:213217	85/205 (41%)
		ABC_membrane	728..994	CDD:294371	75/273 (27%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	109/219 (50%)
mrp-3	NP_001359552.1	MRP_assoc_pro	25..1501	CDD:188098	434/1374 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	1.000	Domainoid score	I5384
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720