Protein Alignment CG10505 and mrp-6

DIOPT Version :9

• Sequence 1: NP_611571.2
• Gene: CG10505 / 37428
• FlyBaseID: FBgn0034612
• Length: 1312
• Species: Drosophila melanogaster
• Sequence 2: NP_001362008.1
• Gene: mrp-6 / 180691
• WormBaseID: WBGene00003412
• Length: 1415
• Species: Caenorhabditis elegans
• Alignment Length: 1398
• Identity: 434/1398 - (31%)
• Similarity: 700/1398 - (50%)
• Gaps: 154/1398 - (11%)

  Fly     9 PKRESNPFIKANIISKWLFLWMHSVFRKGRREELDASKLYEHLPSFDSESLTRNLQPHWEKESKK 73
            |..|.:    |.:||..||.::...:.:.|..:.|...|.:......::...:.|:..|.....|
 Worm    45 PSSEDS----AGLISSILFSFVGFYWWRTRNAQTDTDLLEKPSKGISAKYAAQKLESKWISSGPK 105

  Fly    74 KNPSLMRLIFKVYGWQFVPVCILYSLLEMAIHSF----QPLLLGGLISYF--AYGQTTVTKESAY 132
                  |..|.|..|....|.::...:.:.:...    |||||..|:||:  ..||     |..|
 Worm   106 ------RTHFLVGVWHCTKVSVMAHAISLCLEELTRVAQPLLLRELMSYYDIEEGQ-----EFPY 159

  Fly   133 LYAMGIV----LCSLVTSLVFHPFMFYVFAVGTRVRLACAGLVYRKCLRASASS-GEGLGGQAIS 192
            ..||.:.    |.|.||..:.||:...:..||...|:|...|:|||.||.|.:| .|...||.|.
 Worm   160 WPAMQVALIISLLSFVTVCIHHPYFHGLLKVGNHARVATGVLLYRKSLRISLTSLFETNSGQIIQ 224

  Fly   193 VMSIDLSQFDLTFYFFHDLWKGPVEACIFGYLMTRQVGWTSLIGIAFIVILIPLQAWAAKASASF 257
            :::.|.::.:..|.|.|.:|..|:....:.|::....|:..|:|...::.::..|...:......
 Worm   225 LLNTDAAKLEQAFLFAHYVWLCPLLMFFYAYILWSMFGFCCLLGFLVMMAIVSFQVHYSYQLGVN 289

  Fly   258 GTRSAKHRDARVKLMNEIIGAIQVIKMYAWEKSFGRLIAAVRQSEVKAIRGSMSIYAALQCTNMI 322
            ........|:|:|:|:|||..|:||||:.||.:|...|..:|:.|:||: |:.:.|     ::|:
 Worm   290 RRNIGDKMDSRLKVMSEIINGIKVIKMHGWENAFAEKIRILREDEIKAV-GTSAFY-----SSMV 348

  Fly   323 -------SKISLFLSLVAYVYVGDLVTAKKVFILSSYYGLLNDSLLHYWPMAITTWAQTLVSARR 380
                   :||.||:.:.|..|..:::|.:.||..|:.:..:......:.|:.:....:...::||
 Worm   349 MGIYFISAKIGLFVYIFACDYFDEILTTRGVFASSALFNSVRLPFALFLPLGLLFGRELFSTSRR 413

  Fly   381 VVEFL---------LQVEK-PTEESCCRDNPGLELD--AEKPKPAQSGRLHCVQSETKCLSFRKV 433
            :..|.         |:::. .||:....:..||.|.  .|||    |..|.|.::|...:...||
 Worm   414 IDLFFCLEEYSRITLELDSTDTEDGSKNEKEGLTLKKIGEKP----SWTLKCDKAEKTSVFLNKV 474

  Fly   434 SASW-DKPSIKQPRKPH---------------------------IEGISFHINAGQFVGIVGNVG 470
            :|.| ||....|.:|..                           ::.:||...||...||:|:||
 Worm   475 TAVWYDKDEHDQKKKKKNFKALSDNDATVIAGEKKDEPLHVVYAVQDLSFEFVAGTCYGIIGSVG 539

  Fly   471 SGKSTLLHAILGEIELMQGRVEVHGRISYAAQQPWVFQGSIRENILFVEQYEEKRYRAVVHACQL 535
            ||||:||..||.|..:.:|.:.|:|..:|.||:||:|.|||::||:|..::.::||...:..|.|
 Worm   540 SGKSSLLLTILSESRMTRGNLSVNGSFAYCAQEPWIFTGSIQDNIVFGSEFNKERYENALELCLL 604

  Fly   536 DRDLELLPRGDATVVGERGISLSGGQKARIALARAVYRQADIYLFDDPLAAVDAQVGKLLMDKCF 600
            ..||.....||.|:||:.|.:|||||:||:|||||||..|||||.||||:||||.|||.|.:...
 Worm   605 TPDLRQFANGDMTIVGDNGSTLSGGQRARVALARAVYADADIYLLDDPLSAVDAHVGKKLYENLI 669

  Fly   601 HRLLDGKMRILVTHHVQLLKSVDQLLLLEGGKLTQQGSYEELKDVITHHAALDLEAIEADKQQVK 665
            ...|..|:.|||||.:..|..:|.::|::..|:...||.:|||...|.. .:.|:|:|.:.|..:
 Worm   670 RGFLSDKLVILVTHQIHFLSELDSVILMKNNKMVGNGSLDELKSTFTDD-FIKLQAVETEVQSDE 733

  Fly   666 RVL-----------------------SQVDRTSKQLSKGEEKDPATIQDENGNAEQQLQGAVSYD 707
            ..:                       |...|.:..||..:..:...:::.  ..|.:..|.:|:.
 Worm   734 LFVDGPPSSPPPSPVNIESMEKINKESIFQRANSVLSGSKMSETEYVKEI--VYESRKSGTISWS 796

  Fly   708 TYKAYFRAL------GAPFLVCLVLSMFVLARGCQAVMDIFISRWAT-WEEDRGYDSVDD----Y 761
            .|..|.|.:      |...:||::::.         :|:.|:..|.. |..|...::.|:    .
 Worm   797 VYWEYTRGVINPLKYGIWLVVCVLITQ---------LMNNFVDWWLNKWLVDLDMNNADNSTSKE 852

  Fly   762 EATRTKMVIWYT----------VLLLLTLALFLL---RTFGFFFMCLRISLTLHDQLYHGIIRAW 813
            |..|...|:.||          ..::.|:.:.:|   |:..|....|..|..||:.::..:::..
 Worm   853 EFNRNVDVLGYTFNVTFQTYELTFIISTVIMSILGVVRSVWFRNAQLMASRILHNSMFDCVLKTE 917

  Fly   814 MYFFNANPSGRVLNRFSSDIQNVDVNLPQAMMDSLQFLVDVVAVLVIVAIANYWLLIPAAIMVIL 878
            ..||:.|..|.:|||||.||...|..|.....:.:...:..|.::.:|::....:::..|.:...
 Worm   918 SEFFDKNSEGMILNRFSKDIGLTDDLLAFTYFEFVFGTLTFVGIVGLVSMVRPIVILACAFITAG 982

  Fly   879 LYFCRALYIGASRSLKRIESLTRSPIYSHTNQTFHGHSTIRSMDAMPQLEQTFHGHQNTNSSALF 943
            .||||.:|:..||.|||||:..|||:.:....|.||.||||:.....::.:.|....:...:|..
 Worm   983 FYFCRKMYVHRSRELKRIEAAARSPLNTTITSTVHGLSTIRAYRKENEMIEKFCALHDVYMAAYN 1047

  Fly   944 LYVSANRAFSFWTDLICVIYILAVTFSFLVINQSFYSGDVGLAITQSMTLVIMCQWGMRQTAEME 1008
            :.:.:.|.|....|.:..:::..|....::..::...|:|||.:..::.|.....|.|||:||:|
 Worm  1048 MGLLSARWFGICIDFLVSVFVSIVAIVVVLQYETLTVGEVGLCLVCAVQLSGFFSWIMRQSAELE 1112

  Fly  1009 NNMTSVERVLEYAQTPSEPPLESPKSV----NLAAEWPQAGHLRFQDLRMRYSPGDEDILRGLNF 1069
            |.|.||||||||.:..||.....|...    .|...||..|.:.|:::.:.|  |:..:|:.|:|
 Worm  1113 NGMVSVERVLEYTKLKSEEEARRPHDAYLDKQLLNSWPTKGEIEFENVSVNY--GETKVLKNLSF 1175

  Fly  1070 ESQPMEKIGIVGRTGAGKSSIIQALFRLALNE---GTIEIDGLDIGKLGLHDLRSRISIIPQDPV 1131
            .....:|||:|||||||||::|:.:|  .|.|   |.:.|||:|:..:.|:..|..:|||||:||
 Worm  1176 VVLGGQKIGVVGRTGAGKSTLIKIIF--GLKEYCSGRVTIDGVDLDHISLNFRRGGMSIIPQEPV 1238

  Fly  1132 LFSGTLRFNLDPFDEKSDESLWSALDDVKLKKHVASLEGGLSCRMQDGGSNFSMGQRQLVCLARA 1196
            :||||:|.|||||||..|.::|.||:..:||:.:.. |.||:..:...|.:.|:|||||.|||||
 Worm  1239 IFSGTVRENLDPFDEYDDATIWFALEQCELKRSITK-EKGLNVELGQRGVSLSVGQRQLFCLARA 1302

  Fly  1197 ILRQNRVLVMDEATANVDTETDILIQETIQTKFAECTVLTIAHRLHTVMDNDSVLVMDAGQIVEF 1261
            ::.::::||:||||||||..||..||:||:..|...|::|:||||||:|::|:|:|.:.|::|||
 Worm  1303 MIHRSKILVIDEATANVDGVTDACIQKTIRDFFKNATIITVAHRLHTIMNSDNVMVFEKGELVEF 1367

  Fly  1262 GAPHKLLQRKDGALLKLVNQNDATTVKFLKRIA 1294
            ..|..||..:.....::..|:.|.....|:..|
 Worm  1368 DKPITLLDDQSSLFSRMAAQSGAENFDSLRAAA 1400

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	427/1367 (31%)
		ABC_membrane	95..360	CDD:294371	80/282 (28%)
		ABCC_MRP_domain1	428..632	CDD:213217	94/231 (41%)
		ABC_membrane	728..994	CDD:294371	67/283 (24%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	103/221 (47%)
mrp-6	NP_001362008.1	MRP_assoc_pro	<126..1389	CDD:188098	413/1294 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	136	1.000	Domainoid score	I3053
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0001028
OrthoInspector	1	1.000	-	-		otm14754
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.830