Protein Alignment CG10505 and mrp-1

DIOPT Version :10

• Sequence 1: NP_611571.2
• Gene: CG10505 / 37428
• FlyBaseID: FBgn0034612
• Length: 1312
• Species: Drosophila melanogaster
• Sequence 2: NP_508122.2
• Gene: mrp-1 / 180409
• WormBaseID: WBGene00003407
• Length: 1534
• Species: Caenorhabditis elegans
• Alignment Length: 1392
• Identity: 442/1392 - (31%)
• Similarity: 704/1392 - (50%)
• Gaps: 176/1392 - (12%)

  Fly    11 RESNPFIKANIISKWLFLWMHSVFRKGRREELDASKLYE---------HLPSF------DSESLT 60
            :.|.|...|:.:::..|.|...:...|.::.|:...|::         .:|||      :.|...
 Worm   204 KNSCPEYTASFLNQLTFQWFSGLAYLGNKKSLEKEDLWDLNERDKAENIIPSFIENLIPEVEGYR 268

  Fly    61 RNLQPHWEKESKKKNPSLMRLIFKVYGW---------------QFVPVCILYSLLEMAIHSFQPL 110
            |.::.:.|....|.:||::..|||.|.:               |||...:|..|:.......||:
 Worm   269 RKIKKNPEAAIPKNHPSILIPIFKTYKFTLLAGGCYKLMFDLLQFVAPELLRQLISFIEDKNQPM 333

  Fly   111 LLGGLISYFAYGQTTVTKESAYLYAMGIVLCSLVTSLVFHPFMFYVFAVGTRVRLACAGLVYRKC 175
            .:|..|                  |:.:.|.||:.|::.|.:...:|.:|..:|......||.|.
 Worm   334 WIGVSI------------------ALLMFLSSLLQSMILHQYFHEMFRLGMNIRSVLTSAVYTKT 380

  Fly   176 LRASASSGEG-LGGQAISVMSIDLSQFDLTFYFFHDLWKGPVEACIFGYLMTRQVGWTSLIGIAF 239
            |..|..:.:| ..|..:::||:|:.:......|....|..|::..:..|.:.:.:|.:.|.|...
 Worm   381 LNLSNEARKGKTTGAIVNLMSVDIQRIQDMTTFIMLFWSAPLQILLSLYFLWKLLGVSVLAGFVI 445

  Fly   240 IVILIPLQAWAAKASASFGTRSAKHRDARVKLMNEIIGAIQVIKMYAWEKSFGRLIAAVRQSEVK 304
            :::|||..::.:....:......|.:|.|:|:|:||:..::|:|:|:||||..:::..||:.|::
 Worm   446 LILLIPFNSFISVKMRNCQMEQMKFKDERIKMMSEILNGMKVLKLYSWEKSMEKMVLEVREKEIR 510

  Fly   305 AIRGSMSIYAAL----QCTNMISKISLFLSLVAYVYVGDLVTAKKVFILSSYYGLLNDSLLHYWP 365
            .::....:.||.    .|...:..:..|...|.:....:::|.:..|:..:.:.:|...|. .:.
 Worm   511 VLKKLSYLNAATTLSWACAPFLVAVLTFGLYVLWDPENNVLTPQITFVALALFNILRFPLA-VFA 574

  Fly   366 MAITTWAQTLVSARRVVEFLLQVEKPTEESCCRDNPGLELDAEKPKPAQSGRLHCVQSETKCLSF 430
            |..:...|...|..|:.||....|...:.|.                |..|....::.:..
 Worm   575 MVFSQAVQCSASNTRLKEFFAAEEMSPQTSI----------------AYGGTDSAIKMDGG---- 619

  Fly   431 RKVSASWDKPSIKQPRKPHIEGISFHINAGQFVGIVGNVGSGKSTLLHAILGEIELMQGRVEVHG 495
               |.:|.  |.::.||.|  .|:|:|..||.|.|||.||||||:||||:|||:..:.|.|:|:|
 Worm   620 ---SFAWG--SKEEDRKLH--DITFNIKRGQLVAIVGRVGSGKSSLLHALLGEMNKLSGSVQVNG 677

  Fly   496 RISYAAQQPWVFQGSIRENILFVEQYEEKRYRAVVHACQLDRDLELLPRGDATVVGERGISLSGG 560
            .::|..|..|:...|:|.||||...|:.|.|:.|:..|.|.:|||.||..|.|.:||:||:||||
 Worm   678 SVAYVPQLAWIQNLSLRNNILFNRPYDAKLYQNVIENCALVQDLESLPAEDRTEIGEKGINLSGG 742

  Fly   561 QKARIALARAVYRQADIYLFDDPLAAVDAQVGKLLMDKCFHR---LLDGKMRILVTHHVQLLKSV 622
            ||.|::||||||:.|:|.|.||||:|||:.|||.:.:.....   .|..|.|:|:||.:..||..
 Worm   743 QKQRVSLARAVYQNAEIVLLDDPLSAVDSHVGKHIFENVISTATGCLGTKTRVLLTHGLTYLKHC 807

  Fly   623 DQLLLLEGGKLTQQGSYEEL--------------------------------KDVITHHAALDLE 655
            ||:::|:...:::.|:|:||                                |:|  :....||:
 Worm   808 DQVIVLKDETISEMGTYQELMNSNGAFSEFLEEFLLEESKHKGRSVSFGEDSKEV--NELLRDLD 870

  Fly   656 AIE-ADKQQVKRVLSQV-----DRTSKQLSKGEEKDPATIQDENGNAEQQ--LQGAVS------- 705
            .:. |.:|:::..:||.     |:.::.:..|..||..|.....|.:|::  |.||:|
 Worm   871 QVSPAIRQRIQSQMSQEIEKTDDKNAEIIRNGLHKDEQTAHSSIGKSEEKESLLGAISPKEKTPE 935

  Fly   706 ---------------------YDTYKAYFRALGAPFLVCLVLSMFVLARGCQAVM-DIFISRWAT 748
                                 ::.|.:||||:|  ..:.||..:..:|.....|. :::::||:.
 Worm   936 PPKQTKTQLIEKEAVETGKVKFEVYMSYFRAIG--IKIALVFFLVYVASSMLGVFSNLYLARWSD 998

  Fly   749 WEEDRGYDSVDDYEATRTKMVIWYTVL----LLLTLALFLLRTFGFFFMCLRISLTLHDQLYHGI 809
            ..::...........|:.::.| |.||    .....|..::...|  .:|  .|..||..|...|
 Worm   999 DAKEIALSGNGSSSETQIRLGI-YAVLGMGQATSVCAASIIMALG--MVC--ASRLLHATLLENI 1058

  Fly   810 IRAWMYFFNANPSGRVLNRFSSDIQNVDVNLPQAMMDSLQFLVDVVAVLVIVAIANYWLLIPAAI 874
            :|:.|.||:..|.||:||||..||..:|..||..:|..:..:|..|.:..:...|......|..|
 Worm  1059 MRSPMAFFDVTPLGRILNRFGKDIDVIDYRLPSCIMTFVGAIVQAVTIFAVPIYATPLSSFPITI 1123

  Fly   875 MVILLYFCRALYIGASRSLKRIESLTRSPIYSHTNQTFHGHSTIRSMDAMPQLEQTFHGHQNTNS 939
            ::|..||....|:..||.|||:||.:|||||||..::..|.|:||:...:.:..:......:.|.
 Worm  1124 VLIGYYFLLRFYVSTSRQLKRLESASRSPIYSHFQESIQGASSIRAYGVVDKFIRESQHRVDENL 1188

  Fly   940 SALFLYVSANRAFSFWTDLICVIYILAVTFSFLVINQS--FYSGDVGLAITQSMTLVIMCQWGMR 1002
            :..:..:.|||..:...:::..:.:|:...:.:....|  ..:|.|||:::.::.:.....|.:|
 Worm  1189 ATYYPSIVANRWLAVRLEMVGNLIVLSSAGAAVYFRDSPGLSAGLVGLSVSYALNITQTLNWAVR 1253

  Fly  1003 QTAEMENNMTSVERVLEYAQTPSEPPLESPKSVNLAAE-WPQAGHLRFQDLRMRYSPGDEDILRG 1066
            .|:|:|.|:.:|||:.||..||:    |...|.:||.: ||:.|.:..::..:||.||.:.:|.|
 Worm  1254 MTSELETNIVAVERINEYTITPT----EGNNSQSLAPKSWPENGEISIKNFSVRYRPGLDLVLHG 1314

  Fly  1067 LNFESQPMEKIGIVGRTGAGKSSIIQALFR-LALNEGTIEIDGLDIGKLGLHDLRSRISIIPQDP 1130
            :.....|.|||||||||||||||:..|||| :..:.|.|||||.:|..|.|..||||::|:||||
 Worm  1315 VTAHISPCEKIGIVGRTGAGKSSLTLALFRIIEADGGCIEIDGTNIADLLLEQLRSRLTIVPQDP 1379

  Fly  1131 VLFSGTLRFNLDPFDEKSDESLWSALDDVKLKKHVASLEGGLSCRMQDGGSNFSMGQRQLVCLAR 1195
            ||||||:|.|||||...||:.:|.||.:..|...|.||:.||...:.:||.|.|:|||||:||||
 Worm  1380 VLFSGTMRMNLDPFFAFSDDQIWEALRNAHLDSFVKSLQEGLHHHISEGGENLSVGQRQLICLAR 1444

  Fly  1196 AILRQNRVLVMDEATANVDTETDILIQETIQTKFAECTVLTIAHRLHTVMDNDSVLVMDAGQIVE 1260
            |:||:.:|||:|||.|.||.|||.|:|:||:.:|.:||||||||||:||||:|.:||:|.|.:.|
 Worm  1445 ALLRKTKVLVLDEAAAAVDVETDSLLQKTIREQFKDCTVLTIAHRLNTVMDSDRLLVLDKGCVAE 1509

  Fly  1261 FGAPHKLLQRKDGALLKLVNQNDATTV 1287
            |..|.|||...||....:.  .||..|
 Worm  1510 FDTPKKLLSNPDGIFYSMA--KDANVV 1534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	MRP_assoc_pro	15..1271	CDD:188098	436/1370 (32%)
mrp-1	NP_508122.2	MRP_assoc_pro	23..1531	CDD:188098	439/1387 (32%)