DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG10505 and mrp-2

DIOPT Version :9

Sequence 1:NP_611571.2 Gene:CG10505 / 37428 FlyBaseID:FBgn0034612 Length:1312 Species:Drosophila melanogaster
Sequence 2:NP_508121.1 Gene:mrp-2 / 180408 WormBaseID:WBGene00003408 Length:1525 Species:Caenorhabditis elegans


Alignment Length:1409 Identity:457/1409 - (32%)
Similarity:715/1409 - (50%) Gaps:216/1409 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 KRESN-PFIKANIISKWLFLWMHSVFRKGRREELDASKLYE---------HLPSFDSESLTRNLQ 64
            |.||: |...|:.|::..|.|...:...|.::.|:...|::         .:|||     .:||:
 Worm   202 KSESSCPEYTASFINRLTFQWFTGLAYLGNKKSLENEDLWDLNEIDKAENLIPSF-----MQNLK 261

  Fly    65 PHWEKESK-----------KKNPSLMRLIFKVYGW---------------QFVPVCILYSLLEMA 103
            |..::..:           |.:||.:..|||.|.:               ||:...:|..|:...
 Worm   262 PRIDEYHQNIKKDPSAALPKNHPSFVIPIFKTYKYTLLAGFFYKLCFDMLQFLAPQLLKQLIGFI 326

  Fly   104 IHSFQPLLLGGLISYFAYGQTTVTKESAYLYAMGIV-LCSLVTSLVFHPFMFYVFAVGTRVRLAC 167
            ....||:.:|..|                   :||: ..|.:.|:..|.:...:|.:|..||...
 Worm   327 EDKNQPVWIGCSI-------------------VGIMFFSSFLQSMFLHQYYHSMFRLGMHVRSVL 372

  Fly   168 AGLVYRKCLRAS--ASSGEGLGGQAISVMSIDLSQF-DL--TFYFFHDLWKGPVEACIFGYLMTR 227
            ...||.|.|..|  |..|:.:|. .:::||:|:.:. |:  |...|   |..|::..:..|.:.:
 Worm   373 TSAVYSKALNLSNEARKGKTIGA-IVNLMSVDIQKIQDMAPTIMLF---WSAPLQIFLSIYFLWK 433

  Fly   228 QVGWTSLIGIAFIVILIPLQAWAAKASASFGTRSAKHRDARVKLMNEIIGAIQVIKMYAWEKSFG 292
            .:|..:|.|:..:::.:|:....|.......|...|.:|.|:|:|:||:..::|:|:|:||:|..
 Worm   434 FLGVAALAGLVVLILALPVNGLIAIQMRKCQTEQMKLKDERIKMMSEILNGMKVLKLYSWERSME 498

  Fly   293 RLIAAVRQSEVKAIRGSMSIYAALQ----CTNMISKISLFLSLVAYVYV---GDLVTAKKVFILS 350
            .::..:|:.|:..::......||:.    |...::.:   :|.|.|||:   .:::|.:..|:..
 Worm   499 NMVLKIRERELHILKKLSYFMAAIVFSWICAPFLASV---ISFVVYVYLDPENNVLTPEITFVAL 560

  Fly   351 SYYGLLNDSLLHYWPMAITTW-----AQTLVSARRVVEFLLQVEKPTEESCCRDNPGLELDAEKP 410
            |.:.:|.      .|:|:...     .|..||..|:.||....|...:.|....    |.|:   
 Worm   561 SLFDILR------MPLAMVAMVYGEAVQCSVSNTRLKEFFAAEEMSPQTSISHG----ETDS--- 612

  Fly   411 KPAQSGRLHCVQSETKCLSFRKVSASWDKPSIKQPRKPHIEGISFHINAGQFVGIVGNVGSGKST 475
                     .::.|....|:    :|.:.|::::        |||.|..||.|.|||.||||||:
 Worm   613 ---------AIEVENGLFSW----SSDEDPTLRE--------ISFKIQKGQLVAIVGKVGSGKSS 656

  Fly   476 LLHAILGEIELMQGRVEVHGRISYAAQQPWVFQGSIRENILFVEQYEEKRYRAVVHACQLDRDLE 540
            ||||:|||:..:.|.|:::|.|:|..||.|:...|:|.||||.:.|:.:.|..||..|.|..||.
 Worm   657 LLHALLGEMNKLSGSVQINGNIAYVPQQAWIQNMSLRNNILFNKPYDLENYEDVVKNCALKEDLA 721

  Fly   541 LLPRGDATVVGERGISLSGGQKARIALARAVYRQADIYLFDDPLAAVDAQVGKLLMDKCFHR--- 602
            .||.||.|.:||:||:||||||.|::||||||:..||.|.||||:|||:.|||.:.:.....   
 Worm   722 NLPAGDRTEIGEKGINLSGGQKQRVSLARAVYQNPDIILLDDPLSAVDSHVGKHIFENVISSSTG 786

  Fly   603 LLDGKMRILVTHHVQLLKSVDQLLLLEGGKLTQQGSYEELKDVITHHAA----LDLEAIEADK-- 661
            .|..|.|:||||.:..||..|||::|:.|.:::.|:|:||   :.:..|    |:...||..|  
 Worm   787 CLASKTRVLVTHGLTYLKHCDQLIVLKEGTISELGTYQEL---LNNSGAFAEFLEEFLIEESKTR 848

  Fly   662 -------------QQVKRVLSQV-----DRTSKQLSKGEEKD----------------------P 686
                         .::.|.|.||     .|....||:..:|:                      |
 Worm   849 GRVASIGDGSGEVDEILRDLGQVKPGILKRLESHLSQESDKEDTSARAIEYSRDSSRRSVLLHSP 913

  Fly   687 ATIQDENG----------NAEQQLQ---------GAVSYDTYKAYFRALGAPFLVCLVLSMFVLA 732
            .:..:||.          .|::..|         |.|.::.|.|||:|:..| :..|...::|.:
 Worm   914 RSQHEENEALLGAISEDVPAQENTQLIEKETVETGKVKFEVYIAYFQAISIP-ITLLFFFLYVGS 977

  Fly   733 RGCQAVMDIFISRWATWEEDRGYDSVDDYEATRTKMVIW-YTVL----LLLTLALFLLRTFGFFF 792
            .|...:.:.::::.:...:.....|.|      .||.:. |.||    ..:.|...::.|.|   
 Worm   978 SGLGILSNFYLAKLSDHAKSGNRTSSD------AKMELGIYAVLGMGQSFVVLIASIILTIG--- 1033

  Fly   793 MCLRISLTLHDQLYHGIIRAWMYFFNANPSGRVLNRFSSDIQNVDVNLPQAMMDSLQFLVDVVAV 857
             .||.|..||..|...|:|:.|.||:..|.||:|||...||:.:|..||..:......:.:|||.
 Worm  1034 -VLRASRILHAGLLGNIMRSPMAFFDVTPIGRILNRIGKDIEAIDRTLPDVIRHMSMTIFNVVAT 1097

  Fly   858 LVIVAIANYWLLIPAAIMVILLYFCRALYIGASRSLKRIESLTRSPIYSHTNQTFHGHSTIRSMD 922
            ||::..|..|..|..||:.::.:.....||..||.|||:||.:|||||||..::..|.|:||:..
 Worm  1098 LVVIMWATPWAGIAFAILSVIYFIVLRFYISTSRQLKRLESASRSPIYSHFQESIQGASSIRAFG 1162

  Fly   923 AMPQLEQTFHGHQNTNSSALFLYVSANRAFSFWTDLICVIYILAVTFSFLVINQS--FYSGDVGL 985
            .:....:......:.:..|.:..:.|||..:...:::..:.:|:...:.:....|  ..:|.|||
 Worm  1163 VVDNFIKQSQQRVDDHLIAYYPSIVANRWLAVRLEMVGNLIVLSAAGAAVYFRDSPGLSAGLVGL 1227

  Fly   986 AITQSMTLVIMCQWGMRQTAEMENNMTSVERVLEYAQTPSEPPLESPKSVNLAAE-WPQAGHLRF 1049
            :::.::.:.....|.:|.|:|:|.|:.||||:.||..||:    |...|..|||: ||:.|.:..
 Worm  1228 SVSYALNITQTLNWAVRMTSELETNIVSVERIKEYTVTPT----EGNNSRRLAAKSWPEKGEISI 1288

  Fly  1050 QDLRMRYSPGDEDILRGLNFESQPMEKIGIVGRTGAGKSSIIQALFR-LALNEGTIEIDGLDIGK 1113
            ::..:||.||.:.:|.|::....|.||:||||||||||||:..|||| :..:.|:|||||::|..
 Worm  1289 KNFSVRYRPGLDLVLHGISAHIAPSEKVGIVGRTGAGKSSLTLALFRIIEADGGSIEIDGINIAN 1353

  Fly  1114 LGLHDLRSRISIIPQDPVLFSGTLRFNLDPFDEKSDESLWSALDDVKLKKHVASLEGGLSCRMQD 1178
            |.|..|||.::|:||||||||||::.|||||...||..:|.||::..||..|.||:.||..::.:
 Worm  1354 LQLEQLRSCLTIVPQDPVLFSGTMKMNLDPFSAYSDSQVWEALENAHLKPFVKSLQDGLEHKISE 1418

  Fly  1179 GGSNFSMGQRQLVCLARAILRQNRVLVMDEATANVDTETDILIQETIQTKFAECTVLTIAHRLHT 1243
            ||.|.|:|||||:|||||:||:.:|||:|||.|.||.|||.|||:||:.:|.|||||||||||:|
 Worm  1419 GGENLSVGQRQLICLARALLRKTKVLVLDEAAAAVDVETDSLIQKTIREQFKECTVLTIAHRLNT 1483

  Fly  1244 VMDNDSVLVMDAGQIVEFGAPHKLLQRKDGALLKLVNQNDATTV 1287
            |||:|.:||:|.|::.||.:|..||...||....:.  .||..|
 Worm  1484 VMDSDRLLVLDKGRVAEFDSPKNLLANPDGIFYSMA--KDANVV 1525

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10505NP_611571.2 CFTR_protein 12..1268 CDD:273530 449/1386 (32%)
ABC_membrane 95..360 CDD:294371 65/277 (23%)
ABCC_MRP_domain1 428..632 CDD:213217 96/206 (47%)
ABC_membrane 728..994 CDD:294371 74/272 (27%)
ABCC_MRP_domain2 1045..1264 CDD:213211 122/219 (56%)
mrp-2NP_508121.1 MRP_assoc_pro 25..1522 CDD:188098 454/1404 (32%)
ABC_membrane 309..570 CDD:294371 67/292 (23%)
ABCC_MRP_domain1 614..816 CDD:213217 97/213 (46%)
ABC_membrane 971..1239 CDD:279056 74/277 (27%)
ABCC_MRP_domain2 1284..1504 CDD:213211 122/219 (56%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51855
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.730

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