DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10505 and mrp-7

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_507812.3	Gene:	mrp-7 / 180289	WormBaseID:	WBGene00003413	Length:	1525	Species:	Caenorhabditis elegans

Alignment Length:	1373	Identity:	445/1373 - (32%)
Similarity:	726/1373 - (52%)	Gaps:	153/1373 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KQSSPKRESNPFIKANIISKWLFLWMHSVFRKGRREELDASKLYEHLPSFDSESLTRNLQPHWE- 68
            :::|.|..::|.::::.:::....|.:|:...|.|.:|:...::|......:|.|:...:..||
Worm   198 EKASSKSAASPELQSSFLNRLTLWWFNSIPWTGARRDLEIDDIFELNERSGTEFLSELWESFWEP 262

  Fly    69 KESK---------KKN-----------PSLMRLIFKVYGWQFVPVCILYSLLEMAIHSFQ---PL 110
            |..|         ||:           ||::..:|.::.|:|    :|.|.|:....:.|   |.
Worm   263 KRLKYIHDTSIWAKKDPSEQEKDPVVIPSVVSSLFMMFRWEF----LLASTLKFVSDTMQFASPF 323

  Fly   111 LLGGLISYFAYGQTTVTKESAYLY---AMGIVLCSL--VTSLVFHPFMFYVFAVGTRVRLACAGL 170
            ||..|:::       ::.::|..:   |:.|::.|:  :.||:.:.:.:.:|.:||:::.:....
Worm   324 LLHELLNF-------ISAKNAPFWKGMALSILMFSVSELRSLILNGYFYIMFRMGTKIQTSLTAA 381

  Fly   171 VYRKCLRASASS-GEGLGGQAISVMSIDLSQFDLTFYFFHDLWKGPVE---ACIFGYLMTRQVGW 231
            ||:|.|..|.|: .:...|:.:::|:||:.:|.:........|..|.:   |.::.::   .:|:
Worm   382 VYKKTLLISNSARRDRTVGEIVNLMAIDVERFQMITPQIQQFWSCPYQITFALVYLFI---TLGY 443

  Fly   232 TSLIGIAFIVILIPLQAWAAKASASFGTRSAKHRDARVKLMNEIIGAIQVIKMYAWEKSFGRLIA 296
            ::|.|:..:||.:|:...::.....:.....|.:|.|.|::||::..|:|:|:||||......|.
Worm   444 SALPGVVIMVIFVPMNIISSMIVRKWQIEQMKLKDERTKMVNEVLNGIKVVKLYAWEVPMEAYID 508

  Fly   297 AVRQSEVKAIRGSMSIYAALQCTNMISKISLFLSLVAYVYVGDLVTAKKVFILSSYYGLLNDSLL 361
            .:|..|:..|:.|..:...|...|..|..     |||....|..|.:....:|:.....::.:|.
Worm   509 EIRTKELALIKKSAMVRNILDSFNTASPF-----LVALFSFGTFVLSNPSHLLTPQIAFVSLALF 568

  Fly   362 HYW--PMA-----ITTWAQTLVSARRVVEFLLQVEKPTEESCCRDNPGLELDAEKPKPAQSGRLH 419
            :..  ||.     |....|.:||.:|:.|||  |.:..:|.|...:..:|            |.|
Worm   569 NQLRSPMTMIALLINQAVQAVVSNKRLKEFL--VAEELDEKCVDRSVNIE------------RSH 619

  Fly   420 CVQSETKCLSFRKVSASWDKPSIKQPRKPHIEGISFHINAGQFVGIVGNVGSGKSTLLHAILGEI 484
                  ..:....::|||| |......|. ::.:.........:.:||.||||||:||.|:|||:
Worm   620 ------NAVRVENLTASWD-PEEAAGEKT-LQDVDLTAPRNSLIAVVGKVGSGKSSLLQALLGEM 676

  Fly   485 ELMQGRVEVHGRISYAAQQPWVFQGSIRENILFVEQYEEKRYRAVVHACQLDRDLELLPRGDATV 549
            ..::||:.|:||::|..||||:...::|:||.|...::.|||..|::||.|..|:::||.||.|.
Worm   677 GKLRGRIGVNGRVAYVPQQPWIQNMTLRDNITFGRPFDRKRYDQVLYACALKADIKILPAGDQTE 741

  Fly   550 VGERGISLSGGQKARIALARAVYRQADIYLFDDPLAAVDAQVGKLLMDKCF--HRLLDGKMRILV 612
            :||:||:||||||||::||||||:..|:||.||||:||||.||:.:.:|..  :.||..|.||||
Worm   742 IGEKGINLSGGQKARVSLARAVYQNLDVYLLDDPLSAVDAHVGRHIFEKVIGPNGLLREKTRILV 806

  Fly   613 THHVQLLKSVDQLLLLEGGKLTQQGSYEEL-------KDVITHHAA-------------LDLEAI 657
            ||.:...|..|::|::..||:.:.|::|.|       .|.:..:.:             .|.|||
Worm   807 THGLTYTKMADEILVMLEGKIEESGTFEHLIKRRGLFFDFMEEYKSGSDNSSEAGGSQDDDFEAI 871

  Fly   658 EADKQQ-------VKRVLSQVDRT------SKQLS--KGEEKDP------ATIQDENGNAEQQ-- 699
            ..:.|.       |..|.:.:|.|      :.|:|  ...||.|      |..:.:|...:::
Worm   872 GGEIQDYMNPEDVVLTVTNDLDETIRTPELTTQISTMSSPEKPPTGTSPAAATESQNKLIKKEGI 936

  Fly   700 LQGAVSYDTYKAYFRALGAPFLVCLV-LSMFVLARGCQAVMDIFISRWATWEEDRGYDSVDDYEA 763
            .||.|...||:.|.:|.|  :|:.:. :..|::....|.:...::|   .|.::...||...:..
Worm   937 AQGKVEIATYQLYVKAAG--YLLSIAFIGFFIVYMTLQILRSFWLS---AWSDEYDPDSPSAHPM 996

  Fly   764 TRTKMVIWYTVLLLLTLALFLLRTFGFFFMCLRISLTLHDQLYHGIIRAWMYFFNANPSGRVLNR 828
            .:...:..|..|.....|.|.:......|:..|.|..||..|.|.::|:.|.|::..|.||:|||
Worm   997 AKGWRLGVYGALGFSETACFFVALLALVFVGQRASKNLHGPLIHNLMRSPMSFYDTTPLGRILNR 1061

  Fly   829 FSSDIQNVDVNLPQAMMDSLQFLVDVVAVLVIVAIAN---YWLLIPAAIMVILLYFCRALYIGAS 890
            .:.||:.:|:.||......:..::.|...|:::.|:.   ..:::|.|:  |.|.|.| .|:..|
Worm  1062 CAKDIETIDMMLPMNFRYLVMCVLQVAFTLIVIIISTPLFAVVILPLAL--IYLIFLR-YYVPTS 1123

  Fly   891 RSLKRIESLTRSPIYSHTNQTFHGHSTIRSMDAMPQLEQTFHGHQNTNSSALFLYVSANRAFSFW 955
            |.|||:||:.|||||||..:|..|.::||:...:.:..|......:|.....:..:.:||..:..
Worm  1124 RQLKRLESVHRSPIYSHFGETIQGAASIRAFGKVDEFRQDSGRILDTFIRCRYSSLVSNRWLAVR 1188

  Fly   956 TDLI--CVIYILAVTFSFLVINQSF----YSGDVGLAITQSMTLVIMCQWGMRQTAEMENNMTSV 1014
            .:.:  |:|:..|:   |.|:::.|    ..|.:|::::.::.:..:..:.:||.:|:|.|:.||
Worm  1189 LEFVGNCIIFFAAL---FAVLSKEFGWITSPGVIGVSVSYALNITEVLNFAVRQVSEIEANIVSV 1250

  Fly  1015 ERVLEYAQTPSEPP--LESPKSVNLAAEWPQAGHLRFQDLRMRYSPGDEDILRGLNFESQPMEKI 1077
            |||.||..||:|.|  :|..:.   |..||..|.::|.....||..|.:.:|..::.:....|||
Worm  1251 ERVNEYTNTPNEAPWRIEGREP---APGWPSRGVVKFDGYSTRYREGLDLVLHDISADVAAGEKI 1312

  Fly  1078 GIVGRTGAGKSSIIQALFR-LALNEGTIEIDGLDIGKLGLHDLRSRISIIPQDPVLFSGTLRFNL 1141
            ||||||||||||...|||| :....|.|.||.:::.::|||||||.|:|||||||||||||||||
Worm  1313 GIVGRTGAGKSSFALALFRMIEAAGGRIVIDDVEVSQIGLHDLRSNITIIPQDPVLFSGTLRFNL 1377

  Fly  1142 DPFDEKSDESLWSALDDVKLKKHVASLEGGLSCRMQDGGSNFSMGQRQLVCLARAILRQNRVLVM 1206
            |||...||:.:|.||:...||...|.|..||..::.:.|.|.|:||||||.||||:||..||||:
Worm  1378 DPFFTYSDDQIWRALELAHLKHFAAGLPDGLLYKISEAGENLSVGQRQLVALARALLRHTRVLVL 1442

  Fly  1207 DEATANVDTETDILIQETIQTKFAECTVLTIAHRLHTVMDNDSVLVMDAGQIVEFGAPHKLLQRK 1271
            |||||.||..||.||||||:.:|.||||.||||||:|:||.|.::|:|.|.|:||..|..|:..|
Worm  1443 DEATAAVDVATDALIQETIREEFKECTVFTIAHRLNTIMDYDRIMVLDKGSILEFDTPDALMADK 1507

  Fly  1272 DGALLKLV 1279
            :.|..|:|
Worm  1508 NSAFAKMV 1515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	438/1353 (32%)
		ABC_membrane	95..360	CDD:294371	64/276 (23%)
		ABCC_MRP_domain1	428..632	CDD:213217	91/205 (44%)
		ABC_membrane	728..994	CDD:294371	71/274 (26%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	123/219 (56%)
mrp-7	NP_507812.3	MRP_assoc_pro	14..1518	CDD:188098	445/1373 (32%)
		ABC_membrane	310..575	CDD:294371	63/279 (23%)
		ABCC_MRP_domain1	622..826	CDD:213217	91/205 (44%)
		ABC_membrane	976..1227	CDD:279056	69/259 (27%)
		ABCC_MRP_domain2	1280..1500	CDD:213211	123/219 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.730