DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10505 and haf-3

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_506927.2	Gene:	haf-3 / 180056	WormBaseID:	WBGene00001813	Length:	666	Species:	Caenorhabditis elegans

Alignment Length:	690	Identity:	151/690 - (21%)
Similarity:	280/690 - (40%)	Gaps:	150/690 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   661 KQQVKRV-LSQVDRTSKQLSKGEEKDPATIQDENGNAEQQLQGAVSYDTYKAYFRALGAPFLVCL 724
            ||..:.| :.:..|.|.:|.....||...|....|..:.::...:|:         ||      :
Worm    47 KQAFRNVSVVETKRESYKLKNASWKDLKAILSLAGPYKWRIMLGISF---------LG------I 96

  Fly   725 VLSMFVLARGCQAVMDIFISRWATWEEDRGYDSVDDYEATRTKMVIWYTVLLLLTLALFLLRTF- 788
            ..|:|:..   ..|:...|..|...::|: .|..|.                    ||.|.|.|
Worm    97 SSSIFLFT---PRVLGKLIDEWDETKQDK-MDPNDK--------------------ALLLARFFK 137

  Fly   789 -------GFFFM----------CLRIS--LTLHD---QLYHGIIRAWMYFFNANPSGRVLNRFSS 831
                   |.|.:          |:..:  |.::|   .:::.::|..|.||:.|..|.:::|.|:
Worm   138 ENPIALAGVFMLGAIAIAARIYCMHTAGQLVINDLRKSVFNSVLRQDMAFFDKNKVGEIVSRLST 202

  Fly   832 DIQNVDVNLPQAMMDSLQFLVDVV---AVLVIVAIAN---YWLLIPAAIMVILLYFCRALYIGAS 890
            |...|..::...:.|..:.|:...   .::|..::|.   .::::|..:....::
Worm   203 DALIVGYSVSMNLSDGARALITCFGSGGLMVYTSLAMCKVIFVVVPVIVGTFAVF---------- 257

  Fly   891 RSLKRIESLTRSPIYSHTNQTFHGH-STIRSMDAMPQLEQTFHGHQNTNSSALFLYVSANRAFSF 954
            ..|:|..:|......:..||..... |::|::.                     :.|:..:..:.
Worm   258 GKLQRKYTLMMQEAVAGANQVATERLSSVRTVR---------------------MLVAERKELAA 301

  Fly   955 WTDLICVIYI------LAVTFSF--------LVINQ-SFYSGDVGLAITQSM----TLVIMCQWG 1000
            ::|.|..|:.      ||..|.|        |.::. .||..::   |:|.:    .|...|.:.
Worm   302 YSDKINEIWQISKKEGLAKGFMFGSFQFTGYLALSSILFYGSNL---ISQGLLTYGELSSFCLYA 363

  Fly  1001 MRQTA----------EMENNMTSVERVLEYAQTPSEPPLESPKSVNLAAEWPQAGHLRFQDLRMR 1055
            :....          |:...:.:..|:.|........|||....:....:     .:||:.:...
Worm   364 VLSAGSLSAMSGFYLELMKGLGASSRLFELKNREPRIPLEGGVQIGNVKD-----TIRFEHVAFG 423

  Fly  1056 YSPGDEDILRGLNFESQPMEKI-GIVGRTGAGKSSIIQALFRL-ALNEGTIEIDGLDIGKLGLHD 1118
            |:..| .:...::|: .|..|| .:||.:|:|||:|...|.|| ....|.|.:||.|:..:....
Worm   424 YADRD-PLFHNISFD-VPAGKITAVVGSSGSGKSTIASLLLRLYDPTSGRILVDGTDLKDIDPSY 486

  Fly  1119 LRSRISIIPQDPVLFSGTLRFN-----LDPFDEKSDESLWSALDDVKLKKHVASLEGGLSCRMQD 1178
            .|..|..:.|:|||||.|::.|     |:| :..:|..:.||.|.....:.::........::.:
Worm   487 WRRHIGTVGQEPVLFSTTIKENIIYGSLEP-ENVTDAEIVSAADQSNADEFISRFPIKYDTKVGE 550

  Fly  1179 GGSNFSMGQRQLVCLARAILRQNRVLVMDEATANVDTETDILIQETIQTKFAEC--TVLTIAHRL 1241
            .||..|.||:|.:.:|||::.:..:|:|||||:.:|..::.|::..:....|..  ||:.|||||
Worm   551 HGSTLSGGQKQRIAIARALVNKPNILIMDEATSALDASSEYLVRIALNKLLANSKQTVMIIAHRL 615

  Fly  1242 HTVMDNDSVLVMDAGQIVEFGAPHKLLQRKDGALLKLVNQ 1281
            .|:...|.::|:|.|.:.|.|:..:|:...||...|||.:
Worm   616 STIKHADQIVVVDRGSVAESGSYDELIAIPDGIFRKLVEK 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	145/675 (21%)
		ABC_membrane	95..360	CDD:294371
		ABCC_MRP_domain1	428..632	CDD:213217
		ABC_membrane	728..994	CDD:294371	52/314 (17%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	71/227 (31%)
haf-3	NP_506927.2	MdlB	70..657	CDD:224055	145/667 (22%)
		ABC_membrane	96..366	CDD:279056	55/327 (17%)
		P-loop_NTPase	415..656	CDD:304359	77/244 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910