Protein Alignment CG10505 and pgp-1

DIOPT Version :9

• Sequence 1: NP_611571.2
• Gene: CG10505 / 37428
• FlyBaseID: FBgn0034612
• Length: 1312
• Species: Drosophila melanogaster
• Sequence 2: NP_502413.1
• Gene: pgp-1 / 178215
• WormBaseID: WBGene00003995
• Length: 1321
• Species: Caenorhabditis elegans
• Alignment Length: 1352
• Identity: 321/1352 - (23%)
• Similarity: 573/1352 - (42%)
• Gaps: 295/1352 - (21%)

  Fly    80 RLIFKVYGWQFVPVCILYSLLEM------AIHSFQPLLLGGLISYFAYGQTTVTKESAYLYAM-- 136
            :::....|..|:|....|:..:.      .:.|:..:.:|    .:|.||.|||   .|||..
 Worm   109 QIVINNNGSTFLPTGQNYTKTDFEHDVMNVVWSYAAMTVG----MWAAGQITVT---CYLYVAEQ 166

  Fly   137 --GIVLCSLVTSLVFHPFMFYVFAVGTRVRLACAGLVYRKCLRASASSGEGLGGQAISVMSID-L 198
              ..:....|.|::.....::    .|......|..::....|....:|:.:|      |:.. |
 Worm   167 MNNRLRREFVKSILRQEISWF----DTNHSGTLATKLFDNLERVKEGTGDKIG------MAFQYL 221

  Fly   199 SQFDLTFYFFHDLWKGPVEACIFGYLMTRQVGW-TSLIGIAFIVILIPLQAWA----AKASASFG 258
            |||                  |.|:::.....| .:|:.:|    :.|:||..    ||:.::|.
 Worm   222 SQF------------------ITGFIVAFTHSWQLTLVMLA----VTPIQALCGFAIAKSMSTFA 264

  Fly   259 TRSAKHRDARVKLMNEIIGAIQ-VIKMYAWEKSFGRLIAAVRQSEVKAIRGSMSI---YAALQCT 319
            .|.........|::.|.|.:|: |:.:........|...||.:::...:...:.:   :.|:|.:
 Worm   265 IRETLRYAKAGKVVEETISSIRTVVSLNGLRYELERYSTAVEEAKKAGVLKGLFLGISFGAMQAS 329

  Fly   320 NMISKISLFLSLVAYVYVGD------LVTAKKVFILSSYYGLLNDSLLHYWPMAITTWAQTLVSA 378
            |.||....|...|.:|:.|.      |.|...|.:.|...||....|      |:...||...|.
 Worm   330 NFISFALAFYIGVGWVHDGSLNFGDMLTTFSSVMMGSMALGLAGPQL------AVLGTAQGAASG 388

  Fly   379 RRVVEFLLQVEKPTEESCCRDNPGLELDAEKPKPAQSGRLHCVQSETKC---LSFRKVSASWDKP 440
              :.|.|  ..||..:|                .:::||     .:.|.   ::...|..::  |
 Worm   389 --IYEVL--DRKPVIDS----------------SSKAGR-----KDMKIKGDITVENVHFTY--P 426

  Fly   441 SIKQPRKPHIEGISFHINAGQFVGIVGNVGSGKSTLLHAILGEIELMQGRVEVHG---------- 495
            |  :|..|.:.|::..:||||.|.:||:.|.||||::..:|...::::|::.:.|
 Worm   427 S--RPDVPILRGMNLRVNAGQTVALVGSSGCGKSTIISLLLRYYDVLKGKITIDGVDVRDINLEF 489

  Fly   496 ---RISYAAQQPWVFQGSIRENILFVEQ---YEEKRYRAVVHACQL---DRDLELLPRGDATVVG 551
               .::..:|:|.:|..:|.|||...::   .||     :|.||::   ::.::.||.|..|:||
 Worm   490 LRKNVAVVSQEPALFNCTIEENISLGKEGITREE-----MVAACKMANAEKFIKTLPNGYNTLVG 549

  Fly   552 ERGISLSGGQKARIALARAVYRQADIYLFDDPLAAVDAQVGKLLMDKCFHRLLDGKMRILVTHHV 616
            :||..||||||.|||:|||:.|...|.|.|:..:|:||: .:.::.:...:...|:..|::.|.:
 Worm   550 DRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDAE-SEGIVQQALDKAAKGRTTIIIAHRL 613

  Fly   617 QLLKSVDQLLLLEGGK----------LTQQGSYEELKDVITHHAALD--LEAIEADKQQVKRVLS 669
            ..:::.|.::..:.|:          :.|||.|.:|....|...|:|  .|...:.:..|.|..|
 Worm   614 STIRNADLIISCKNGQVVEVGDHRALMAQQGLYYDLVTAQTFTDAVDSAAEGKFSRENSVARQTS 678

  Fly   670 QVDRTSKQLSKG---------------------EEKDPATIQDENGNAEQQLQ--GAVSYDTYKA 711
            :.:..|:|.|:.                     :||:....:|.....:|:|:  .|...:.::.
 Worm   679 EHEGLSRQASEMDDIMNRVRSSTIGSITNGPVIDEKEERIGKDALSRLKQELEENNAQKTNLFEI 743

  Fly   712 YFRALGAPFLVCLVLSMFVLARG----------CQAVMDIFISRWATWEEDRGYDSVDDYEATRT 766
            .:.|  .|..:.|.:.|.....|          ..:.|::|....|.: ..:|:
 Worm   744 LYHA--RPHALSLFIGMSTATIGGFIYPTYSVFFTSFMNVFAGNPADF-LSQGH----------- 794

  Fly   767 KMVIWYTVLLLLTLALFLLRTFGFFFMCLRI-SLT--LHDQLYHGIIRAWMYFFNA--NPSGRVL 826
               .|..:.|:|..|..:......|||.:.. |||  |.::|:..::...:.||::  |.||::.
 Worm   795 ---FWALMFLVLAAAQGICSFLMTFFMGIASESLTRDLRNKLFRNVLSQHIGFFDSPQNASGKIS 856

  Fly   827 NRFSSDIQNVDVNLPQAMMDSLQFLVDVVAVLVIVAIANYWL-LIPAAIMVILLYFCRALYIGAS 890
            .|.::|:.|:...:.......:..||.:||.:.:.....:.: |:..||:.|:.:   ..|:...
 Worm   857 TRLATDVPNLRTAIDFRFSTVITTLVSMVAGIGLAFFYGWQMALLIIAILPIVAF---GQYLRGR 918

  Fly   891 R-SLKRIESLTRSPIYSHTNQ-TFHGHSTIRSMDAMPQLEQTFH---------GHQNTNSSALFL 944
            | :.|.::|.:.   ::.:.: .......:|::.|:.: |.||:         .|:.....|...
 Worm   919 RFTGKNVKSASE---FADSGKIAIEAIENVRTVQALAR-EDTFYENFCEKLDIPHKEAIKEAFIQ 979

  Fly   945 YVSANRAFSFWTDLICVIYILAVTFSFLVINQSFYSGDVGLAITQSMTLVIMCQWGMRQTAEMEN 1009
            .:|...|.|       |:|:|         |...|...:.|.||...|:..|
 Worm   980 GLSYGCASS-------VLYLL---------NTCAYRMGLALIITDPPTMQPM------------- 1015

  Fly  1010 NMTSVERVLE--YAQTPSEPPL--------ESPK-------------------SVNLAAEWPQA- 1044
                  |||.  ||.|.|...|        |..|                   |::||.|..:.
 Worm  1016 ------RVLRVMYAITISTSTLGFATSYFPEYAKATFAGGIIFGMLRKISKIDSLSLAGEKKKLY 1074

  Fly  1045 GHLRFQDLRMRYSPGDE-DILRGLNFESQPMEKIGIVGRTGAGKSSIIQALFRL--ALNEGTIEI 1106
            |.:.|:::|..|....| :||:||:|..:|.:.:.:||.:|.|||:::..|.|.  .|. |.|.|
 Worm  1075 GKVIFKNVRFAYPERPEIEILKGLSFSVEPGQTLALVGPSGCGKSTVVALLERFYDTLG-GEIFI 1138

  Fly  1107 DGLDIGKLGLHDLRSRISIIPQDPVLFSGTLR----FNLDPFDEKSDESLWSALDDVKL---KKH 1164
            ||.:|..|.....||:|:|:.|:|.||..::.    :.|||    |..::....:..:|   ...
 Worm  1139 DGSEIKTLNPEHTRSQIAIVSQEPTLFDCSIAENIIYGLDP----SSVTMAQVEEAARLANIHNF 1199

  Fly  1165 VASLEGGLSCRMQDGGSNFSMGQRQLVCLARAILRQNRVLVMDEATANVDTETDILIQETIQTKF 1229
            :|.|..|...|:.|.|:..|.||:|.:.:|||::|..::|::||||:.:|||::.::||.:....
 Worm  1200 IAELPEGFETRVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEKVVQEALDRAR 1264

  Fly  1230 AECTVLTIAHRLHTVMDNDSVLVMDAGQIVEFGAPHKLLQRKDGALLKLVNQ 1281
            ...|.:.|||||:|||:.|.:.|:..|.|:|.|. |..|..:.||..||..:
 Worm  1265 EGRTCIVIAHRLNTVMNADCIAVVSNGTIIEKGT-HTQLMSEKGAYYKLTQK 1315

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	316/1337 (24%)
		ABC_membrane	95..360	CDD:294371	59/290 (20%)
		ABCC_MRP_domain1	428..632	CDD:213217	64/222 (29%)
		ABC_membrane	728..994	CDD:294371	57/292 (20%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	79/228 (35%)
pgp-1	NP_502413.1	PTZ00265	38..1311	CDD:240339	319/1346 (24%)
		ABC_membrane	81..367	CDD:279056	59/296 (20%)
		ABC_MTABC3_MDL1_MDL2	416..653	CDD:213216	70/246 (28%)
		ABC_membrane	760..1028	CDD:279056	63/324 (19%)
		ABC_MTABC3_MDL1_MDL2	1077..1316	CDD:213216	84/245 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000