DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10505 and haf-2

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_495537.2	Gene:	haf-2 / 174204	WormBaseID:	WBGene00001812	Length:	773	Species:	Caenorhabditis elegans

Alignment Length:	717	Identity:	165/717 - (23%)
Similarity:	303/717 - (42%)	Gaps:	119/717 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   603 LLDGKMRILVTHHVQLLKSVDQLLLLEGGKLTQQGSYEELKDVITHHAALDLEAIEADKQQVKRV 667
            :|.|.:::||.:.|......|               |..|.:....:|...:....|:..:....
Worm   128 ILSGFIQVLVWYFVFTSNPFD---------------YHRLLNTTAENAGTSVTETAAETVRDTET 177

  Fly   668 LSQVDRTSKQLSKGEEKDPATIQDENGNAEQQLQGAVSYDTYKAYFRALGAPFLVCLVLSMFVLA 732
            .|.|:..|....:..             ..:.|...:||..::..:.|.|..|     |:::.||
Worm   178 ASNVESGSSTAPRAP-------------LHKVLLRLLSYCGHQWPWFASGFVF-----LTVYALA 224

  Fly   733 RGCQAVMDIFISRWATWEEDRGYDSVDDYEATRTKMVIWYTVLLL----LTLALF-LLRTFGFFF 792
            |       :||..:..       ..:.|....|....:.:::::|    .|.:|| .||...|.:
Worm   225 R-------VFIPNYTA-------QVISDIVNKRGIQALIHSIIVLTCLTATSSLFGGLRGGCFDY 275

  Fly   793 MCLRISLTLHDQLYHGIIRAWMYFFNANPSGRVLNRFSSDIQ--------NVDVNLPQAMMDSLQ 849
            ....::|.:...|:..:||..:.|::...:|..::|.:||.|        ||:|.:...:|
Worm   276 ATALVTLRIRLDLFTSLIRQDIAFYDTAKTGDTMSRLTSDCQTISSTVSTNVNVFMRNGVM---- 336

  Fly   850 FLVDVVAVLVIVAIANYW-LLIPAAIMVILLYFCRALYIGASRSLKRIESLTRSPIYSHTNQTFH 913
             |:..:|.:::::    | |.:...|.|.|:.|....|   |....:|....:..| :.|||...
Worm   337 -LIGALAFMILMS----WRLAMVTFIAVPLVGFITKAY---SSFYDKISEKLQQTI-AETNQMAE 392

  Fly   914 G-HSTIRSMDAMPQLEQTFHGHQNTNSSALFLYVSANR----AFSF--WTDLICVIYILAVTFSF 971
            . .||:|::.:....::.....::..||.|    |.||    |:.|  |.:..|...||....
Worm   393 EVVSTMRTVRSFACEKKELKRFEDRLSSTL----SVNRKKSIAYLFYTWNNEFCDNAILVAVL-- 451

  Fly   972 LVINQSFYSGDVGLAITQSM---TLVIMCQWGMRQTAEMENNMTSVERVLEYAQTPSEPPLESPK 1033
                  ||.|.  |.:|..|   .|:....:.|    ::..|:..:..|:....   |....|.|
Worm   452 ------FYGGH--LVMTGKMEKEQLITFLLYQM----QLGENLYYLSYVMSGLM---EAVGASRK 501

  Fly  1034 SVNLAAEWPQ-----------AGHLRFQDLRMRY-SPGDEDILRGLNFESQPMEKIGIVGRTGAG 1086
            ..:|....||           .|::.|..:...| |..:..:|:.|....:..|.:.:||.:|.|
Worm   502 VFDLMNRKPQFELDGMQRPFVNGNITFSHVGFTYPSRPNNPVLKDLTLSIKSGETVALVGPSGGG 566

  Fly  1087 KSSIIQALFRL-ALNEGTIEIDGLDIGKLGLHDLRSRISIIPQDPVLFSGTLRFN-LDPFDEKSD 1149
            ||||:..:... ..:||::.:||:.|..:.......:::::.|:|||::|::|.| |...|..::
Worm   567 KSSIVSLIEHFYEPDEGSVTLDGVPIKDINHVYYHQKVALVAQEPVLYNGSVRHNILYGCDFATE 631

  Fly  1150 ESLWSALDDVKLKKHVASLEGGLSCRMQDGGSNFSMGQRQLVCLARAILRQNRVLVMDEATANVD 1214
            :.:.:|.....:...|..||.|......:.|...|.||:|.:.:|||::|...||::||||:.:|
Worm   632 DDMLNASKMANVHDFVMELEKGYDTNCGEKGVQMSGGQKQRIAIARALVRNPAVLILDEATSALD 696

  Fly  1215 TETDILIQETIQTKFAECTVLTIAHRLHTVMDNDSVLVMDAGQIVEFGAPHKLLQRKDGALLKLV 1279
            ||::.|:|:.:.....|.||:.:||||.|:...:.:.|:..|.:|:.|...:|:...||....||
Worm   697 TESEALVQQALSRCAQERTVIIVAHRLSTIEKANKIAVIVKGCLVQMGTHTELMTDTDGMYYSLV 761

  Fly  1280 NQ 1281
            ::
Worm   762 SR 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	160/702 (23%)
		ABC_membrane	95..360	CDD:294371
		ABCC_MRP_domain1	428..632	CDD:213217	6/28 (21%)
		ABC_membrane	728..994	CDD:294371	64/289 (22%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	66/221 (30%)
haf-2	NP_495537.2	3a01208	15..761	CDD:273363	163/713 (23%)
		ABC_membrane	215..478	CDD:279056	68/312 (22%)
		ABC_MTABC3_MDL1_MDL2	526..764	CDD:213216	70/238 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000