Protein Alignment CG10505 and haf-4

DIOPT Version :9

• Sequence 1: NP_611571.2
• Gene: CG10505 / 37428
• FlyBaseID: FBgn0034612
• Length: 1312
• Species: Drosophila melanogaster
• Sequence 2: NP_001021666.1
• Gene: haf-4 / 171639
• WormBaseID: WBGene00001814
• Length: 787
• Species: Caenorhabditis elegans
• Alignment Length: 573
• Identity: 145/573 - (25%)
• Similarity: 263/573 - (45%)
• Gaps: 103/573 - (17%)

  Fly   773 TVLLLLTLALFLLRTFGFFFMCLRISLTLHDQLYHGIIRAWMYFFNANPSGRVLNRFSSDIQ--- 834
            |::.|::......|...|.:...||...:...|:||:::..:.|::|:.:|.|.:|.::|.|
 Worm   227 TIISLVSAVAAGFRGGSFEYAYARIQRAIRYDLFHGLVKQDVAFYDAHKTGEVTSRLAADCQTMS 291

  Fly   835 -----NVDVNLPQAMM--DSLQFLVDVVAVLVIVAIANYWLLIPAAIMVILLYFCRALYIGASRS 892
                 ||:|.|...:|  .|:.|::.:           .|.|.....:::.:.|..:...|....
 Worm   292 DTVALNVNVFLRNCVMLLGSMIFMMKL-----------SWRLSLVTFILVPIIFVASKIFGTYYD 345

  Fly   893 LKRIESLTRSPIYSHTN---QTFHGHSTIRSMDAMPQLEQTFHGHQNTNSSALFLYVSANRAFSF 954
            |  :...|:..|....:   :......|:||..........|:| :.|::    |.|:..:|.::
 Worm   346 L--LSERTQDTIAESNDVAEEVLSTMRTVRSFSCENVEADRFYG-KLTHT----LDVTRTKAIAY 403

  Fly   955 WTDLICVIYILAVTFSFLVINQSFYSGDVGLAITQSMT-------LVIMCQWG--MRQTAEMENN 1010
                |..:::..:..||::::..:|.|.  |.:||.|.       |:...|.|  :||..|:...
 Worm   404 ----IGFLWVSELFQSFIIVSVLWYGGH--LVLTQKMKGDLLVSFLLYQMQLGDNLRQMGEVWTG 462

  Fly  1011 -MTSV---ERVLEYAQTPSEPPLE-----SPKSVNLAAEWPQAGHLRFQDLRMRY-SPGDEDILR 1065
             |.||   .:|.||..  .||.::     .|::|        .|.:.|:::...| :..|:.||:
 Worm   463 LMQSVGASRKVFEYID--REPQIQHNGEYMPENV--------VGKIEFRNVHFSYPTRSDQPILK 517

  Fly  1066 GLNFESQPMEKIGIVGRTGAGKSSIIQALFRLAL-NEGTIEIDGLDIGKLGLHDLRSRISIIPQD 1129
            .|:|..:|.|.:.:||.:|:||||.|..|....: |.|.:.:||:.:.:...|.:..:|:::.|:
 Worm   518 DLSFTVEPGETVALVGPSGSGKSSCISLLENFYVPNAGQVLVDGVPLEEFEHHYIHKKIALVGQE 582

  Fly  1130 PVLFSGTLRFNLDPFDEKSDESLWSALDDVKLKKHVASLEGGLSCRMQDG--------------- 1179
            ||||:.                  |.:::|:....||..|...||.|.:.
 Worm   583 PVLFAR------------------SVMENVRYGVEVADTEIIRSCEMANAHGFIMQTTLKYETNV 629

  Fly  1180 ---GSNFSMGQRQLVCLARAILRQNRVLVMDEATANVDTETDILIQETIQTKFAECTVLTIAHRL 1241
               |:..|.||:|.:.:|||::|:..:|::||||:.:|||::.|:||.|.......:|:.|||||
 Worm   630 GEKGTQMSGGQKQRIAIARALVREPAILLLDEATSALDTESEHLVQEAIYKNLDGKSVILIAHRL 694

  Fly  1242 HTVMDNDSVLVMDAGQIVEFGAPHKLLQRKDGALLKLVNQNDATTVKFLKRIA 1294
            .||...|.::|::.|::.:.|....||:..:|...|||.:......|..||.|
 Worm   695 STVEKADKIVVINKGRVEQIGNHETLLKDTNGTYAKLVQRQMMGDQKPRKRPA 747

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	135/545 (25%)
		ABC_membrane	95..360	CDD:294371
		ABCC_MRP_domain1	428..632	CDD:213217
		ABC_membrane	728..994	CDD:294371	48/240 (20%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	71/238 (30%)
haf-4	NP_001021666.1	3a01208	16..732	CDD:273363	139/556 (25%)
		ABC_membrane	189..449	CDD:279056	49/245 (20%)
		ABC_MTABC3_MDL1_MDL2	498..735	CDD:213216	76/254 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000