DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10505 and Abcc4

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	XP_038948894.1	Gene:	Abcc4 / 170924	RGDID:	620266	Length:	1382	Species:	Rattus norvegicus

Alignment Length:	1380	Identity:	524/1380 - (37%)
Similarity:	795/1380 - (57%)	Gaps:	122/1380 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 NPFIKANIISKWLFLWMHSVFRKGRREELDASKLYEHLPSFDSESLTRNLQPHWEKE---SKK-- 73
            ||...||:.|:..|.|::.:|:.|.:..|:...::..||...|:.|...||.:|:||   :||
  Rat    11 NPLQDANLCSRLFFWWLNPLFKAGHKRRLEEDDMFSVLPEDRSKHLGEELQGYWDKEVLRAKKDA 75

  Fly    74 KNPSLMRLIFKVYGWQFVPVCILYSLLEMAIHSFQPLLLGGLISYFAY--GQTTVTKESAYLYAM 136
            :.|||.:.|.|.| |:...:..:::|:|......||:.||.:|.||..  ...:....:||.||.
  Rat    76 RKPSLTKAIVKCY-WKSYLILGIFTLIEETTRVVQPIFLGKIIDYFEKYDSDDSAALHTAYGYAA 139

  Fly   137 GIVLCSLVTSLVFHPFMFYVFAVGTRVRLACAGLVYRKCLRASASS-GEGLGGQAISVMSIDLSQ 200
            .:.||:|:.:::.|.:.::|...|.|:|:|...::|||.||.|.|: |:...||.::::|.|:::
  Rat   140 VLSLCTLILAILHHLYFYHVQCAGMRIRVAMCHMIYRKALRLSNSAMGKTTTGQIVNLLSNDVNK 204

  Fly   201 FDLTFYFFHDLWKGPVEACIFGYLMTRQVGWTSLIGIAFIVILIPLQAWAAKASASFGTRSAKHR 265
            ||....|.|.||.||::|.....|:..::|.:.|.|:|.:|||:|||:...|..:|..:::|...
  Rat   205 FDQVTIFLHFLWAGPLQAIGVTILLWVEIGISCLAGLAILVILLPLQSCIGKLFSSLRSKTAAFT 269

  Fly   266 DARVKLMNEIIGAIQVIKMYAWEKSFGRLIAAVRQSEVKAIRGSMSIYAALQCTNMIS-----KI 325
            |||::.|||:|..:::||||||||||..||..:|:.|:..|.||    :.|:..||.|     |:
  Rat   270 DARIRTMNEVITGMRIIKMYAWEKSFADLITNLRKKEISKILGS----SYLRGMNMASFFIANKV 330

  Fly   326 SLFLSLVAYVYVGDLVTAKKVFILSSYYGLLNDSLLHYWPMAITTWAQTLVSARRVVEFLLQVEK 390
            .||::...||.:|:.:||..||:..:.||.:..::..::|.||...::.:||.||:..|||..|.
  Rat   331 ILFVTFTTYVLLGNKITASHVFVAMTLYGAVRLTVTLFFPSAIERVSEAVVSVRRIKNFLLLDEL 395

  Fly   391 PTEESCCRDNPGLELDAEKPKPAQSGRLHCVQSETKCLSFRKVSASWDKPSIKQPRKPHIEGISF 455
            |            |..|::|...::           .:..:..:|.|||..    ..|.::|:||
  Rat   396 P------------ERKAQEPSDGKA-----------IVHVQDFTAFWDKAL----DTPTLQGLSF 433

  Fly   456 HINAGQFVGIVGNVGSGKSTLLHAILGEIELMQGRVEVHGRISYAAQQPWVFQGSIRENILFVEQ 520
            ....|:.:.:||.||:|||:||.|:|||:....|.|.|||||:|.:||||||.|::|.||||..:
  Rat   434 TARPGELLAVVGPVGAGKSSLLSAVLGELPPTSGLVSVHGRIAYVSQQPWVFSGTVRSNILFGRK 498

  Fly   521 YEEKRYRAVVHACQLDRDLELLPRGDATVVGERGISLSGGQKARIALARAVYRQADIYLFDDPLA 585
            ||::||..|:.||.|.:||:||..||.||:|:||.:||||||||:.||||||:.|||||.||||:
  Rat   499 YEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGATLSGGQKARVNLARAVYQDADIYLLDDPLS 563

  Fly   586 AVDAQVGKLLMDKCFHRLLDGKMRILVTHHVQLLKSVDQLLLLEGGKLTQQGSYEE-LKDVITHH 649
            ||||:|||.|...|..:.|..|:.|||||.:|.||:...:|:|:.|::.|:|:|.| ||..:...
  Rat   564 AVDAEVGKHLFQLCICQTLHEKITILVTHQLQYLKAASHILILKDGEMVQKGTYTEFLKSGVDFG 628

  Fly   650 AALDLEAIEADKQQV-------KRVLSQVDRTSKQLSKGEEKD--PATIQDENGNA----EQQLQ 701
            :.|..|..||:...|       .|..|:....|:|.|:...||  |.....||..|    |.:.:
  Rat   629 SLLKKENEEAEPSPVPGTPTLRNRTFSEASIWSQQSSRPSLKDGVPDAQDAENTQAAQPEESRSE 693

  Fly   702 GAVSYDTYKAYFRALGAPFLVCLVLSMFVLARGCQAVMDIFISRWATWEEDRGYDSVDDYEATRT 766
            |.:.:..||.||.|..:.|.:..::.:.::.:....:.|.::|.||..:.........:...|.|
  Rat   694 GRIGFKAYKNYFSAGASWFFIIFLVLLNLMGQVFYVLQDWWLSHWANRQGALNDTKNANGNVTGT 758

  Fly   767 KMVIW----YTVLLLLTLALFLLRTFGFFFMCLRISLTLHDQLYHGIIRAWMYFFNANP------ 821
            ..:.|    ||.|..:|:...:.|:...|::.:..|.|||::::..|::|.:.||:.||
  Rat   759 LDLSWYLGIYTGLTAVTVLFGIARSLLVFYVLVNASQTLHNRMFESILKAPVLFFDRNPIELTQL 823

  Fly   822 ---------------------------------------------------SGRVLNRFSSDIQN 835
                                                               .||:|||||.||.:
  Rat   824 EVFRVVDGALDSHRHLSHPHPWPQNGSLQASVTSVTGSDVIRFPEVLLLALPGRILNRFSKDIGH 888

  Fly   836 VDVNLPQAMMDSLQFLVDVVAVLVIVAIANYWLLIPAAIMVILLYFCRALYIGASRSLKRIESLT 900
            :|..||...:|.:|.|:.||:|:.:.|....|:|||...:.|:....|..::..||.:||:||.|
  Rat   889 MDDLLPLTFLDFIQTLLLVVSVIAVAAAVIPWILIPLVPLSIIFVVLRRYFLETSRDVKRLESTT 953

  Fly   901 RSPIYSHTNQTFHGHSTIRSMDAMPQLEQTFHGHQNTNSSALFLYVSANRAFSFWTDLICVIYIL 965
            |||::||.:.:..|..|||:..|..:.::.|..||:.:|.|.||:::.:|.|:...|.||.::::
  Rat   954 RSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAVFVI 1018

  Fly   966 AVTFSFLVINQSFYSGDVGLAITQSMTLVIMCQWGMRQTAEMENNMTSVERVLEYAQTPSEPPLE 1030
            .|.|..||:.::..:|.||||::.|:||:.|.||.:||:||:||.|.|||||:||.....|.|.|
  Rat  1019 VVAFGSLVLAKTLDAGQVGLALSYSLTLMGMFQWSVRQSAEVENMMISVERVIEYTDLEKEAPWE 1083

  Fly  1031 SPKSVNLAAEWPQAGHLRFQDLRMRYSPGDEDILRGLNFESQPMEKIGIVGRTGAGKSSIIQALF 1095
            ..|  .....||..|.:.|.::...||.....:|:.|....:..||:||||||||||||:|.|||
  Rat  1084 CRK--RPPPGWPHEGVIVFDNVNFTYSLDGPLVLKHLTALIKSREKVGIVGRTGAGKSSLISALF 1146

  Fly  1096 RLALNEGTIEIDGLDIGKLGLHDLRSRISIIPQDPVLFSGTLRFNLDPFDEKSDESLWSALDDVK 1160
            ||:..||.|.||.:...::||||||.::|||||:||||:||:|.|||||:|.|||.||.||::|:
  Rat  1147 RLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHSDEELWKALEEVQ 1211

  Fly  1161 LKKHVASLEGGLSCRMQDGGSNFSMGQRQLVCLARAILRQNRVLVMDEATANVDTETDILIQETI 1225
            ||:.:..|.|.:...:.:.|||||:|||||||||||||::||:|::||||||||..||.|||:.|
  Rat  1212 LKEAIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILKKNRILIIDEATANVDPRTDELIQQKI 1276

  Fly  1226 QTKFAECTVLTIAHRLHTVMDNDSVLVMDAGQIVEFGAPHKLLQRKDGALLKLVNQNDATTVKFL 1290
            :.|||:||||||||||:|::|:|.::|:|:|::.|:..|:.|||..:....|:|.|........|
  Rat  1277 REKFAQCTVLTIAHRLNTIIDSDKIMVLDSGRLREYDEPYVLLQNPESLFYKMVQQLGKGEAAAL 1341

  Fly  1291 KRIASESYMRRNRRD 1305
            ...|.:.|.|||..|
  Rat  1342 TETAKQVYFRRNYPD 1356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	511/1341 (38%)
		ABC_membrane	95..360	CDD:294371	97/272 (36%)
		ABCC_MRP_domain1	428..632	CDD:213217	105/203 (52%)
		ABC_membrane	728..994	CDD:294371	88/326 (27%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	122/218 (56%)
Abcc4	XP_038948894.1	MRP_assoc_pro	6..1334	CDD:188098	517/1356 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345056
Domainoid	1	1.000	98	1.000	Domainoid score	I6989
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0001028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.760