Protein Alignment CG10505 and Abcc4

DIOPT Version :10

• Sequence 1: NP_611571.2
• Gene: CG10505 / 37428
• FlyBaseID: FBgn0034612
• Length: 1312
• Species: Drosophila melanogaster
• Sequence 2: XP_038948894.1
• Gene: Abcc4 / 170924
• RGDID: 620266
• Length: 1382
• Species: Rattus norvegicus
• Alignment Length: 1380
• Identity: 524/1380 - (37%)
• Similarity: 795/1380 - (57%)
• Gaps: 122/1380 - (8%)

  Fly    14 NPFIKANIISKWLFLWMHSVFRKGRREELDASKLYEHLPSFDSESLTRNLQPHWEKE---SKK-- 73
            ||...||:.|:..|.|::.:|:.|.:..|:...::..||...|:.|...||.:|:||   :||
  Rat    11 NPLQDANLCSRLFFWWLNPLFKAGHKRRLEEDDMFSVLPEDRSKHLGEELQGYWDKEVLRAKKDA 75

  Fly    74 KNPSLMRLIFKVYGWQFVPVCILYSLLEMAIHSFQPLLLGGLISYFAY--GQTTVTKESAYLYAM 136
            :.|||.:.|.|.| |:...:..:::|:|......||:.||.:|.||..  ...:....:||.||.
  Rat    76 RKPSLTKAIVKCY-WKSYLILGIFTLIEETTRVVQPIFLGKIIDYFEKYDSDDSAALHTAYGYAA 139

  Fly   137 GIVLCSLVTSLVFHPFMFYVFAVGTRVRLACAGLVYRKCLRASASS-GEGLGGQAISVMSIDLSQ 200
            .:.||:|:.:::.|.:.::|...|.|:|:|...::|||.||.|.|: |:...||.::::|.|:::
  Rat   140 VLSLCTLILAILHHLYFYHVQCAGMRIRVAMCHMIYRKALRLSNSAMGKTTTGQIVNLLSNDVNK 204

  Fly   201 FDLTFYFFHDLWKGPVEACIFGYLMTRQVGWTSLIGIAFIVILIPLQAWAAKASASFGTRSAKHR 265
            ||....|.|.||.||::|.....|:..::|.:.|.|:|.:|||:|||:...|..:|..:::|...
  Rat   205 FDQVTIFLHFLWAGPLQAIGVTILLWVEIGISCLAGLAILVILLPLQSCIGKLFSSLRSKTAAFT 269

  Fly   266 DARVKLMNEIIGAIQVIKMYAWEKSFGRLIAAVRQSEVKAIRGSMSIYAALQCTNMIS-----KI 325
            |||::.|||:|..:::||||||||||..||..:|:.|:..|.||    :.|:..||.|     |:
  Rat   270 DARIRTMNEVITGMRIIKMYAWEKSFADLITNLRKKEISKILGS----SYLRGMNMASFFIANKV 330

  Fly   326 SLFLSLVAYVYVGDLVTAKKVFILSSYYGLLNDSLLHYWPMAITTWAQTLVSARRVVEFLLQVEK 390
            .||::...||.:|:.:||..||:..:.||.:..::..::|.||...::.:||.||:..|||..|.
  Rat   331 ILFVTFTTYVLLGNKITASHVFVAMTLYGAVRLTVTLFFPSAIERVSEAVVSVRRIKNFLLLDEL 395

  Fly   391 PTEESCCRDNPGLELDAEKPKPAQSGRLHCVQSETKCLSFRKVSASWDKPSIKQPRKPHIEGISF 455
            |            |..|::|...::           .:..:..:|.|||..    ..|.::|:||
  Rat   396 P------------ERKAQEPSDGKA-----------IVHVQDFTAFWDKAL----DTPTLQGLSF 433

  Fly   456 HINAGQFVGIVGNVGSGKSTLLHAILGEIELMQGRVEVHGRISYAAQQPWVFQGSIRENILFVEQ 520
            ....|:.:.:||.||:|||:||.|:|||:....|.|.|||||:|.:||||||.|::|.||||..:
  Rat   434 TARPGELLAVVGPVGAGKSSLLSAVLGELPPTSGLVSVHGRIAYVSQQPWVFSGTVRSNILFGRK 498

  Fly   521 YEEKRYRAVVHACQLDRDLELLPRGDATVVGERGISLSGGQKARIALARAVYRQADIYLFDDPLA 585
            ||::||..|:.||.|.:||:||..||.||:|:||.:||||||||:.||||||:.|||||.||||:
  Rat   499 YEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGATLSGGQKARVNLARAVYQDADIYLLDDPLS 563

  Fly   586 AVDAQVGKLLMDKCFHRLLDGKMRILVTHHVQLLKSVDQLLLLEGGKLTQQGSYEE-LKDVITHH 649
            ||||:|||.|...|..:.|..|:.|||||.:|.||:...:|:|:.|::.|:|:|.| ||..:...
  Rat   564 AVDAEVGKHLFQLCICQTLHEKITILVTHQLQYLKAASHILILKDGEMVQKGTYTEFLKSGVDFG 628

  Fly   650 AALDLEAIEADKQQV-------KRVLSQVDRTSKQLSKGEEKD--PATIQDENGNA----EQQLQ 701
            :.|..|..||:...|       .|..|:....|:|.|:...||  |.....||..|    |.:.:
  Rat   629 SLLKKENEEAEPSPVPGTPTLRNRTFSEASIWSQQSSRPSLKDGVPDAQDAENTQAAQPEESRSE 693

  Fly   702 GAVSYDTYKAYFRALGAPFLVCLVLSMFVLARGCQAVMDIFISRWATWEEDRGYDSVDDYEATRT 766
            |.:.:..||.||.|..:.|.:..::.:.::.:....:.|.::|.||..:.........:...|.|
  Rat   694 GRIGFKAYKNYFSAGASWFFIIFLVLLNLMGQVFYVLQDWWLSHWANRQGALNDTKNANGNVTGT 758

  Fly   767 KMVIW----YTVLLLLTLALFLLRTFGFFFMCLRISLTLHDQLYHGIIRAWMYFFNANP------ 821
            ..:.|    ||.|..:|:...:.|:...|::.:..|.|||::::..|::|.:.||:.||
  Rat   759 LDLSWYLGIYTGLTAVTVLFGIARSLLVFYVLVNASQTLHNRMFESILKAPVLFFDRNPIELTQL 823

  Fly   822 ---------------------------------------------------SGRVLNRFSSDIQN 835
                                                               .||:|||||.||.:
  Rat   824 EVFRVVDGALDSHRHLSHPHPWPQNGSLQASVTSVTGSDVIRFPEVLLLALPGRILNRFSKDIGH 888

  Fly   836 VDVNLPQAMMDSLQFLVDVVAVLVIVAIANYWLLIPAAIMVILLYFCRALYIGASRSLKRIESLT 900
            :|..||...:|.:|.|:.||:|:.:.|....|:|||...:.|:....|..::..||.:||:||.|
  Rat   889 MDDLLPLTFLDFIQTLLLVVSVIAVAAAVIPWILIPLVPLSIIFVVLRRYFLETSRDVKRLESTT 953

  Fly   901 RSPIYSHTNQTFHGHSTIRSMDAMPQLEQTFHGHQNTNSSALFLYVSANRAFSFWTDLICVIYIL 965
            |||::||.:.:..|..|||:..|..:.::.|..||:.:|.|.||:::.:|.|:...|.||.::::
  Rat   954 RSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAVFVI 1018

  Fly   966 AVTFSFLVINQSFYSGDVGLAITQSMTLVIMCQWGMRQTAEMENNMTSVERVLEYAQTPSEPPLE 1030
            .|.|..||:.::..:|.||||::.|:||:.|.||.:||:||:||.|.|||||:||.....|.|.|
  Rat  1019 VVAFGSLVLAKTLDAGQVGLALSYSLTLMGMFQWSVRQSAEVENMMISVERVIEYTDLEKEAPWE 1083

  Fly  1031 SPKSVNLAAEWPQAGHLRFQDLRMRYSPGDEDILRGLNFESQPMEKIGIVGRTGAGKSSIIQALF 1095
            ..|  .....||..|.:.|.::...||.....:|:.|....:..||:||||||||||||:|.|||
  Rat  1084 CRK--RPPPGWPHEGVIVFDNVNFTYSLDGPLVLKHLTALIKSREKVGIVGRTGAGKSSLISALF 1146

  Fly  1096 RLALNEGTIEIDGLDIGKLGLHDLRSRISIIPQDPVLFSGTLRFNLDPFDEKSDESLWSALDDVK 1160
            ||:..||.|.||.:...::||||||.::|||||:||||:||:|.|||||:|.|||.||.||::|:
  Rat  1147 RLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHSDEELWKALEEVQ 1211

  Fly  1161 LKKHVASLEGGLSCRMQDGGSNFSMGQRQLVCLARAILRQNRVLVMDEATANVDTETDILIQETI 1225
            ||:.:..|.|.:...:.:.|||||:|||||||||||||::||:|::||||||||..||.|||:.|
  Rat  1212 LKEAIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILKKNRILIIDEATANVDPRTDELIQQKI 1276

  Fly  1226 QTKFAECTVLTIAHRLHTVMDNDSVLVMDAGQIVEFGAPHKLLQRKDGALLKLVNQNDATTVKFL 1290
            :.|||:||||||||||:|::|:|.::|:|:|::.|:..|:.|||..:....|:|.|........|
  Rat  1277 REKFAQCTVLTIAHRLNTIIDSDKIMVLDSGRLREYDEPYVLLQNPESLFYKMVQQLGKGEAAAL 1341

  Fly  1291 KRIASESYMRRNRRD 1305
            ...|.:.|.|||..|
  Rat  1342 TETAKQVYFRRNYPD 1356

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	MRP_assoc_pro	15..1271	CDD:188098	513/1343 (38%)
Abcc4	XP_038948894.1	MRP_assoc_pro	6..1334	CDD:188098	517/1356 (38%)