DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10505 and Cftr

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_066388.1	Gene:	Cftr / 12638	MGIID:	88388	Length:	1476	Species:	Mus musculus

Alignment Length:	1494	Identity:	401/1494 - (26%)
Similarity:	688/1494 - (46%)	Gaps:	256/1494 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ESNPFIKANIISKWLFLWMHSVFRKGRREELDASKLYEHLPSFDS-ESLTRNLQPHWEKE-SKKK 74
            :.:|..||:.|||..|.|...:.|||.|..|:.|.:|: .||.|| :.|:..|:..|::| :.||
Mouse     2 QKSPLEKASFISKLFFSWTTPILRKGYRHHLELSDIYQ-APSADSADHLSEKLEREWDREQASKK 65

  Fly    75 NPSLMRLIFKVYGWQFVPVCILYSLLEMAIHSFQPLLLGGLISYFAYGQTTVTKESAYLYAMGIV 139
            ||.|:..:.:.:.|:|:...||..|.|:. .:.||:|||.:|:  :|......:.|..:| :||.
Mouse    66 NPQLIHALRRCFFWRFLFYGILLYLGEVT-KAVQPVLLGRIIA--SYDPENKVERSIAIY-LGIG 126

  Fly   140 LCSL--VTSLVFHPFMFYVFAVGTRVRLACAGLVYRKCLRASASSGEGLG-GQAISVMSIDLSQF 201
            ||.|  |.:|:.||.:|.:..:|.::|.|...|:|:|.|:.|:...:.:. ||.:|::|.:|::|
Mouse   127 LCLLFIVRTLLLHPAIFGLHRIGMQMRTAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKF 191

  Fly   202 DLTFYFFHDLWKGPVEACIFGYLMTRQVGWTSLIGIAFIVILIPLQAWAAKASASFGTRSAKHRD 266
            |......|.:|..|::..:...|:...:.:::..|:..::||:..||...|....:..:.|...:
Mouse   192 DEGLALAHFIWIAPLQVTLLMGLLWDLLQFSAFCGLGLLIILVIFQAILGKMMVKYRDQRAAKIN 256

  Fly   267 ARVKLMNEIIGAIQVIKMYAWEKSFGRLIAAVRQSEVKAIRGSMSIYAALQCTNMISK-ISLFLS 330
            .|:.:.:|||..|..:|.|.||.:..::|..:|:.|:|..|.:..:..........|. ..:|||
Mouse   257 ERLVITSEIIDNIYSVKAYCWESAMEKMIENLREVELKMTRKAAYMRFFTSSAFFFSGFFVVFLS 321

  Fly   331 LVAYVYVGDLVTAKKVFILSSYYGLLNDSLLHYWPMAITTWAQTLVSARRVVEFLLQVE-KPTEE 394
            ::.|..:..:| .:|:|...|:..:|..|:...:|.|:..|..:....|::.:||.:.| |..|.
Mouse   322 VLPYTVINGIV-LRKIFTTISFCIVLRMSVTRQFPTAVQIWYDSFGMIRKIQDFLQKQEYKVLEY 385

  Fly   395 SCCRDNPGLELD-------------AEKPKPAQSGRLHCVQSETKCLSFRKVSASWDKPSIKQPR 446
            :..  ..|:.::             .||.:.:...|.|  .|:...:||..:....:
Mouse   386 NLM--TTGIIMENVTAFWEEGFGELLEKVQQSNGDRKH--SSDENNVSFSHLCLVGN-------- 438

  Fly   447 KPHIEGISFHINAGQFVGIVGNVGSGKSTLLHAILGEIELMQGRVEVHGRISYAAQQPWVFQGSI 511
             |.::.|:.:|..|:.:.|.|:.||||::||..||||:|..:|.::..||:|:.:|..|:..|:|
Mouse   439 -PVLKNINLNIEKGEMLAITGSTGSGKTSLLMLILGELEASEGIIKHSGRVSFCSQFSWIMPGTI 502

  Fly   512 RENILFVEQYEEKRYRAVVHACQLDRDLELLPRGDATVVGERGISLSGGQKARIALARAVYRQAD 576
            :|||:|...|:|.||::||.||||.:|:......|.||:||.|::|||||:|||:||||||:.||
Mouse   503 KENIIFGVSYDEYRYKSVVKACQLQQDITKFAEQDNTVLGEGGVTLSGGQRARISLARAVYKDAD 567

  Fly   577 IYLFDDPLAAVDAQVGKLLMDKCFHRLLDGKMRILVTHHVQLLKSVDQLLLLEGGKLTQQGSYEE 641
            :||.|.|...:|....:.:.:.|..:|:..|.|||||..::.|:..|::|:|..|.....|::.|
Mouse   568 LYLLDSPFGYLDVFTEEQVFESCVCKLMANKTRILVTSKMEHLRKADKILILHQGSSYFYGTFSE 632

  Fly   642 LKDV------------------------------------------------------------- 645
            |:.:
Mouse   633 LQSLRPDFSSKLMGYDTFDQFTEERRSSILTETLRRFSVDDSSAPWSKPKQSFRQTGEVGEKRKN 697

  Fly   646 -------------ITHHAALDLEAIEADKQQVKRV------------------------------ 667
                         |.....|.::. |:|..|.||:
Mouse   698 SILNSFSSVRKISIVQKTPLCIDG-ESDDLQEKRLSLVPDSEQGEAALPRSNMIATGPTFPGRRR 761

  Fly   668 -----------------------------------LSQVDRTSKQLSKGEEKDPATIQDENGNAE 697
                                               |::||..|::||    :|......|..|.|
Mouse   762 QSVLDLMTFTPNSGSSNLQRTRTSIRKISLVPQISLNEVDVYSRRLS----QDSTLNITEEINEE 822

  Fly   698 Q----------QLQGAVSYDTYKAYFRALGAPFLVCLVLSMFVLARGCQAVMDIFISRWATW--- 749
            .          ::....:::||..|| .|....|:.|:..:.|.      ::::..|.:..|
Mouse   823 DLKECFLDDVIKIPPVTTWNTYLRYF-TLHKGLLLVLIWCVLVF------LVEVAASLFVLWLLK 880

  Fly   750 -----EEDRGYD-SVDDYEATRTKMVIWYTVLLLL-----TLALFLLRTFGFFFMCLRISLTLHD 803
                 ..:.|.. |...|....|....:|...:.:     .|||.|.|........:..|..||.
Mouse   881 NNPVNSGNNGTKISNSSYVVIITSTSFYYIFYIYVGVADTLLALSLFRGLPLVHTLITASKILHR 945

  Fly   804 QLYHGIIRAWMYFFNANPSGRVLNRFSSDIQNVDVNLPQAMMDSLQFLVDVV-AVLVIVAIANYW 867
            ::.|.|:.|.|...:...:|.:|||||.||..:|..||..:.|.:|.:..|: |::|:.|:..|.
Mouse   946 KMLHSILHAPMSTISKLKAGGILNRFSKDIAILDDFLPLTIFDFIQLVFIVIGAIIVVSALQPYI 1010

  Fly   868 LL--IPAAIMVILLYFCRALYIGASRSLKRIESLTRSPIYSHTNQTFHGHSTIRSMDAMPQLEQT 930
            .|  :|..::.|||   ||.::..::.||::||..||||::|...:..|..|:|:.......|..
Mouse  1011 FLATVPGLVVFILL---RAYFLHTAQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFRRQTYFETL 1072

  Fly   931 FHGHQNTNSSALFLYVSANRAFSFWTDLICVIYILAVTF-SFLVINQSFYSGDVGLAITQSMTLV 994
            ||...|.:::..|:|::..|.|....|:|.|::.:.||| |.|...:.  .|..|:.:|.:|.::
Mouse  1073 FHKALNLHTANWFMYLATLRWFQMRIDMIFVLFFIVVTFISILTTGEG--EGTAGIILTLAMNIM 1135

  Fly   995 IMCQWGMRQTAEMENNMTSVERVLE----------YAQTPSEPPLESPKSVNLAAE--------W 1041
            ...||.:..:.:.::.|.||.||.:          |.|...|.|.|....|.:...        |
Mouse  1136 STLQWAVNSSIDTDSLMRSVSRVFKFIDIQTEESMYTQIIKELPREGSSDVLVIKNEHVKKSDIW 1200

  Fly  1042 PQAGHLRFQDLRMRYSPGDEDILRGLNFESQPMEKIGIVGRTGAGKSSIIQALFRLALNEGTIEI 1106
            |..|.:..:||.::|......:|..::|...|.:::|::||||:|||:::.|..|:...:|.|||
Mouse  1201 PSGGEMVVKDLTVKYMDDGNAVLENISFSISPGQRVGLLGRTGSGKSTLLSAFLRMLNIKGDIEI 1265

  Fly  1107 DGLDIGKLGLHDLRSRISIIPQDPVLFSGTLRFNLDPFDEKSDESLWSALDDVKLKKHVASLEGG 1171
            ||:....:.|.:.|....:|.|...:||||.|.||||..:..||.:|...|:|.||..:....|.
Mouse  1266 DGVSWNSVTLQEWRKAFGVITQKVFIFSGTFRQNLDPNGKWKDEEIWKVADEVGLKSVIEQFPGQ 1330

  Fly  1172 LSCRMQDGGSNFSMGQRQLVCLARAILRQNRVLVMDEATANVDTETDILIQETIQTKFAECTVLT 1236
            |:..:.|||...|.|.:||:||||::|.:.:::::||.:|::|..|..:|:..::..||.|||:.
Mouse  1331 LNFTLVDGGYVLSHGHKQLMCLARSVLSKAKIILLDEPSAHLDPITYQVIRRVLKQAFAGCTVIL 1395

  Fly  1237 IAHRLHTVMDNDSVLVMDAGQIVEFGAPHKLLQRKDGALLKLVNQNDATTVKFLKRIASESYMR 1300
            ..||:..::|....||::...:.::.:...||..|.               .|.:.|:|...||
Mouse  1396 CEHRIEAMLDCQRFLVIEESNVWQYDSLQALLSEKS---------------IFQQAISSSEKMR 1444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	393/1460 (27%)
		ABC_membrane	95..360	CDD:294371	73/268 (27%)
		ABCC_MRP_domain1	428..632	CDD:213217	81/203 (40%)
		ABC_membrane	728..994	CDD:294371	77/283 (27%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	73/218 (33%)
Cftr	NP_066388.1	CFTR_protein	1..1464	CDD:273530	401/1494 (27%)
		ABC_membrane	85..303	CDD:294371	63/221 (29%)
		ABCC_CFTR1	389..670	CDD:213258	91/291 (31%)
		CFTR_R	639..844	CDD:291094	17/209 (8%)
		Disordered R region. /evidence=ECO:0000250\|UniProtKB:P13569	654..826		17/176 (10%)
		ABC_membrane	861..1142	CDD:279056	79/291 (27%)
		ABCC_CFTR2	1204..1464	CDD:213256	81/256 (32%)
		Interaction with GORASP2. /evidence=ECO:0000250\|UniProtKB:P13569	1382..1476		18/78 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1446..1476
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:P13569	1474..1476
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841714
Domainoid	1	1.000	58	1.000	Domainoid score	I10724
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.850