Protein Alignment CG10505 and ABCC2

DIOPT Version :10

• Sequence 1: NP_611571.2
• Gene: CG10505 / 37428
• FlyBaseID: FBgn0034612
• Length: 1312
• Species: Drosophila melanogaster
• Sequence 2: NP_000383.2
• Gene: ABCC2 / 1244
• HGNCID: 53
• Length: 1545
• Species: Homo sapiens
• Alignment Length: 1400
• Identity: 472/1400 - (33%)
• Similarity: 739/1400 - (52%)
• Gaps: 199/1400 - (14%)

  Fly     8 SPKRES--NPFIKANIISKWLFLWMHSVFRKGRREELDASKLYEHLPSFDSESLTRNLQPHWEKE 70
            |...||  ||...|:.:|...:.|..|:..||.:..|....::|......:::|....:.|.::|
Human   185 SENNESSNNPSSIASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMKTKTLVSKFETHMKRE 249

  Fly    71 -------------------------------------------SKKKNPS----------LMRLI 82
                                                       .|||..|          ||:.:
Human   250 LQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKSGTKKDVPKSWLMKAL 314

  Fly    83 FKVYGWQFVPVCILYSLLEMA--IHSF-QPLLLGGLISYFAYGQTTVTKESAYLYAMGIVLCSLV 144
            ||.    |..|.:...||::.  |.:| .|.||..|||:.:...|.:.  ..||.|:.:...:|:
Human   315 FKT----FYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFASDRDTYLW--IGYLCAILLFTAALI 373

  Fly   145 TSLVFHPFMFYVFAVGTRVRLACAGLVYRKCLRAS-ASSGEGLGGQAISVMSIDLSQ-FDLTFYF 207
            .|.....:....|.:|.:||.|....||:|.|..| .:..|...|:.:::||:|..: .|:| .|
Human   374 QSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGETVNLMSVDAQKLMDVT-NF 437

  Fly   208 FHDLWKGPVEACIFGYLMTRQVGWTSLIGIAFIVILIPLQAWAAKASASFGTRSAKHRDARVKLM 272
            .|.||...::..:..:.:.|::|.:.|.|:..:|::||:.|..:..|.:...::.|::|.|:|:|
Human   438 MHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKTIQVKNMKNKDKRLKIM 502

  Fly   273 NEIIGAIQVIKMYAWEKSFGRLIAAVRQSEVKAIRGSMSIYAALQCT--NMISKISLFLSLVAY- 334
            |||:..|:::|.:|||.||...:..:|:.|:|    ::..::.|||.  .:.....:.:|:|.:
Human   503 NEILSGIKILKYFAWEPSFRDQVQNLRKKELK----NLLAFSQLQCVVIFVFQLTPVLVSVVTFS 563

  Fly   335 VYV----GDLVTAKKVFILSSYYGLLNDSLLHYWPMAITTWAQTLVSARRVVEFLLQVEKPTEES 395
            |||    .:::.|:|.|...:.:.:|... |...||.|::..|..||..|:.::|
Human   564 VYVLVDSNNILDAQKAFTSITLFNILRFP-LSMLPMMISSMLQASVSTERLEKYL---------- 617

  Fly   396 CCRDNPGLELDAEKPKPAQSGRLHCVQSETKCLSFRKVSASWDKPSIKQPRKPHIEGISFHINAG 460
                 .|.:||      ..:.|..|  :..|.:.|.:.|.:|:..|     :..:..::..|.||
Human   618 -----GGDDLD------TSAIRHDC--NFDKAMQFSEASFTWEHDS-----EATVRDVNLDIMAG 664

  Fly   461 QFVGIVGNVGSGKSTLLHAILGEIELMQGRVEVHGRISYAAQQPWVFQGSIRENILFVEQYEEKR 525
            |.|.::|.||||||:|:.|:|||:|.:.|.:.:.|..:|..||.|:..|:|::||||..::.|||
Human   665 QLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTAYVPQQSWIQNGTIKDNILFGTEFNEKR 729

  Fly   526 YRAVVHACQLDRDLELLPRGDATVVGERGISLSGGQKARIALARAVYRQADIYLFDDPLAAVDAQ 590
            |:.|:.||.|..|||:||.||...:||:||:||||||.||:||||.|:..||||.||||:||||.
Human   730 YQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAH 794

  Fly   591 VGKLLMDKCF--HRLLDGKMRILVTHHVQLLKSVDQLLLLEGGKLTQQGSY-----------EEL 642
            |||.:.:|..  :.||.||.|:||||.:..|..||::::|..|.:.::|||           :.|
Human   795 VGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNL 859

  Fly   643 KDVITH---------HAALD-----------LEAIEADKQQV--------KRVLSQVDRTSKQLS 679
            |..:.|         |...:           :|.|..|...:        :|.||:..|::.:..
Human   860 KTFLRHTGPEEEATVHDGSEEEDDDYGLISSVEEIPEDAASITMRRENSFRRTLSRSSRSNGRHL 924

  Fly   680 KGEEKDPAT------IQDENGNAEQQL-------QGAVSYDTYKAYFRALGAPFLVCLVLSMFVL 731
            |.......|      .:||.....|:|       .|.|.:..|..|.:|:|. |.:..::..||:
Human   925 KSLRNSLKTRNVNSLKEDEELVKGQKLIKKEFIETGKVKFSIYLEYLQAIGL-FSIFFIILAFVM 988

  Fly   732 ARGCQAVMDIFISRW-ATWEEDRGYDSVDDYEATRTKMVIWYTVLLLLTLALFLL-----RTFGF 790
                .:|..|..:.| :.|..|....:..||.|::..|.:.....|.|...:|:.     ..|||
Human   989 ----NSVAFIGSNLWLSAWTSDSKIFNSTDYPASQRDMRVGVYGALGLAQGIFVFIAHFWSAFGF 1049

  Fly   791 FFMCLRISLTLHDQLYHGIIRAWMYFFNANPSGRVLNRFSSDIQNVDVNLPQAMMDSLQFLVDVV 855
                :..|..||.||.:.|:||.|.||:..|:||::|||:.||..||..|||::...:...:.::
Human  1050 ----VHASNILHKQLLNNILRAPMRFFDTTPTGRIVNRFAGDISTVDDTLPQSLRSWITCFLGII 1110

  Fly   856 AVLVIVAIAN---YWLLIPAAIMVILLYFCRALYIGASRSLKRIESLTRSPIYSHTNQTFHGHST 917
            :.||::.:|.   ..::||..|:.:.:   :..|:..||.|:|::|:||||||||.::|..|...
Human  1111 STLVMICMATPVFTIIVIPLGIIYVSV---QMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGLPV 1172

  Fly   918 IRSMDAMPQLEQTFHGHQ----NTNSSALFLYVSANRAFSFWTDLICVIYILAVTFS--FLVINQ 976
            ||:.:.    :|.|..|.    :||...:|.::::||..:...:|   :..|.|.||  .:||.:
Human  1173 IRAFEH----QQRFLKHNEVRIDTNQKCVFSWITSNRWLAIRLEL---VGNLTVFFSALMMVIYR 1230

  Fly   977 SFYSGD-VGLAITQSMTLVIMCQWGMRQTAEMENNMTSVERVLEYAQTPSEPPLESPKSVNLAAE 1040
            ...||| ||..::.::.:.....|.:|.|:|:|.|:.:|||:.||.:..:|.|..:.|  ....:
Human  1231 DTLSGDTVGFVLSNALNITQTLNWLVRMTSEIETNIVAVERITEYTKVENEAPWVTDK--RPPPD 1293

  Fly  1041 WPQAGHLRFQDLRMRYSPGDEDILRGLNFESQPMEKIGIVGRTGAGKSSIIQALFR-LALNEGTI 1104
            ||..|.::|.:.::||.|..:.:|||:..:...|||||:||||||||||:...||| |....|.|
Human  1294 WPSKGKIQFNNYQVRYRPELDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQI 1358

  Fly  1105 EIDGLDIGKLGLHDLRSRISIIPQDPVLFSGTLRFNLDPFDEKSDESLWSALDDVKLKKHVASLE 1169
            .|||:||..:||||||.:::||||||:||||:||.|||||:..|||.:|.||:...||..||||:
Human  1359 IIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQ 1423

  Fly  1170 GGLSCRMQDGGSNFSMGQRQLVCLARAILRQNRVLVMDEATANVDTETDILIQETIQTKFAECTV 1234
            .|||..:.:.|.|.|:|||||:||.||:||::::||:|||||.||.|||.|||.|||.:||.|||
Human  1424 LGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTV 1488

  Fly  1235 LTIAHRLHTVMDNDSVLVMDAGQIVEFGAPHKLLQ 1269
            :||||||||:||:|.|:|:|.|:|:|.|:|.:|||
Human  1489 ITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQ 1523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	MRP_assoc_pro	15..1271	CDD:188098	467/1390 (34%)
ABCC2	NP_000383.2	MRP_assoc_pro	8..1537	CDD:188098	471/1399 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	253..284		0/30 (0%)