DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG10505 and ABCC2

DIOPT Version :9

Sequence 1:NP_611571.2 Gene:CG10505 / 37428 FlyBaseID:FBgn0034612 Length:1312 Species:Drosophila melanogaster
Sequence 2:NP_000383.2 Gene:ABCC2 / 1244 HGNCID:53 Length:1545 Species:Homo sapiens


Alignment Length:1400 Identity:472/1400 - (33%)
Similarity:739/1400 - (52%) Gaps:199/1400 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 SPKRES--NPFIKANIISKWLFLWMHSVFRKGRREELDASKLYEHLPSFDSESLTRNLQPHWEKE 70
            |...||  ||...|:.:|...:.|..|:..||.:..|....::|......:::|....:.|.::|
Human   185 SENNESSNNPSSIASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMKTKTLVSKFETHMKRE 249

  Fly    71 -------------------------------------------SKKKNPS----------LMRLI 82
                                                       .|||..|          ||:.:
Human   250 LQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKSGTKKDVPKSWLMKAL 314

  Fly    83 FKVYGWQFVPVCILYSLLEMA--IHSF-QPLLLGGLISYFAYGQTTVTKESAYLYAMGIVLCSLV 144
            ||.    |..|.:...||::.  |.:| .|.||..|||:.:...|.:.  ..||.|:.:...:|:
Human   315 FKT----FYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFASDRDTYLW--IGYLCAILLFTAALI 373

  Fly   145 TSLVFHPFMFYVFAVGTRVRLACAGLVYRKCLRAS-ASSGEGLGGQAISVMSIDLSQ-FDLTFYF 207
            .|.....:....|.:|.:||.|....||:|.|..| .:..|...|:.:::||:|..: .|:| .|
Human   374 QSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGETVNLMSVDAQKLMDVT-NF 437

  Fly   208 FHDLWKGPVEACIFGYLMTRQVGWTSLIGIAFIVILIPLQAWAAKASASFGTRSAKHRDARVKLM 272
            .|.||...::..:..:.:.|::|.:.|.|:..:|::||:.|..:..|.:...::.|::|.|:|:|
Human   438 MHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKTIQVKNMKNKDKRLKIM 502

  Fly   273 NEIIGAIQVIKMYAWEKSFGRLIAAVRQSEVKAIRGSMSIYAALQCT--NMISKISLFLSLVAY- 334
            |||:..|:::|.:|||.||...:..:|:.|:|    ::..::.|||.  .:.....:.:|:|.: 
Human   503 NEILSGIKILKYFAWEPSFRDQVQNLRKKELK----NLLAFSQLQCVVIFVFQLTPVLVSVVTFS 563

  Fly   335 VYV----GDLVTAKKVFILSSYYGLLNDSLLHYWPMAITTWAQTLVSARRVVEFLLQVEKPTEES 395
            |||    .:::.|:|.|...:.:.:|... |...||.|::..|..||..|:.::|          
Human   564 VYVLVDSNNILDAQKAFTSITLFNILRFP-LSMLPMMISSMLQASVSTERLEKYL---------- 617

  Fly   396 CCRDNPGLELDAEKPKPAQSGRLHCVQSETKCLSFRKVSASWDKPSIKQPRKPHIEGISFHINAG 460
                 .|.:||      ..:.|..|  :..|.:.|.:.|.:|:..|     :..:..::..|.||
Human   618 -----GGDDLD------TSAIRHDC--NFDKAMQFSEASFTWEHDS-----EATVRDVNLDIMAG 664

  Fly   461 QFVGIVGNVGSGKSTLLHAILGEIELMQGRVEVHGRISYAAQQPWVFQGSIRENILFVEQYEEKR 525
            |.|.::|.||||||:|:.|:|||:|.:.|.:.:.|..:|..||.|:..|:|::||||..::.|||
Human   665 QLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTAYVPQQSWIQNGTIKDNILFGTEFNEKR 729

  Fly   526 YRAVVHACQLDRDLELLPRGDATVVGERGISLSGGQKARIALARAVYRQADIYLFDDPLAAVDAQ 590
            |:.|:.||.|..|||:||.||...:||:||:||||||.||:||||.|:..||||.||||:||||.
Human   730 YQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAH 794

  Fly   591 VGKLLMDKCF--HRLLDGKMRILVTHHVQLLKSVDQLLLLEGGKLTQQGSY-----------EEL 642
            |||.:.:|..  :.||.||.|:||||.:..|..||::::|..|.:.::|||           :.|
Human   795 VGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNL 859

  Fly   643 KDVITH---------HAALD-----------LEAIEADKQQV--------KRVLSQVDRTSKQLS 679
            |..:.|         |...:           :|.|..|...:        :|.||:..|::.:..
Human   860 KTFLRHTGPEEEATVHDGSEEEDDDYGLISSVEEIPEDAASITMRRENSFRRTLSRSSRSNGRHL 924

  Fly   680 KGEEKDPAT------IQDENGNAEQQL-------QGAVSYDTYKAYFRALGAPFLVCLVLSMFVL 731
            |.......|      .:||.....|:|       .|.|.:..|..|.:|:|. |.:..::..||:
Human   925 KSLRNSLKTRNVNSLKEDEELVKGQKLIKKEFIETGKVKFSIYLEYLQAIGL-FSIFFIILAFVM 988

  Fly   732 ARGCQAVMDIFISRW-ATWEEDRGYDSVDDYEATRTKMVIWYTVLLLLTLALFLL-----RTFGF 790
                .:|..|..:.| :.|..|....:..||.|::..|.:.....|.|...:|:.     ..|||
Human   989 ----NSVAFIGSNLWLSAWTSDSKIFNSTDYPASQRDMRVGVYGALGLAQGIFVFIAHFWSAFGF 1049

  Fly   791 FFMCLRISLTLHDQLYHGIIRAWMYFFNANPSGRVLNRFSSDIQNVDVNLPQAMMDSLQFLVDVV 855
                :..|..||.||.:.|:||.|.||:..|:||::|||:.||..||..|||::...:...:.::
Human  1050 ----VHASNILHKQLLNNILRAPMRFFDTTPTGRIVNRFAGDISTVDDTLPQSLRSWITCFLGII 1110

  Fly   856 AVLVIVAIAN---YWLLIPAAIMVILLYFCRALYIGASRSLKRIESLTRSPIYSHTNQTFHGHST 917
            :.||::.:|.   ..::||..|:.:.:   :..|:..||.|:|::|:||||||||.::|..|...
Human  1111 STLVMICMATPVFTIIVIPLGIIYVSV---QMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGLPV 1172

  Fly   918 IRSMDAMPQLEQTFHGHQ----NTNSSALFLYVSANRAFSFWTDLICVIYILAVTFS--FLVINQ 976
            ||:.:.    :|.|..|.    :||...:|.::::||..:...:|   :..|.|.||  .:||.:
Human  1173 IRAFEH----QQRFLKHNEVRIDTNQKCVFSWITSNRWLAIRLEL---VGNLTVFFSALMMVIYR 1230

  Fly   977 SFYSGD-VGLAITQSMTLVIMCQWGMRQTAEMENNMTSVERVLEYAQTPSEPPLESPKSVNLAAE 1040
            ...||| ||..::.::.:.....|.:|.|:|:|.|:.:|||:.||.:..:|.|..:.|  ....:
Human  1231 DTLSGDTVGFVLSNALNITQTLNWLVRMTSEIETNIVAVERITEYTKVENEAPWVTDK--RPPPD 1293

  Fly  1041 WPQAGHLRFQDLRMRYSPGDEDILRGLNFESQPMEKIGIVGRTGAGKSSIIQALFR-LALNEGTI 1104
            ||..|.::|.:.::||.|..:.:|||:..:...|||||:||||||||||:...||| |....|.|
Human  1294 WPSKGKIQFNNYQVRYRPELDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQI 1358

  Fly  1105 EIDGLDIGKLGLHDLRSRISIIPQDPVLFSGTLRFNLDPFDEKSDESLWSALDDVKLKKHVASLE 1169
            .|||:||..:||||||.:::||||||:||||:||.|||||:..|||.:|.||:...||..||||:
Human  1359 IIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQ 1423

  Fly  1170 GGLSCRMQDGGSNFSMGQRQLVCLARAILRQNRVLVMDEATANVDTETDILIQETIQTKFAECTV 1234
            .|||..:.:.|.|.|:|||||:||.||:||::::||:|||||.||.|||.|||.|||.:||.|||
Human  1424 LGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTV 1488

  Fly  1235 LTIAHRLHTVMDNDSVLVMDAGQIVEFGAPHKLLQ 1269
            :||||||||:||:|.|:|:|.|:|:|.|:|.:|||
Human  1489 ITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQ 1523

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10505NP_611571.2 CFTR_protein 12..1268 CDD:273530 468/1393 (34%)
ABC_membrane 95..360 CDD:294371 76/276 (28%)
ABCC_MRP_domain1 428..632 CDD:213217 95/205 (46%)
ABC_membrane 728..994 CDD:294371 85/281 (30%)
ABCC_MRP_domain2 1045..1264 CDD:213211 127/219 (58%)
ABCC2NP_000383.2 SunT 8..1537 CDD:331423 471/1399 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 253..284 0/30 (0%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165151616
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51855
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.760

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