DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10505 and Abcc5

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_446376.1	Gene:	Abcc5 / 116721	RGDID:	70913	Length:	1436	Species:	Rattus norvegicus

Alignment Length:	1364	Identity:	432/1364 - (31%)
Similarity:	720/1364 - (52%)	Gaps:	151/1364 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 RESNPFIKANIISKWLFLWM----HSVFRKGR--REELDASKLYEHLPSFDSESLTRNLQPHWEK 69
            :..:|...|.:.|...|.|:    ..|.:||.  .|::.....||     .|:...|.|:..|::
  Rat    96 KHQHPVDNAGLFSYMTFSWLSPLAQVVHKKGELLMEDVWPLSKYE-----SSDVNCRRLERLWQE 155

  Fly    70 ESKKKNP---SLMRLIFKVYGWQFVPVCILYSLL-----EMAIHSFQPLLLGGLISYFAYGQTTV 126
            |..:..|   ||.|::     |.|....::.|::     ::|..|....::..|:.|      |.
  Rat   156 ELNEVGPDAASLRRVV-----WIFCRTRLILSIVCLMITQLAGFSGPAFVVKHLLEY------TQ 209

  Fly   127 TKESAYLYAMGIVLCSLVTSLVFHPFMFYVFAV----GTRVRLACAGLVYRKCLRASASSGEGLG 187
            ..||...|::.:||..|:|.:|....:...:|:    |.|:|.|...:.::|.|:......:.|
  Rat   210 ATESNLQYSLLLVLGLLLTEVVRSWSLALTWALNYRTGVRLRGAVLTMAFKKILKLKNIKEKSL- 273

  Fly   188 GQAISVMSIDLSQFDLTFYFFHDLWKGPVEA---CIFGYLMTRQVGWTSLIGIAFIVILIPLQAW 249
            |:.|::.|.|..:..........|..|||.|   .|:..::   :|.|..:|.|..::..|...:
  Rat   274 GELINICSNDGQRMFEAAAVGSLLAGGPVVAILGMIYNVII---LGPTGFLGSAVFILFYPAMMF 335

  Fly   250 AAKASASFGTRSAKHRDARVKLMNEIIGAIQVIKMYAWEKSFGRLIAAVRQSEVKAIRGS---MS 311
            .::.:|.|..:.....|.||:.|||::..|:.||||||.|:|.:.:..:|:.|.:.:..:   .|
  Rat   336 VSRLTAYFRRKCVAATDDRVQKMNEVLTYIKFIKMYAWVKAFSQCVQKIREEERRILEKAGYFQS 400

  Fly   312 IYAALQCTNMISKISLFLSLVAYVYVGDLVTAKKVFILSSYYGLLNDSLLHYWPMAITTWAQTLV 376
            |...:  ..::..|:..::...::.:|..:||.:.|.:.:.:..:..: |...|.::.:.::..|
  Rat   401 ITVGV--APIVVVIASVVTFSVHMTLGFDLTAAQAFTVVTVFNSMTFA-LKVTPFSVKSLSEASV 462

  Fly   377 SARRVVEFLLQVE------KP-----------------TEESCCRDNPGLELDAEKPKPAQSGRL 418
            :..|.....|..|      ||                 :..|..:.:|.|....:|.|.|..|:
  Rat   463 AVDRFKSLFLMEEVHMIKNKPASPHIKIEMKNATLAWDSSHSSTQSSPKLTPKVKKDKRAPKGK- 526

  Fly   419 HCVQSETKCLSFRKVSA------------SWDKPSIKQPRKPHIE-----------GISFHINAG 460
               :.:::.|...:..|            |.::||.::.....|.           .|...|..|
  Rat   527 ---KEKSRQLQHTEHQAVLAEQKGHLLLDSDERPSPEEEEGKQIHAGSMRLQRTLYNIDLEIEEG 588

  Fly   461 QFVGIVGNVGSGKSTLLHAILGEIELMQGRVEVHGRISYAAQQPWVFQGSIRENILFVEQYEEKR 525
            :.|||.|:|||||::|:.||||::.|::|.:.|.|..:|.|||.|:...::|:||||.::::|:|
  Rat   589 KLVGICGSVGSGKTSLISAILGQMTLLEGSIAVSGTFAYVAQQAWILNATLRDNILFGKEFDEER 653

  Fly   526 YRAVVHACQLDRDLELLPRGDATVVGERGISLSGGQKARIALARAVYRQADIYLFDDPLAAVDAQ 590
            |.:|:::|.|..||.:||..|.|.:||||.:|||||:.||:||||:|....||:.||||:|:||.
  Rat   654 YNSVLNSCCLRPDLAILPNSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAH 718

  Fly   591 VGKLLMDKCFHRLLDGKMRILVTHHVQLLKSVDQLLLLEGGKLTQQGSYEELKDVITHHAALDLE 655
            ||..:.:....:.|..|..:.|||.:|.|...|:::.::.|.:|::|::|||.::...:|.:...
  Rat   719 VGNHIFNSAIRKRLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNN 783

  Fly   656 AIEADKQQVKRVLSQVDRTSKQLSKGEEKDPATIQDENG---------NAEQQLQGAVSYDTYKA 711
            .:..:...|: :.|:.:.:..|.|:.:...|.:::.|..         ..|::.||:|.:..|..
  Rat   784 LLLGETPPVE-INSKKEASGSQKSQDKGPKPGSVKKEKAVKSEEGQLVQVEEKGQGSVPWSVYWV 847

  Fly   712 YFRALGAPFLVCLVLSMFVLARGCQAVMDIFISRWATWEEDRGYDSVDDYEATRTKM-------- 768
            |.:|.|.|....:::.:|:|..|..|....::|.|.  ::..|..:|  :|..|:.:
  Rat   848 YIQAAGGPLAFLVIMVLFMLNVGSTAFSTWWLSYWI--KQGSGNSTV--FEGNRSSVSDSMRDNP 908

  Fly   769 -VIWYTVLLLLTLALFL----LRTFGFFFMCLRISLTLHDQLYHGIIRAWMYFFNANPSGRVLNR 828
             :.:|..:..|::|:.|    :|...|....||.|..|||:|:..|:|:.|.||:..|:||:|||
  Rat   909 FLQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNR 973

  Fly   829 FSSDIQNVDVNLP-QAMMDSLQFLVDVVAVLVIVA-IANY--WLLI---PAAIMVILLYFCRALY 886
            ||.|:..|||.|| ||.|    |:.:|:.|...|. ||..  |.|:   |..|:..:|:....:.
  Rat   974 FSKDMDEVDVRLPFQAEM----FIQNVILVFFCVGMIAGVFPWFLVAVGPLLILFSVLHIVSRVL 1034

  Fly   887 IGASRSLKRIESLTRSPIYSHTNQTFHGHSTIRSMDAMPQLEQTFHGHQ---NTNSSALFLYVSA 948
            |   |.|||::::|:||..||...:..|.:||.   |..:.::..|.:|   :.|.:..||:..|
  Rat  1035 I---RELKRLDNITQSPFLSHITSSIQGLATIH---AYNKRQEFLHRYQELLDDNQAPFFLFTCA 1093

  Fly   949 NRAFSFWTDLICVIYILAVTFSFLVINQSFYSGDVGLAITQSMTLVIMCQWGMRQTAEMENNMTS 1013
            .|..:...|||.:..|.......::::....|...||||:.::.|..:.|:.:|..:|.|...||
  Rat  1094 MRWLAVRLDLISIALITTTGLMIVLMHGQIPSAYAGLAISYAVQLTGLFQFTVRLASETEARFTS 1158

  Fly  1014 VERVLEYAQTPSEPPLESPKSVNLAA---EWPQAGHLRFQDLRMRYSPGDEDILRGLNFESQPME 1075
            |||:..|.:|.|   ||:|..:...|   :|||.|.:.|::..|||......:|:.::|..:|.|
  Rat  1159 VERINHYIKTLS---LEAPARIKNKAPPHDWPQEGEITFENAEMRYRENLPLVLKKVSFTIKPKE 1220

  Fly  1076 KIGIVGRTGAGKSSIIQALFRLA-LNEGTIEIDGLDIGKLGLHDLRSRISIIPQDPVLFSGTLRF 1139
            |||||||||:||||:..|||||. |:.|.|:|||:.|..:||.||||:::||||:|||||||:|.
  Rat  1221 KIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLTIIPQEPVLFSGTVRS 1285

  Fly  1140 NLDPFDEKSDESLWSALDDVKLKKHVASLEGGLSCRMQDGGSNFSMGQRQLVCLARAILRQNRVL 1204
            |||||::.::|.:|.||:...:|:.:|.|...|...:.:.|.|||:|:|||:|:|||:||..::|
  Rat  1286 NLDPFNQYTEEQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKIL 1350

  Fly  1205 VMDEATANVDTETDILIQETIQTKFAECTVLTIAHRLHTVMDNDSVLVMDAGQIVEFGAPHKLL 1268
            ::|||||.:|||||:||||||:..||:||:||||||||||:.:|.::|:..||:|||..|..||
  Rat  1351 ILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLL 1414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	430/1361 (32%)
		ABC_membrane	95..360	CDD:294371	63/279 (23%)
		ABCC_MRP_domain1	428..632	CDD:213217	84/226 (37%)
		ABC_membrane	728..994	CDD:294371	86/288 (30%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	117/219 (53%)
Abcc5	NP_446376.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	12..38
		PLN03130	100..1424	CDD:215595	432/1360 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	499..569		13/73 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	795..822		5/26 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345036
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.660