DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10505 and CFTR

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_000483.3	Gene:	CFTR / 1080	HGNCID:	1884	Length:	1480	Species:	Homo sapiens

Alignment Length:	1507	Identity:	410/1507 - (27%)
Similarity:	714/1507 - (47%)	Gaps:	265/1507 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ESNPFIKANIISKWLFLWMHSVFRKGRREELDASKLYEHLPSFDS-ESLTRNLQPHWEKE-SKKK 74
            :.:|..||:::||..|.|...:.|||.|:.|:.|.:|: :||.|| ::|:..|:..|::| :.||
Human     2 QRSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQ-IPSVDSADNLSEKLEREWDRELASKK 65

  Fly    75 NPSLMRLIFKVYGWQFVPVCILYSLLEMAIHSFQPLLLGGLISYFAYGQTTVTKESAYLYAMGIV 139
            ||.|:..:.:.:.|:|:...|...|.|:. .:.||||||.:|:  :|......:.|..:| :||.
Human    66 NPKLINALRRCFFWRFMFYGIFLYLGEVT-KAVQPLLLGRIIA--SYDPDNKEERSIAIY-LGIG 126

  Fly   140 LCSL--VTSLVFHPFMFYVFAVGTRVRLACAGLVYRKCLRASASSGEGLG-GQAISVMSIDLSQF 201
            ||.|  |.:|:.||.:|.:..:|.::|:|...|:|:|.|:.|:...:.:. ||.:|::|.:|::|
Human   127 LCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKF 191

  Fly   202 DLTFYFFHDLWKGPVEACIFGYLMTRQVGWTSLIGIAFIVILIPLQAWAAKASASFGTRSAKHRD 266
            |......|.:|..|::..:...|:...:..::..|:.|:::|...||...:....:..:.|....
Human   192 DEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKIS 256

  Fly   267 ARVKLMNEIIGAIQVIKMYAWEKSFGRLIAAVRQSEVKAIRGSMSI-YAALQCTNMISKISLFLS 330
            .|:.:.:|:|..||.:|.|.||::..::|..:||:|:|..|.:..: |.............:|||
Human   257 ERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLS 321

  Fly   331 LVAYVYVGDLVTAKKVFILSSYYGLLNDSLLHYWPMAITTWAQTLVSARRVVEFLLQVEKPTEES 395
            ::.|..:..:: .:|:|...|:..:|..::...:|.|:.||..:|.:..::.:||.:.|..|.|
Human   322 VLPYALIKGII-LRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLE- 384

  Fly   396 CCRDNPGLELDAEKPKPAQSGRLHCVQSETKCLSFRKVSASWDK------PSIKQ---PRK---- 447
                                     ....|..:....|:|.|::      ...||   .||
Human   385 -------------------------YNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNG 424

  Fly   448 --------------PHIEGISFHINAGQFVGIVGNVGSGKSTLLHAILGEIELMQGRVEVHGRIS 498
                          |.::.|:|.|..||.:.:.|:.|:||::||..|:||:|..:|:::..||||
Human   425 DDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRIS 489

  Fly   499 YAAQQPWVFQGSIRENILFVEQYEEKRYRAVVHACQLDRDLELLPRGDATVVGERGISLSGGQKA 563
            :.:|..|:..|:|:|||:|...|:|.|||:|:.||||:.|:......|..|:||.||:|||||:|
Human   490 FCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRA 554

  Fly   564 RIALARAVYRQADIYLFDDPLAAVDAQVGKLLMDKCFHRLLDGKMRILVTHHVQLLKSVDQLLLL 628
            ||:||||||:.||:||.|.|...:|....|.:.:.|..:|:..|.|||||..::.||..|::|:|
Human   555 RISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILIL 619

  Fly   629 EGGKLTQQGSYEELKD-------------------------VIT---HHAALDLEA----IEADK 661
            ..|.....|::.||::                         ::|   |..:|:.:|    .|..|
Human   620 HEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNSILTETLHRFSLEGDAPVSWTETKK 684

  Fly   662 QQVK--------------------RVLSQVDRTSKQLSKGEEKDPATIQ--------DENGNA-- 696
            |..|                    |..|.|.:|..|::..||.....::        .|.|.|
Human   685 QSFKQTGEFGEKRKNSILNPINSIRKFSIVQKTPLQMNGIEEDSDEPLERRLSLVPDSEQGEAIL 749

  Fly   697 ----------------------------------------------------------------- 696

Human   750 PRISVISTGPTLQARRRQSVLNLMTHSVNQGQNIHRKTTASTRKVSLAPQANLTELDIYSRRLSQ 814

  Fly   697 -----------EQQLQ-----------GAVSYDTYKAYF---RALGAPFLVCLVLSMFVLARGCQ 736
                       |:.|:           ...:::||..|.   ::|....:.|||:.:..:|..
Human   815 ETGLEISEEINEEDLKECFFDDMESIPAVTTWNTYLRYITVHKSLIFVLIWCLVIFLAEVAAS-- 877

  Fly   737 AVMDIFISRWA---TWEEDRG---YDSVDDYEATRTKMVIWYTVLLLLTLALFLLRTFGFF---- 791
                 .:..|.   |..:|:|   :...:.|....|....:|...:.:.:|..|| ..|||
Human   878 -----LVVLWLLGNTPLQDKGNSTHSRNNSYAVIITSTSSYYVFYIYVGVADTLL-AMGFFRGLP 936

  Fly   792 --FMCLRISLTLHDQLYHGIIRAWMYFFNANPSGRVLNRFSSDIQNVDVNLPQAMMDSLQFLVDV 854
              ...:.:|..||.::.|.:::|.|...|...:|.:|||||.||..:|..||..:.|.:|.|:.|
Human   937 LVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIV 1001

  Fly   855 VAVLVIVAIANYWLLIPAAIMVILLYFCRALYIGASRSLKRIESLTRSPIYSHTNQTFHGHSTIR 919
            :..:.:||:...::.:....:::.....||.::..|:.||::||..||||::|...:..|..|:|
Human  1002 IGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLR 1066

  Fly   920 SMDAMPQLEQTFHGHQNTNSSALFLYVSANRAFSFWTDLICVIYILAVTF-SFLVINQSFYSGDV 983
            :....|..|..||...|.:::..|||:|..|.|....::|.||:.:|||| |.|...:.  .|.|
Human  1067 AFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEG--EGRV 1129

  Fly   984 GLAITQSMTLVIMCQWGMRQTAEMENNMTSVERVLEYAQTPSE-PPLESPK-------SVNLAAE 1040
            |:.:|.:|.::...||.:..:.::::.|.||.||.::...|:| .|.:|.|       |..:..|
Human  1130 GIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIE 1194

  Fly  1041 ---------WPQAGHLRFQDLRMRYSPGDEDILRGLNFESQPMEKIGIVGRTGAGKSSIIQALFR 1096
                     ||..|.:..:||..:|:.|...||..::|...|.:::|::||||:|||:::.|..|
Human  1195 NSHVKKDDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLR 1259

  Fly  1097 LALNEGTIEIDGLDIGKLGLHDLRSRISIIPQDPVLFSGTLRFNLDPFDEKSDESLWSALDDVKL 1161
            |...||.|:|||:....:.|...|....:|||...:||||.|.||||:::.||:.:|...|:|.|
Human  1260 LLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGL 1324

  Fly  1162 KKHVASLEGGLSCRMQDGGSNFSMGQRQLVCLARAILRQNRVLVMDEATANVDTETDILIQETIQ 1226
            :..:....|.|...:.|||...|.|.:||:||||::|.:.::|::||.:|::|..|..:|:.|::
Human  1325 RSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLK 1389

  Fly  1227 TKFAECTVLTIAHRLHTVMDNDSVLVMDAGQIVEFGAPHKLLQRKD--------GALLKLVNQND 1283
            ..||:|||:...||:..:::....||::..::.::.:..|||..:.        ...:||....:
Human  1390 QAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVKLFPHRN 1454

  Fly  1284 ATTVKFLKRIAS 1295
            ::..|...:||:
Human  1455 SSKCKSKPQIAA 1466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	403/1470 (27%)
		ABC_membrane	95..360	CDD:294371	72/268 (27%)
		ABCC_MRP_domain1	428..632	CDD:213217	88/230 (38%)
		ABC_membrane	728..994	CDD:294371	78/278 (28%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	77/218 (35%)
CFTR	NP_000483.3	CFTR_protein	1..1480	CDD:273530	410/1507 (27%)
		ABC_membrane	85..303	CDD:279056	63/221 (29%)
		ABCC_CFTR1	389..670	CDD:213258	95/280 (34%)
		CFTR_R	639..849	CDD:291094	20/209 (10%)
		Disordered R region. /evidence=ECO:0000269\|PubMed:10792060	654..831		20/176 (11%)
		ABC_membrane	866..1147	CDD:279056	83/290 (29%)
		ABCC_CFTR2	1208..1480	CDD:213256	85/259 (33%)
		Interaction with GORASP2. /evidence=ECO:0000269\|PubMed:21884936	1386..1480		18/81 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1452..1480		3/15 (20%)
		PDZ-binding. /evidence=ECO:0000269\|PubMed:11707463, ECO:0000269\|PubMed:16331976	1478..1480
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151596
Domainoid	1	1.000	62	1.000	Domainoid score	I10331
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.850