DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10505 and ABCC4

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_005836.2	Gene:	ABCC4 / 10257	HGNCID:	55	Length:	1325	Species:	Homo sapiens

Alignment Length:	1329	Identity:	528/1329 - (39%)
Similarity:	802/1329 - (60%)	Gaps:	83/1329 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 NPFIKANIISKWLFLWMHSVFRKGRREELDASKLYEHLPSFDSESLTRNLQPHWEK-----ESKK 73
            ||...||:.|:..|.|::.:|:.|.:..|:...:|..||...|:.|...||..|:|     |:..
Human    11 NPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRAENDA 75

  Fly    74 KNPSLMRLIFKVYGWQFVPVCILYSLLEMAIHSFQPLLLGGLISYFA-YG-QTTVTKESAYLYAM 136
            :.|||.|.|.|.| |:...|..:::|:|.:....||:.||.:|:||. |. ..:|...:||.||.
Human    76 QKPSLTRAIIKCY-WKSYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYAT 139

  Fly   137 GIVLCSLVTSLVFHPFMFYVFAVGTRVRLACAGLVYRKCLRAS-ASSGEGLGGQAISVMSIDLSQ 200
            .:..|:|:.:::.|.:.::|...|.|:|:|...::|||.||.| .:.|:...||.::::|.|:::
Human   140 VLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNK 204

  Fly   201 FDLTFYFFHDLWKGPVEACIFGYLMTRQVGWTSLIGIAFIVILIPLQAWAAKASASFGTRSAKHR 265
            ||....|.|.||.||::|.....|:..::|.:.|.|:|.::||:|||:...|..:|..:::|...
Human   205 FDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFT 269

  Fly   266 DARVKLMNEIIGAIQVIKMYAWEKSFGRLIAAVRQSEV-KAIRGS-------MSIYAALQCTNMI 322
            |||::.|||:|..|::||||||||||..||..:|:.|: |.:|.|       .|.::|
Human   270 DARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSA------- 327

  Fly   323 SKISLFLSLVAYVYVGDLVTAKKVFILSSYYGLLNDSLLHYWPMAITTWAQTLVSARRVVEFLLQ 387
            |||.:|::...||.:|.::||.:||:..:.||.:..::..::|.||...::.:||.||:..|||.
Human   328 SKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLL 392

  Fly   388 VEKPTEESCCRDNPGLELDAEKPKPAQSGRLHCVQSETKCLSFRKVSASWDKPSIKQPRKPHIEG 452
                  :...:.|..|..|.:|       .:| ||..|         |.|||.|    ..|.::|
Human   393 ------DEISQRNRQLPSDGKK-------MVH-VQDFT---------AFWDKAS----ETPTLQG 430

  Fly   453 ISFHINAGQFVGIVGNVGSGKSTLLHAILGEIELMQGRVEVHGRISYAAQQPWVFQGSIRENILF 517
            :||.:..|:.:.:||.||:|||:||.|:|||:....|.|.|||||:|.:||||||.|::|.||||
Human   431 LSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILF 495

  Fly   518 VEQYEEKRYRAVVHACQLDRDLELLPRGDATVVGERGISLSGGQKARIALARAVYRQADIYLFDD 582
            .::||::||..|:.||.|.:||:||..||.||:|:||.:||||||||:.||||||:.|||||.||
Human   496 GKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDD 560

  Fly   583 PLAAVDAQVGKLLMDKCFHRLLDGKMRILVTHHVQLLKSVDQLLLLEGGKLTQQGSYEE-LKDVI 646
            ||:||||:|.:.|.:.|..::|..|:.|||||.:|.||:..|:|:|:.||:.|:|:|.| ||..|
Human   561 PLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGI 625

  Fly   647 THHAALDLEAIEADKQQV-------KRVLSQVDRTSKQLSKGEEKD-----------PATIQDEN 693
            ...:.|..:..|:::..|       .|..|:....|:|.|:...||           |.|:.:||
Human   626 DFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGALESQDTENVPVTLSEEN 690

  Fly   694 GNAEQQLQGAVSYDTYKAYFRALGAPFLVCLVLSMF-VLARGCQAVMDIFISRWATWEEDRGYDS 757
                 :.:|.|.:..||.|||| ||.::|.:.|.:. ..|:....:.|.::|.||..:.......
Human   691 -----RSEGKVGFQAYKNYFRA-GAHWIVFIFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTV 749

  Fly   758 VDDYEATRTKMVIW----YTVLLLLTLALFLLRTFGFFFMCLRISLTLHDQLYHGIIRAWMYFFN 818
            ......|....:.|    |:.|.:.|:...:.|:...|::.:..|.|||::::..|::|.:.||:
Human   750 NGGGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFD 814

  Fly   819 ANPSGRVLNRFSSDIQNVDVNLPQAMMDSLQFLVDVVAVLVIVAIANYWLLIPAAIMVILLYFCR 883
            .||.||:|||||.||.::|..||...:|.:|.|:.||.|:.:......|:.||...:.|:..|.|
Human   815 RNPIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLR 879

  Fly   884 ALYIGASRSLKRIESLTRSPIYSHTNQTFHGHSTIRSMDAMPQLEQTFHGHQNTNSSALFLYVSA 948
            ..::..||.:||:||.||||::||.:.:..|..|||:..|..:.::.|..||:.:|.|.||:::.
Human   880 RYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTT 944

  Fly   949 NRAFSFWTDLICVIYILAVTFSFLVINQSFYSGDVGLAITQSMTLVIMCQWGMRQTAEMENNMTS 1013
            :|.|:...|.||.::::.|.|..|::.::..:|.||||::.::||:.|.||.:||:||:||.|.|
Human   945 SRWFAVRLDAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMIS 1009

  Fly  1014 VERVLEYAQTPSEPPLESPKSVNLAAEWPQAGHLRFQDLRMRYSPGDEDILRGLNFESQPMEKIG 1078
            ||||:||.....|.|.|..|....|  ||..|.:.|.::...||||...:|:.|....:..||:|
Human  1010 VERVIEYTDLEKEAPWEYQKRPPPA--WPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVG 1072

  Fly  1079 IVGRTGAGKSSIIQALFRLALNEGTIEIDGLDIGKLGLHDLRSRISIIPQDPVLFSGTLRFNLDP 1143
            |||||||||||:|.|||||:..||.|.||.:...::||||||.::|||||:||||:||:|.||||
Human  1073 IVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDP 1137

  Fly  1144 FDEKSDESLWSALDDVKLKKHVASLEGGLSCRMQDGGSNFSMGQRQLVCLARAILRQNRVLVMDE 1208
            |:|.:||.||:||.:|:||:.:..|.|.:...:.:.|||||:||||||||||||||:|::|::||
Human  1138 FNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDE 1202

  Fly  1209 ATANVDTETDILIQETIQTKFAECTVLTIAHRLHTVMDNDSVLVMDAGQIVEFGAPHKLLQRKDG 1273
            ||||||..||.|||:.|:.|||.||||||||||:|::|:|.::|:|:|::.|:..|:.|||.|:.
Human  1203 ATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKES 1267

  Fly  1274 ALLKLVNQNDATTVKFLKRIASESYMRRN 1302
            ...|:|.|........|...|.:.|.:||
Human  1268 LFYKMVQQLGKAEAAALTETAKQVYFKRN 1296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	516/1293 (40%)
		ABC_membrane	95..360	CDD:294371	96/275 (35%)
		ABCC_MRP_domain1	428..632	CDD:213217	105/203 (52%)
		ABC_membrane	728..994	CDD:294371	84/270 (31%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	123/218 (56%)
ABCC4	NP_005836.2	CFTR_protein	11..1269	CDD:273530	520/1300 (40%)
		ABC_membrane	96..365	CDD:294371	96/275 (35%)
		ABCC_MRP_domain1	410..610	CDD:213217	109/213 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	657..688		7/30 (23%)
		ABC_membrane	718..991	CDD:279056	85/272 (31%)
		ABCC_MRP_domain2	1039..1258	CDD:213211	123/218 (56%)
		PDZ-binding	1322..1325
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151553
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0001028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.860