DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG10505 and ABCC9

DIOPT Version :9

Sequence 1:NP_611571.2 Gene:CG10505 / 37428 FlyBaseID:FBgn0034612 Length:1312 Species:Drosophila melanogaster
Sequence 2:NP_001364202.1 Gene:ABCC9 / 10060 HGNCID:60 Length:1549 Species:Homo sapiens


Alignment Length:1394 Identity:415/1394 - (29%)
Similarity:710/1394 - (50%) Gaps:160/1394 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MDASKQSSPK-------RESNPFIKANIISKWLFLWMHSVFRKGRREELDASKLYEHLPSFDSES 58
            |:..|...|:       |...||:  |::||..:.||:::.....::.:|. |....|| ....:
Human   197 MNPQKVKPPEDLQDLGVRFLQPFV--NLLSKATYWWMNTLIISAHKKPIDL-KAIGKLP-IAMRA 257

  Fly    59 LTRN--LQPHWEKESKK------KNPSLMRLIFKVYGWQFVPVCI------LYSLLEMAIHSFQP 109
            :|..  |:..:|::.||      :.||:...:::.:|   .|:.:      |..||..|    .|
Human   258 VTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFG---RPILLSSTFRYLADLLGFA----GP 315

  Fly   110 LLLGGLI-----------SYFAYGQTTVTK---ESAYLYAMGIVLCSLVTSLVFHPFMFYV-FAV 159
            |.:.|::           :.....:|..:|   |:||:.|: ::..:|:....|....:|| ...
Human   316 LCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAV-LLFLALILQRTFLQASYYVTIET 379

  Fly   160 GTRVRLACAGLVYRKCLRASASS---GEGLGGQAISVMSIDLSQFDLTFYFFHDLWKGPVEACIF 221
            |..:|.|...::|.|.||.|.|:   ||...||..::::|:.:|.....:...:||..||:..:.
Human   380 GINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMG 444

  Fly   222 GYLMTRQVGWTSLIGIAFIVILIPLQAWAAKASASFGTRSAKHRDARVKLMNEIIGAIQVIKMYA 286
            ..|:...:|.::|:|.|.||:|.|:|.:.|...|.....:..:...|:|..|||:..|:::|:||
Human   445 VILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYA 509

  Fly   287 WEKSFGRLIAAVRQSEVKAIRGSMSIYAALQC-TNMISKISLFLSLV---AYVYVGDLVTAKKVF 347
            ||..|.:.:...|..|:.::: :.::|.:|.. .|....|:..|:..   ||....:|..|:...
Human   510 WEHIFCKSVEETRMKELSSLK-TFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFA 573

  Fly   348 ILSSYYGLLNDSLLHYWPMAITTWAQTLVSARRVVEFLLQVE------KPTEES----CCRDNPG 402
            .||.::.|:..  |......:....:.::|.:::.||||..|      :..|.|    .|:.:.|
Human   574 SLSLFHILVTP--LFLLSTVVRFAVKAIISVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTG 636

  Fly   403 LELDAEKPKP---AQSGRLHCVQ----------SETKCLSFRKVSA--SWDKPSIKQPRKPHIEG 452
            ::     ||.   .|.||.|...          :||:.::.:..:.  ||......      :..
Human   637 VQ-----PKTINRKQPGRYHLDSYEQSTRRLRPAETEDIAIKVTNGYFSWGSGLAT------LSN 690

  Fly   453 ISFHINAGQFVGIVGNVGSGKSTLLHAILGEIELMQGRVE-------------VHGR----ISYA 500
            |...|..||...|||.||.|||:||.|||||::.::|:|.             ...|    ::||
Human   691 IDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYA 755

  Fly   501 AQQPWVFQGSIRENILFVEQYEEKRYRAVVHACQLDRDLELLPRGDATVVGERGISLSGGQKARI 565
            ||:||:...::.|||.|...:.::||:||..||.|..|::|||.||.|.:|||||:|||||:.||
Human   756 AQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRI 820

  Fly   566 ALARAVYRQADIYLFDDPLAAVDAQVGKLLMDKCFHRLL--DGKMRILVTHHVQLLKSVDQLLLL 628
            .:|||:|:..:|...|||.:|:|..:...||.:...:.|  |.:..:||||.:|.|...|.::.:
Human   821 CVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAM 885

  Fly   629 EGGKLTQQGSYEELKDVITHHAAL-----------------DLEAIEA--DKQQVKRVLSQVDRT 674
            :.|.:.::|:   |||:.|....|                 |:||.:.  :::.::|.:...:..
Human   886 KDGSVLREGT---LKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAK 947

  Fly   675 SKQLSKGEEKDPATIQDENGNAEQQLQGAVSYDTYKAYFRALGAPFLVCLVLSMFVLARGCQAVM 739
            ::...:.||::....:|:|.:...:|:..:.:.|...|..: |..||:.|::...:|.......:
Human   948 AQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYLTS-GGFFLLILMIFSKLLKHSVIVAI 1011

  Fly   740 DIFISRWATWEEDRGYDSVDDYEATRTKMVIWYTVLLLLTLALFLLRTFGFFFMCLRISLTLHDQ 804
            |.::   |||..:  |...:..:|.:|..|..:::|....:.|.|:.:....:|.|..:..||..
Human  1012 DYWL---ATWTSE--YSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHN 1071

  Fly   805 LYHGIIRAWMYFFNANPSGRVLNRFSSDIQNVDVNLPQAMMDSLQFLVDVVAVLVIVAIANYWLL 869
            |.:.||...:.||:..|.|.:|||||:|...:|.::|..:....:..:..::.:.:::.|....|
Human  1072 LLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFL 1136

  Fly   870 IPAAIMVILLYFCRALYIGASRSLKRIESLTRSPIYSHTNQTFHGHSTIRSMDAMPQLEQTFHGH 934
            :....:.:..||.:..:..||:.|:.::..|:.|:..|.::|..|.:|||:.....:.:|.....
Human  1137 VALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLEL 1201

  Fly   935 QNTNSSALFLYVSANRAFSFWTDLI--CVIYILAVTFSFLVINQSFYSGDVGLAITQSMTLVIMC 997
            .:||:.|.....:|||.....||.:  |::    :|.|...|:.|..||.|||.:..::|:....
Human  1202 TDTNNIAYLFLSAANRWLEVRTDYLGACIV----LTASIASISGSSNSGLVGLGLLYALTITNYL 1262

  Fly   998 QWGMRQTAEMENNMTSVERVLEYAQTPSE------PPLESPKSVNLAAEWPQAGHLRFQDLRMRY 1056
            .|.:|..|::|..|.:|::|..:....||      .|.:.|:      .|||.|.::..||.:||
Human  1263 NWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPE------HWPQEGEIKIHDLCVRY 1321

  Fly  1057 SPGDEDILRGLNFESQPMEKIGIVGRTGAGKSSIIQALFRLA-LNEGTIEIDGLDIGKLGLHDLR 1120
            ....:.:|:.:....:|.:|:||.||||:||||:..|.||:. :.:|.|.|||:||.||.||.||
Human  1322 ENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLR 1386

  Fly  1121 SRISIIPQDPVLFSGTLRFNLDPFDEKSDESLWSALDDVKLKKHVASLEGGLSCRMQDGGSNFSM 1185
            ||:|||.|||:||||::||||||..:.:|:.||.||:..:||..|.||.|||...:.:||.|||:
Human  1387 SRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSV 1451

  Fly  1186 GQRQLVCLARAILRQNRVLVMDEATANVDTETDILIQETIQTKFAECTVLTIAHRLHTVMDNDSV 1250
            |||||.|||||.:|::.:|:||||||::|..|:.::|:.:.|.||:.||:|||||:||::..|.|
Human  1452 GQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILTADLV 1516

  Fly  1251 LVMDAGQIVEFGAPHKLLQRKDGALLKLV 1279
            :||..|.|:|:..|..||.:::|.....|
Human  1517 IVMKRGNILEYDTPESLLAQENGVFASFV 1545

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10505NP_611571.2 CFTR_protein 12..1268 CDD:273530 407/1363 (30%)
ABC_membrane 95..360 CDD:294371 74/292 (25%)
ABCC_MRP_domain1 428..632 CDD:213217 81/224 (36%)
ABC_membrane 728..994 CDD:294371 66/267 (25%)
ABCC_MRP_domain2 1045..1264 CDD:213211 110/219 (50%)
ABCC9NP_001364202.1 MRP_assoc_pro 222..1546 CDD:188098 408/1367 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 944..967 3/22 (14%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165151543
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.650

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