DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10505 and abcc12

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	XP_002937916.3	Gene:	abcc12 / 100493828	XenbaseID:	XB-GENE-6465370	Length:	1430	Species:	Xenopus tropicalis

Alignment Length:	1440	Identity:	445/1440 - (30%)
Similarity:	703/1440 - (48%)	Gaps:	218/1440 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 RESNPFIKANIISKWLFLWMHSVFRKG-RREELDASKLYEHLPSFD-SESLTRNLQPHWEKESK- 72
            |..:|...|.:.|.....|:..:.||. :..||..:.|:. ||..: ||:..:.||..||:|.:
Frog    27 RNQHPIDNAGLFSFMTLNWITPLARKAYKLSELQMNDLWS-LPFHESSETNCQRLQSLWEEELQN 90

  Fly    73 --KKNPSLMRLIFKVYGWQFVPVCILYSLLEMAI---HSF--QPLLLGGLISYFAYGQTTVTKES 130
              |:..||..::     |:|.....|.:.|.:.|   .||  ..:.:..|:.|    ..|:..:.
Frog    91 HGKRKASLSLVL-----WRFCRTRSLLAFLSLIITMTASFIGPAIFIRALLEY----ANTLKHDL 146

  Fly   131 AY--LYAMGIVLCSLVTSLVFHPFMFYVFAVGTRVRLACAGLVYRKCLRASASSGEGLGGQAISV 193
            .|  :.|.||....||.|..|.......:..|.|::.|...|.::|.|:.. .|.:...|:.:::
Frog   147 RYGLILASGIFAAELVRSWSFALHWAMNYRTGVRLKGAVLALAFKKMLKLK-QSNDIRTGELLNM 210

  Fly   194 MSIDLSQFDLTFYFFHDLWKGPVEACIFGYLMTRQ-VGWTSLIGIAFIVILIPLQAWAAKASASF 257
            .|.|..:..........|..|||.. |.|.:.|.. :|.::|:|.:..:|..|....|:|.:|.|
Frog   211 CSSDGQRLFEAASIGCMLAAGPVIG-IMGLVYTALFLGPSALLGSSVFIIFYPFMMLASKLTAYF 274

  Fly   258 GTRSAKHRDARVKLMNEIIGAIQVIKMYAWEKSFGRLIAAVRQSE---------VKAIRGSMS-- 311
            ..:.....|.||:|||||:.:|:.|||||||.:|...|..:|..|         |::|...::
Frog   275 RKKCIVVTDRRVRLMNEILNSIKFIKMYAWENTFRNKIQDIRSEEKTFLEKAGYVQSITSGVAPV 339

  Fly   312 -IYAALQCTNMISKISLFLSLVAYVYVGDLVTAKKVFILSSYYGLLNDSLLHYWPMAITTWAQTL 375
             :..|..||     .:|.::|      |..:.|.:.|.:.:.:..:. |.|...|:|:...::..
Frog   340 VVVVASVCT-----FTLHMAL------GYNLNAAEAFTVVTVFNSMT-SALKMIPLAVKAASEAS 392

  Fly   376 VSARRVVEFLLQVEKPTEESCCRDNPGL--------------------ELDAEKPKPAQ------ 414
            :|..|..:..|.     |||..|:|..|                    ....||.|.|:
Frog   393 ISISRFQKLFLM-----EESDMRNNQRLLSNDLIDFSGAYFSWSSDVRSSTLEKQKEAEQKQEEF 452

  Fly   415 -------SGRLHCVQSETKCLSFRKVSASWDKPSIKQPRKPHIEGISFHINAGQFVGIVGNVGSG 472
                   :|......||:|.:    |:.:.....|....|..:..|:|.:...:.:||.|:||||
Frog   453 KETQNLINGHYLFSSSESKQI----VNGTNASEYIVCEHKAALININFTVQKSKLIGICGSVGSG 513

  Fly   473 KSTLLHAILGEIELMQGRVEVHGRISYAAQQPWVFQGSIRENILFVEQYEEKRYRAVVHACQLDR 537
            |::|:.:|||::.|::|.|.|.|||:|||||.|:|..|:||||||.|:|:||:|:.|:..|.|..
Frog   514 KTSLILSILGQMTLLEGTVTVSGRIAYAAQQAWIFNESLRENILFGEEYKEKKYQRVLKTCCLYP 578

  Fly   538 DLELLPRGDATVVGERGISLSGGQKARIALARAVYRQADIYLFDDPLAAVDAQVGKLLMDKCFHR 602
            |:|.||.||.|.:||||.:|||||:.||:||||:|.:..:.|.||||:|||.|||..|..|....
Frog   579 DIESLPHGDLTEIGERGTNLSGGQRQRISLARALYSERSVVLLDDPLSAVDVQVGAQLFKKAIKH 643

  Fly   603 LLDGKMRILVTHHVQLLKSVDQLLLLEGGKLTQQGSYEELKDVITHHAAL-----DLEAIEADKQ 662
            .:..::.:.|||.:|.|...|::|:::.|.:.:||::|||......:|.|     .:.:|::|.|
Frog   644 GMMNRIVLFVTHQLQYLVECDEVLMMKNGSIAEQGTHEELMKYQGDYAVLFQSMQQVNSIKSDVQ 708

  Fly   663 QVKRVLSQVDR--------------------------------TSKQLSK--------------- 680
            .......|:||                                ||:.:|.
Frog   709 CSPMKYEQLDRQVTSSHHATVVQQSKEQGTLSELTNQEETGHFTSEDVSADHLTHKSEMVNRDFM 773

  Fly   681 ---------------GEEKDPATIQDENG----------NAEQQLQ----------GAVSYDTYK 710
                           |:::|.|. :||.|          |.|:|.:          |:|....|.
Frog   774 VTDGQITGCKQADQYGDQEDDAD-EDEKGSVLGNTIIVNNNERQNRDLMEPEEKGCGSVPCPIYW 837

  Fly   711 AYFRALGAPFLVCLVLSMFVLARGCQAVMDIFISRW--------------ATWEEDRGYDSVDDY 761
            .|.:|.|......|...:|:...|..|..:.::|.|              .|...|...|:.|
Frog   838 VYIKAAGGALFCVLNAVLFIFTTGSMAFSNWWLSYWIKQGSGNTSVVTSNVTLSSDNMSDNPD-- 900

  Fly   762 EATRTKMVIWYTVLLLLTLALFL----LRTFGFFFMCLRISLTLHDQLYHGIIRAWMYFFNANPS 822
                   :.:|..:.:.|||..|    :|.:.|....|:.|..|||||:..::.:.:..|:..|.
Frog   901 -------LEFYIYVYISTLAAVLGFRFIRGYVFVKSTLKASTKLHDQLFQKVLHSPLKLFDTTPL 958

  Fly   823 GRVLNRFSSDIQNVDVNLPQAMMDSLQFLVDVVAVLVIVAIANYWLLIPAAIMVILLYFCRALYI 887
            ||:||||:.|:..||..||..:...:|.::.|:..|.:::....|.|:....:.||.:....:..
Frog   959 GRILNRFTKDMDEVDARLPCQLEQLIQNMILVLFCLGMISFVFPWFLVSVLPLSILFFLINKVSR 1023

  Fly   888 GASRSLKRIESLTRSPIYSHTNQTFHGHSTIRSMDAMPQLEQTFHGHQNTNSSALFLYVSANRAF 952
            ...|.|||::::::||..||...:.||.:||::.:........|....:.|....||:..|:|..
Frog  1024 VLIRELKRLDNISQSPFLSHVTASLHGITTIQAYNKNTDFILRFQKLLDINQVPCFLFSCASRWL 1088

  Fly   953 SFWTDLICVIYILAVTFSFLVINQSFYSGDVGLAITQSMTLVIMCQWGMRQTAEMENNMTSVERV 1017
            :...|||.:|.|...:...::::........||||:.::.|..:.|:.:|...|.|...|||||:
Frog  1089 AVRLDLISMIVITLTSVCIVLMHGHIPPAYAGLAISYAVQLTGLFQYTVRLVTETEARFTSVERI 1153

  Fly  1018 LEYAQT-PSEPPLE----SPKSVNLAAEWPQAGHLRFQDLRMRYSPGDEDILRGLNFESQPMEKI 1077
            ..|.:. .||.||:    :||:      |||.|.:.|:::.|||......:|:.::|..:|.|||
Frog  1154 NHYIKNLESEEPLKAKEITPKT------WPQEGAITFENVEMRYRDKLPLVLKNISFSIRPKEKI 1212

  Fly  1078 GIVGRTGAGKSSIIQALFRLA-LNEGTIEIDGLDIGKLGLHDLRSRISIIPQDPVLFSGTLRFNL 1141
            |||||||:||||:...||||. |..|::.||...|..:||.:||.::|::|||||||.|::|.||
Frog  1213 GIVGRTGSGKSSLGMVLFRLVDLAGGSVTIDNFCINTIGLKNLRGKLSVLPQDPVLFVGSIRSNL 1277

  Fly  1142 DPFDEKSDESLWSALDDVKLKKHVASLEGGLSCRMQDGGSNFSMGQRQLVCLARAILRQNRVLVM 1206
            ||.:..:||.:|:||:...:|:||:.|.|.|:..:.:.|||||:|:|||:|:|||:||.::||::
Frog  1278 DPLNLHTDEEVWNALERTHMKQHVSKLVGKLNYEVSENGSNFSVGERQLLCMARALLRSSKVLLL 1342

  Fly  1207 DEATANVDTETDILIQETIQTKFAECTVLTIAHRLHTVMDNDSVLVMDAGQIVEFGAPHKLLQRK 1271
            |||||.:|.|||.|||||::..|.:||||.|||||:|::..|.::|||.|:||||..|..||..|
Frog  1343 DEATAAIDNETDALIQETVKEAFHDCTVLIIAHRLNTILHCDRIMVMDKGKIVEFEKPSVLLSNK 1407

  Fly  1272 DGALLKLVNQ 1281
            ......:..|
Frog  1408 KSRFHAMATQ 1417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	440/1424 (31%)
		ABC_membrane	95..360	CDD:294371	72/284 (25%)
		ABCC_MRP_domain1	428..632	CDD:213217	89/203 (44%)
		ABC_membrane	728..994	CDD:294371	70/283 (25%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	111/219 (51%)
abcc12	XP_002937916.3	MRP_assoc_pro	27..1415	CDD:188098	444/1436 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010