Protein Alignment CG10505 and LOC100493583

DIOPT Version :9

• Sequence 1: NP_611571.2
• Gene: CG10505 / 37428
• FlyBaseID: FBgn0034612
• Length: 1312
• Species: Drosophila melanogaster
• Sequence 2: XP_031752469.1
• Gene: LOC100493583 / 100493583
• -ID: -
• Length: 1289
• Species: Xenopus tropicalis
• Alignment Length: 1356
• Identity: 441/1356 - (32%)
• Similarity: 702/1356 - (51%)
• Gaps: 174/1356 - (12%)

  Fly     7 SSPKRESNPFIKANIISKWLFLWMHSVFRKGRREELDASKLYEHLPSFDSESLTRNLQPHW---- 67
            ||..::.||...|:::|:..:.|...:...|.::.|:...|:|...:..|.::....:.:|
 Frog    16 SSNGKKDNPEKNASLLSRLTYSWYSRIITLGYKKPLEREDLFELNDNDSSYTVIPIFEKNWRNEV 80

  Fly    68 ----EKESKKKNPSLMRLIFKVYGWQFVPVCILYSLLEMAIHSFQPLLLGGLISYFAYGQTTVTK 128
                :|.:..||.||:|.::..:.:..:.|..:..:.::...| .|.:|..:|::        |:
 Frog    81 ARQAQKGTVSKNVSLLRALWNTFKYSLIQVAFMKVIADILAFS-SPQILKRMIAF--------TE 136

  Fly   129 E------SAYLYAMGIVLCSLVTSLVFHPFMFYVFAVGTRVRLACAGLVYRKCLRASASSGEGL- 186
            |      :.|..|:.:::.::..:|:...:..:......:::.:..||:|||.|:.:.||.:..
 Frog   137 ERPDEGWTGYALALLLLVVTVSQTLILQLYQRFNMLAAVKMKTSVIGLIYRKALQLAYSSRKKFT 201

  Fly   187 GGQAISVMSIDLSQ-FDLTFYFFHDLWKGPVEACIFGYLMTRQVGWTSLIGIAFIVILIPLQAWA 250
            .|:.:::||.|..| .|||.. .:.||..|.:..:....:.:::|.:.|.|:..::::||:.|:.
 Frog   202 TGELVNLMSSDAQQLMDLTVN-LNLLWSAPFQILMAVVFLWQELGASVLAGVGVLILVIPINAFI 265

  Fly   251 AKASASFGTRSAKHRDARVKLMNEIIGAIQVIKMYAWEKSFGRLIAAVRQSEVKAIR--GSMSIY 313
            |...........|.:|.|:||:|||:..|:::|:||||.|:.|.:|.:|:||:..::  |.::.:
 Frog   266 ASRVKQLKKSHLKSKDQRIKLLNEILHGIKILKLYAWEPSYQRKVADIRESEMDVLKSSGYLTTF 330

  Fly   314 AALQCTNMISKISLFLSLVAY-VYV----GDLVTAKKVFILSSYYGLLNDSLLHYWPMAITTWAQ 373
            :.|..|    .|...:|:..: ||.    .:::||.|||...|.:.:|...|... |..|::..|
 Frog   331 SMLTLT----CIPFLVSMATFGVYFLLDDANVLTASKVFTTISLFNILRLPLFDL-PTVISSVVQ 390

  Fly   374 TLVSARRVVEFLLQVEKPTEESCCRDNPGLELDAEKPKPAQSGRLHCVQSETKCLSFRKVSASWD 438
            |.||..|:..|.           |    |.|::.|..:...||. |.|       .|...|..||
 Frog   391 TRVSLGRLENFF-----------C----GEEINTENIETKYSGS-HAV-------GFSGASFQWD 432

  Fly   439 K--PSIKQPRKPHIEGISFHINAGQFVGIVGNVGSGKSTLLHAILGEIELMQGRVEVHGRISYAA 501
            |  |||       ::.:.|.|..|..|.:||.||||||:||.|||||:..::|:|:..|.::|.:
 Frog   433 KTGPSI-------LKDLDFKIPEGSLVAVVGQVGSGKSSLLSAILGEMNTLEGKVQRKGAVAYVS 490

  Fly   502 QQPWVFQGSIRENILFVEQYEEKRYRAVVHACQLDRDLELLPRGDATVVGERGISLSGGQKARIA 566
            ||.|:.....:|||||...:.::.|..|:.||.|..||||||.||.|.:||||::||||||.|::
 Frog   491 QQAWIQNALFQENILFGLAFNKQHYERVLEACALLPDLELLPNGDQTEIGERGVNLSGGQKQRVS 555

  Fly   567 LARAVYRQADIYLFDDPLAAVDAQVGKLLMDKCF--HRLLDGKMRILVTHHVQLLKSVDQLLLLE 629
            ||||||..|||||.||||:|||..|||.|.||..  ..|:..|.|:||||.:.:|...|.::::|
 Frog   556 LARAVYSNADIYLLDDPLSAVDVHVGKHLFDKLIGPKGLIKNKTRVLVTHSLTVLPQTDLIIVME 620

  Fly   630 GGKLTQQGSYEEL-------KDVI------THHAAL-DLEAIEADKQQVKRVLSQ-------VDR 673
            .|:....|:|:||       .|:|      |.:..| |...:..|.:.::|..||       .||
 Frog   621 EGRAAHIGTYQELMSKRQNFADMIQTFNKGTENEQLSDTAGVFRDPKALQRTKSQHEDGFIKKDR 685

  Fly   674 TSKQLSKGEEKDPATIQDENGNAEQQLQGAVSYDTYKAYFRALG---APFLVCLVLSMFVLARGC 735
            |..::||....          ..|:...|.:.......|..|.|   ..|.|...:....||.|
 Frog   686 TLTEMSKMPSM----------KKEKVATGNMRMSIVMKYLYAFGWSWVWFTVIAYIGQNALAVG- 739

  Fly   736 QAVMDIFISRWATWEEDRGYDSVDDYEATRTKMVIWYTVLLLLTLALFLLRTFGFFFM---CLRI 797
               .::::|||||  |.:|.....::...|...:..|.   ||.....:|..:|.:.:   .:..
 Frog   740 ---QNVWLSRWAT--EAKGIRETSEWTELRNNRLGIYG---LLGFVQGILVCYGAYVVTRGTICA 796

  Fly   798 SLTLHDQLYHGIIRAWMYFFNANPSGRVLNRFSSDIQNVDVNLPQAMMDSLQFLVDVVAVLVIVA 862
            |..||:|:...::...:.||...|.|::||||:.|:..:|......:...|..::||:..::::.
 Frog   797 SRLLHNQMLDNVLHLPLQFFETTPMGQLLNRFTKDVYVIDERFHYYLRTWLNCMLDVLGTIIVIV 861

  Fly   863 IANYWLLIPAAIMVILLYFCRALYIGASRSLKRIESLTRSPIYSHTNQTFHGHSTIRSMDAMPQL 927
            .|....::....:..|....:..||.:||.::|::..:|||:.||..:|..|..|||:
 Frog   862 YATPIFILAVVPLGFLYLLIQRYYISSSRQIRRLDGASRSPVISHFGETLMGAPTIRA------- 919

  Fly   928 EQTFHGHQ-----------NTNSSALFLYVSANRAFSFWTDLICVIYILAVTFSFLVINQSFY-- 979
                :|||           |.|....:..|.:||    |         |||...||.....|:
 Frog   920 ----YGHQERFINQNKDVVNENLVCYYNNVISNR----W---------LAVRLEFLGSLMIFFAA 967

  Fly   980 -----------SGDVGLAITQSMTLVIMCQWGMRQTAEMENNMTSVERVLEYAQTPSEPPLESPK 1033
                       ||.|||:||.::.:.....:.:|:..|:|.|..::||:.||.:...|.|....|
 Frog   968 LFAVQAGDKMNSGIVGLSITYALNITQTLNFWVRKACEIETNGVAIERICEYEEMQKEAPWIMGK 1032

  Fly  1034 SVNLAAEWPQAGHLRFQDLRMRYSPGDEDILRGLNFESQPMEKIGIVGRTGAGKSSIIQALFRLA 1098
              .....||..|.:.|.:.:.||....:..|:.:.|.....||:|||||||||||::...|||..
 Frog  1033 --RPPVRWPDQGIIEFVNYKARYREDHDLALQDITFRLHATEKLGIVGRTGAGKSTLTNCLFRTV 1095

  Fly  1099 LNEGT---IEIDGLDIGKLGLHDLRSRISIIPQDPVLFSGTLRFNLDPFDEKSDESLWSALDDVK 1160
              |||   |.|||:||..:|||||||:::|||||||||||||:.||||.::.||..||.||:...
 Frog  1096 --EGTGGKIIIDGIDIATIGLHDLRSKLNIIPQDPVLFSGTLQMNLDPLEQHSDAELWEALELCH 1158

  Fly  1161 LKKHVASLEGGLSCRMQDGGSNFSMGQRQLVCLARAILRQNRVLVMDEATANVDTETDILIQETI 1225
            ||..|.||...|...:.:||.|.|:|||||:|||||:||:.::||:|||||::|.|||.|:|.||
 Frog  1159 LKPFVMSLPKRLYHDISEGGENLSVGQRQLICLARALLRKAKILVLDEATASIDMETDNLVQATI 1223

  Fly  1226 QTKFAECTVLTIAHRLHTVMDNDSVLVMDAGQIVEFGAPHKLLQRKDGALLKLVNQ 1281
            :..|::|||||||||||:|:|::.|||:|||::||||.|.:|:::| |...:::::
 Frog  1224 RKAFSDCTVLTIAHRLHSVLDSERVLVLDAGRVVEFGEPQRLIEKK-GYFSRMISE 1278

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	436/1336 (33%)
		ABC_membrane	95..360	CDD:294371	69/279 (25%)
		ABCC_MRP_domain1	428..632	CDD:213217	98/207 (47%)
		ABC_membrane	728..994	CDD:294371	72/292 (25%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	122/221 (55%)
LOC100493583	XP_031752469.1	MRP_assoc_pro	24..1279	CDD:188098	438/1348 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920