DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10505 and abcc4

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	XP_002939329.2	Gene:	abcc4 / 100491006	XenbaseID:	XB-GENE-957302	Length:	1324	Species:	Xenopus tropicalis

Alignment Length:	1345	Identity:	509/1345 - (37%)
Similarity:	802/1345 - (59%)	Gaps:	77/1345 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 QSSPK-RESNPFIKANIISKWLFLWMHSVFRKGRREELDASKLYEHLPSFDSESLTRNLQPHWEK 69
            |..|| .::||...||..||..|.|::.:|..|.:.:|:...:||.||...|..|...||.:|||
Frog     2 QPVPKGSKANPSQHANFCSKIFFWWLNPLFILGHKRKLEEDDMYEVLPEDASRKLGEELQWYWEK 66

  Fly    70 ESKK-----KNPSLMRLIFKVYGWQFVPVCILYSLLEMAIHSFQPLLLGGLISYFAY--GQTTVT 127
            |.:|     :.|.|.:.|.:.: |:...|..|::..|.:|...||:.||.:||||..  ...:..
Frog    67 ELQKAQNEGRKPRLTKAIIRCH-WKTFSVLGLFTFFEESIRVVQPIFLGNVISYFERYDANDSAV 130

  Fly   128 KESAYLYAMGIVLCSLVTSLVFHPFMFYVFAVGTRVRLACAGLVYRKCLRAS-ASSGEGLGGQAI 191
            ..:||:.|..:..|:|:.::|.|.:.:::...|.::|:|...::|||.||.| .:.|:...||.:
Frog   131 LANAYINAAALSACTLILAVVHHIYFYHLLRAGMKLRVAMCHMIYRKALRLSNTAMGKTTTGQIV 195

  Fly   192 SVMSIDLSQFDLTFYFFHDLWKGPVEACIFGYLMTRQVGWTSLIGIAFIVILIPLQAWAAKASAS 256
            :::|.|:::||....|.|.||.||::|.....|:..::|.:.|.|:|.::||:|||....|...|
Frog   196 NLLSNDVNKFDQVTIFLHFLWAGPLQAIAVTVLLWMEIGPSCLAGMAVLIILMPLQLCLGKFFTS 260

  Fly   257 FGTRSAKHRDARVKLMNEIIGAIQVIKMYAWEKSFGRLIAAVRQSEV-KAIRGSMSIYAALQCTN 320
            ...::|...|.|::.|||:|..:::|||||||:||..|:..:|:.|: |.:|.|......|....
Frog   261 LRGKTAAFTDTRIRTMNEVISGMRIIKMYAWEQSFTELVNNIRKKEINKVLRSSYLRALNLASFF 325

  Fly   321 MISKISLFLSLVAYVYVGDLVTAKKVFILSSYYGLLNDSLLHYWPMAITTWAQTLVSARRVVEFL 385
            :.|||.||::...||.:|::::|.:||:..|.|..:..::..::|.|:...::..||.||:..||
Frog   326 VASKIILFVTFTTYVLLGNVISASRVFVAVSLYSAVRLTVTLFFPSAVERASEAKVSIRRIKNFL 390

  Fly   386 L--QVEKPTEESCCRDNPGLELDAEKPKPAQSGRLHCVQSETKCLSFRKVSASWDKPSIKQPRKP 448
            |  ::.|          |.|||..|             ..|...:..:.|:..|||..    ..|
Frog   391 LLDEIFK----------PALELPEE-------------NEENLLVQIQDVTCYWDKTL----EIP 428

  Fly   449 HIEGISFHINAGQFVGIVGNVGSGKSTLLHAILGEIELMQGRVEVHGRISYAAQQPWVFQGSIRE 513
            .::.||..:..|:.:.::|.||:|||:||.|:|||:...:|.|::.|||:|.:||||||.|::|.
Frog   429 TLQNISCSVRPGELLAVIGPVGAGKSSLLSAVLGELPKDKGFVDIRGRIAYVSQQPWVFSGTVRS 493

  Fly   514 NILFVEQYEEKRYRAVVHACQLDRDLELLPRGDATVVGERGISLSGGQKARIALARAVYRQADIY 578
            ||||.::|.:::|..|:..|.|.:|:..|..||.|::|:||::||||||||:.||||||:.||||
Frog   494 NILFGKEYVQEKYDKVLRVCALKKDMLQLDDGDLTIIGDRGVTLSGGQKARVNLARAVYQDADIY 558

  Fly   579 LFDDPLAAVDAQVGKLLMDKCFHRLLDGKMRILVTHHVQLLKSVDQLLLLEGGKLTQQGSYEELK 643
            |.||||:||||:||:.|.:||..:.|..|:.|||||.:|.|.:..|:|:|:.|::..:|:::||.
Frog   559 LLDDPLSAVDAEVGRHLFEKCICQALRKKLCILVTHQLQYLSAAKQILILKEGRMVGKGTFQELL 623

  Fly   644 DVITHHAAL--DLEAIEADKQQVKRVLSQVDRTSKQLSKGEEKDPATIQDENGNA---------- 696
            ......|:|  ..|..::..|:.:.:.|..:||..|.|...:  .:|:|.....|
Frog   624 QSGIDFASLLKSEEEEQSQSQEGQLIKSSRNRTFSQSSVWSQ--DSTVQSHKEGATDNLAAEPVL 686

  Fly   697 -----EQQLQGAVSYDTYKAYFRALGAPFLVCLVLSMFVLARGCQAVMDIFISRWATWEEDRGYD 756
                 |.:.:|.|.:..||.||.:..:..::.:||.:.:|::....:.|.::|.||..:......
Frog   687 TAIPEESRSEGTVGFKVYKKYFTSGSSYLMLFVVLLLNILSQVTYVLQDWWLSYWANEQGKLNIT 751

  Fly   757 SVDDYEATRTK---MVIW---YTVLLLLTLALFLLRTFGFFFMCLRISLTLHDQLYHGIIRAWMY 815
            |..:...::|:   :.::   |..|.:.|:...:||....|.:.:..:..||:|::..:::|.:.
Frog   752 SGTNSTGSKTEQLDLTLYLGVYAGLTVATIIFGVLRCLLVFHVLVCAAQALHNQMFQSLLKAPVL 816

  Fly   816 FFNANPSGRVLNRFSSDIQNVDVNLPQAMMDSLQFLVDVVAVLVIVAIANYWLLIPAAIMVILLY 880
            ||:.||.||:|||||.||.::|..:|...:|.:|.|:.::.|:.:......|:|||...:||:.|
Frog   817 FFDRNPIGRILNRFSKDIGHLDDLMPFTFLDFMQVLLQILGVIAVAVAVIPWILIPLLPLVIVFY 881

  Fly   881 FCRALYIGASRSLKRIESLTRSPIYSHTNQTFHGHSTIRSMDAMPQLEQTFHGHQNTNSSALFLY 945
            |.|..::..||.:||:||.||||::||.:.:..|..|||:..|..:.:..|...|:.:|.|.||:
Frog   882 FLRRYFLDTSRDIKRLESTTRSPVFSHLSSSLQGLWTIRAFKAEKRFQDLFDAQQDLHSEAWFLF 946

  Fly   946 VSANRAFSFWTDLICVIYILAVTFSFLVINQSFYSGDVGLAITQSMTLVIMCQWGMRQTAEMENN 1010
            ::.:|..:...|.||.::::|:.|..:::.::..:|.||||::..||::...|||:||:||:||.
Frog   947 LTTSRWLAVRLDAICAVFVIAIAFGSIILAENLDAGQVGLALSYGMTIMGSFQWGVRQSAEVENL 1011

  Fly  1011 MTSVERVLEYAQTPSEPPLESPKSVNLAAEWPQAGHLRFQDLRMRYSPGDEDILRGLNFESQPME 1075
            |.|.|||:||.|...|...||....  .|:||..|.:.|:::...||.....:||.||...:|.|
Frog  1012 MISAERVMEYTQLEKEAEWESKNPP--PADWPNKGMITFENVNFSYSLDGPVVLRHLNALIRPKE 1074

  Fly  1076 KIGIVGRTGAGKSSIIQALFRLALNEGTIEIDGLDIGKLGLHDLRSRISIIPQDPVLFSGTLRFN 1140
            |:||||||||||||:|.||||||..||.|.||.....||||||||.::|||||:||||:||:|.|
Frog  1075 KVGIVGRTGAGKSSLIAALFRLAEPEGKIWIDKYLTSKLGLHDLRKKMSIIPQEPVLFTGTMRKN 1139

  Fly  1141 LDPFDEKSDESLWSALDDVKLKKHVASLEGGLSCRMQDGGSNFSMGQRQLVCLARAILRQNRVLV 1205
            ||||||.:||.||..|::|:||:.|..|.|.:..::.:.|||||:||||||||||||||:||:|:
Frog  1140 LDPFDEHADEELWDVLEEVQLKEAVEELPGKIETQLSESGSNFSVGQRQLVCLARAILRRNRILI 1204

  Fly  1206 MDEATANVDTETDILIQETIQTKFAECTVLTIAHRLHTVMDNDSVLVMDAGQIVEFGAPHKLLQR 1270
            :||||||||..||.|||:||:.||||||||||||||:|::|:|.::|:|||::.|:..|:.|||.
Frog  1205 IDEATANVDPRTDELIQKTIREKFAECTVLTIAHRLNTIIDSDKIMVLDAGRVKEYDEPYLLLQN 1269

  Fly  1271 KDGALLKLVNQ---------NDATTVKFLKRIASESYMRRNRRDS 1306
            |:....|:|.|         |:|....:||:|..|: .:.:.||:
Frog  1270 KESLFYKMVQQVGKAEATALNEAAKQVYLKKIHQEN-TKNSTRDN 1313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	491/1289 (38%)
		ABC_membrane	95..360	CDD:294371	89/268 (33%)
		ABCC_MRP_domain1	428..632	CDD:213217	95/203 (47%)
		ABC_membrane	728..994	CDD:294371	81/271 (30%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	132/218 (61%)
abcc4	XP_002939329.2	PLN03130	2..1289	CDD:215595	501/1318 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0001028
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.110