DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10505 and tap2

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	XP_002942649.3	Gene:	tap2 / 100489020	XenbaseID:	XB-GENE-481680	Length:	728	Species:	Xenopus tropicalis

Alignment Length:	536	Identity:	135/536 - (25%)
Similarity:	243/536 - (45%)	Gaps:	74/536 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   772 YTVLLLLTLALFLLRTFG-FFFMCLRISLTLHDQLYHGIIRAWMYFFNANPSGRVLNRFSSDIQN 835
            :..:..:|.::|.....| |.|...|::..|...|:..:|:..:.||.|..||.:.:|.::|...
Frog   211 FMAMFSITSSIFAGSRGGLFMFSLARLTQRLRLLLFRSVIKQEIAFFEATKSGDITSRLTNDTAR 275

  Fly   836 VDVNLPQAMMDSLQFLVDVVAVLVIVAIANYWLLIPAAIMVILLYFCRALYIGASRSL-KRI-ES 898
            |..::...:..:|:.||..|.|...:...::.|.:...|...|.:..:.:|....:.| ||: :|
Frog   276 VSRSIAANVNITLRMLVKCVGVYSFMFSLSWQLTLLTFISSPLTWIIQKVYNYYHQDLVKRVQDS 340

  Fly   899 LTRSP------------IYSHTNQTFHGHSTIRSMDAMPQLEQTFHGHQNTNSSALFLYVSANRA 951
            :.||.            :||...:.........|:       |..|..|........||:...|.
Frog   341 IARSSELAKEIIESVRNVYSFAAEEEEAKRYENSL-------QETHVLQTRRDFVTALYLLVTRL 398

  Fly   952 FSFWTDLICVIYILAVTFSFLVINQSFY-SGDVGLAITQSM-------TLVIMCQWGMRQTAEME 1008
            .:..|.:..:.|      ..::|...|. ||.:...|...|       |||.|       .:|:.
Frog   399 VNLGTQVTMLYY------GQILIRSGFISSGKMVSFILYQMESDSYIRTLVHM-------LSEIT 450

  Fly  1009 NNMTSVERVLEYAQTPSEPPLES-----PKSVNLAAEWPQAGHLRFQDLRMRYSPGDEDI--LRG 1066
            :...:.|:|.:|..  .||.:.:     |.::.        |...|.::...| |...:|  |:.
Frog   451 HAAGAAEKVFQYLD--REPQVSASGCLCPGTLQ--------GRFEFSNVTFSY-PSRPEILALQN 504

  Fly  1067 LNFESQPMEKIGIVGRTGAGKSSIIQALFRLALNE-GTIEIDGLDIGKLGLHDLRSRISIIPQDP 1130
            ::|...|.....:||.:|.||::.:..|.|....: |.|.:||..:.:.....|.|:::::.|:|
Frog   505 VSFTLPPGSVTALVGPSGGGKTTCVSLLERFYEPQGGNILLDGKPLKEYKHEYLHSKVALVAQEP 569

  Fly  1131 VLFSGTLRFNLD------PFDEKSDESLWSALDDVKLKKHVASLEGGLSCRMQDGGSNFSMGQRQ 1189
            |||:|::|.|:.      |     :|.|.:|....|.:..:..:|......:.:.|:..|.||:|
Frog   570 VLFAGSVRENISYGLYNIP-----EEKLKAAARKAKAEDFIEGMEKAYDTDVGNSGAQLSAGQKQ 629

  Fly  1190 LVCLARAILRQNRVLVMDEATANVDTETDILIQETIQTKFAECTVLTIAHRLHTVMDNDSVLVMD 1254
            .|.||||:.|:.::|::|||::.:|.||:..||:::|: ..:.::|.|||||.||...|.:||::
Frog   630 RVALARALARKPKLLILDEASSCLDAETEHEIQKSLQS-IEDLSLLIIAHRLRTVQKADQILVLE 693

  Fly  1255 AGQIVEFGAPHKLLQR 1270
            ||.:||.|...||:|:
Frog   694 AGNLVEQGTHEKLVQK 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	133/532 (25%)
		ABC_membrane	95..360	CDD:294371
		ABCC_MRP_domain1	428..632	CDD:213217
		ABC_membrane	728..994	CDD:294371	50/244 (20%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	72/227 (32%)
tap2	XP_002942649.3	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000