DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10505 and cftr

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	XP_031754831.1	Gene:	cftr / 100486085	XenbaseID:	XB-GENE-853972	Length:	1485	Species:	Xenopus tropicalis

Alignment Length:	1518	Identity:	407/1518 - (26%)
Similarity:	709/1518 - (46%)	Gaps:	261/1518 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ESNPFIKANIISKWLFLWMHSVFRKGRREELDASKLYEHLPSFDSESLTRNLQPHWEKE--SKKK 74
            :.:|..||:|.|:..|.|...:..||.|:.|:.|.:|:..|...:::|:..|:..|::|  :.||
Frog     2 QRSPLEKASIFSQIFFSWTKPILWKGYRQRLELSDIYQIHPGDSADNLSERLEREWDREVATSKK 66

  Fly    75 NPSLMRLIFKVYGWQFVPVCILYSLLEMAIHSFQPLLLGGLISYFAYGQTTVTKES-AYLYAMGI 138
            ||.|:..:.:.:.|:|:...||..|.|:. .:.||||||.:|:  :|.:....:.| ||..|:|:
Frog    67 NPKLINALKRCFFWKFLFYGILLYLGEVT-KAVQPLLLGRIIA--SYDRDNEHERSIAYYLAIGL 128

  Fly   139 VLCSLVTSLVFHPFMFYVFAVGTRVRLACAGLVYRKCLRASASSGEGLG-GQAISVMSIDLSQFD 202
            .|..:|..|:.||.:|.:..:|.::|:|...|:|:|.|:.|:...:.:. ||.:|::|.:|::||
Frog   129 CLLFVVRMLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISTGQLVSLLSNNLNKFD 193

  Fly   203 LTFYFFHDLWKGPVEACIFGYLMTRQVGWTSLIGIAFIVILIPLQAWAAKASASFGTRSAKHRDA 267
            ......|.:|..|::..:...|:...:..::..|:.|::||...|||..:....:..:.|...:.
Frog   194 EGLALAHFVWIAPLQVLLLMGLLWDLLQASAFCGLGFLIILALFQAWLGRMMMKYRDKRAGKINE 258

  Fly   268 RVKLMNEIIGAIQVIKMYAWEKSFGRLIAAVRQSEVKAIRGSMSI-YAALQCTNMISKISLFLSL 331
            |:.:.:|||..||.:|.|.||.:..::|..:|::|:|..|.:..: |.............:||.:
Frog   259 RLVITSEIIENIQSVKAYCWESAMEKIIETIRETELKLTRKAAYVRYFNSSAFFFSGFFVVFLCI 323

  Fly   332 VAYVYVGDLVTAKKVFILSSYYGLLNDSLLHYWPMAITTWAQTLVSARRVVEFLLQVEKPTEESC 396
            |.::.: |.::.:|:|...|:..:|..::...:|.|:.||..:|....::.|||.:.|..:.|
Frog   324 VPHLLL-DGISLRKIFTTISFSIVLRMAVTRQFPWAVQTWYDSLGVINKIQEFLQKEEYKSLE-- 385

  Fly   397 CRDNPGLELDAEKPKPAQSGRLHCVQSETKCLSFRKVSASWDKP-----------------SIKQ 444
                                    ....|..::...||||||:.                 |.:.
Frog   386 ------------------------YNLTTTEVAMENVSASWDEGIGEFFEKAKQEVNGGNISNED 426

  Fly   445 PR----------KPHIEGISFHINAGQFVGIVGNVGSGKSTLLHAILGEIELMQGRVEVHGRISY 499
            |.          .|.:..|:|.|..||.:.|.|:.|:||::||..|:||:|...|:::..||||:
Frog   427 PSPFFSNFSLHVAPVLRNINFKIEKGQLLAIAGSTGAGKTSLLMMIMGELEPSAGKIKHSGRISF 491

  Fly   500 AAQQPWVFQGSIRENILFVEQYEEKRYRAVVHACQLDRDLELLPRGDATVVGERGISLSGGQKAR 564
            :.|..|:..|:|:|||:|...|::.||.:|:.||||:.|:...|..|.||:||.||:|||||:||
Frog   492 SPQVSWIMPGTIKENIIFGVSYDQYRYLSVIKACQLEEDISKFPEKDNTVLGEGGITLSGGQRAR 556

  Fly   565 IALARAVYRQADIYLFDDPLAAVDAQVGKLLMDKCFHRLLDGKMRILVTHHVQLLKSVDQLLLLE 629
            |:||||||:.||:||.|.|.:.:|....|.:.:.|..:|:..|.|||||..|:.||..|::|:|.
Frog   557 ISLARAVYKDADLYLMDSPFSYLDLFTEKEIFESCVCKLMANKTRILVTSKVEQLKKADKVLILH 621

  Fly   630 GGKLTQQGSYEELKD----------------------VITHHAALDLEAIEAD----KQQVK--- 665
            .|.....|::.||:|                      :||.  .|...:|::|    :.:||
Frog   622 EGSCYFYGTFSELQDQRPEFSSHLTGFDHFNAERRNSIITE--TLRRCSIDSDPTAVRNEVKNKS 684

  Fly   666 ----------------------RVLSQVDRTSKQLSKGEEKD-------------PATIQDE--- 692
                                  |..|.:.::..|:|..||:|             |.:.|.|
Frog   685 FKQVADFSEKRKNSVINPRKSSRKFSIMQKSQPQMSGIEEEDIPPNQGERKLSLVPESEQGEASL 749

  Fly   693 ------------NGNAEQQL----------QGA-------------------------------V 704
                        .|...|.:          ||:                               :
Frog   750 PRSNVLNTGPTFQGRRRQSVLNLMTRTSVSQGSNAFATRNTSVRKMSVGSFSNSSFEVDIYNRRL 814

  Fly   705 SYD-----------------------------TYKAYFRALGA--PFLVCLVLSMFVLARGCQAV 738
            |.|                             |:..|.|.|.|  .|:..||..:.:.      :
Frog   815 SQDSILEVSEEINEEDLKECFLDDTDSPSPTTTWNTYIRFLTAHKNFIFILVFCIVIF------L 873

  Fly   739 MDIFISRWATW------------EEDRGYDSVDDYEATRTKMVIWYTVLLLL-----TLALFLLR 786
            .::..|....|            ..:...::.|......|....:|...:.:     .|||.:.|
Frog   874 AEVIASSAGLWIIKRNAPVSNMTSNENISEASDILSVIVTHTSFYYVFYIYVGVADSLLALGIFR 938

  Fly   787 TFGFFFMCLRISLTLHDQLYHGIIRAWMYFFNANPSGRVLNRFSSDIQNVDVNLPQAMMDSLQFL 851
            ........:.:|..||.::.|.|:.|.|..||...:||:|||||.|...:|..||.::.|..|.:
Frog   939 GLPLVHSLISVSRVLHKKMLHSILHAPMSTFNTMRAGRILNRFSKDTAILDDILPLSIFDFTQLV 1003

  Fly   852 VDVVAVLVIVAIANYWLLIPAAIMVILLYFCRALYIGASRSLKRIESLTRSPIYSHTNQTFHGHS 916
            :.|:..:.:|::...::.:....::......|:.::..|:.||::||..||||::|...:..|..
Frog  1004 LIVIGAITVVSLLEPYIFLATVPVIAAFILLRSYFLHTSQQLKQLESEARSPIFAHLITSLKGLW 1068

  Fly   917 TIRSMDAMPQLEQTFHGHQNTNSSALFLYVSANRAFSFWTDLICVIYILAVTFSFLVINQSFYSG 981
            |:|:....|..|..||...|.:::..|||:|..|.|....::|.||:.:||:|..:..:.   :|
Frog  1069 TLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMTIEMIFVIFFIAVSFISIATSG---AG 1130

  Fly   982 D--VGLAITQSMTLVIMCQWGMRQTAEMENNMTSVERVLEYAQTPSEPPL------ESPKSVNLA 1038
            :  ||:.:|.:|.::...||.:..:.::::.|.||.|:..:...|.|..:      :...|..|.
Frog  1131 EEKVGIVLTLAMNIMNTLQWAVNASIDVDSLMRSVSRIFRFIDMPREELIHDNNHKDDQLSEVLI 1195

  Fly  1039 AE---------WPQAGHLRFQDLRMRYSPGDEDILRGLNFESQPMEKIGIVGRTGAGKSSIIQAL 1094
            .|         ||..|.:..::|..:|..|...:|..::|...|.:::|::||||:|||:::.|.
Frog  1196 YENDYIKKNQVWPSGGQMTVKNLSAKYKDGGHTVLENISFSLNPGQRVGLLGRTGSGKSTLLSAF 1260

  Fly  1095 FRLALNEGTIEIDGLDIGKLGLHDLRSRISIIPQDPVLFSGTLRFNLDPFDEKSDESLWSALDDV 1159
            .||...:|.|:|||:....:.|...|....::||...:||||:|.||||:.:.|||.|....::|
Frog  1261 LRLLSTQGDIQIDGVSWQTIPLQKWRKAFGVVPQKVFIFSGTIRKNLDPYGKWSDEELLKVTEEV 1325

  Fly  1160 KLKKHVASLEGGLSCRMQDGGSNFSMGQRQLVCLARAILRQNRVLVMDEATANVDTETDILIQET 1224
            .||..:....|.|...:.|||...|.|.:|||||||::|.:.::|::||.:|::|..|..:|::|
Frog  1326 GLKSIIDQFPGQLDFVLLDGGCVLSHGHKQLVCLARSVLSKAKILLLDEPSAHLDPITFQIIRKT 1390

  Fly  1225 IQTKFAECTVLTIAHRLHTVMDNDSVLVMDAGQIVEFGAPHKLLQRKDGALLKLVNQNDATTVKF 1289
            ::..||.|||:...|||..:::....||::...:.::.:..||:..| ....:.::|:|...:..
Frog  1391 LKHAFANCTVILSEHRLEAMLECQHFLVIEDNTVRQYDSIQKLMNEK-SFFKQAISQSDRLKLFP 1454

  Fly  1290 LKRIASESYMRRNRRDSLTISEE 1312
            |.|  ..|..|::|.....:.||
Frog  1455 LHR--RNSSKRKSRPKISALQEE 1475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	396/1472 (27%)
		ABC_membrane	95..360	CDD:294371	74/267 (28%)
		ABCC_MRP_domain1	428..632	CDD:213217	91/230 (40%)
		ABC_membrane	728..994	CDD:294371	69/284 (24%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	76/218 (35%)
cftr	XP_031754831.1	CFTR_protein	1..1472	CDD:273530	405/1513 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10481
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.110