Protein Alignment CG10505 and abcc8b

DIOPT Version :10

• Sequence 1: NP_611571.2
• Gene: CG10505 / 37428
• FlyBaseID: FBgn0034612
• Length: 1312
• Species: Drosophila melanogaster
• Sequence 2: XP_068071075.1
• Gene: abcc8b / 100329706
• ZFINID: ZDB-GENE-120215-45
• Length: 1608
• Species: Danio rerio
• Alignment Length: 1427
• Identity: 431/1427 - (30%)
• Similarity: 696/1427 - (48%)
• Gaps: 219/1427 - (15%)

  Fly    15 PFIKANIISKWLFLWMHSVFRKGRREELDASKLYEHLP--------------SFDS--ESLTRNL 63
            ||:  |::||..:.||::......:..:|. |....||              :|||  ||...:|
Zfish   235 PFV--NLLSKSTYWWMNTFITSAHQRPIDL-KTIGKLPKSMRALSNFQQLRKAFDSQMESGCVHL 296

  Fly    64 Q-PHWEKESKKK---NPSLMRLIFKVYGWQFVPVCILYSLLEMAIHSFQPLLLGGLISYFAYGQT 124
            | ..|...:.::   .|.|:.:.|:          .:..||..|    .||.:.|::.:.:....
Zfish   297 QGSGWMWRALRQAFGAPLLLSICFR----------FISDLLGFA----GPLCISGILQHISRDNH 347

  Fly   125 T------------VTKE----SAYLYAMGIVLCSLVTSLVFHPFMFYVFAV--GTRVRLACAGLV 171
            |            ::.|    :||:.|: ::..:|:....|....:|| |:  |..:|.|....:
Zfish   348 TAPPPVKLLGVHFISSEVFFANAYVLAV-LLFLALLLQRTFLQASYYV-AIENGINLRGAVQTKI 410

  Fly   172 YRKCLR---ASASSGEGLGGQAISVMSIDLSQFDLTFYFFHDLWKGPVEACIFGYLMTRQVGWTS 233
            |.|.:|   ::.|.|:....|..::::.|.:|....|:...:||..||:..|...|:...:|.::
Zfish   411 YNKIMRLCTSNMSMGDMTTAQICNLVARDTNQLMWFFFLCPNLWAMPVQIVIGVLLLYYLLGASA 475

  Fly   234 LIGIAFIVILIPLQAWAAKASASFGTRSAKHRDARVKLMNEIIGAIQVIKMYAWEKSFGRLIAAV 298
            |||...|.:|.|||.:.|...:.....:.::...|:|..||::..|:::|:||||..|...:...
Zfish   476 LIGATVITVLAPLQYFVATRLSRAQKSTLEYTSERLKKTNELLRGIKLLKLYAWEHIFRSSVEET 540

  Fly   299 RQSEVKAIRGSMSIYAALQC-TNMISKISLFLSL-VAYVYV--------------GDL----VTA 343
            |:.|:.::| :.::|.:|.. .|....|:..|:: |.:|::              |.|    :..
Zfish   541 RRQELTSLR-TFALYTSLSIFMNAAIPIAAVLTIFVVHVHLQSSSDFALSPAVAFGSLSLFHILV 604

  Fly   344 KKVFILSSYYGLLNDSLLHYWPMAITTWAQTLVSARRVVEFLLQVEKPTEESCCRDNP------- 401
            ..:|:||        |:||       :..:.|||.:::.|||...|..|::......|
Zfish   605 TPLFLLS--------SVLH-------STVKALVSVQKLSEFLSSAEIETDQDPIAQTPANNNGNI 654

  Fly   402 ----GLELDAE----KPKPAQSGRLHCVQSETK-----------CLSFRKVSASWDKPSIKQPRK 447
                .|:|.|:    |.|..|....:..|.:.:           |:.......||.:..
Zfish   655 KSVYALQLQAKLVNRKNKAKQDVNRNFEQQDQELRASAQHEDNICIKIVNGYFSWTQGC------ 713

  Fly   448 PHIEGISFHINAGQFVGIVGNVGSGKSTLLHAILGEIELMQG--------------RVEVH---- 494
            |.:..|...:..||...|||.||||||:||.|.|||::.:.|              .:..|
Zfish   714 PTLTNIDIKVPFGQLTMIVGQVGSGKSSLLLAALGEMQKISGSITWNSLPRSDSDENIRAHDMSG 778

  Fly   495 -------GRISYAAQQPWVFQGSIRENILFVEQYEEKRYRAVVHACQLDRDLELLPRGDATVVGE 552
                   |.::||:|:||:...::.|||||......|||:.|:..|||..|::.||:||.||:||
Zfish   779 RQSFTRRGSVAYASQRPWLLNATVEENILFDTAPNVKRYKDVIEVCQLGPDIDTLPQGDQTVIGE 843

  Fly   553 R----GISLSGGQKARIALARAVYRQADIYLFDDPLAAVDAQVGKLLMDKCFHRLLDGKMR--IL 611
            |    ||.|||||:.||::|||:|:|.::...|||.:|:|..:...||.:...:.|..:.|  :|
Zfish   844 RVRHLGIILSGGQRQRISVARALYQQTNVVFLDDPFSALDIHLSDHLMHEGILKFLRQEKRSVVL 908

  Fly   612 VTHHVQLLKSVDQLLLLEGGKLTQQGSYEELKDVITHHAAL-----------DLE-AIEADKQQV 664
            |||.:|.|...|.::.:..|.:..||:   |||:......|           |.| :.|..::..
Zfish   909 VTHKLQYLPHADWIIAMRDGTVQTQGT---LKDIQCAEPELFEQWRTLMNRQDKENSTELKRKSF 970

  Fly   665 KRVL---------SQVDRTSKQLSKGEEKDPATIQDENG-NAEQQLQGAVSYDTYKAYFRALGAP 719
            :|.:         ...|.....::..|.||.:|..||:. .||.:.:..:.:.::..|.:|.|..
Zfish   971 RRAMMYSRDTVATDDEDEAVADVAVSEVKDSSTSTDEDSLGAELRHRTTIPWSSFATYLKAAGLF 1035

  Fly   720 FLVCLVLSMFVLAR-GCQAVMDIFISRWATWEEDRGYDSVDDYEATRTKMVI----WY----TVL 775
            .|..|::|.  ||: .....:|.:::.| |.:.........:...|.||..:    ||    .:|
Zfish  1036 LLPLLIVSQ--LAKHSLMVAIDFWLAHW-TSDVIAAQSESAERNCTFTKDCVFSHSWYLQVFCLL 1097

  Fly   776 LLLTLALFLLRTFGFFFMCLRISLTLHDQLYHGIIRAWMYFFNANPSGRVLNRFSSDIQNVDVNL 840
            ..|.:.|.|:.:....:..||::..||..|...|:.|.|..|...|.|.:|||||:|...:|.::
Zfish  1098 CALGIVLCLVTSLAVEWTGLRVAKELHCSLLRIIVLAPMRLFETTPLGNILNRFSTDTNTIDQHI 1162

  Fly   841 PQAM-MDSLQFLVDVVAVLVIVAIANYWL--LIPAAIMVILLYFCRALYIGASRSLKRIESLTRS 902
            |..| ..|...|:.|.||.||..:...:|  |:|   :.:..||.:..:..|||.|:::|..|..
Zfish  1163 PVTMECLSRSTLLCVSAVGVISYVTPVFLIALLP---LTVACYFIQKYFRVASRDLQQLEDSTEM 1224

  Fly   903 PIYSHTNQTFHGHSTIRSMDAMPQLEQTFHGHQNTNS-SALFLYVSANRAFSFWTDL------IC 960
            |:.||.:||..|.:|||:.....:.::....|.:.|: |:||| .:|||    |.::      ..
Zfish  1225 PLLSHYSQTIEGLTTIRAFRHEQRFKKKLLEHTDANNISSLFL-TAANR----WLEVRMEYIGAL 1284

  Fly   961 VIYILAVTFSFLVINQSFYSGDVGLAITQSMTLVIMCQWGMRQTAEMENNMTSVERV--LEYAQT 1023
            |:.|.||......:.:...:|.|||.:|.::.:.....|.:|..|:||..:..|:||  |.:.|.
Zfish  1285 VVLIAAVASITNALYRQLSAGLVGLGLTYALMVSNYLNWIVRNLADMEVQLGCVKRVSGLIHTQP 1349

  Fly  1024 PSEPPLESPKSVNLAAEWPQAGHLRFQDLRMRYSPGDEDILRGLNFESQPMEKIGIVGRTGAGKS 1088
            .|...:.:|..|  .|.||:.|.::.|:|.:||....:.:|:.::...:|.:|:||.||||:|||
Zfish  1350 ESYDNIMTPAQV--PAGWPKYGEIQIQNLSVRYDSSLKPVLKHVSAHIRPGQKVGICGRTGSGKS 1412

  Fly  1089 SIIQALFRLA-LNEGTIEIDGLDIGKLGLHDLRSRISIIPQDPVLFSGTLRFNLDPFDEKSDESL 1152
            |...||||:. ..||.|.|||:||.||.|..|||:.|||.|||:|||||:||||||..:.:||.|
Zfish  1413 SFSLALFRMVDTFEGQISIDGIDISKLPLQTLRSKFSIILQDPILFSGTIRFNLDPERKATDEML 1477

  Fly  1153 WSALDDVKLKKHVASLEGGLSCRMQDGGSNFSMGQRQLVCLARAILRQNRVLVMDEATANVDTET 1217
            |.||:..:|...|.:|.|||...:.:||.|||.|||||.|||||.:|::.:|:||||||::|..|
Zfish  1478 WEALEIAQLMPVVKALPGGLDAVVTEGGENFSQGQRQLFCLARAFVRKSSILIMDEATASIDMAT 1542

  Fly  1218 DILIQETIQTKFAECTVLTIAHRLHTVMDNDSVLVMDAGQIVEFGAPHKLLQRKDGALLKLV 1279
            :.::|:.:.|.||:.||:|||||:||::.:|.|:||..|.|:|:..|..||::||......|
Zfish  1543 ESILQKVVMTAFADRTVVTIAHRVHTILGSDVVIVMKHGGIIEYDEPDVLLEQKDSVFSAFV 1604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	MRP_assoc_pro	15..1271	CDD:188098	428/1417 (30%)
abcc8b	XP_068071075.1	MRP_assoc_pro	239..1601	CDD:188098	427/1416 (30%)