DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10505 and abcc8b

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	XP_021323602.1	Gene:	abcc8b / 100329706	ZFINID:	ZDB-GENE-120215-45	Length:	1607	Species:	Danio rerio

Alignment Length:	1430	Identity:	432/1430 - (30%)
Similarity:	698/1430 - (48%)	Gaps:	226/1430 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PFIKANIISKWLFLWMHSVFRKGRREELDASKLYEHLP--------------SFDS--ESLTRNL 63
            ||:  |::||..:.||::......:..:|. |....||              :|||  ||...:|
Zfish   235 PFV--NLLSKSTYWWMNTFITSAHQRPIDL-KTIGKLPKSMRALSNFQQLRKAFDSQMESGCVHL 296

  Fly    64 Q-PHWEKESKKK---NPSLMRLIFKVYGWQFVPVCILYSLLEMAIHSFQPLLLGGLISYFAYGQT 124
            | ..|...:.::   .|.|:.:.|:          .:..||..|    .||.:.|::.:.:....
Zfish   297 QGSGWMWRALRQAFGAPLLLSICFR----------FISDLLGFA----GPLCISGILQHISRDNH 347

  Fly   125 T------------VTKE----SAYLYAMGIVLCSLVTSLVFHPFMFYVFAV--GTRVRLACAGLV 171
            |            ::.|    :||:.|: ::..:|:....|....:|| |:  |..:|.|....:
Zfish   348 TAPPPVKLLGVHFISSEVFFANAYVLAV-LLFLALLLQRTFLQASYYV-AIENGINLRGAVQTKI 410

  Fly   172 YRKCLR---ASASSGEGLGGQAISVMSIDLSQFDLTFYFFHDLWKGPVEACIFGYLMTRQVGWTS 233
            |.|.:|   ::.|.|:....|..::::.|.:|....|:...:||..||:..|...|:...:|.::
Zfish   411 YNKIMRLCTSNMSMGDMTTAQICNLVARDTNQLMWFFFLCPNLWAMPVQIVIGVLLLYYLLGASA 475

  Fly   234 LIGIAFIVILIPLQAWAAKASASFGTRSAKHRDARVKLMNEIIGAIQVIKMYAWEKSFGRLIAAV 298
            |||...|.:|.|||.:.|...:.....:.::...|:|..||::..|:::|:||||..|...:...
Zfish   476 LIGATVITVLAPLQYFVATRLSRAQKSTLEYTSERLKKTNELLRGIKLLKLYAWEHIFRSSVEET 540

  Fly   299 RQSEVKAIRGSMSIYAALQC-TNMISKISLFLSL-VAYVYV--------------GDL----VTA 343
            |:.|:.::| :.::|.:|.. .|....|:..|:: |.:|::              |.|    :..
Zfish   541 RRQELTSLR-TFALYTSLSIFMNAAIPIAAVLTIFVVHVHLQSSSDFALSPAVAFGSLSLFHILV 604

  Fly   344 KKVFILSSYYGLLNDSLLHYWPMAITTWAQTLVSARRVVEFLLQVEKPTEESCCRDNP------- 401
            ..:|:||        |:||       :..:.|||.:::.|||...|..|::......|
Zfish   605 TPLFLLS--------SVLH-------STVKALVSVQKLSEFLSSAEIETDQDPIAQTPANNNGNI 654

  Fly   402 ----GLELDAE----KPKPAQSGRLHCVQSETK-----------CLSFRKVSASWDKPSIKQPRK 447
                .|:|.|:    |.|..|....:..|.:.:           |:.......||.:..
Zfish   655 KSVYALQLQAKLVNRKNKAKQDVNRNFEQQDQELRASAQHEDNICIKIVNGYFSWTQGC------ 713

  Fly   448 PHIEGISFHINAGQFVGIVGNVGSGKSTLLHAILGEIELMQG--------------RVEVH---- 494
            |.:..|...:..||...|||.||||||:||.|.|||::.:.|              .:..|
Zfish   714 PTLTNIDIKVPFGQLTMIVGQVGSGKSSLLLAALGEMQKISGSITWNSLPRSDSDENIRAHDMSG 778

  Fly   495 -------GRISYAAQQPWVFQGSIRENILFVEQYEEKRYRAVVHACQLDRDLELLPRGDATVVGE 552
                   |.::||:|:||:...::.|||||......|||:.|:..|||..|::.||:||.||:||
Zfish   779 RQSFTRRGSVAYASQRPWLLNATVEENILFDTAPNVKRYKDVIEVCQLGPDIDTLPQGDQTVIGE 843

  Fly   553 R----GISLSGGQKARIALARAVYRQADIYLFDDPLAAVDAQVGKLLMDKCFHRLLDGKMR--IL 611
            |    ||.|||||:.||::|||:|:|.::...|||.:|:|..:...||.:...:.|..:.|  :|
Zfish   844 RVRHLGIILSGGQRQRISVARALYQQTNVVFLDDPFSALDIHLSDHLMHEGILKFLRQEKRSVVL 908

  Fly   612 VTHHVQLLKSVDQLLLLEGGKLTQQGSYEELKDVITHHAALDLEAIE--------ADKQ---QVK 665
            |||.:|.|...|.::.:..|.:..||:   |||:    ...:.|..|        .||:   ::|
Zfish   909 VTHKLQYLPHADWIIAMRDGTVQTQGT---LKDI----QCAEPELFEQWRTLMNRQDKENSTELK 966

  Fly   666 R-------------VLSQVDRTSKQLSKGEEKDPATIQDENG-NAEQQLQGAVSYDTYKAYFRAL 716
            |             |.:..:.....::..|.||.:|..||:. .||.:.:..:.:.::..|.:|.
Zfish   967 RKSFRRAMMYSRDTVATDDEDEVADVAVSEVKDSSTSTDEDSLGAELRHRTTIPWSSFATYLKAA 1031

  Fly   717 GAPFLVCLVLSMFVLAR-GCQAVMDIFISRWATWEEDRGYDSVDDYEATRTKMVI----WY---- 772
            |...|..|::|.  ||: .....:|.:::.| |.:.........:...|.||..:    ||
Zfish  1032 GLFLLPLLIVSQ--LAKHSLMVAIDFWLAHW-TSDVIAAQSESAERNCTFTKDCVFSHSWYLQVF 1093

  Fly   773 TVLLLLTLALFLLRTFGFFFMCLRISLTLHDQLYHGIIRAWMYFFNANPSGRVLNRFSSDIQNVD 837
            .:|..|.:.|.|:.:....:..||::..||..|...|:.|.|..|...|.|.:|||||:|...:|
Zfish  1094 CLLCALGIVLCLVTSLAVEWTGLRVAKELHCSLLRIIVLAPMRLFETTPLGNILNRFSTDTNTID 1158

  Fly   838 VNLPQAM-MDSLQFLVDVVAVLVIVAIANYWL--LIPAAIMVILLYFCRALYIGASRSLKRIESL 899
            .::|..| ..|...|:.|.||.||..:...:|  |:|   :.:..||.:..:..|||.|:::|..
Zfish  1159 QHIPVTMECLSRSTLLCVSAVGVISYVTPVFLIALLP---LTVACYFIQKYFRVASRDLQQLEDS 1220

  Fly   900 TRSPIYSHTNQTFHGHSTIRSMDAMPQLEQTFHGHQNTNS-SALFLYVSANRAFSFWTDL----- 958
            |..|:.||.:||..|.:|||:.....:.::....|.:.|: |:||| .:|||    |.::
Zfish  1221 TEMPLLSHYSQTIEGLTTIRAFRHEQRFKKKLLEHTDANNISSLFL-TAANR----WLEVRMEYI 1280

  Fly   959 -ICVIYILAVTFSFLVINQSFYSGDVGLAITQSMTLVIMCQWGMRQTAEMENNMTSVERV--LEY 1020
             ..|:.|.||......:.:...:|.|||.:|.::.:.....|.:|..|:||..:..|:||  |.:
Zfish  1281 GALVVLIAAVASITNALYRQLSAGLVGLGLTYALMVSNYLNWIVRNLADMEVQLGCVKRVSGLIH 1345

  Fly  1021 AQTPSEPPLESPKSVNLAAEWPQAGHLRFQDLRMRYSPGDEDILRGLNFESQPMEKIGIVGRTGA 1085
            .|..|...:.:|..|  .|.||:.|.::.|:|.:||....:.:|:.::...:|.:|:||.||||:
Zfish  1346 TQPESYDNIMTPAQV--PAGWPKYGEIQIQNLSVRYDSSLKPVLKHVSAHIRPGQKVGICGRTGS 1408

  Fly  1086 GKSSIIQALFRLA-LNEGTIEIDGLDIGKLGLHDLRSRISIIPQDPVLFSGTLRFNLDPFDEKSD 1149
            ||||...||||:. ..||.|.|||:||.||.|..|||:.|||.|||:|||||:||||||..:.:|
Zfish  1409 GKSSFSLALFRMVDTFEGQISIDGIDISKLPLQTLRSKFSIILQDPILFSGTIRFNLDPERKATD 1473

  Fly  1150 ESLWSALDDVKLKKHVASLEGGLSCRMQDGGSNFSMGQRQLVCLARAILRQNRVLVMDEATANVD 1214
            |.||.||:..:|...|.:|.|||...:.:||.|||.|||||.|||||.:|::.:|:||||||::|
Zfish  1474 EMLWEALEIAQLMPVVKALPGGLDAVVTEGGENFSQGQRQLFCLARAFVRKSSILIMDEATASID 1538

  Fly  1215 TETDILIQETIQTKFAECTVLTIAHRLHTVMDNDSVLVMDAGQIVEFGAPHKLLQRKDGALLKLV 1279
            ..|:.::|:.:.|.||:.||:|||||:||::.:|.|:||..|.|:|:..|..||::||......|
Zfish  1539 MATESILQKVVMTAFADRTVVTIAHRVHTILGSDVVIVMKHGGIIEYDEPDVLLEQKDSVFSAFV 1603

Fly 1280 1279
Zfish 1604 1603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	427/1417 (30%)
		ABC_membrane	95..360	CDD:294371	70/305 (23%)
		ABCC_MRP_domain1	428..632	CDD:213217	81/234 (35%)
		ABC_membrane	728..994	CDD:294371	80/284 (28%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	110/219 (50%)
abcc8b	XP_021323602.1	SunT	239..1600	CDD:331423	428/1419 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586044
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.740