Protein Alignment CG10505 and abcc10

DIOPT Version :9

• Sequence 1: NP_611571.2
• Gene: CG10505 / 37428
• FlyBaseID: FBgn0034612
• Length: 1312
• Species: Drosophila melanogaster
• Sequence 2: NP_001135594.1
• Gene: abcc10 / 100216149
• XenbaseID: XB-GENE-6465377
• Length: 1501
• Species: Xenopus tropicalis
• Alignment Length: 1356
• Identity: 437/1356 - (32%)
• Similarity: 711/1356 - (52%)
• Gaps: 158/1356 - (11%)

  Fly     8 SPKRESNPFIKANIISKWLFLWMHSVFRKGRR-------------EELDASKLYEHLPSFDSESL 59
            :|:|:.......:.:|::.:||::.:.|:|.|             ..|..:::.:|..|..|.::
 Frog   217 TPERQHPAEDGESWLSRFFYLWLNPLLRQGARGGLKHPGDVLLLPHCLGTARICQHFQSKSSSTI 281

  Fly    60 TRNLQPHWEKESKKKNPSLMRLIFKVYGWQFVPVCILYSLLEMAIHSFQPLLLGGLISYFAYGQT 124
            .|                |:..:...:|.::..:.:| .|..:.:....||||..|:::......
 Frog   282 LR----------------LLPTLHASFGARYYALGLL-KLGAVTLAFLGPLLLNLLVNFMEAADE 329

  Fly   125 TVTKESAYLYAMGIVLCSLVTSLVFHPFMFYVFAVGTRVRLACAGLVYRKCLRASASSGEGLG-- 187
            .::  ...||.:|:.....:.:|:.:.|...|..:...||.:....||||.:|   ..|.||.
 Frog   330 PLS--WGILYTLGLFSSCFLAALLQNQFTHEVNKLILAVRASVLTSVYRKAIR---GVGTGLAGF 389

  Fly   188 --GQAISVMSIDLSQFDLTFYFFHDLWKGPVEACIFGYLMTRQVGWTSLIGIAFIVILIPLQAWA 250
              |:.::.||.|..:.......||::|..|::..:..||:..|||...|.|:...|:|:|:....
 Frog   390 SKGEIVNFMSTDADRISNFCRSFHEVWSLPLQFSVTLYLLYLQVGIAFLGGLGLAVLLLPINKVI 454

  Fly   251 AKASASFGTRSAKHRDARVKLMNEIIGAIQVIKMYAWEKSFGRLIAAVRQSEVKAIRGSMSIYAA 315
            |.....:.:....|:|||||||.|::..::|:|.|.|||.|...:.::|:.|::::|....:.|.
 Frog   455 ANRIVDYNSDLLNHKDARVKLMTELLSGMRVVKFYTWEKHFAEAVTSLREKELRSLRALKMLDAV 519

  Fly   316 LQCTNMISKISLFLSL---VAYVYVGDLVTAKKVFILSSYYGLLNDSLLHYWPMAITTWAQTLVS 377
              |..:.:.:.:.:|:   :.||.:|..:||.|||...:..|:|...|.:: |..:....:..||
 Frog   520 --CVYLWAALPVLISIITFITYVLLGHQLTAAKVFTALALVGMLILPLNNF-PWVLNGVLEAKVS 581

  Fly   378 ARRVVEFLLQVEKPTEESCCRDNPGLELDAEKPKPAQSGRLHCVQSETKCLSFRKVSASW----- 437
            ..|:..|:   :.|.::.       |...:::| ||         ..:..|..|..:.||
 Frog   582 LERIQLFM---DLPEQDL-------LNYYSQEP-PA---------DPSSALELRSAAFSWMPEES 626

  Fly   438 -DKPSIKQPRKPHIEGISFHINAGQFVGIVGNVGSGKSTLLHAILGEI-----ELMQGRVEVHGR 496
             |..|::.    .||.:|  :..|..||:||.||.|||:||.|:.||:     ||.....|:  .
 Frog   627 EDSGSLQL----FIEHLS--VQKGVLVGVVGKVGCGKSSLLAALTGELSRSGGELFASHQEL--G 683

  Fly   497 ISYAAQQPWVFQGSIRENILFVEQYEEKRYRAVVHACQLDRDLELLPRGDATVVGERGISLSGGQ 561
            ..:|||:||:...:|||||||.:::..|.|:.|:.||.|:.||.:||.||.|.|||.|::|||||
 Frog   684 FGFAAQEPWIQFATIRENILFGKEFNGKLYQGVLEACALNDDLSILPSGDQTEVGENGVTLSGGQ 748

  Fly   562 KARIALARAVYRQADIYLFDDPLAAVDAQVGKLLMDKCFHRLLDGKMRILVTHHVQLLKSVDQLL 626
            |||:|||||||:..||||.|||||||||.|...||:||...:|..|.|||.||..:||...|.:|
 Frog   749 KARLALARAVYQDKDIYLLDDPLAAVDADVAAHLMEKCILGILKNKTRILCTHRTELLDKADIVL 813

  Fly   627 LLEGGKLTQQGSYEELKDVITHHAALDLEAIEADKQQVKRVLSQVDRTSKQLSKGEEKDPATIQD 691
            |:||||:...|:.:::           |..:|:.:.:..|..:|::..|:...:..|:|....::
 Frog   814 LMEGGKMVGSGTPDKI-----------LPLVESSRNRGSRGQTQMNHISQAAEQSLEEDEEEAEN 867

  Fly   692 ENGN----------AEQQLQGAVSYDTYKAYFRALGAPFLVCLVLSMFVLARGCQAVMDIFISRW 746
            | ||          .|::.:|||:...|.||::|:|......::|::| |.:..:.:.|.::|.|
 Frog   868 E-GNPIQPITAEVGQEEKQEGAVALQVYWAYWKAVGGCLAGSVLLALF-LMQASRNISDWWLSHW 930

  Fly   747 ATWEED------------------------RG-----YDSVDDYEATRTKMVIWYTVL---LLLT 779
            .:..:|                        :|     ..||...|...:..:.:|..:   :.:.
 Frog   931 ISSLQDSPRNVSLTNLTPSSFPSASLLLFSQGGLVSPISSVHSAEKNSSLDITFYLSVYGGIAVA 995

  Fly   780 LALF-LLRTFGFFFMCLRISLTLHDQLYHGIIRAWMYFFNANPSGRVLNRFSSDIQNVDVNLPQA 843
            .::| .||.|.|....:..::.:|.:|...:::|.:.||::.|.||::||||||:..||.:||..
 Frog   996 NSIFTALRAFLFALGTVHAAVVIHRRLLSSVLQATVSFFDSTPIGRIINRFSSDLYCVDDSLPFV 1060

  Fly   844 MMDSLQFLVDVVAVLVIVAIANYWLLIPAAIMVILLYFCRALYIGASRSLKRIESLTRSPIYSHT 908
            :...|.|...::.:||:::....|:|.....:.:|.|:.:..|..:||.|||::|:|.||||:|.
 Frog  1061 LNIFLAFTFGLLGMLVMISYGLPWILPVLLPLCLLYYYLQRFYRHSSRELKRLQSITLSPIYTHF 1125

  Fly   909 NQTFHGHSTIRSMDAMPQLEQTFHGHQNTNSSALFLYVSANRAFSFWTD----LICVIYILAVTF 969
            ::|..|.:|||:.....:.|.........|...:|    |:.|...|.|    :|.|:.:.|::.
 Frog  1126 SETLTGLTTIRATRHADRFEAECVSRLEVNQRCMF----ASNAAVQWLDIRLQMIGVMVVAAISV 1186

  Fly   970 SFLVINQSFYSGD---VGLAITQSMTLVIMCQWGMRQTAEMENNMTSVERVLEYAQT-PSEPPLE 1030
             ..:|.....|||   ||||::.::::..:....:....:.|..|.||||..||:.| |||   .
 Frog  1187 -IAIIQHQRKSGDPGLVGLALSYALSITGILSGLISSFTQTEAMMVSVERTEEYSTTLPSE---S 1247

  Fly  1031 SPKSVNLAAEWPQAGHLRFQDLRMRYSPGDEDILRGLNFESQPMEKIGIVGRTGAGKSSIIQALF 1095
            :..|:.:..:||..||:.|:::.:.|..|..:.|.|::|...|.||||||||||:|||::..|||
 Frog  1248 AEGSLQVELDWPTNGHIEFRNVVLCYRLGLPNALDGISFTISPGEKIGIVGRTGSGKSTLFLALF 1312

  Fly  1096 R-LALNEGTIEIDGLDIGKLGLHDLRSRISIIPQDPVLFSGTLRFNLDPFDEKSDESLWSALDDV 1159
            | :.|.||:|.||.:....|.|..||||::|||||..||||::|.||||....:|..:...||..
 Frog  1313 RMMELKEGSILIDNVPSHLLNLELLRSRLAIIPQDAFLFSGSVRVNLDPLSYHTDVEILKVLDQC 1377

  Fly  1160 KLKKHVASLEGGLSCRMQDGGSNFSMGQRQLVCLARAILRQNRVLVMDEATANVDTETDILIQET 1224
            .|:..|..: |||...:.|.|.|||:|||||:|||||:|...::|.:|||||:||.:||.|:|.|
 Frog  1378 HLQDVVRRI-GGLDADVGDRGKNFSLGQRQLLCLARALLTHAKILCIDEATASVDHQTDELLQRT 1441

  Fly  1225 IQTKFAECTVLTIAHRLHTVMDNDSVLVMDAGQIVEFGAPHKLLQRKDGALLKLVN 1280
            |:.:|.|.|||||||||:|:||:|.||||.||::||..:|..|.:|:|....:|::
 Frog  1442 IRERFRERTVLTIAHRLNTIMDSDRVLVMHAGKLVELDSPANLSKREDSNFYRLIH 1497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	431/1338 (32%)
		ABC_membrane	95..360	CDD:294371	74/271 (27%)
		ABCC_MRP_domain1	428..632	CDD:213217	103/214 (48%)
		ABC_membrane	728..994	CDD:294371	78/305 (26%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	113/219 (52%)
abcc10	NP_001135594.1	MRP_assoc_pro	180..1484	CDD:188098	433/1341 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920