DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10505 and abcb4

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_001303643.1	Gene:	abcb4 / 100136865	ZFINID:	ZDB-GENE-080204-52	Length:	1275	Species:	Danio rerio

Alignment Length:	1442	Identity:	319/1442 - (22%)
Similarity:	581/1442 - (40%)	Gaps:	347/1442 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KQSSPKRESNPFIKANIISKWLFLWMHSVFRKGRREELDASK--------LYEHLPSFDSESLTR 61
            |.||.|:|.|..:...              :.|:.|:.:..|        |:.:..|.|...:..
Zfish     8 KVSSDKKEENGDVSGE--------------KNGKEEKEEKEKLEMVGPIELFRYADSIDILLMML 58

  Fly    62 NLQPHWEKESKKKNPSLMRLIFKVYG---WQFVPVCILYSLLEMAIHSFQPLLLGGLISYFAYGQ 123
            .|      .....|.:::.|:..|:|   ..||...:|.:|..:.           |...|.:.:
Zfish    59 GL------IMSMANGAVLPLMVIVFGDMTDSFVDDTLLDNLKNIT-----------LPPNFTFPE 106

  Fly   124 TT-------VTKESAYLYAMGIVLCSLVTSLVFHPFMFYVFAVGTRVRLACAGLVYRKCLRASAS 181
            |:       :|..:.|...||.|:  ||.:  :....|:..|.|.:|:      ..||..
Zfish   107 TSNITLGEKMTTHAIYYSIMGFVV--LVAA--YMQVAFWTLAAGRQVK------KLRKIF----- 156

  Fly   182 SGEGLGGQAISVMSIDLSQFD------LTFYFFHDLWK-------------GPVEACIFGYLMTR 227
                    ..|:|..::..||      |......|::|             ..:...|.|.::..
Zfish   157 --------FHSIMKQEIGWFDVNETGQLNTRLTDDVYKINEGIGDKLGMLIQNLTTFIVGIIIGF 213

  Fly   228 QVGW---------TSLIGIAFIVILIPLQAWAAKASASFGTRSAKHRDARVKLMNEIIGAIQVIK 283
            ..||         :.|:||:..||...:..:.:|...::....|        :..|::.:|:.:.
Zfish   214 AKGWKLTLVILAVSPLLGISAAVIGKVMTTFTSKEQTAYAKAGA--------VAEEVLSSIRTVF 270

  Fly   284 MYAWE-KSFGRLIAAVRQSEVKAIRGSMSIYAALQCTNMISKISLFLSLVAYVY----------- 336
            .:..: |...|....:..::...:|.::::..|:..|..:..:|..|   |:.|
Zfish   271 AFGGQKKEIKRYHKNLEDAKNVGVRKAITVNIAMGFTFFMIYMSYAL---AFWYGSTLILGGEYT 332

  Fly   337 VGDLVTAKKVF--ILSSYYGLLNDSLLHYWPMAITTWAQTLVSARRVVEFLLQV--EKPTEESCC 397
            :|.|:|   :|  :|...:||...|     |.     .||..|||.....:.|:  .:|...|..
Zfish   333 IGMLLT---IFFAVLIGAFGLGQTS-----PN-----IQTFSSARGAAHKVFQIIDHEPKINSFS 384

  Fly   398 RDNPGLELDAEKPKPAQSGRLHCVQSETKCLSFRKVSASWDKPSIKQPRKPHIEGISFHINAGQF 462
            .:  |.:||..|      |.:     |.|.:.||..|    :..:|.     :.|::..:.:||.
Zfish   385 EE--GYKLDVVK------GNI-----EFKNIHFRYPS----RDDVKV-----LNGMNLKVMSGQT 427

  Fly   463 VGIVGNVGSGKSTLLHAILGEIELMQGRVEVHGR-------------ISYAAQQPWVFQGSIREN 514
            :.:||:.|.||||.:..:....:..:|.|.:.|.             |...:|:|.:|..:|.||
Zfish   428 IALVGSSGCGKSTTIQLLQRFYDPQEGSVSIDGHDIRSLNVRGLRELIGVVSQEPVLFATTIAEN 492

  Fly   515 ILF---------VEQ--YEEKRYRAVVHACQLDRDLELLPRGDATVVGERGISLSGGQKARIALA 568
            |.:         :||  .|...|..::.          ||....|:||:||..:|||||.|||:|
Zfish   493 IRYGRQDVTQDEIEQAAREANAYNFIMK----------LPDKFETLVGDRGTQMSGGQKQRIAIA 547

  Fly   569 RAVYRQADIYLFDDPLAAVDAQVGKLLMDKCFHRLLDGKMRILVTHHVQLLKSVDQLLLLEGGKL 633
            ||:.|...|.|.|:..:|:||: .:.::.....::..|:..|:|.|.:..:::.|.:...:.|::
Zfish   548 RALVRNPKILLLDEATSALDAE-SETIVQAALDKVRLGRTTIVVAHRLSTIRNADVIAGFQNGEI 611

  Fly   634 TQQGSYEEL---KDVITHHAALDL------EAIEADKQQV------KRVLSQVDRT-SKQLSK-G 681
            .:.|:::||   |.:  :|:.:::      |..|.|.:::      ..|.|..:|| .:|.|: |
Zfish   612 VELGTHDELMERKGI--YHSLVNMQMFKSTEVAEEDSEEMTMDEKSPSVSSMNERTLFRQKSRSG 674

  Fly   682 EEKDPATIQDENGNAEQQLQGAVSYDT-----YKAYFRALGAPFLVCLVLSMFVLARGCQAVMDI 741
            .||:   :::|....|::....||:.|     |..:      |::|..:|.. .:..|.|....:
Zfish   675 SEKE---LKEEEKPTEEEKVPNVSFLTVLKLNYPEW------PYMVVGILCA-TINGGMQPAFAV 729

  Fly   742 FISR-WATWEEDRGYDSVDDYEATRTKMVIWYTVLL--LLTLALFLLRTFGFFF--MCLRISLTL 801
            ..|: .|.:.|       .|....|.:..: |::|.  :..|:.|.|...||.|  ....:::.|
Zfish   730 IFSKIIAVFAE-------PDQNLVRQRCDL-YSLLFAGIGVLSFFTLFLQGFCFGKAGELLTMRL 786

  Fly   802 HDQLYHGIIR---AWMYFFNANPSGRVLNRFSSD---------------IQNVDVNLPQAMMDSL 848
            ..:.::.::|   || |....|..|.:..|.::|               .||| .||..|::.|.
Zfish   787 RFKAFNAMMRQDLAW-YDDTKNSVGALTTRLAADTAQVQGATGVRLATLAQNV-ANLGTAIVISF 849

  Fly   849 ----QFLVDVVAVLVIVAIANYWLLIPAAIMVILLYFCRALYIGASRSLKRIESLTRSPIYSHTN 909
                |..:.:::::.|:|:|       .||.:.||         |..:||..:.|.::.  ....
Zfish   850 VYGWQLTLLILSIVPIMAVA-------GAIQMKLL---------AGHALKDKKELEQAG--KIAT 896

  Fly   910 QTFHGHSTIRSMDAMPQLEQTFH-----GHQNTNSSA-----------LFLYVSANRAFSFWTDL 958
            :......|:.|:....:.|..:.     .::|....|           ..:|.:....|.|.:.|
Zfish   897 EAIENVRTVVSLTRESKFESLYEENLIVPYKNAKKKAHVFGLTFSFSQAMIYFAYAGCFKFGSWL 961

  Fly   959 I---------CVIYILAVTFSFLVINQ--SFYSGDVGLAITQSMTLVIMCQWGMRQTAEMENNMT 1012
            |         ..:.|.||.:..:.:.:  ||........::.|..|:::            |...
Zfish   962 IEQKLMTFEGVFLVISAVVYGAMAVGEANSFTPNYAKAKMSASHVLMLI------------NRAP 1014

  Fly  1013 SVERVLEYAQTPSEPPLESPKSVNLAAEWPQAGHLRFQDLRMRY-SPGDEDILRGLNFESQPMEK 1076
            :::...|....|.:                ..|::.|:.:..:| |..|..:|:||....:..:.
Zfish  1015 AIDNSSEDGDKPDK----------------FEGNVGFEHVYFKYPSRPDVPVLQGLKLRVKKGQT 1063

  Fly  1077 IGIVGRTGAGKSSIIQALFRL-ALNEGTIEIDGLDIGKLGLHDLRSRISIIPQDPVLFSGTLRFN 1140
            :.:||.:|.|||:.||.|.|. ...:|.:.:|..|..:|.:|.|||:|.|:.|:||||..:|..|
Zfish  1064 LALVGSSGCGKSTTIQLLERFYDPQQGRVMLDDNDAKQLNIHWLRSQIGIVSQEPVLFDCSLAEN 1128

  Fly  1141 L---DPFDEKSDESLWSALDDVKLKKHVASLEGGLSCRMQDGGSNFSMGQRQLVCLARAILRQNR 1202
            :   |...|...|.:..|.....:...:.:|......:..|.|:..|.||:|.:.:||||||..:
Zfish  1129 IAYGDNSREVDQEEIVEAAKAANIHSFIENLPQRYQTQAGDKGTQLSGGQKQRIAIARAILRNPK 1193

  Fly  1203 VLVMDEATANVDTETDILIQETIQTKFAECTVLTIAHRLHTVMDNDSVLVMDAGQIVEFGAPHKL 1267
            ||::||||:.:|||::.::|:.:.......|.:.:||||.|:.:.|.:.|:..|.:||.|. |:.
Zfish  1194 VLLLDEATSALDTESEKIVQDALDKASKGRTCIIVAHRLSTIQNADCIAVVQNGVVVEQGT-HQQ 1257

  Fly  1268 LQRKDGALLKLV 1279
            |..:.||...||
Zfish  1258 LLSQQGAYYTLV 1269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	310/1422 (22%)
		ABC_membrane	95..360	CDD:294371	54/313 (17%)
		ABCC_MRP_domain1	428..632	CDD:213217	59/227 (26%)
		ABC_membrane	728..994	CDD:294371	59/319 (18%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	74/223 (33%)
abcb4	NP_001303643.1	PTZ00265	55..1266	CDD:240339	305/1376 (22%)
		ABC_membrane	60..348	CDD:279056	59/341 (17%)
		ABC_MTABC3_MDL1_MDL2	397..634	CDD:213216	67/263 (25%)
		ABC_membrane	714..984	CDD:279056	57/298 (19%)
		ABC_MTABC3_MDL1_MDL2	1035..1272	CDD:213216	79/236 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000