DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10505 and abcc3

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_001107301.1	Gene:	abcc3 / 100135090	XenbaseID:	XB-GENE-1003737	Length:	1531	Species:	Xenopus tropicalis

Alignment Length:	1402	Identity:	468/1402 - (33%)
Similarity:	718/1402 - (51%)	Gaps:	219/1402 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SPKR-ESNPFIK--ANIISKWLFLWMHSVFRKGRREELDASKLYEHLPSFDSESLTRNLQPHWEK 69
            ||.| |.||..:  |..:|:..|.|...:...|.:..|:...|:.......|..:..||...|||
Frog   198 SPVRDEINPCPESDAGFLSRLTFWWFTKMAILGYKRPLEDKDLWSLNEDDTSNVVVTNLIKEWEK 262

  Fly    70 E-----------SKK-------------------------KNPSLMRLIFKVYGWQFVPVCILYS 98
            |           |||                         |.||.::::.:.:|..|: :...:.
Frog   263 EKSNLAQMQVSYSKKPEAVLNHTDEKAYESDVLIVDNKKPKEPSFLKVLLRTFGPYFL-IGSFFK 326

  Fly    99 LLEMAIHSFQPLLLGGLISYFAYGQTTVTKES----AYLYAMGIVLCSLVTSLVFHPFMFYVFAV 159
            |.:..:....|.||..||::..      .|::    .:..|:.:.|.|||.:|:.|....|.|..
Frog   327 LFQDLLSFVNPQLLSILITFIK------NKDAPSWWGFCIAVLMFLTSLVQTLILHQHFQYCFVT 385

  Fly   160 GTRVRLACAGLVYRKCL-RASASSGEGLGGQAISVMSIDLSQF-DLTFYFFHDLWKGPVEACIFG 222
            |.|:|.|..|::|||.| ..:::......|:.:::||:|..:| ||| .|.:.||..|::.|:..
Frog   386 GMRLRSAITGIIYRKSLVITNSAKRSSTVGEVVNLMSVDAQRFQDLT-TFLNMLWSAPLQICLAL 449

  Fly   223 YLMTRQVGWTSLIGIAFIVILIPLQAWAAKASASFGTRSAKHRDARVKLMNEIIGAIQVIKMYAW 287
            |.:.:.:|.:.|.|:|.:|:|||:.|:.|..:.:|.....:::|:|:||||||:..|:|:|:|||
Frog   450 YFLWQALGPSVLAGVAVMVLLIPINAFIAMKTRAFQVEQMQYKDSRIKLMNEILNGIKVLKLYAW 514

  Fly   288 EKSFGRLIAAVRQSEVKAIR-----GSMSIYAALQCTNMISKISLFLSLVAYVYVGD--LVTAKK 345
            |.||.:.:..:|..|:..::     .::|.:|......:::    ..:...||.|.:  ::.|:|
Frog   515 EPSFAQKVLEIRNKELNILKKAAYLNALSTFAWTSAPFLVA----LTTFAVYVTVDEKNILDAEK 575

  Fly   346 VFILSSYYGLLNDSLLHYWPMAITTWAQTLVSARRVVEFLLQVEKPTEESCCRDNPGLELDA--- 407
            .|:..|.:.:|... |:..|..|:..||..||.:|:..||.             |..|:|:|
Frog   576 AFVSLSLFNILRFP-LNMLPQVISNLAQASVSIKRIQNFLA-------------NDELDLNAVTK 626

  Fly   408 EKPKPAQSGRLHCVQSETKCLSFRKVSASWDKPSIKQPRKPHIEGISFHINAGQFVGIVGNVGSG 472
            :|..|..:..:|            ..:.||.|..     ...::.|:..:.:|..|.:||.||.|
Frog   627 DKTLPGNAITVH------------NGTFSWAKNG-----GAILQNINLLVPSGSLVAVVGQVGCG 674

  Fly   473 KSTLLHAILGEIELMQGRVEVHGRISYAAQQPWVFQGSIRENILFVEQYEEKRYRAVVHACQLDR 537
            ||:|:.|:|||:|..:|.|.|.|.::|..||.|:...::::||||.....||.|:.|:.||.|..
Frog   675 KSSLVSALLGEMEKEEGEVSVRGSVAYVPQQAWIQNCTLKDNILFGRAANEKNYKKVLEACALVT 739

  Fly   538 DLELLPRGDATVVGERGISLSGGQKARIALARAVYRQADIYLFDDPLAAVDAQVGKLLMDKCF-- 600
            |||:||.||.|.:||:||:||||||.|::|||||:..||:||.||||:||||.|.|.:.|...
Frog   740 DLEVLPGGDQTEIGEKGINLSGGQKQRVSLARAVFSNADVYLLDDPLSAVDAHVAKHIFDNVIGP 804

  Fly   601 HRLLDGKMRILVTHHVQLLKSVDQLLLLEGGKLTQQGSYEEL----------------------- 642
            ..||.||.|:||||.:..|..||.:::|..|::|:.|||:||
Frog   805 DGLLRGKTRVLVTHGISFLPQVDHIVVLVDGRVTEMGSYQELLKQNGAFSEFLRNYAFDDEVEEE 869

  Fly   643 -------KDVITHHAALDLEAIEADKQQV-----KRVLSQVDRTSKQLSKGE------------E 683
                   ::|:.....|......||.:.|     |:.:.|:    ..||.||            |
Frog   870 DITIPDEEEVLLAEETLSTHTDLADNEPVANEARKKFIRQI----SILSDGEPSHAMSTRRRFTE 930

  Fly   684 KDPATIQDENGNAEQ-------QLQ----GAVSYDTYKAYFRALGAPFLVCLVLSMFV-LARGCQ 736
            |.|:    ||..|:|       |.:    |.|....:..|.:|:|      |.:|:|: ....||
Frog   931 KKPS----ENLVAKQPPTEKLIQTETTETGRVKMTVFWQYMKAVG------LAISVFICFLYSCQ 985

  Fly   737 AVMDIFISRW-ATWEEDRGYDSVDDYEATRTKMVIW-YTVLLLLTLALFLLRTFGFFFMCLRISL 799
            ....|..:.| :.|..    :.|.:.....|:|.:. |..|.:|...|.:..:|......:..:.
Frog   986 NAAAIGANVWLSDWTN----EPVINQTQQNTQMRVGVYAALGILQGLLVMTSSFSLAIAGIGAAR 1046

  Fly   800 TLHDQLYHGIIRAWMYFFNANPSGRVLNRFSSDIQNVDVNLPQAMMDSL-QFLVDVVAVLVIVAI 863
            .||..|....:.....|::..|.||::||||.||..:|..:|..::..| .|...:..::||||.
Frog  1047 KLHSALLDNKMHTPQSFYDTTPIGRIINRFSKDIYVIDEVIPGTILMFLATFFTSLSTMIVIVAS 1111

  Fly   864 ANYW--LLIPAAIMVILLYFCRALYIGASRSLKRIESLTRSPIYSHTNQTFHGHSTIRSMDAMPQ 926
            ...:  ::||.||..|   |.:..|:..||.|||:||::|||||||.::|..|.|.||:
Frog  1112 TPLFAVVIIPLAIAYI---FVQRFYVATSRQLKRLESVSRSPIYSHFSETITGASIIRA------ 1167

  Fly   927 LEQTFHGHQNT-----------NSSALFLYVSANRAFSFWTDLI--CVIYILAVTFSFLVINQSF 978
                 :|.||:           |..:.:..:.:||......:.:  ||:...|:   |.|:.:..
Frog  1168 -----YGRQNSFIVLSDNKVDENQKSYYPGIVSNRWLGVRVEFVGNCVVLFAAL---FAVLGREH 1224

  Fly   979 YS-GDVGLAITQSMTLVIMCQWGMRQTAEMENNMTSVERVLEYAQTPSEPP--LESPKSVNLAAE 1040
            .| |.|||:::.::.:.:...|.:|.|:::|.|:.:||||.|||:..:|.|  :|..|.   ..:
Frog  1225 LSPGLVGLSVSYALQVTMSLNWMVRMTSDLETNIVAVERVKEYAENETEAPWHIEDTKP---PED 1286

  Fly  1041 WPQAGHLRFQDLRMRYSPGDEDILRGLNFESQPMEKIGIVGRTGAGKSSIIQALFR-LALNEGTI 1104
            ||..|.:...:..:||..|.:.:|:.||.:....||:||||||||||||:...||| |...||.:
Frog  1287 WPSKGEVELSNYSVRYRAGLDLVLKNLNLKVNGGEKVGIVGRTGAGKSSMTLCLFRILEPAEGIV 1351

  Fly  1105 EIDGLDIGKLGLHDLRSRISIIPQDPVLFSGTLRFNLDPFDEKSDESLWSALDDVKLKKHVASLE 1169
            :||.::|.::||.|||||::||||||||||||||.|||||::.||:.:|.||:...|||.||...
Frog  1352 KIDNVNISEIGLQDLRSRLTIIPQDPVLFSGTLRMNLDPFNKYSDDEIWKALELSNLKKFVAGQP 1416

  Fly  1170 GGLSCRMQDGGSNFSMGQRQLVCLARAILRQNRVLVMDEATANVDTETDILIQETIQTKFAECTV 1234
            ..|.....:||.|.|:|||||||||||:||:.|:|::|||||.:|.|||.|||.||:|:|.:|||
Frog  1417 SQLEYECSEGGENLSVGQRQLVCLARALLRKTRILILDEATAAIDLETDDLIQMTIRTQFEDCTV 1481

  Fly  1235 LTIAHRLHTVMDNDSVLVMDAGQIVEFGAPHKLLQRK 1271
            |||||||:|:||...|||:|.|:|.||..|..|:..|
Frog  1482 LTIAHRLNTIMDYTRVLVLDKGRIAEFDTPTNLIALK 1518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	463/1392 (33%)
		ABC_membrane	95..360	CDD:294371	79/277 (29%)
		ABCC_MRP_domain1	428..632	CDD:213217	90/205 (44%)
		ABC_membrane	728..994	CDD:294371	77/285 (27%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	123/219 (56%)
abcc3	NP_001107301.1	MRP_assoc_pro	7..1530	CDD:188098	468/1402 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010