DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10505 and abcc1

DIOPT Version :9

Sequence 1:	NP_611571.2	Gene:	CG10505 / 37428	FlyBaseID:	FBgn0034612	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	XP_001341895.3	Gene:	abcc1 / 100002010	ZFINID:	ZDB-GENE-050517-15	Length:	1518	Species:	Danio rerio

Alignment Length:	1378	Identity:	446/1378 - (32%)
Similarity:	711/1378 - (51%)	Gaps:	165/1378 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KQSSPKRESNPFIKANIISKWLFLWMHSVFRKGRREELDASKLYEHLPSFDSESLTRNLQPHWEK 69
            |.|:|..||.    |:.:||..|.|:..:..||.:..|:...|:.......||.:...|...|::
Zfish   203 KDSNPCPESG----ASFLSKITFWWITGLMVKGYKRPLEEKDLWSLNNEDKSERVVPQLVRRWDQ 263

  Fly    70 E--------------------SKKKN--------------------PSLMRLIFKVYGWQFVPVC 94
            |                    .:||:                    |||...:.:.:|..|: |.
Zfish   264 ECVKVKRPVDKTLYSPKRSTRGEKKDGQPVEESEILLAKALQKTGEPSLFFALCRTFGPYFL-VS 327

  Fly    95 ILYSLLEMAIHSFQPLLLGGLISYFAYGQTTVTKESA-----YLYAMGIVLCSLVTSLVFHPFMF 154
            .||.::...:....|.:|..||.:       |...||     |.|...:.:|:.:.:|:...:..
Zfish   328 SLYKIIHDVLMFVGPEILRLLILF-------VNDSSAPTWHGYFYTALLFVCTCLQTLILQKYFH 385

  Fly   155 YVFAVGTRVRLACAGLVYRKCL-RASASSGEGLGGQAISVMSIDLSQF-DLTFYFFHDLWKGPVE 217
            ..|..|.|:|.|..|.||||.| ..:|:......|:.:::||:|..:| ||..| .:.:|..|::
Zfish   386 VCFVTGMRLRTAIVGAVYRKALVITNAARRTSTVGEIVNLMSVDAQRFMDLITY-INMIWSAPLQ 449

  Fly   218 ACIFGYLMTRQVGWTSLIGIAFIVILIPLQAWAAKASASFGTRSAKHRDARVKLMNEIIGAIQVI 282
            ..:..|.:.:.:|.:.|.|:|.:|:::||.|..|..:.::.....|.:|.|:|||||::..|:|:
Zfish   450 VILALYFLWQNLGASVLAGVAVMVLMVPLNAVIAMKTKTYQVAQMKSKDNRIKLMNEVLNGIKVL 514

  Fly   283 KMYAWEKSFGRLIAAVRQSEVKAIR-----GSMSIYAALQCTNMISKISLFLSLVAYVYV--GDL 340
            |:||||.:|...::|:|:||::.::     |::|.:..: |...:..:|.|   ..||.|  .::
Zfish   515 KLYAWELAFKGKVSAIRESELRVLKKMAYLGAISTFTWV-CAPFLVALSTF---AVYVLVDENNI 575

  Fly   341 VTAKKVFILSSYYGLLNDSLLHYWPMAITTWAQTLVSARRVVEFLLQVEKPTEESCCRDNPGLEL 405
            :.|:|.|:..:.:.:|... |:..||.|::..|..||.:|:..||...|        .|:..:|
Zfish   576 LDAQKAFVSLALFNILRFP-LNMLPMVISSMVQASVSMQRLRVFLSHEE--------LDDDNVE- 630

  Fly   406 DAEKPKPAQSGRLHCVQSETKCLSFRKVSASWDKPSIKQPRKPHIEGISFHINAGQFVGIVGNVG 470
                 :||.||....::......|:.|     |.|       |.::.|:..|..|..|.:||:||
Zfish   631 -----RPAISGTPDSIRIADGAFSWSK-----DDP-------PTLKRINVSIPEGALVAVVGHVG 678

  Fly   471 SGKSTLLHAILGEIELMQGRVEVHGRISYAAQQPWVFQGSIRENILFVEQYEEKRYRAVVHACQL 535
            ||||:||.|:|||:...:|.|.:.|.::|..||.|:...::::||||..:.::..|:.||.||.|
Zfish   679 SGKSSLLSALLGEMHKQEGSVSIKGSVAYVPQQAWIQNATLKDNILFGRETKDSWYQKVVEACAL 743

  Fly   536 DRDLELLPRGDATVVGERGISLSGGQKARIALARAVYRQADIYLFDDPLAAVDAQVGKLLMDKCF 600
            ..|||:||.||.|.:||:|::||||||.|:::|||||....:||.||||:||||.|||.:.:|..
Zfish   744 LPDLEILPGGDTTEIGEKGVNLSGGQKQRVSVARAVYCNCSVYLLDDPLSAVDAHVGKHIFEKVI 808

  Fly   601 --HRLLDGKMRILVTHHVQLLKSVDQLLLLEGGKLTQQGSYEEL--------KDVITHHAALDLE 655
              ..||.|:.|:||||.:..|...|.:|::..|::|:.|||.||        :.:.|:......|
Zfish   809 GPQGLLQGRTRVLVTHGLSFLPQADLILVMVDGEITEMGSYTELLGRQGAFAEFLRTYTNTEQEE 873

  Fly   656 AIEADKQQVKRV------------LSQVDRTSKQLSKGEEK-----DPATIQDENGNAEQQLQ-- 701
            ..|:....|.|.            .||:...:....|..:|     |.|..:.::..|.:..:
Zfish   874 GEESLGDAVPRKGLENGGPAALLRQSQISLNATGAGKTTQKTEANDDAAATKTKSAEASRLTEAD 938

  Fly   702 ----GAVSYDTYKAYFRALGAPFLVCLVLSMFVLARGCQAVMDIFISRW-ATWEEDRGYDSVDDY 761
                |.|....:..|.:|:|.|..:..:...|     |..:..:..:.| :.|.:|   ..|::.
Zfish   939 KANTGRVKLSVFWEYMKAIGLPLSIFSIFLFF-----CHHLSSLGSNYWLSLWTDD---PVVNNT 995

  Fly   762 EATRTKMVIWYTVLLLLTLALFLLRTFGFFFMCLRISLT---------LHDQLYHGIIRAWMYFF 817
            :..|...:..|..|.:         :.|....|..:|::         ||..:.:.::|:.|.||
Zfish   996 QPKREMRLGVYGALGI---------SQGIAVFCYSVSVSVGGILASRYLHQTMLYNVLRSPMSFF 1051

  Fly   818 NANPSGRVLNRFSSDIQNVDVNLPQAMMDSLQFLVDVVAVLVIVAIANYWLLIPAAIMVILLYFC 882
            ...|||.::|||:.:...:|..:|..:...:..:.:|:....::.||...:.|....:.:|.:|.
Zfish  1052 ERTPSGNLVNRFAKETDTIDSVIPSIIKMFMGSMFNVLGSCAVILIATPLVAIIIPPLGLLYFFV 1116

  Fly   883 RALYIGASRSLKRIESLTRSPIYSHTNQTFHGHSTIRSMDAMPQLEQTFHGHQNTNSSALFLYVS 947
            :..|:.:||.:||:||::|||:|:|.|:|..|.|.||:.....:..:...|..:.|..|.|..:.
Zfish  1117 QRFYVASSRQMKRLESVSRSPVYTHFNETLLGTSVIRAFGEQQRFIKESDGRVDHNQKAYFPSIV 1181

  Fly   948 ANRAFSFWTDLI--CVIYILAVTFSFLVINQSFYSGDVGLAITQSMTLVIMCQWGMRQTAEMENN 1010
            |||..:...:.:  |:: ..|..|:.:..| :...|.:||:|:.::.:.....|.:|.::|:|.|
Zfish  1182 ANRWLAVRLEFVGNCIV-TFAALFAVMARN-NLSPGIMGLSISYALQVTASLNWLVRMSSELETN 1244

  Fly  1011 MTSVERVLEYAQTPSEPPLESPKSVNLAAEWPQAGHLRFQDLRMRYSPGDEDILRGLNFESQPME 1075
            :.:||||.||..|..|...:...| ||...||.|||:......:||....|..:..::......|
Zfish  1245 IVAVERVKEYGDTEKEAEWKLENS-NLPPGWPTAGHIEIHKFGLRYREDLELAICDISVNIAGGE 1308

  Fly  1076 KIGIVGRTGAGKSSIIQALFR-LALNEGTIEIDGLDIGKLGLHDLRSRISIIPQDPVLFSGTLRF 1139
            |:||||||||||||:...||| :...||.|.|||::|..||||:|||||:|||||||||||:||.
Zfish  1309 KVGIVGRTGAGKSSLTLGLFRIIEAAEGEIRIDGVNIADLGLHELRSRITIIPQDPVLFSGSLRM 1373

  Fly  1140 NLDPFDEKSDESLWSALDDVKLKKHVASLEGGLSCRMQDGGSNFSMGQRQLVCLARAILRQNRVL 1204
            ||||||..:||.:|.:|:...||..|:.|...|:....:||.|.|:|||||||||||:||:.::|
Zfish  1374 NLDPFDGYTDEEVWRSLELAHLKTFVSGLPDKLNHECSEGGENLSLGQRQLVCLARALLRKTKIL 1438

  Fly  1205 VMDEATANVDTETDILIQETIQTKFAECTVLTIAHRLHTVMDNDSVLVMDAGQIVEFGAPHKLLQ 1269
            |:|||||.||.|||.|||.||:|:|.:||||||||||:|:||...|||:|.||:.||.:|..|:.
Zfish  1439 VLDEATAAVDLETDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVLVLDKGQMAEFDSPSNLIA 1503

  Fly  1270 RKDGALLKLVNQN 1282
            :| |...|:...:
Zfish  1504 KK-GIFYKMAKDS 1515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10505	NP_611571.2	CFTR_protein	12..1268	CDD:273530	439/1355 (32%)
		ABC_membrane	95..360	CDD:294371	77/278 (28%)
		ABCC_MRP_domain1	428..632	CDD:213217	88/205 (43%)
		ABC_membrane	728..994	CDD:294371	65/277 (23%)
		ABCC_MRP_domain2	1045..1264	CDD:213211	123/219 (56%)
abcc1	XP_001341895.3	MRP_assoc_pro	7..1517	CDD:188098	446/1378 (32%)
		ABC_membrane	331..595	CDD:279056	75/276 (27%)
		ABCC_MRP_domain1	641..842	CDD:213217	88/212 (42%)
		ABC_membrane	966..1231	CDD:279056	65/283 (23%)
		ABCC_MRP_domain2	1278..1498	CDD:213211	123/219 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585974
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.760