Protein Alignment MFS16 and SLC2A4

DIOPT Version :10

• Sequence 1: NP_726048.1
• Gene: MFS16 / 37427
• FlyBaseID: FBgn0034611
• Length: 566
• Species: Drosophila melanogaster
• Sequence 2: NP_001033.1
• Gene: SLC2A4 / 6517
• HGNCID: 11009
• Length: 509
• Species: Homo sapiens
• Alignment Length: 501
• Identity: 104/501 - (20%)
• Similarity: 189/501 - (37%)
• Gaps: 113/501 - (22%)

  Fly   110 KSVLQGNCSTALAASGQDCGYAPFDVPDA--TTLFGMLDSAFLFSYAIAMFASGFVAERVSLRYF 172
            |.:.|....|.|...|.:   .|..:|..  |||:.:..:.|.....|:.|..|.:::.:..:..
Human    50 KVIEQSYNETWLGRQGPE---GPSSIPPGTLTTLWALSVAIFSVGGMISSFLIGIISQWLGRKRA 111

  Fly   173 LSMGMILTGVFTYMFGIARTSNIHSLWYFIIVQIFAGIFQTTGWPGVVA-LVGRWFGKSKRGLIF 236
            :.:..:|..:...:.|:|..:..:.:       :..|.|....:.|:.: ||..:.|:.....:.
Human   112 MLVNNVLAVLGGSLMGLANAAASYEM-------LILGRFLIGAYSGLTSGLVPMYVGEIAPTHLR 169

  Fly   237 GIWNSHTSIGNILGTLIAAHY-------VESDWALSF---VVPGIIIAAVGFLLFLFLVDQPE-- 289
            |...:...:..::|.|||...       ..|.|.|..   |:|    |.:..:|..|..:.|.
Human   170 GALGTLNQLAIVIGILIAQVLGLESLLGTASLWPLLLGLTVLP----ALLQLVLLPFCPESPRYL 230

  Fly   290 --IVGCYPQAGQHERRVANESDV-----EQDDEEQVRHNDAEIN---YRSAPTERTPILPRSQPE 344
              |......|.:..:|:...:||     |..||::....:..::   ...:.|.|.|::     .
Human   231 YIIQNLEGPARKSLKRLTGWADVSGVLAELKDEKRKLERERPLSLLQLLGSRTHRQPLI-----I 290

  Fly   345 AVPRGRGRPISLIDALFIPGVVEFSLCLFFTKLVSYTFMYWLPLYIQKSSTLGPELSADLSTLFD 409
            ||.....:.:|.|:|:|.     :|..:|.|..|..      |.|    :|:|   :..::|:|.
Human   291 AVVLQLSQQLSGINAVFY-----YSTSIFETAGVGQ------PAY----ATIG---AGVVNTVFT 337

  Fly   410 VGGILGAIAAG----YLSDVSGMSATVCTGMLFVASPILLMYQQYGALSMTISIVLLIVVGIFVN 470
            :..:|....||    :|..::||..  |..::.||   ||:.::..|:|....:.:...|..|..
Human   338 LVSVLLVERAGRRTLHLLGLAGMCG--CAILMTVA---LLLLERVPAMSYVSIVAIFGFVAFFEI 397

  Fly   471 GPYALITTSVSAELGQHSSLEGNANALATVTAIIDGTGS---------IGAAVGPLLAGLISTAG 526
            || ..|...:.|||..    :|...|...|....:.|.:         :..|:||
Human   398 GP-GPIPWFIVAELFS----QGPRPAAMAVAGFSNWTSNFIIGMGFQYVAEAMGP---------- 447

  Fly   527 WQYVFHMLIAADIIAMVLLGRLVF----------KEFAALRRASHR 562
              |||.      :.|::|||..:|          :.|..:..|.||
Human   448 --YVFL------LFAVLLLGFFIFTFLRVPETRGRTFDQISAAFHR 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MFS16	NP_726048.1	MFS_SLC37A1_2	85..552	CDD:340902	100/489 (20%)
SLC2A4	NP_001033.1	Interaction with SRFBP1. /evidence=ECO:0000269|PubMed:16647043	7..13
		MFS_GLUT_Class1	26..474	CDD:340989	100/488 (20%)
		Dileucine internalization motif. /evidence=ECO:0000269|PubMed:8300557	489..490