DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MFS16 and Slc37a2

DIOPT Version :9

Sequence 1:	NP_726048.1	Gene:	MFS16 / 37427	FlyBaseID:	FBgn0034611	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_001139432.1	Gene:	Slc37a2 / 56857	MGIID:	1929693	Length:	506	Species:	Mus musculus

Alignment Length:	498	Identity:	264/498 - (53%)
Similarity:	334/498 - (67%)	Gaps:	35/498 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 RDLLYKMSVFVLTFLAYACYHMCRKPISVVKSVLQGNCSTALAASGQD--------CGYAPFDVP 136
            ||..::..:.:||||.||||||.|||||:|||.|..|||..:......        |.::|||..
Mouse    17 RDSWFRGFILLLTFLIYACYHMSRKPISIVKSRLHQNCSEMVRPVNDTHDLNDTTWCSWSPFDKD 81

  Fly   137 DATTLFGMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIARTSNIHSLWYF 201
            |...|.|.:|:|||.:|||.||.||...||:.|||:||.||:|:|:||.:||:....|||.||||
Mouse    82 DYKELLGAVDNAFLVAYAIGMFISGIFGERLPLRYYLSAGMVLSGLFTSLFGLGYFWNIHMLWYF 146

  Fly   202 IIVQIFAGIFQTTGWPGVVALVGRWFGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVESDWALSF 266
            :::||..|:.||||||.||..||.||||.|||.|.||||||||:|||||:|||..:|...|.|||
Mouse   147 VLIQICNGLVQTTGWPSVVTCVGNWFGKGKRGFIMGIWNSHTSVGNILGSLIAGVWVNQHWGLSF 211

  Fly   267 VVPGIIIAAVGFLLFLFLVDQPEIVGCYPQAGQHERRVANESDVEQDDEE-------QVRHNDAE 324
            :|||||.|.:|.:.||||::.||.|.|.|.      |..::.:.|||:.|       ..|.::.:
Mouse   212 IVPGIITAIMGVITFLFLIEYPEDVDCTPP------RHHDDPEKEQDNPEDPVNSPYSSRESNVD 270

  Fly   325 INYRSAPTERTPILPRSQPEAVPRGRGRPISLIDALFIPGVVEFSLCLFFTKLVSYTFMYWLPLY 389
            | ..|:..|:.|     :|||        ||.:.||.||||:||||||.|.|||||||:||||||
Mouse   271 I-AASSSKEQGP-----EPEA--------ISFLGALRIPGVIEFSLCLLFAKLVSYTFLYWLPLY 321

  Fly   390 IQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLMYQQYGALS 454
            |...:....:.:.|||||||||||:|.|.||.:||.:...||.|..||.:|:|::.:|...|...
Mouse   322 IFNVAHFSAKEAGDLSTLFDVGGIIGGIMAGLISDYTNSRATTCCIMLILAAPMMFLYNYIGQNG 386

  Fly   455 MTISIVLLIVVGIFVNGPYALITTSVSAELGQHSSLEGNANALATVTAIIDGTGSIGAAVGPLLA 519
            :|.|||:||:.|:.||||||||||:|||:||.|.||:|||.||:|||||||||||||||:|||||
Mouse   387 ITSSIVMLIICGVLVNGPYALITTAVSADLGTHESLKGNAKALSTVTAIIDGTGSIGAALGPLLA 451

  Fly   520 GLISTAGWQYVFHMLIAADIIAMVLLGRLVFKEFAALRRASHR 562
            ||||..||..||:|||:||::|.:||.|||:||..|.:.|..|
Mouse   452 GLISPTGWNNVFYMLISADVLACLLLCRLVYKEILAWKTACGR 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS16	NP_726048.1	UhpC	84..545	CDD:225180	252/475 (53%)
MFS16	NP_726048.1	MFS	139..549	CDD:119392	228/416 (55%)
Slc37a2	NP_001139432.1	UhpC	25..478	CDD:332119	253/472 (54%)
Slc37a2	NP_001139432.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	240..266		6/31 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838832
Domainoid	1	1.000	347	1.000	Domainoid score	I1033
eggNOG	1	0.900	-	-		E2759_KOG2533
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41357
Inparanoid	1	1.050	498	1.000	Inparanoid score	I1365
Isobase	1	0.950	-	0.928771	Normalized mean entropy	S3312
OMA	1	1.010	-	-		QHG57781
OrthoDB	1	1.010	-	-		D292288at33208
OrthoFinder	1	1.000	-	-		FOG0000756
OrthoInspector	1	1.000	-	-		otm43514
orthoMCL	1	0.900	-	-		OOG6_100970
Panther	1	1.100	-	-	LDO	PTHR43184
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5223
SonicParanoid	1	1.000	-	-		X449
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750