DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS16 and slc37a2

DIOPT Version :9

Sequence 1:	NP_726048.1	Gene:	MFS16 / 37427	FlyBaseID:	FBgn0034611	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_001011395.1	Gene:	slc37a2 / 496867	XenbaseID:	XB-GENE-990247	Length:	499	Species:	Xenopus tropicalis

Alignment Length:	509	Identity:	264/509 - (51%)
Similarity:	330/509 - (64%)	Gaps:	43/509 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 IRAVQRLSRQCCTRFHARRDLLYKMSVFVLTFLAYACYHMCRKPISVVKSVLQGNCSTALAA--- 123
            ||.:|.:||..|          |:..:.|:|||.|.||||.|||||:||..|..||| ||.:
Frog     9 IRLMQSVSRDSC----------YRGFIIVMTFLFYTCYHMSRKPISIVKGQLHRNCS-ALPSPPN 62

  Fly   124 -SGQD---CGYAPFDVPDATTLFGMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFT 184
             |..|   |.:|||:..:...|.|.||:|||.||||.||.||...||:.|||:||.|||:.|:||
Frog    63 ISANDTTWCSWAPFENSNYKELLGSLDTAFLVSYAIGMFFSGIFGERLPLRYYLSGGMIICGIFT 127

  Fly   185 YMFGIARTSNIHSLWYFIIVQIFAGIFQTTGWPGVVALVGRWFGKSKRGLIFGIWNSHTSIGNIL 249
            ...|:....|||:|||:|:.||..|:.||||||.||..:|.||||.|||.|.|||||||::||||
Frog   128 SFMGLGYYWNIHALWYYILFQILNGLAQTTGWPSVVTCMGNWFGKGKRGFIMGIWNSHTAVGNIL 192

  Fly   250 GTLIAAHYVESDWALSFVVPGIIIAAVGFLLFLFLVDQPEIVGCYPQAGQHERRVANESDVEQDD 314
            |:|||..:|.:.|.|||:||||||||.|...|.|||:.||.|||.|.              :|.:
Frog   193 GSLIAGAFVSTAWGLSFIVPGIIIAAFGIFCFFFLVEYPEDVGCTPP--------------QQPE 243

  Fly   315 EEQVRHNDAEINYRSAPTERTPILPRSQPEAVPRGRG-------RPISLIDALFIPGVVEFSLCL 372
            :.:....|..::|.|..|    |...::......|..       :.||...||.|||||||||||
Frog   244 DTKENLEDMPVSYNSTDT----ICKSTESNEDDSGNAHTETEHPQAISFFGALRIPGVVEFSLCL 304

  Fly   373 FFTKLVSYTFMYWLPLYIQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGML 437
            .|.|||||||:|||||||...:...|:.:.|||||||||||:|.|.||.:||.:|.||..||.||
Frog   305 LFAKLVSYTFLYWLPLYIANDAQFDPKAAGDLSTLFDVGGIIGGILAGGISDYTGKSAITCTIML 369

  Fly   438 FVASPILLMYQQYGALSMTISIVLLIVVGIFVNGPYALITTSVSAELGQHSSLEGNANALATVTA 502
            .:.:|:|.:|...|...::.::.:|||.||.|||||:||||:|||:||.|.||:|||.||:||||
Frog   370 ILTAPMLFIYNYLGQTGVSTTVAMLIVCGILVNGPYSLITTAVSADLGTHESLQGNAKALSTVTA 434

  Fly   503 IIDGTGSIGAAVGPLLAGLISTAGWQYVFHMLIAADIIAMVLLGRLVFKEFAAL 556
            ||||:||||||:||.|||::|:.||.|||:|||||||.|.:||.|||:||...|
Frog   435 IIDGSGSIGAALGPSLAGVLSSRGWNYVFYMLIAADICACLLLVRLVYKEIRTL 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS16	NP_726048.1	UhpC	84..545	CDD:225180	250/474 (53%)
MFS16	NP_726048.1	MFS	139..549	CDD:119392	224/416 (54%)
slc37a2	NP_001011395.1	MFS_SLC37A1_2	22..484	CDD:340902	254/480 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	348	1.000	Domainoid score	I1027
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41357
Inparanoid	1	1.050	492	1.000	Inparanoid score	I1376
OMA	1	1.010	-	-		QHG57781
OrthoDB	1	1.010	-	-		D292288at33208
OrthoFinder	1	1.000	-	-		FOG0000756
OrthoInspector	1	1.000	-	-		otm48667
Panther	1	1.100	-	-	LDO	PTHR43184
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5223
SonicParanoid	1	1.000	-	-		X449
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110