DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS16 and slc37a1

DIOPT Version :9

Sequence 1:	NP_726048.1	Gene:	MFS16 / 37427	FlyBaseID:	FBgn0034611	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_001007440.1	Gene:	slc37a1 / 492798	ZFINID:	ZDB-GENE-041114-151	Length:	529	Species:	Danio rerio

Alignment Length:	549	Identity:	262/549 - (47%)
Similarity:	340/549 - (61%)	Gaps:	75/549 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 VPFGIRAVQRLSRQCCTRFHARRDLLYKMSVFVLTFLAYACYHMCRKPISVVKSVLQGNCS---- 118
            ||.|||.:...:          ||..||...|.||||.|..:|:.|||||:|||.|..|||
Zfish     4 VPPGIRFLASFN----------RDQWYKAFTFALTFLLYTSFHLSRKPISIVKSELHKNCSHAVE 58

  Fly   119 --TALAASGQ--------DCGYAPFDVPDATTLFGMLDSAFLFSYAIAMFASGFVAERVSLRYFL 173
              |.:::|.|        ||.:.|||..:...|.|.:|.:|||:|||.||.||.:.||:.:|.:|
Zfish    59 APTEISSSSQQPGHHPEFDCSWKPFDRNNYKQLLGAMDYSFLFAYAIGMFLSGIIGERLPIRLYL 123

  Fly   174 SMGMILTGVFTYMFGIARTSNIHSLWYFIIVQIFAGIFQTTGWPGVVALVGRWFGKSKRGLIFGI 238
            ::||:.:|:||.:||:....:||||.::|.||:..|:.||||||.||..:|.||||.:||||.|:
Zfish   124 TVGMLTSGLFTCLFGLGYIYDIHSLGFYIFVQVANGLVQTTGWPSVVTCIGNWFGKGRRGLIMGL 188

  Fly   239 WNSHTSIGNILGTLIAAHYVESDWALSFVVPGIIIAAVGFLLFLFLVDQPEIVGCYPQAGQHERR 303
            ||||||:|||||:|||.:||.|:|.|||:|||:||||:|.:.|.||::.|           ::.:
Zfish   189 WNSHTSVGNILGSLIAGYYVSSNWGLSFIVPGVIIAAMGVICFFFLIEHP-----------NDLK 242

  Fly   304 VANESDVEQDDEEQVR-------HNDAEINYR------SAPTER----------TPILPRSQPEA 345
            .|:........::..:       |.|..:.|:      |..||.          .|:    |...
Zfish   243 TASTQSSAPSSQKFHKSCNGVNGHKDLYLQYKPGAKAQSWDTELLLGQESIGVCVPV----QQVV 303

  Fly   346 VPRGRGRP--ISLIDALFIPGVVEFSLCLFFTKLVSYTFMYWLPLYIQKSSTLGPELSADLSTLF 408
            |.:....|  ||.:.||.|||||||||||.|.|||||||::||||||.|::.|..:.:.||||||
Zfish   304 VVKSEAEPSAISFMGALRIPGVVEFSLCLLFAKLVSYTFLFWLPLYITKAAHLDAKKAGDLSTLF 368

  Fly   409 DVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILL---MYQQYGALSMTISIVLLIVVGIFVN 470
            |||||:|.|.||.:||.....||.|..||.:|:|:|.   |..|:| |..||.  :|:|.|..||
Zfish   369 DVGGIVGGILAGVISDKMHKRATTCAVMLLLAAPMLYGFSMMSQFG-LGPTIG--MLLVCGGLVN 430

  Fly   471 GPYALITTSVSAELGQHSSLEGNANALATVTAIIDGTGSIGAAVGPLLAGLISTAGWQYVFHMLI 535
            ||||||||:|||:||.|.||:|||.||:|||||||||||:|||||||||||:|..||..||:||:
Zfish   431 GPYALITTAVSADLGTHKSLKGNARALSTVTAIIDGTGSVGAAVGPLLAGLLSARGWDQVFYMLM 495

  Fly   536 AADIIAMVLLGRLVFKEFAALRRASHRIR 564
            .||..|::||.|||.||   ||  .||.|
Zfish   496 TADFFALLLLLRLVMKE---LR--YHRNR 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS16	NP_726048.1	UhpC	84..545	CDD:225180	243/502 (48%)
MFS16	NP_726048.1	MFS	139..549	CDD:119392	217/437 (50%)
slc37a1	NP_001007440.1	UhpC	92..501	CDD:332119	212/426 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582664
Domainoid	1	1.000	345	1.000	Domainoid score	I1023
eggNOG	1	0.900	-	-		E2759_KOG2533
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	493	1.000	Inparanoid score	I1361
OMA	1	1.010	-	-		QHG57781
OrthoDB	1	1.010	-	-		D292288at33208
OrthoFinder	1	1.000	-	-		FOG0000756
OrthoInspector	1	1.000	-	-		otm25177
orthoMCL	1	0.900	-	-		OOG6_100970
Panther	1	1.100	-	-	O	PTHR43184
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X449
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770