DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS16 and Slc17a8

DIOPT Version :9

Sequence 1:	NP_726048.1	Gene:	MFS16 / 37427	FlyBaseID:	FBgn0034611	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_714947.1	Gene:	Slc17a8 / 266767	RGDID:	628870	Length:	588	Species:	Rattus norvegicus

Alignment Length:	470	Identity:	98/470 - (20%)
Similarity:	167/470 - (35%)	Gaps:	109/470 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 CRKPISVVKSVLQGNCSTALAASGQDCGYAPFDVPDATTLFGMLDSAFLFSYAIAMFASGFVAER 166
            |...:::|:.|   |.||.......:...|.|:....|.  |::..:|.:.|.:.....||::.:
  Rat    94 CNLGVAIVEMV---NNSTVYVDGKPEIQTAQFNWDPETV--GLIHGSFFWGYIVTQIPGGFISNK 153

  Fly   167 VSLRYFLSMGMILTGVFTYMFGIARTSNIHSLWY--FIIVQIFAGIFQTTGWPGVVALVGRWFGK 229
            .:........:.||.... || |...:.:|   |  .:.|:|..|:.:...:|....:..:|...
  Rat   154 FAANRVFGAAIFLTSTLN-MF-IPSAARVH---YGCVMCVRILQGLVEGVTYPACHGMWSKWAPP 213

  Fly   230 SKRGLIFGIWNSHTSI-GNILGTLIA-------AHYVESDWALSFVVPGIIIAAVGFLLFLF-LV 285
            .:|..:     :.||. |:..|.::|       ..|:  .||..|.:.|:.    |.:.::| |:
  Rat   214 LERSRL-----ATTSFCGSYAGAVVAMPLAGVLVQYI--GWASVFYIYGMF----GIIWYMFWLL 267

  Fly   286 DQPEIVGCYPQAGQHERRVANESDVEQDDEEQVRHNDAEINYRSAPTERTPILPRSQPEAVPRGR 350
            ...|....:|.....||.....|..|       ..|.|.::..:.|..|
  Rat   268 QAYECPAVHPTISNEERTYIETSIGE-------GANLASLSKFNTPWRR---------------- 309

  Fly   351 GRPISLIDALFIPGVVEFSLCLFFTKLVSYTFMYWL---PLY--------IQKSSTLGPELSADL 404
                 ...:|.:..::..:.|.      |:||...|   |.|        |.|...|.......:
  Rat   310 -----FFTSLPVYAIIVANFCR------SWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVM 363

  Fly   405 STLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLMYQQYGALSMTISIVLLIVVGIFV 469
            :.:..:||.|    |.||.....::.|....::           ..|...|  ...||:||| |.
  Rat   364 TIVVPIGGQL----ADYLRSRKILTTTAVRKIM-----------NCGGFGM--EATLLLVVG-FS 410

  Fly   470 NGPYALITTSVSAELGQHSSLEG-NANAL-------ATVTAIIDGTGSIGAAVGPLLAGLI---- 522
            :.....|:..|.|......::.| |.|.|       :.:..|.:|.|::...|.||:.|.:
  Rat   411 HTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTKHK 475

  Fly   523 STAGWQYVFHMLIAA 537
            :...||.||  ||||
  Rat   476 TREEWQNVF--LIAA 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS16	NP_726048.1	UhpC	84..545	CDD:225180	98/470 (21%)
MFS16	NP_726048.1	MFS	139..549	CDD:119392	90/433 (21%)
Slc17a8	NP_714947.1	MFS_SLC17A6_7_8_VGluT	79..502	CDD:340940	98/470 (21%)
Slc17a8	NP_714947.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	539..588
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342516
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840