Protein Alignment MFS16 and SLC17A8

DIOPT Version :10

• Sequence 1: NP_726048.1
• Gene: MFS16 / 37427
• FlyBaseID: FBgn0034611
• Length: 566
• Species: Drosophila melanogaster
• Sequence 2: NP_647480.1
• Gene: SLC17A8 / 246213
• HGNCID: 20151
• Length: 589
• Species: Homo sapiens
• Alignment Length: 576
• Identity: 113/576 - (19%)
• Similarity: 196/576 - (34%)
• Gaps: 167/576 - (28%)

  Fly     3 TSEQKSSWHYSQ---PKRIREPSHLDEQHLHLAHC---PRRSMRASL-GLGRTRKMSNNYNDVPF 60
            |:|::.:...::   |.:...||    ..|...||   |:|.:.|.: |||..         :.|
Human    39 TTEEEDNIELNEEGRPVQTSRPS----PPLCDCHCCGLPKRYIIAIMSGLGFC---------ISF 90

  Fly    61 GIRAVQRLSRQCCTRFHARRDLLYKMSVFVLTFLAYACYHMCRKPISVVKSVLQGNCSTALAASG 125
            |||                                      |...:::|:.|   |.||......
Human    91 GIR--------------------------------------CNLGVAIVEMV---NNSTVYVDGK 114

  Fly   126 QDCGYAPFDVPDATTLFGMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIA 190
            .:...|.|:....|.  |::..:|.:.|.:.....||::.:.:........:.||.... || |.
Human   115 PEIQTAQFNWDPETV--GLIHGSFFWGYIMTQIPGGFISNKFAANRVFGAAIFLTSTLN-MF-IP 175

  Fly   191 RTSNIHSLWY--FIIVQIFAGIFQTTGWPGVVALVGRWFGKSKRGLIFGIWNSHTSI-GNILGTL 252
            ..:.:|   |  .:.|:|..|:.:...:|....:..:|....:|..:     :.||. |:..|.:
Human   176 SAARVH---YGCVMCVRILQGLVEGVTYPACHGMWSKWAPPLERSRL-----ATTSFCGSYAGAV 232

  Fly   253 IA-------AHYVESDWALSFVVPGIIIAAVGFLLFLF-LVDQPEIVGCYPQAGQHERRVANESD 309
            :|       ..|:  .|:..|.:.|:.    |.:.::| |:...|....:|.....|:.....|.
Human   233 VAMPLAGVLVQYI--GWSSVFYIYGMF----GIIWYMFWLLQAYECPAAHPTISNEEKTYIETSI 291

  Fly   310 VEQDDEEQVRHNDAEINYRSAPTERTPILPRSQPEAVPRGRGRPISLIDALFIPGVVEFSLC--- 371
            .|       ..|...::..|.|.:|                     ...:|.:..::..:.|
Human   292 GE-------GANVVSLSKFSTPWKR---------------------FFTSLPVYAIIVANFCRSW 328

  Fly   372 LFFTKLVSYTFMYWLPLY--------IQKSSTLGPELSADLSTLFDVGGILGAIAAGYLSDVSGM 428
            .|:..|:|.      |.|        |.|...|.......::.:..:||.|    |.||.....:
Human   329 TFYLLLISQ------PAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQL----ADYLRSRQIL 383

  Fly   429 SATVCTGMLFVASPILLMYQQYGALSMTISIVLLIVVGIFVNGPYALITTSVSAELGQHSSLEG- 492
            :.|....::           ..|...|  ...||:||| |.:.....|:..|.|......::.|
Human   384 TTTAVRKIM-----------NCGGFGM--EATLLLVVG-FSHTKGVAISFLVLAVGFSGFAISGF 434

  Fly   493 NANAL-------ATVTAIIDGTGSIGAAVGPLLAGLI----STAGWQYVFHMLIAA 537
            |.|.|       :.:..|.:|.|::...|.||:.|.:    :...||.||  ||||
Human   435 NVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTRHKTREEWQNVF--LIAA 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MFS16	NP_726048.1	MFS_SLC37A1_2	85..552	CDD:340902	95/487 (20%)
SLC17A8	NP_647480.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	40..61		2/20 (10%)
		MFS_SLC17A6_7_8_VGluT	79..502	CDD:340940	103/532 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	559..589