DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS16 and Slc37a1

DIOPT Version :9

Sequence 1:	NP_726048.1	Gene:	MFS16 / 37427	FlyBaseID:	FBgn0034611	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_001229356.1	Gene:	Slc37a1 / 224674	MGIID:	2446181	Length:	531	Species:	Mus musculus

Alignment Length:	526	Identity:	242/526 - (46%)
Similarity:	330/526 - (62%)	Gaps:	42/526 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 VPFGIRAVQRLSRQCCTRFHARRDLLYKMSVFVLTFLAYACYHMCRKPISVVKSVLQGNCSTA-- 120
            :|.|||.:...|          ||..|:..:|:||||.||.:|:.|||||:||..|...|:..
Mouse     4 LPVGIRFIISFS----------RDQWYRAFIFMLTFLLYASFHLSRKPISIVKGELHKQCTAGDG 58

  Fly   121 -------------------LAASGQDCGYAPFDVPDATTLFGMLDSAFLFSYAIAMFASGFVAER 166
                               |..:..|||:||||..:...|.|.||.|||.:|||.|:.||.:.||
Mouse    59 PESPFSDPSSSTRHGPTHWLLNNETDCGWAPFDKNNYQQLLGALDYAFLCAYAIGMYLSGIIGER 123

  Fly   167 VSLRYFLSMGMILTGVFTYMFGIARTSNIHSLWYFIIVQIFAGIFQTTGWPGVVALVGRWFGKSK 231
            :.:||:|:.||:.:|.||.:||:....|||||.::::.||..|:.||||||.||..:..||||.:
Mouse   124 LPIRYYLTFGMLASGAFTALFGLGYFYNIHSLGFYVVTQIINGLVQTTGWPSVVTCLSNWFGKGR 188

  Fly   232 RGLIFGIWNSHTSIGNILGTLIAAHYVESDWALSFVVPGIIIAAVGFLLFLFLVDQPEIVGCYPQ 296
            ||||.||||||||:|||||:|||.::|.:.|.|||:|||.|:||:|.:.||||::.|:.|.|...
Mouse   189 RGLIMGIWNSHTSVGNILGSLIAGYWVSTCWGLSFIVPGAIVAAMGIVCFLFLIEHPKDVKCSST 253

  Fly   297 AGQHERRVANESDVEQDD-EEQVRHN------DAEINYRSAPTERTPILPRSQPEAVPR-GRGRP 353
            ...|.|  |:|:.:.:.. ::|..::      |.|:........:.|:.| |....:|. |....
Mouse   254 LPTHPR--ASENGINRFRLQKQTTYSEKNGPLDPELQCLLLSDGKNPLHP-SHIVVLPADGNMAA 315

  Fly   354 ISLIDALFIPGVVEFSLCLFFTKLVSYTFMYWLPLYIQKSSTLGPELSADLSTLFDVGGILGAIA 418
            ||...||.||||:||||||.|.|||||||::||||||.....|..:.:.:||||||||||.|.|.
Mouse   316 ISFTGALRIPGVIEFSLCLLFAKLVSYTFLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGIL 380

  Fly   419 AGYLSDVSGMSATVCTGMLFVASPILLMYQQYGALSMTISIVLLIVVGIFVNGPYALITTSVSAE 483
            ||.:||.....|:.|..||.:|:|.|.::.....:.:..:|.:|::.|..|:||||||||:|||:
Mouse   381 AGVISDRLEKRASTCGLMLLLAAPTLYVFSSVSRMGLEATIAMLLLSGALVSGPYALITTAVSAD 445

  Fly   484 LGQHSSLEGNANALATVTAIIDGTGSIGAAVGPLLAGLISTAGWQYVFHMLIAADIIAMVLLGRL 548
            ||.|.||:||::||:|||||||||||:|||:|||||||||.:||..||:||:.||..|::.|.||
Mouse   446 LGTHKSLKGNSHALSTVTAIIDGTGSVGAALGPLLAGLISPSGWSNVFYMLMFADACALLFLVRL 510

  Fly   549 VFKEFA 554
            :.||.:
Mouse   511 IHKELS 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS16	NP_726048.1	UhpC	84..545	CDD:225180	230/489 (47%)
MFS16	NP_726048.1	MFS	139..549	CDD:119392	206/417 (49%)
Slc37a1	NP_001229356.1	MFS_SLC37A1_2	21..514	CDD:340902	232/495 (47%)
Slc37a1	NP_001229356.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	53..72		1/18 (6%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838830
Domainoid	1	1.000	347	1.000	Domainoid score	I1033
eggNOG	1	0.900	-	-		E2759_KOG2533
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	498	1.000	Inparanoid score	I1365
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57781
OrthoDB	1	1.010	-	-		D292288at33208
OrthoFinder	1	1.000	-	-		FOG0000756
OrthoInspector	1	1.000	-	-		otm43514
orthoMCL	1	0.900	-	-		OOG6_100970
Panther	1	1.100	-	-	O	PTHR43184
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X449
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770