DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MFS16 and SLC37A2

DIOPT Version :9

Sequence 1:	NP_726048.1	Gene:	MFS16 / 37427	FlyBaseID:	FBgn0034611	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_938018.1	Gene:	SLC37A2 / 219855	HGNCID:	20644	Length:	505	Species:	Homo sapiens

Alignment Length:	496	Identity:	261/496 - (52%)
Similarity:	324/496 - (65%)	Gaps:	31/496 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 RDLLYKMSVFVLTFLAYACYHMCRKPISVVKSVLQGNCSTALAASGQD--------CGYAPFDVP 136
            ||..::..:.:||||.||||||.|||||:|||.|..|||..:......        |.:||||..
Human    17 RDSWFRGLILLLTFLIYACYHMSRKPISIVKSRLHQNCSEQIKPINDTHSLNDTMWCSWAPFDKD 81

  Fly   137 DATTLFGMLDSAFLFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIARTSNIHSLWYF 201
            :...|.|.:|:|||.:|||.||.||...||:.|||:||.||:|:|:||.:||:....|||.||||
Human    82 NYKELLGGVDNAFLIAYAIGMFISGVFGERLPLRYYLSAGMLLSGLFTSLFGLGYFWNIHELWYF 146

  Fly   202 IIVQIFAGIFQTTGWPGVVALVGRWFGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVESDWALSF 266
            :::|:..|:.||||||.||..||.||||.|||.|.||||||||:|||||:|||..:|...|.|||
Human   147 VVIQVCNGLVQTTGWPSVVTCVGNWFGKGKRGFIMGIWNSHTSVGNILGSLIAGIWVNGQWGLSF 211

  Fly   267 VVPGIIIAAVGFLLFLFLVDQPEIVGCYPQAGQHERRVANESDVEQDDEE---QVRHNDAEINYR 328
            :|||||.|.:|.:.||||::.||.|.|.|.  ||....|...|..:|...   .:|.:..|...:
Human   212 IVPGIITAVMGVITFLFLIEHPEDVDCAPP--QHHGEPAENQDNPEDPGNSPCSIRESGLETVAK 274

  Fly   329 SAPTERTPILPRSQPEAVPRGRGRPISLIDALFIPGVVEFSLCLFFTKLVSYTFMYWLPLYIQKS 393
            .:..      |..:|.|        ||...||.|||||||||||.|.|||||||:|||||||...
Human   275 CSKG------PCEEPAA--------ISFFGALRIPGVVEFSLCLLFAKLVSYTFLYWLPLYIANV 325

  Fly   394 STLGPELSADLSTLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLMYQQYGALSMTIS 458
            :....:.:.|||||||||||:|.|.||.:||.:...||.|..||.:|:|::.:|...|...:..|
Human   326 AHFSAKEAGDLSTLFDVGGIIGGIVAGLVSDYTNGRATTCCVMLILAAPMMFLYNYIGQDGIASS 390

  Fly   459 IVLLIVVGIFVNGPYALITTSVSAELGQHSSLEGNANALATVTAIIDGTGSIGAAVGPLLAGLIS 523
            ||:||:.|..||||||||||:|||:||.|.||:|||.||:|||||||||||||||:|||||||||
Human   391 IVMLIICGGLVNGPYALITTAVSADLGTHKSLKGNAKALSTVTAIIDGTGSIGAALGPLLAGLIS 455

  Fly   524 TAGWQYVFHMLIAADIIAMVLLGRLVFKEFAA----LRRAS 560
            ..||..||:|||:||::|.:||.|||:||..|    |.|.|
Human   456 PTGWNNVFYMLISADVLACLLLCRLVYKEILAWKVSLSRGS 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS16	NP_726048.1	UhpC	84..545	CDD:225180	248/471 (53%)
MFS16	NP_726048.1	MFS	139..549	CDD:119392	224/412 (54%)
SLC37A2	NP_938018.1	UhpC	25..478	CDD:332119	249/468 (53%)
SLC37A2	NP_938018.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	240..262		6/23 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148744
Domainoid	1	1.000	336	1.000	Domainoid score	I1124
eggNOG	1	0.900	-	-		E2759_KOG2533
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41357
Inparanoid	1	1.050	490	1.000	Inparanoid score	I1429
Isobase	1	0.950	-	0.928771	Normalized mean entropy	S3312
OMA	1	1.010	-	-		QHG57781
OrthoDB	1	1.010	-	-		D292288at33208
OrthoFinder	1	1.000	-	-		FOG0000756
OrthoInspector	1	1.000	-	-		otm41463
orthoMCL	1	0.900	-	-		OOG6_100970
Panther	1	1.100	-	-	LDO	PTHR43184
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5223
SonicParanoid	1	1.000	-	-		X449
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	16	15.790