DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MFS16 and R10D12.1

DIOPT Version :9

Sequence 1:	NP_726048.1	Gene:	MFS16 / 37427	FlyBaseID:	FBgn0034611	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_506456.1	Gene:	R10D12.1 / 179888	WormBaseID:	WBGene00011185	Length:	485	Species:	Caenorhabditis elegans

Alignment Length:	565	Identity:	109/565 - (19%)
Similarity:	191/565 - (33%)	Gaps:	143/565 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 LAHCPRRSMRASLGLGRTRKMSNNYNDVPFGIRAVQRLSRQCCTRFHARRDLLYKMSVFVLTFLA 95
            :|..|::.:  ::.:..|:..:::..|.|..:|.:..:|...|.     ..|:..:..|..|.|.
Worm     6 VAPLPQKGV--AVAIPDTKSSNDDSKDQPGYVRYLIMISTMLCL-----TSLMSNVVCFNFTVLC 63

  Fly    96 YACYHMCRKPISVVKSVLQGNCS----------TAL---AASGQDCGYAPFDVPDATTLFGMLDS 147
                    .|.|.....|.||.:          |.|   .|.|..||..|       .:.|:
Worm    64 --------MPGSGETGELVGNRTHFVGYTRQEKTVLLSTVAIGAVCGVFP-------VIIGI--- 110

  Fly   148 AFLFSYAIAMFASGFVAERVSL-RYFLSMGMILTGVFTYMFGIARTSNIHSLWYFIIVQIFAGIF 211
                             .::.| :.|::.| :||.:.|::..|....:.|   .||:::...|:.
Worm   111 -----------------SKLGLKKVFMTSG-VLTAISTFLIPILAPLHFH---LFIMLRFVQGLS 154

  Fly   212 QTTGWPGVVALVGRWFGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVES--DWALSFVVPGIIIA 274
            ....:|.|.|:...|...:::||......:.....:|....:|.....|  .|...|.:..||..
Worm   155 YAACFPAVGAITSSWASLAQQGLFIAALTTFGQTSSIFSMPVAGELCTSVFGWKSVFYLHAIISL 219

  Fly   275 AVGFLLFLFLVDQPEIVGCYPQAGQHERRVANESDVEQDDEEQVRHND-AEINYRSAPTE----- 333
            .|..:.|....|.||                        |.:.||..: |||.:..:..|
Worm   220 VVFTIWFALFTDSPE------------------------DNKLVRPAELAEIEFGKSEDEIHEHS 260

  Fly   334 RTPILPRSQPEAVPRGRGRPISLIDALFIPGVVEFSLCLFFTKLVSYTFMYWLPLYIQKSSTLGP 398
            .||.|   :....|...|..|.....|....::.....:|...:..|:|        :|:.
Worm   261 NTPYL---EILTTPSVWGIWIGAFGDLIAVQLIHIYSPVFLHDVGGYSF--------EKTG---- 310

  Fly   399 ELSADLSTLFDVGGILGAIAAGYLSD-VSGMSATVCTGMLFVASPILLMYQQYGALSMTISIVLL 462
             .:|.:..||.   ....:.||:.|| |.|:|.|.             ..:.|..:::..|.:.|
Worm   311 -FAAAVPVLFQ---FFVKMFAGHSSDKVHGISETT-------------KLRIYNTIALGASAIFL 358

  Fly   463 IVVGIFVNGPYAL---ITTSVSAELGQHSSLEGNANALAT------VTAIIDGTGSIGAAVGPLL 518
            :.:|....|...|   :.|..:...|.:........||.:      |.||......:...|.|::
Worm   359 VSLGFVKQGQGVLGLVLMTLATGMFGFNGGGFSKCAALVSRQYNHFVMAIQQILVCLSMIVCPII 423

  Fly   519 AGLI----STAGWQYVFHMLIAADIIAMVLLGRLVFKEFAALRRA 559
            ...|    :||.|:.||.:     ..|::|:...:|...|..:.|
Worm   424 VSTILQHGTTAEWRIVFFV-----HAAILLICNAIFCWLATAKPA 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS16	NP_726048.1	UhpC	84..545	CDD:225180	96/496 (19%)
MFS16	NP_726048.1	MFS	139..549	CDD:119392	82/432 (19%)
R10D12.1	NP_506456.1	MFS	55..455	CDD:391944	97/499 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160340
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930