DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MFS16 and T22F3.8

DIOPT Version :9

Sequence 1:	NP_726048.1	Gene:	MFS16 / 37427	FlyBaseID:	FBgn0034611	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_504013.1	Gene:	T22F3.8 / 178781	WormBaseID:	WBGene00020698	Length:	482	Species:	Caenorhabditis elegans

Alignment Length:	574	Identity:	105/574 - (18%)
Similarity:	193/574 - (33%)	Gaps:	170/574 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 QHLHLAHCPRR---SMRASLGLGR---TRKMSNNYNDVPFGIRAVQRLSRQCCTRFHARRDLLYK 85
            |.|...||..|   :::.:..||.   |..:.|||                            |:
Worm     4 QTLFTLHCLYRTFFNLKVAFFLGSAGLTMMLLNNY----------------------------YR 40

  Fly    86 MSVFVLTFLAYACYHMCRKPISVVKSVLQGNCS--------TALAASGQDC-GYAPFD------V 135
            ..|.::.||..|  .:|...:.:..:.:   |.        |.:..:.|.. .|.|.|      .
Worm    41 FIVLLVGFLCLA--SLCSNYLIINFTFI---CMKHDFSDGFTEINGTRQSIYDYTPDDKKWILWA 100

  Fly   136 PDATTLFGMLDSAFL---FSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFGIARTSNIHS 197
            ..|.|:.|.:....|   :......|.||.|:            .|.|.:..:.          :
Worm   101 VAAGTIIGTVPMNLLLVKYGARFPFFLSGIVS------------CISTSLIPFA----------A 143

  Fly   198 LWYF---IIVQIFAGIFQTTGWPGVVALVGRWFGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVE 259
            .|.|   ||::...|...:..:..:..|..||...::..:...:.....:|.:::..:.......
Worm   144 KWNFAFLIILRFIQGFSFSADFAAIGLLAVRWAPLAETAIFVAVLTCFNAIASMITNMATGLICV 208

  Fly   260 SD--WALSFVVPGIIIAAVGFLLFLFL-VDQPEIVGCYPQAGQHERRVANE--SDVEQDDEEQVR 319
            |.  |..|:.:.. |:.|:.|:|:.|: :|.|          |..|||:.:  ..::::..|...
Worm   209 SSLGWKWSYYLHS-IVGAILFVLWYFVYIDHP----------QDTRRVSGKELQSIQKNKSEAHL 262

  Fly   320 HNDAEINYRSAPTERTPILPRSQPEAVPRGRGRPISLIDALFIPGVVEFSLCL----FFTKLVSY 380
            ....::.|....|  :|::                               ||:    ||....:.
Worm   263 SKKCDVPYIKLAT--SPVI-------------------------------LCVWANAFFDLTAAI 294

  Fly   381 TFMYWLPLYIQKSSTLGPELSADLSTLFDVGGIL--GAIAAGYLSD-VSGMSA--------TVCT 434
            .|..::|||:.:....|...:...|:|  :.||.  ..:..|.:|| :..:|.        |:..
Worm   295 MFSTYIPLYLHEVLKFGVTETGFYSSL--IHGICLPVRLCFGIISDKIQFISEPVKIQIFNTISV 357

  Fly   435 G--MLFVASPILLMYQQYGALSMTISIVLLIVVGIFVNGPYALITTSVSAELGQHSSLEGNANAL 497
            |  .||.|| |.|:..:|...|:...|:.:..:|:...|.|.:            :.|.....|.
Worm   358 GGSGLFFAS-IGLIPMEYRGWSVFSCIMTMSCIGVNPGGFYKV------------AVLHSRQFAH 409

  Fly   498 ATVTAIIDGTGSIGAAVGPLLAGLIST-----AGWQYVFHMLIAADIIAMVLLG 546
            ..:|| |.....:...|.|.|..:..|     ..|.:|| :::...::...:||
Worm   410 VVLTA-IQWIKCLALFVAPALVSIFVTNESIRQQWIWVF-LIVGGGMVITNILG 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS16	NP_726048.1	UhpC	84..545	CDD:225180	92/508 (18%)
MFS16	NP_726048.1	MFS	139..549	CDD:119392	81/441 (18%)
T22F3.8	NP_504013.1	MFS	87..464	CDD:391944	85/458 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160344
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930