DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS16 and T11G6.2

DIOPT Version :9

Sequence 1:	NP_726048.1	Gene:	MFS16 / 37427	FlyBaseID:	FBgn0034611	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_001076702.1	Gene:	T11G6.2 / 177977	WormBaseID:	WBGene00011717	Length:	502	Species:	Caenorhabditis elegans

Alignment Length:	548	Identity:	178/548 - (32%)
Similarity:	261/548 - (47%)	Gaps:	102/548 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 HCPRRSMRASLGLGRTRKMSNNYNDVPFGIRAVQRLSRQCCTRFHARRDLLYKMSVFVLTFLAYA 97
            |.||..:|               |||.         |....||...::...:.:.:||.||::||
Worm     7 HMPRIRLR---------------NDVS---------SSSFWTRITGQKWSKHHVFIFVHTFMSYA 47

  Fly    98 CYHMCRKPISVVKSVL----QGNCSTALAASGQDCGYAPFDVPD---------ATTLFGMLDSAF 149
            ..|..||.:|.||..|    ..|.||                ||         |....|:||:.|
Worm    48 MLHATRKTLSTVKPSLIHTWISNTST----------------PDGPVFPSQQAAAEFLGVLDTGF 96

  Fly   150 LFSYAIAMFASGFVAERVSLRYFLSMGMILTGVFTYMFG-IARTSNIHSLWYFIIVQIFAGIFQT 213
            |.:|||.::..|.:.:..:.|..|:.||:|:.:..:.|| :..|.:.:|...:..:.|..|..|:
Worm    97 LVAYAIGLYICGILGDNYNPRRLLTAGMMLSSIIVFCFGYLTETFHFYSPMVYSFLWILNGFIQS 161

  Fly   214 TGWPGVVALVGRWFGKSKRGLIFGIWNSHTSIGNILGTLIAAHYVESDWALSFVVPGIIIAAVGF 278
            .|||..|:::|.|||.:.||.:.|.|:|..|:|||:|||||::.:...:..||::...::....|
Worm   162 VGWPVEVSIMGNWFGHNARGAVMGAWSSCASVGNIIGTLIASYTLFLGYQYSFLIACSLLFIYSF 226

  Fly   279 LLFLFLVDQPEIVGCYPQAGQHERRVANESDV--EQDDEEQVRHNDAEINYRSAPTERTPILPRS 341
            |:|..|...|..|               .||:  ||.:||:   .|.|      ||||.|
Worm   227 LVFFQLPSAPWEV---------------SSDILPEQMEEEE---TDDE------PTERPP----- 262

  Fly   342 QPEAVPRGRGRPISLIDALFIPGVVEFSLCLFFTKLVSYTFMYWLPLYIQKSSTLGPELSAD-LS 405
                       ||..:.|..:|||:.:||.....|||:|.|.:|||.|:. :....||..|| ||
Worm   263 -----------PIGFLKAWLLPGVIAYSLAYACLKLVNYGFFFWLPYYLH-AGLHWPESYADSLS 315

  Fly   406 TLFDVGGILGAIAAGYLSDVSGMSATVCTGMLFVASPILLMYQQYGALSMTISIVLLIVVGIFVN 470
            |.:|||||:.|:.||..||.......|...||.:|:..|.:| .:...|...:..||:|.|.|:.
Worm   316 TWYDVGGIVAAVLAGAFSDHMRSRTPVVFIMLLMATVSLYIY-AHSPESYNWNAFLLLVAGFFIG 379

  Fly   471 GPYALITTSVSAELGQHSSLEGNANALATVTAIIDGTGSIGAAVGP-LLAGLISTAGWQYVFHML 534
            ||..:|::|::|:||:...|.|||.||:|||.|||||||||||:|. .:..:....||..||:..
Worm   380 GPANMISSSITADLGKCDQLRGNAEALSTVTGIIDGTGSIGAAIGQWFIPSVQHWFGWDAVFYGF 444

  Fly   535 IAADIIAMVLLGRLVFKEFAALRRASHR 562
            |...:...:.|..:::||..  .|..||
Worm   445 IVMILCTALCLVPVLWKEHK--ERRIHR 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS16	NP_726048.1	UhpC	84..545	CDD:225180	162/478 (34%)
MFS16	NP_726048.1	MFS	139..549	CDD:119392	144/414 (35%)
T11G6.2	NP_001076702.1	MFS_SLC37A3	35..459	CDD:340900	163/481 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160346
Domainoid	1	1.000	175	1.000	Domainoid score	I2173
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	244	1.000	Inparanoid score	I2066
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57781
OrthoDB	1	1.010	-	-		D292288at33208
OrthoFinder	1	1.000	-	-		FOG0000756
OrthoInspector	1	1.000	-	-		otm14201
orthoMCL	1	0.900	-	-		OOG6_100970
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X449
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.810