DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ASPP and ppp1r13l

DIOPT Version :9

Sequence 1:	NP_788423.1	Gene:	ASPP / 37422	FlyBaseID:	FBgn0034606	Length:	1069	Species:	Drosophila melanogaster
Sequence 2:	XP_031746367.1	Gene:	ppp1r13l / 733947	XenbaseID:	XB-GENE-5848597	Length:	840	Species:	Xenopus tropicalis

Alignment Length:	938	Identity:	231/938 - (24%)
Similarity:	379/938 - (40%)	Gaps:	196/938 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 KLRRELMYRNQLSLQQDARLHMQ--------REALQQRQAELRSTDQRIYELQTRLQRKKQANTH 273
            ||.|   :.:.|||.:..:|..:        |:.:::...|.....|.::::..:....::.:..
Frog     9 KLSR---FGSVLSLSEGKKLRSRVWTKLIGWRDTIRKMAGEKVRPTQSLFDINFQSLASQELDLK 70

  Fly   274 HQQQQQQQQQHQQQQHQQQHQQTTVQQQQQQQQQLHVQSAQLLAAAAAATAQQQQQHQQHQQQQQ 338
            ..:......:..:.:...::::.||:...::..|:   |:|..::::.:.|..::.|
Frog    71 QMELDSAAAKLDELKRDLENRRETVKNSNKEGLQV---SSQQTSSSSLSPALTRRAH-------- 124

  Fly   339 QQQQQSASNLGKHGGVAALKQQLLQKQVNQLAAAAAAAAA---------------GRARGNV--A 386
                 |:|.|.....:.:||.:|.:..::..::.|.::::               ..||.::  .
Frog   125 -----SSSALNATPSLISLKPRLSESSLSTASSHAISSSSSVPSISISSTVITSPSMARRSIPTE 184

  Fly   387 AVEPFI----------------------HTPQKSTITSTASYLSGGMKHAAATANTNQQNQLIQD 429
            :|||::                      ||  .||..|::||........|:.:.......:..|
Frog   185 SVEPYLTLNSQIPLGRPSSPRHQYYDRPHT--VSTRLSSSSYDYALGPRTASPSLEGHSGAMYSD 247

  Fly   430 LTHVKLGQNSGFFAGSVPVPVASSSCESDESKLAKKLLAAPAKTEAELRKQAQTE---AMDSTT- 490
            ...:   |..|:.|     |...:|...|:       :.:|.:.:.:.|...:::   |.|..|
Frog   248 WGSL---QRRGYEA-----PHGYTSRFPDD-------VGSPRRRQQQQRSWNESDLDVAYDKKTP 297

  Fly   491 -----HIYAEVGP-KKRDREAAAAAAAAAAAAAAAAQAAAEAANQAATAAAASAISPPATANASK 549
                 |..|:..| .|..:|::...|:.:...::::.........|....:..|:.|...|....
Frog   298 QGRADHGIAQSLPIVKAWKESSLDPASISKGDSSSSTLPRGYKFSAGAEPSFQAVEPGWRAGTGS 362

  Fly   550 IPKSTTSSSSSASALISKLNQQATAKESQDQQQSQAKKNEISVTSETLSERNTQQQLTVHSMPLG 614
            :|:|..     |...||::  |...:|.:.|.......:.|.         ..|..|..|..|..
Frog   363 LPRSIL-----AQQPISRI--QVPPQEGKGQPHRPLPLSMIC---------RLQNALWEHQAPTL 411

  Fly   615 AISKSVALAVSNASKPLQVQVSNVAVPPRKPISSVAPNSVSSGSSIPKMITYSPKVNRVAPNVVM 679
            :...|.|..|..|          |::|   |:.|| |..|.....:|.:....|..|...|..:.
Frog   412 SYGMSPAPTVPTA----------VSMP---PVPSV-PLPVVPEWELPAVTPVPPPANEEVPRPLS 462

  Fly   680 -TDPRPALPPKPSKMSPTEQPSPVEANTSGSAGGAGSGAASASTANKTQTATFGLQSLNINDNLP 743
             |..:|.|||..:::....:..|......||                              ..|.
Frog   463 PTRLQPNLPPSMAEVQKVLEDIPRPLRRRGS------------------------------QELT 497

  Fly   744 IKAKPLTIRKQP-------LFEQPRLKSSQSSSNGQQKPPLLQLQNQRKS-----EPSARQPTEN 796
            .:|:||...::.       ||.:|..|  |||:..|.|.......:..||     ||...:...|
Frog   498 TQAQPLPSHRRQYRQIMGRLFGRPTPK--QSSAPEQTKAEDKLQGSAVKSIISPKEPPLEEDLNN 560

  Fly   797 LPDTSPQHSPSSESSADETDRMVAPSITTSQQETSTSATSTTTTVT-------------TSNIKE 848
            ..|..|:...:.|....:....|.       .|.|.|....:..|.             :.|:..
Frog   561 KIDPIPEEFRTDEKPMPDDKLCVI-------MEASESRVGASAPVPGDVEFKVPLVISGSQNLGL 618

  Fly   849 RT---GNGKPKLGR--RVSFDPLALLLDASLEGELELVKKTAMQVANPSAANDEGITALHNAICA 908
            |:   |.|.|:..|  ....|||.|||||:|.||:::|.:...:|.:||..|:|||||||||||.
Frog   619 RSALKGQGSPQRQRPPHARLDPLILLLDAALTGEMDVVNQALKEVNDPSQPNEEGITALHNAICG 683

  Fly   909 GHIDIVKFLVEFGCDVNAQDSDGWTPLHCAASCNNLSMVKFLVESGACLFASTLSDHETPAEKCE 973
            .:.:||..||..|.:|||:||.||||||||||||:|.:...||..||.:||:|.||.....|||:
Frog   684 ANYNIVNLLVSNGANVNAEDSHGWTPLHCAASCNDLQICLLLVRHGAAIFATTHSDGSLAVEKCD 748

  Fly   974 EDEEGFDGCSEYLYSIQEKLGILHNGDVYAVFSYEAQNGDELSFHVNEPLIVLRKGDDAENEWWW 1038
            ...||:..|..||.::.:.:|...:|.|||::.|.|:..||||....:.:.|||| |.....|||
Frog   749 PYREGYQECVNYLTNVGQCMGEAQSGVVYALWDYSAEFADELSLKEGDTVTVLRK-DGEGGSWWW 812

  Fly  1039 ARNAAGEEGYVPRNLLGLYPRV-PPHSP 1065
            | :..|.|||||||..|||||| |..||
Frog   813 A-SLCGREGYVPRNYFGLYPRVRPTRSP 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ASPP	NP_788423.1	ANK	867..968	CDD:238125	56/100 (56%)
		Ank_2	869..955	CDD:289560	48/85 (56%)
		ANK repeat	869..895	CDD:293786	11/25 (44%)
		ANK repeat	897..928	CDD:293786	19/30 (63%)
		ANK repeat	930..955	CDD:293786	15/24 (63%)
		SH3_ASPP	999..1056	CDD:212741	27/56 (48%)
ppp1r13l	XP_031746367.1	Ank_2	644..730	CDD:403870	48/85 (56%)
		ANK repeat	644..670	CDD:293786	11/25 (44%)
		ANK repeat	672..703	CDD:293786	19/30 (63%)
		ANK repeat	705..734	CDD:293786	17/28 (61%)
		SH3_iASPP	774..829	CDD:212885	27/56 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I10689
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1041229at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010