Protein Alignment ASPP and TP53BP2

DIOPT Version :10

• Sequence 1: NP_788423.1
• Gene: ASPP / 37422
• FlyBaseID: FBgn0034606
• Length: 1069
• Species: Drosophila melanogaster
• Sequence 2: NP_001026855.2
• Gene: TP53BP2 / 7159
• HGNCID: 12000
• Length: 1134
• Species: Homo sapiens
• Alignment Length: 1161
• Identity: 354/1161 - (30%)
• Similarity: 510/1161 - (43%)
• Gaps: 291/1161 - (25%)

  Fly    50 GVVVTSEPK-----LNVPSR-LTSAELRAMALRQQQQIDSQHQLLATKEQRLRFLKSQEVRSAVA 108
            ||.|..|.:     :|.|.. ||.|||:.||.||||||::|.||||||||||:|||.|:.|....
Human   111 GVKVPGEYRRKENGVNSPRMDLTLAELQEMASRQQQQIEAQQQLLATKEQRLKFLKQQDQRQQQQ 175

  Fly   109 SAEGERLRRLRERVEAQESKLRRLRALRGQVDLQKTYNVTLSNDLDSIRALFSEKEKELSLAVAK 173
            .||.|:|:||:|..|.||:||:::|||:|.|:.::..|..|..:::.:..||.:|::||.|||:|
Human   176 VAEQEKLKRLKEIAENQEAKLKKVRALKGHVEQKRLSNGKLVEEIEQMNNLFQQKQRELVLAVSK 240

  Fly   174 VEALTRQLEELRRDRRCPVNILTAAGNGVGGQSLPPQASRELEKLRRELMYRNQLSLQQDARLHM 238
            ||.||||||.|:..|             :........|..||::|.:||..||:|:.:|:|:|..
Human   241 VEELTRQLEMLKNGR-------------IDSHHDNQSAVAELDRLYKELQLRNKLNQEQNAKLQQ 292

  Fly   239 QREALQQRQAELRSTDQRIYELQTRLQRKKQANTHHQQQQQQQQQHQQQQHQQQ----------- 292
            |||.|.:|.:|:...|:|:.||:.||.:||.|    .||::...........||
Human   293 QRECLNKRNSEVAVMDKRVNELRDRLWKKKAA----LQQKENLPVSSDGNLPQQAASAPSRVAAV 353

  Fly   293 --HQQTTVQQQQQQQQQLHVQSA-----------------QLLAAAAAATAQQQQQHQQH----- 333
              :.|::...:...:.:|.|:.|                 |.|....:..|.|.:..:.|
Human   354 GPYIQSSTMPRMPSRPELLVKPALPDGSLVIQASEGPMKIQTLPNMRSGAASQTKGSKIHPVGPD 418

  Fly   334 ---------QQQQQQQQQQSASNL--GKHGGVAALKQQLLQKQVNQLAAAAAAAAAGR------- 380
                     ..|......||..|.  ....|...|:::  :|:|...:...|...:..
Human   419 WSPSNADLFPSQGSASVPQSTGNALDQVDDGEVPLREK--EKKVRPFSMFDAVDQSNAPPSFGTL 481

  Fly   381 ---------------ARGNVAAVEPFIHTPQK--------------------------STITSTA 404
                           |..|||.|.|.:.|..|                          ||:..
Human   482 RKNQSSEDILRDAQVANKNVAKVPPPVPTKPKQINLPYFGQTNQPPSDIKPDGSSQQLSTVVP-- 544

  Fly   405 SYLSGGMKHAAATANTNQQNQLIQDLTHVKLGQNSGFFAGSVPVPVASSSCESDESKLAKKLLAA 469
               |.|.|...|    .||.:::...:...:||:.....|        |..||..:...:.....
Human   545 ---SMGTKPKPA----GQQPRVLLSPSIPSVGQDQTLSPG--------SKQESPPAAAVRPFTPQ 594

  Fly   470 PAK-TEAELRKQAQTEAMDSTTHIYA-EVGPKKRDREAAAAA------------AAAAAAAAAAA 520
            |:| |.....::.||.|..|...:|. :..|.|..::|..:|            :.......|||
Human   595 PSKDTLLPPFRKPQTVAASSIYSMYTQQQAPGKNFQQAVQSALTKTHTRGPHFSSVYGKPVIAAA 659

  Fly   521 QAAAEAANQAATAAAASAISP-PATANASKIPKSTTSSSSSASALISKL---------NQQATAK 575
            |...:......:.:.....|| |.|...|.:.::..:.........:||         ||.....
Human   660 QNQQQHPENIYSNSQGKPGSPEPETEPVSSVQENHENERIPRPLSPTKLLPFLSNPYRNQSDADL 724

  Fly   576 ESQDQQQSQAK---KNEISVT----------SETLSERNT---QQQLTVHSMPLGAISKSVALAV 624
            |:..::.|.|.   |...|:|          .:.|.:|.|   .:.::|.|.|    |||.::..
Human   725 EALRKKLSNAPRPLKKRSSITEPEGPNGPNIQKLLYQRTTIAAMETISVPSYP----SKSASVTA 785

  Fly   625 SNASKPLQVQVSNVAVPPRKPISSVAPNSVSSGSSIPKMITYSPKVNRVAPNVVMTDPRPALPPK 689
            |:.| |:::|...:.|.|.|.:.|:.|.|:|     |:.:.     |....|..|..|.|.|..:
Human   786 SSES-PVEIQNPYLHVEPEKEVVSLVPESLS-----PEDVG-----NASTENSDMPAPSPGLDYE 839

  Fly   690 PSKMSPTEQPSPVEANTSGSAGGAGSGAASASTANKTQTATFGLQSLNINDNLPIKAKPLTIRKQ 754
            |.                                             .:.||.|
Human   840 PE---------------------------------------------GVPDNSP----------- 848

  Fly   755 PLFEQPRLKSSQSSSNGQQKPPLLQLQNQRKSEPSARQP------TENLPDTSPQHSPSS--ESS 811
                                    .||| ...||:...|      .|..|...|...||.  |..
Human   849 ------------------------NLQN-NPEEPNPEAPHVLDVYLEEYPPYPPPPYPSGEPEGP 888

  Fly   812 ADETDRMVAPSITTSQQETSTSATSTTTTVTTSNIKERTGNGKPKLGRRVSFDPLALLLDASLEG 876
            .:::..|..|.||   .:.|......|      |:: :||:.:...|.||.|:|||||||:||||
Human   889 GEDSVSMRPPEIT---GQVSLPPGKRT------NLR-KTGSERIAHGMRVKFNPLALLLDSSLEG 943

  Fly   877 ELELVKKTAMQVANPSAANDEGITALHNAICAGHIDIVKFLVEFGCDVNAQDSDGWTPLHCAASC 941
            |.:||::...:|.:||..|||||||||||:||||.:||||||:||.:|||.||||||||||||||
Human   944 EFDLVQRIIYEVDDPSLPNDEGITALHNAVCAGHTEIVKFLVQFGVNVNAADSDGWTPLHCAASC 1008

  Fly   942 NNLSMVKFLVESGACLFASTLSDHETPAEKCEEDEEGFDGCSEYLYSIQEKLGILHNGDVYAVFS 1006
            ||:.:.||||||||.:||.|.||.:|.|:||||.|||:..||::||.:|||:||::.|.:||::.
Human  1009 NNVQVCKFLVESGAAVFAMTYSDMQTAADKCEEMEEGYTQCSQFLYGVQEKMGIMNKGVIYALWD 1073

  Fly  1007 YEAQNGDELSFHVNEPLIVLRKGDDAENEWWWARNAAGEEGYVPRNLLGLYPRVPP 1062
            ||.||.|||.....:.:.::.:.|:.|.|||||| ...:||||||||||||||:.|
Human  1074 YEPQNDDELPMKEGDCMTIIHREDEDEIEWWWAR-LNDKEGYVPRNLLGLYPRIKP 1128

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ASPP	NP_788423.1	COG4913	<123..>270	CDD:443941	57/146 (39%)
		ANKYR	<868..>955	CDD:440430	62/86 (72%)
		ANK repeat	869..895	CDD:293786	13/25 (52%)
		ANK repeat	897..928	CDD:293786	24/30 (80%)
		ANK repeat	930..955	CDD:293786	20/24 (83%)
		SH3_ASPP	999..1056	CDD:212741	27/56 (48%)
TP53BP2	NP_001026855.2	RA_ASPP2	10..89	CDD:340745
		SMC_prok_B	<129..>330	CDD:274008	96/217 (44%)
		PHA03247	<331..863	CDD:223021	109/646 (17%)
		ANK repeat	936..962	CDD:293786	13/25 (52%)
		ANKYR	<957..>1037	CDD:440430	58/79 (73%)
		ANK repeat	964..995	CDD:293786	24/30 (80%)
		ANK repeat	997..1026	CDD:293786	22/28 (79%)
		SH3_ASPP2	1066..1122	CDD:212886	27/56 (48%)