Protein Alignment ASPP and tp53bp2

DIOPT Version :9

• Sequence 1: NP_788423.1
• Gene: ASPP / 37422
• FlyBaseID: FBgn0034606
• Length: 1069
• Species: Drosophila melanogaster
• Sequence 2: NP_001016036.2
• Gene: tp53bp2 / 548790
• XenbaseID: XB-GENE-962014
• Length: 1101
• Species: Xenopus tropicalis
• Alignment Length: 1145
• Identity: 346/1145 - (30%)
• Similarity: 504/1145 - (44%)
• Gaps: 287/1145 - (25%)

  Fly    50 GVVVTSEPKL----NVPSR-LTSAELRAMALRQQQQIDSQHQLLATKEQRLRFLKSQEVRSAVAS 109
            ||.:.||.::    |.|.. :|.|||:.||.||||||::|.::||||||||::||.||.|....:
 Frog   102 GVKMPSERRMENGVNGPRMDMTLAELQEMAARQQQQIETQQRMLATKEQRLKYLKQQEQRQQQQA 166

  Fly   110 AEGERLRRLRERVEAQESKLRRLRALRGQVDLQKTYNVTLSNDLDSIRALFSEKEKELSLAVAKV 174
            .|.|:|:|||:..|.||:||:::|||:|.|:.::..|..|..:::.:..||.:|:|||:.||:||
 Frog   167 NEQEKLKRLRDIAENQEAKLKKVRALKGHVERKRISNGRLVEEIEQMSNLFQQKQKELTAAVSKV 231

  Fly   175 EALTRQLEELRRDRRCPVNILTAAGNGVGGQSLPPQASRELEKLRRELMYRNQLSLQQDARLHMQ 239
            |.|:||||.|:..|             :.|......|..||::|.:||..||:|:.:|:|:|..|
 Frog   232 EELSRQLEMLKNGR-------------IEGYHDNQAAVSELDRLYKELQLRNKLNQEQNAKLQQQ 283

  Fly   240 REALQQRQAELRSTDQRIYELQTRLQRKKQANTHHQQQQQQQQQHQQQQHQQQH--------QQT 296
            |:.|.:|.||:.:.|:|:.||:.||.:||.|       .||::...|.......        |..
 Frog   284 RDNLNKRNAEVATMDKRVNELRERLWKKKVA-------LQQKENVPQVPSTPSRVAAVGPYIQSA 341

  Fly   297 TVQQQQQQQQQLHVQSAQLLAAAAAATAQQQQQHQQHQQQQQQQQQQSASNLGKHGGVAALKQQL 361
            |:.:....:.:|.|:.|   .....:|.|......:.|.....:......|....||. ::|.|.
 Frog   342 TMPRGPSSRPELVVKPA---FPEGTSTTQVPDVPLKSQTLPNMKSASQGKNSQGSGGY-SIKPQA 402

  Fly   362 ----LQKQVNQLAAAAAAAAAGRARGNVAAVEPFIHTPQKSTITSTASYLSGGMKHAAATAN--T 420
                .......:....|...||:|.           :.:|...|..:| :...::......|  |
 Frog   403 GGNNWSDANGDIQGTGALGTAGQAT-----------SAEKDKKTRPSS-MFDSVEPPPGPPNFGT 455

  Fly   421 NQQNQLIQDLTHVKLGQNSGFFAGSVPVPVASSSCESDESKLAKKLLAAPAKTEAELRKQAQTEA 485
            .::||..:||.......|.|..  .||.||.|...:...|:....  ..|..||
 Frog   456 LRKNQSSEDLLRDPQATNKGVI--KVPPPVPSKPKQISLSQYGPP--PPPPVTE----------- 505

  Fly   486 MDSTTHIYAEVGPKKRDREAAAAAAAAAAAAAAAAQAAAEAANQAATAAAASAISPPA------T 544
                        ||.........|:.......||.||.....:....|.|.....|||      |
 Frog   506 ------------PKSDGSSQKPPASLQGNKQRAAQQARVPVPSNPELAPAPKVDIPPAIAVRPFT 558

  Fly   545 ANASKIP------KSTTSSSSSASALISKLNQQATAKESQDQQQSQAKKNEISVTSETLSERNTQ 603
            ...:|.|      |..|.::||..::.:|             ||:..|...:.
 Frog   559 PQPAKEPPPPPLRKPQTVATSSIYSMYTK-------------QQTPGKNYTVQ------------ 598

  Fly   604 QQLTVHSMPLGAISKSVALAVSNASKPLQVQVSNVAVPPRKPISSVAPNSVSSGSSIPKMITYSP 668
                      ||:::|                     ..|:|.|||....|.:||...:.:..|.
 Frog   599 ----------GALARS---------------------QTRQPFSSVYGKPVLNGSQSQQTMNQSA 632

  Fly   669 KVNRVAPNVVMTDPRPALPPKPSKMSPTEQPSPVEANTSGSAGGAGSGAASASTANKTQTATFGL 733
            ....|...:....|.|            |..:||                   |..::|......
 Frog   633 DSTCVDGQIKSNSPEP------------EGDTPV-------------------TGQESQETERIP 666

  Fly   734 QSLNINDNLPIKAKP--------LTIRKQPLFEQPR---LKSSQSSSNGQQKPPLLQLQNQRK-- 785
            :.|:....||..:.|        |...::.|:..||   .:||.:...|...|.:.:|..||.
 Frog   667 RPLSPTKLLPFLSNPYRNQSDADLEALRKKLYNAPRPLKKRSSITEPEGPNGPNIQKLLYQRTTL 731

  Fly   786 -----------------SEPSARQPTENLPDTSPQHSPSSESSAD-------ET-DRMVAP---- 821
                             ||.|...|..::  |:.|...|.|.||.       || |.:|.|
 Frog   732 AAMETISAPKQSPVASISENSGEGPGVHV--TADQEVESLEESASSLQDLEPETRDPIVVPEEIE 794

  Fly   822 -----------------------------SITTSQQETS--------------TSATSTTTTVTT 843
                                         ::.|:|...:              |:....:.....
 Frog   795 LLSPVLGPDCVPEGIPGDILPLPPPPEELNVVTAQPPDTYIEEYPPYPPPPYPTTGEQDSLVEDP 859

  Fly   844 SNIK--ERTG--------------NGKPKL--GRRVSFDPLALLLDASLEGELELVKKTAMQVAN 890
            ||::  |.||              ||..::  |.||.|:|||||||||||||.:||::...:|.:
 Frog   860 SNLRPPEITGQFSLPPGKRTNLRKNGSERIAHGMRVKFNPLALLLDASLEGEFDLVQRIIYEVED 924

  Fly   891 PSAANDEGITALHNAICAGHIDIVKFLVEFGCDVNAQDSDGWTPLHCAASCNNLSMVKFLVESGA 955
            ||..|||||||||||:||||.:||||||:||.:|||.||||||||||||||||:.:.||||||||
 Frog   925 PSQPNDEGITALHNAVCAGHTEIVKFLVQFGVNVNAADSDGWTPLHCAASCNNVQVCKFLVESGA 989

  Fly   956 CLFASTLSDHETPAEKCEEDEEGFDGCSEYLYSIQEKLGILHNGDVYAVFSYEAQNGDELSFHVN 1020
            .:||:|.||.:|.|:||||.|||:..||::||.:|||:||::.|.:|:::.|||::.||:|....
 Frog   990 AVFATTYSDRQTAADKCEEMEEGYSQCSQFLYGVQEKMGIMNRGILYSLWDYEAESDDEMSLREG 1054

  Fly  1021 EPLIVLRKGDDAENEWWWARNAAGEEGYVPRNLLGLYPRV 1060
            :.:.:||:.|:.|.|||||| .:.:||||||||||||||:
 Frog  1055 DCMSILRREDEDETEWWWAR-LSDKEGYVPRNLLGLYPRI 1093

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ASPP	NP_788423.1	ANK	867..968	CDD:238125	71/100 (71%)
		Ank_2	869..955	CDD:289560	62/85 (73%)
		ANK repeat	869..895	CDD:293786	14/25 (56%)
		ANK repeat	897..928	CDD:293786	24/30 (80%)
		ANK repeat	930..955	CDD:293786	20/24 (83%)
		SH3_ASPP	999..1056	CDD:212741	27/56 (48%)
tp53bp2	NP_001016036.2	ANK	897..1020	CDD:238125	85/122 (70%)
		Ank_2	903..994	CDD:289560	65/90 (72%)
		ANK repeat	903..929	CDD:293786	14/25 (56%)
		ANK repeat	931..962	CDD:293786	24/30 (80%)
		ANK repeat	964..993	CDD:293786	22/28 (79%)
		SH3	1033..1089	CDD:302595	27/56 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	203	1.000	Domainoid score	I2901
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	455	1.000	Inparanoid score	I1541
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1041229at2759
OrthoFinder	1	1.000	-	-		FOG0002975
OrthoInspector	1	1.000	-	-		otm49499
Panther	1	1.100	-	-	O	PTHR24131
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3074
SonicParanoid	1	1.000	-	-		X1975
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.190