DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ASPP and Mbs

DIOPT Version :9

Sequence 1:	NP_788423.1	Gene:	ASPP / 37422	FlyBaseID:	FBgn0034606	Length:	1069	Species:	Drosophila melanogaster
Sequence 2:	NP_001246786.1	Gene:	Mbs / 49070	FlyBaseID:	FBgn0005536	Length:	1273	Species:	Drosophila melanogaster

Alignment Length:	194	Identity:	63/194 - (32%)
Similarity:	99/194 - (51%)	Gaps:	38/194 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   858 GRRVSFDPLALLLDASLEGELELVKKTAMQVANPSAANDEGITALHNAICAGHIDIVKFLVEFGC 922
            |||:.|....:.|.|.|.|:.:.|.:...|.|:.:.||.:|:||||.|....::|:|:||||.|.
  Fly    39 GRRIKFSSGCVFLAACLSGDKDEVVQLLDQGADINTANVDGLTALHQACIDDNLDMVEFLVERGA 103

  Fly   923 DVNAQDSDGWTPLHCAASCNNLSMVKFLVESGACLFASTLSDHETPAEKCEEDEEGFDGCSEYLY 987
            |:|.||::||||||..|||..:|:.::|||:||.: |:..||.:                    .
  Fly   104 DINRQDNEGWTPLHATASCGFVSIARYLVENGADV-AAVNSDGD--------------------L 147

  Fly   988 SIQEKLGILHNGDVYAVFSYEAQNGDELSFHVNEPLIVLRKGD------DAENEWWWARNAAGE 1045
            ::...:.:.|    .|:..|..:...||:.:|:|    .||.:      ||:.   |.|:.|.|
  Fly   148 ALDLAIDVQH----MAMIDYMEKMVQELNINVDE----ARKAEELAMLNDAKK---WLRSDAAE 200

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ASPP	NP_788423.1	ANK	867..968	CDD:238125	44/100 (44%)
		Ank_2	869..955	CDD:289560	39/85 (46%)
		ANK repeat	869..895	CDD:293786	7/25 (28%)
		ANK repeat	897..928	CDD:293786	15/30 (50%)
		ANK repeat	930..955	CDD:293786	13/24 (54%)
		SH3_ASPP	999..1056	CDD:212741	14/53 (26%)
Mbs	NP_001246786.1	ANK	50..164	CDD:238125	46/138 (33%)
		Ank_2	53..142	CDD:289560	41/89 (46%)
		ANK repeat	78..109	CDD:293786	15/30 (50%)
		ANK	106..290	CDD:238125	36/127 (28%)
		ANK repeat	111..142	CDD:293786	16/31 (52%)
		ANK repeat	209..239	CDD:293786
		Ank_2	213..300	CDD:289560
		ANK repeat	241..272	CDD:293786
		PRKG1_interact	1177..1272	CDD:292521
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910