DRSC/TRiP Functional Genomics Resources

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Protein Alignment ASPP and tp53bp2a

DIOPT Version :9

Sequence 1:NP_788423.1 Gene:ASPP / 37422 FlyBaseID:FBgn0034606 Length:1069 Species:Drosophila melanogaster
Sequence 2:NP_999979.1 Gene:tp53bp2a / 407983 ZFINID:ZDB-GENE-040516-8 Length:1060 Species:Danio rerio


Alignment Length:1141 Identity:343/1141 - (30%)
Similarity:502/1141 - (43%) Gaps:260/1141 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 PPASLMPAHRASASSASSSTSSTASLAFVSPTRGVVVTSEPKL----NVP-SRLTSAELRAMALR 76
            |.......|..:||..|.|.:...:        ||...::.:|    |.| ..:|.|||:.||.|
Zfish    75 PEVRFFLRHGRAASQPSDSRTQKRN--------GVKKPADRRLENGVNGPWMDMTLAELQEMASR 131

  Fly    77 QQQQIDSQHQLLATKEQRLRFLKSQEVRSAVASAEGERLRRLRERVEAQESKLRRLRALRGQVDL 141
            ||:|||||.|||:|||||||:|:.||.|.|.:|:|.::|.:|||.:|.||::|:.:|||:|||:.
Zfish   132 QQRQIDSQQQLLSTKEQRLRYLQQQEQRQAQSSSEQKKLLQLRETLEQQEAQLKMVRALKGQVEQ 196

  Fly   142 QKTYNVTLSNDLDSIRALFSEKEKELSLAVAKVEALTRQLEELRRDRRCPVNILTAAGNGVGGQS 206
            ::..|..|...::.:..|..:|:|||.:||||||.|::|||.|:..:   ::.:.:..:.|.   
Zfish   197 KRLSNGKLVEQVEQMNNLLHQKQKELVVAVAKVEELSKQLETLKSGQ---MDAMNSNHSSVA--- 255

  Fly   207 LPPQASRELEKLRRELMYRNQLSLQQDARLHMQREALQQRQAELRSTDQRIYELQTRLQRKKQAN 271
                   ||::|.|||..|..|:::|:|:|..|||.|.:|..|:.:.|:|:.||..||.:||.| 
Zfish   256 -------ELDRLYRELQMRKNLNVEQNAKLQQQRENLNKRNQEVANMDKRVSELPERLWKKKAA- 312

  Fly   272 THHQQQQQQ----------------------------------QQQHQQQQHQQQHQQTTVQQQQ 302
               .||::.                                  .:|....:|.......|...|.
Zfish   313 ---LQQKENLPLPPDGQAPPQTPGSRVAAVGPYIQSSTMPRGPDRQDLPIKHNYPEFTATAGHQD 374

  Fly   303 QQQQQ---LHV-QSAQLLAAAAAATAQQQQQHQQHQQQQQQQQQQSASNLGKHGGVAALKQQLLQ 363
            :..|.   ||. :::..||..:.|.|:....|......:...|...:.:     .....|:....
Zfish   375 RSAQPGAGLHSGKASSKLANWSLANAKSGNNHVTSSLPRMVSQASKSQD-----NTDVQKRDPRV 434

  Fly   364 KQVNQLAAAAAAAAAGR--------ARGNVAAVEPFIHTPQK-STITSTASYLSGGMKHAAATAN 419
            :.|:...:....|||.|        .|...:||:..:..|.. .:....|::.|||:        
Zfish   435 RPVSMFESTDLPAAALRKNQSSEDLVRDAQSAVKTIVKVPPPVPSKPKQANFPSGGL-------- 491

  Fly   420 TNQQNQLIQDLTHVKLGQNSGFFAG--SVPVPVASSSCESDESKLAKKLLAAPAKTEAELRKQAQ 482
                         :.||:|:|.:.|  :.|.|.|.    .....|..||.|.||           
Zfish   492 -------------MGLGKNTGTYPGKSASPQPPAG----PQTGTLPSKLEAPPA----------- 528

  Fly   483 TEAMDSTTHIYAEVGPKKRDREAAAAAAAAAAAAAAAAQAAAEAANQAATAAAASAISPPATANA 547
                 :|.|.::...|..:|                               .....:..|.|..|
Zfish   529 -----ATVHPFSPDPPGAKD-------------------------------TGGQMLLKPQTVTA 557

  Fly   548 SKIPKSTTSSSSSASALISKLNQQATAKESQDQQQSQAKKNEISVTSETLSERNTQQQLTVHSMP 612
            |.|....|...||..|               .||..|...:.        ::..|...::|:..|
Zfish   558 SSIYSMYTQQPSSGKA---------------TQQSIQGALSR--------AQTRTGHFISVYGKP 599

  Fly   613 LGAISKSVALAVSNASKPLQVQVSNVAVPPRKPISSVAPNSVS---SGSSIPKMITYSPKVNRVA 674
                       |::|.:|.|..      .|..|.  :.|.|||   :..|..:.|:.:|:..|: 
Zfish   600 -----------VTSAGQPSQTP------HPENPY--LDPPSVSETLTDHSPAEPISETPETERI- 644

  Fly   675 PNVVMTDPRPALPPK--PSKMSPTEQ----------------PSPVEANTS-GSAGGAGSGAASA 720
                   |||..|.|  |...:|...                |.|::..:| ....|.|......
Zfish   645 -------PRPLSPTKLLPFISNPYRHQSDLDLEALRKKLYNAPRPLKKRSSITEPEGPGGPNIQK 702

  Fly   721 STANKTQTATFGLQSLNINDNLPIKAKPL-------TIRKQPLFEQPRLKSSQSSSNGQQKPP-- 776
            ....||..|.....|....:.....|||.       .:.::.|.|.|.....::.......||  
Zfish   703 LLYQKTTLAAMETVSPPGEEEKETLAKPQGYDAETPEVPEETLPEFPIAPEVEAEDVPPPPPPHP 767

  Fly   777 -------LLQLQNQRKSEPSARQPTENLPDTSPQHSPSSESSA-----DETDRMVAPSITTSQQE 829
                   ::....|.:|.|....|...:.|..|...|...|||     |:|..|..|.:|.....
Zfish   768 APKIDASIIIPPPQPESPPPPPPPDSFMEDFPPYPPPPYPSSAEQDNPDDTFNMKPPEVTGQVPF 832

  Fly   830 TSTSATSTTTTVTTSNIKERTGNGKPKLGRRVSFDPLALLLDASLEGELELVKKTAMQVANPSAA 894
            .....|         |:: ::|:.:.....||.|:|||||||:|||||.:||::...:|.:||..
Zfish   833 PPGKRT---------NLR-KSGSERIDHSMRVRFNPLALLLDSSLEGEFDLVQRVIYEVEDPSQP 887

  Fly   895 NDEGITALHNAICAGHIDIVKFLVEFGCDVNAQDSDGWTPLHCAASCNNLSMVKFLVESGACLFA 959
            |||||||||||:||||.:||||||::|.:|||.||||||||||||||||:.:.||||||||.:||
Zfish   888 NDEGITALHNAVCAGHTEIVKFLVQYGVNVNAADSDGWTPLHCAASCNNVQVCKFLVESGAAVFA 952

  Fly   960 STLSDHETPAEKCEEDEEGFDGCSEYLYSIQEKLGILHNGDVYAVFSYEAQNGDELSFHVNEPLI 1024
            .|.||.:|.|:||||.|||:..||::||.:|||:||::.|.||.::.|||...||.||...:.:.
Zfish   953 MTYSDMQTAADKCEEMEEGYTQCSQFLYGVQEKMGIMNRGVVYGLWDYEAAQEDECSFREGDCMS 1017

  Fly  1025 VLRKGDDAENEWWWARNAAGEEGYVPRNLLGLYPRV 1060
            |:|:.|:.|.:|||. ...|.||||||||||||||:
Zfish  1018 VIRREDELETDWWWV-CCGGAEGYVPRNLLGLYPRI 1052

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ASPPNP_788423.1 ANK 867..968 CDD:238125 69/100 (69%)
Ank_2 869..955 CDD:289560 60/85 (71%)
ANK repeat 869..895 CDD:293786 13/25 (52%)
ANK repeat 897..928 CDD:293786 23/30 (77%)
ANK repeat 930..955 CDD:293786 20/24 (83%)
SH3_ASPP 999..1056 CDD:212741 27/56 (48%)
tp53bp2aNP_999979.1 UBQ <22..83 CDD:294102 1/7 (14%)
RILP-like <170..301 CDD:304877 52/143 (36%)
Ank_2 862..948 CDD:289560 60/85 (71%)
ANK repeat 862..888 CDD:293786 13/25 (52%)
ANK 868..979 CDD:238125 73/110 (66%)
ANK repeat 890..921 CDD:293786 23/30 (77%)
ANK repeat 923..952 CDD:293786 22/28 (79%)
SH3 992..1048 CDD:302595 27/56 (48%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170581520
Domainoid 1 1.000 211 1.000 Domainoid score I2738
eggNOG 1 0.900 - - E1_KOG0515
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 472 1.000 Inparanoid score I1468
OMA 1 1.010 - - QHG47177
OrthoDB 1 1.010 - - D1041229at2759
OrthoFinder 1 1.000 - - FOG0002975
OrthoInspector 1 1.000 - - otm24304
orthoMCL 1 0.900 - - OOG6_104019
Panther 1 1.100 - - O PTHR24131
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3074
SonicParanoid 1 1.000 - - X1975
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
1413.890

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