DRSC/TRiP Functional Genomics Resources

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Protein Alignment ASPP and Tp53bp2

DIOPT Version :9

Sequence 1:NP_788423.1 Gene:ASPP / 37422 FlyBaseID:FBgn0034606 Length:1069 Species:Drosophila melanogaster
Sequence 2:XP_223012.6 Gene:Tp53bp2 / 305025 RGDID:1305461 Length:1128 Species:Rattus norvegicus


Alignment Length:1148 Identity:363/1148 - (31%)
Similarity:525/1148 - (45%) Gaps:271/1148 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    50 GVVVTSE----------PKLNVPSRLTSAELRAMALRQQQQIDSQHQLLATKEQRLRFLKSQEVR 104
            ||.|..|          |:|:    ||.|||:.||.||||||::|.|:||||||||:|||.|:.|
  Rat   111 GVKVPGEHRRKENGVNSPRLD----LTLAELQEMASRQQQQIEAQQQMLATKEQRLKFLKQQDQR 171

  Fly   105 SAVASAEGERLRRLRERVEAQESKLRRLRALRGQVDLQKTYNVTLSNDLDSIRALFSEKEKELSL 169
            ....:||.|:|:||||..|:||:||:::|||:|.|:.::..|..|..:::.:.:||.:|::||.|
  Rat   172 QQQQAAEQEKLKRLREIAESQEAKLKKVRALKGHVEQKRLSNGKLVEEIEQMNSLFQQKQRELVL 236

  Fly   170 AVAKVEALTRQLEELRRDRRCPVNILTAAGNGVGGQSLPPQASRELEKLRRELMYRNQLSLQQDA 234
            ||:|||.||||||.|:..|             :.|......|..||::|.:||..||:|:.:|:|
  Rat   237 AVSKVEELTRQLEMLKNGR-------------IDGHHDNQSAVAELDRLYKELQLRNKLNQEQNA 288

  Fly   235 RLHMQREALQQRQAELRSTDQRIYELQTRLQRKKQANTHHQQQQQQQQQHQQQQHQQQ------- 292
            :|..|||.|.:|.:|:...|:|:.||:.||.:||.|    .||::...........||       
  Rat   289 KLQQQRECLNKRNSEVAVMDKRVNELRDRLWKKKAA----LQQKENLPVSPDGNPPQQAVSAPSR 349

  Fly   293 -------HQQTTVQQQQQQQQ----------QLHVQSA------QLLAAAAAATAQQQQQHQQHQ 334
                   .|.:|:.:...:.:          .|.:|||      |.|....:..|.|.:..:.| 
  Rat   350 VAAVGPYMQSSTMPRMPSRPELLGKPALPDSSLVMQSAEGPMKIQTLPNMRSGAASQSKGPKAH- 413

  Fly   335 QQQQQQQQQSASNLGKHGGVAALKQQLLQKQVNQLAAAAAAAAAGRARGNVA------AVEPFIH 393
            .........|...|...|..:||      .||::              |.:|      .|.||  
  Rat   414 SASSDWNPSSTDLLPSQGSGSAL------DQVDE--------------GEIALREKEKKVRPF-- 456

  Fly   394 TPQKSTITSTASYLSGGMKHAAATANTNQQNQLIQDLTHVKLGQNSGFFAGSVPVPVASSSCESD 458
             ....|:...|...|.|         |.::||..:|:  ::..|........||.||        
  Rat   457 -SMFDTVDQCAPPPSFG---------TLRKNQSSEDI--LRDAQTVNKNVAKVPPPV-------- 501

  Fly   459 ESKLAKKLLAAPAKTEAELRKQAQTEAMDSTTHIYAEVGPKKRDREAAAAAAAAAA--------A 515
                       |.|.     ||........|....::|.|....::...||.:..|        |
  Rat   502 -----------PTKP-----KQINLPYFGQTAQSSSDVKPDGNPQQLPIAATSMGAKLKPAGPQA 550

  Fly   516 AAAAAQAAAEAANQAATAAAASAISPPATANASKIPKSTTSS---------SSSASALISKLNQ- 570
            ....:.:|.........:.|:...||||.|.....|:.:..:         :.:||::.|...| 
  Rat   551 RVLLSPSAPSGGQDQVLSPASKQESPPAAAVRPFTPQPSKDTFPPAFRKPQTVAASSIYSMYTQH 615

  Fly   571 QATAKESQDQQQSQAKKNE------ISVTSETL--SERNTQQQ---------------------- 605
            |...|..|...||.:.|..      .||..:.:  :.:|.||.                      
  Rat   616 QVPGKNFQQAVQSASTKTHPRGPHFSSVYGKPVIAAAQNPQQHPENIYSCSQGKPGSPEPETEPV 680

  Fly   606 LTVHS--------MPLG-----------------AISKSVALAVSNASKPLQVQVSNVAVP--PR 643
            .:||.        .||.                 |..:::...:|||.:||:.: |::..|  |.
  Rat   681 SSVHESHENERIPRPLSPTKLLPFLSNPYRNQSDADLEALRKKLSNAPRPLKKR-SSITEPEGPN 744

  Fly   644 KP---------ISSVAPNSVSSGSSIPKMITYSPKVNRVAPNVVMTDPRPALPPKPSKMSPTEQP 699
            .|         .:..|..::    |:|...:.||....|.|...:..|.|.|..:|.|.:.:..|
  Rat   745 GPNIQKLLYQRTTIAAMETI----SVPSYPSKSPSSVTVNPESPIEIPNPYLHVEPEKEAGSLVP 805

  Fly   700 SPVEANTSGSAGGAGSGAASASTANKTQTA-TFGLQSLNINDNLPIKAKPLTIRKQPLFEQPRLK 763
            .|:.....|          ||||.|....| ..||:.  :::.:|..:..|              
  Rat   806 EPLSPEDMG----------SASTENSDMPAPPPGLEC--VSEGVPDNSTTL-------------- 844

  Fly   764 SSQSSSNG--QQKPPLLQLQNQRKSEPSARQPTENLPDTSPQHSPSSESSADETD--RMVAPSIT 824
              |.::.|  .:.|.||::.            .|..|...|...||.|....|.|  ||..|.:|
  Rat   845 --QDNTEGTNPEAPHLLEVY------------LEEYPPYPPPPYPSGEPEVSEEDSARMRPPEVT 895

  Fly   825 TSQQETSTSATSTTTTVTTSNIKERTGNGKPKLGRRVSFDPLALLLDASLEGELELVKKTAMQVA 889
               .:.|......|      |:: :||:.:...|.||.|:|||||||:|||||.:||::...:|.
  Rat   896 ---GQVSLPPGKRT------NLR-KTGSERIAHGMRVKFNPLALLLDSSLEGEFDLVQRIIYEVD 950

  Fly   890 NPSAANDEGITALHNAICAGHIDIVKFLVEFGCDVNAQDSDGWTPLHCAASCNNLSMVKFLVESG 954
            :||..|||||||||||:||||.:||||||:||.:|||.||||||||||||||||:.:.|||||||
  Rat   951 DPSLPNDEGITALHNAVCAGHTEIVKFLVQFGVNVNAADSDGWTPLHCAASCNNVQVCKFLVESG 1015

  Fly   955 ACLFASTLSDHETPAEKCEEDEEGFDGCSEYLYSIQEKLGILHNGDVYAVFSYEAQNGDELSFHV 1019
            |.:||.|.||.:|.|:||||.|||:..||::||.:|||:||::.|.:||::.|:.|:.|||....
  Rat  1016 AAVFAMTYSDMQTAADKCEEMEEGYTQCSQFLYGVQEKMGIMNKGVIYALWDYQPQHDDELLLKE 1080

  Fly  1020 NEPLIVLRKGDDAENEWWWARNAAGEEGYVPRNLLGLYPRVPP 1062
            .:.:.|:|:.|:.|.|||||| ...:||||||||||||||:.|
  Rat  1081 GDCMAVVRREDEDETEWWWAR-LNDKEGYVPRNLLGLYPRIKP 1122

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ASPPNP_788423.1 ANK 867..968 CDD:238125 70/100 (70%)
Ank_2 869..955 CDD:289560 61/85 (72%)
ANK repeat 869..895 CDD:293786 13/25 (52%)
ANK repeat 897..928 CDD:293786 24/30 (80%)
ANK repeat 930..955 CDD:293786 20/24 (83%)
SH3_ASPP 999..1056 CDD:212741 27/56 (48%)
Tp53bp2XP_223012.6 UBQ 17..90 CDD:294102
Ank_2 930..1016 CDD:289560 61/85 (72%)
ANK repeat 930..956 CDD:293786 13/25 (52%)
ANK 936..1047 CDD:238125 74/110 (67%)
ANK repeat 958..989 CDD:293786 24/30 (80%)
ANK repeat 991..1020 CDD:293786 22/28 (79%)
SH3 1060..1116 CDD:302595 27/56 (48%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166341519
Domainoid 1 1.000 176 1.000 Domainoid score I3522
eggNOG 1 0.900 - - E1_KOG0515
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 436 1.000 Inparanoid score I1636
OMA 1 1.010 - - QHG47177
OrthoDB 1 1.010 - - D1041229at2759
OrthoFinder 1 1.000 - - FOG0002975
OrthoInspector 1 1.000 - - otm46420
orthoMCL 1 0.900 - - OOG6_104019
Panther 1 1.100 - - O PTHR24131
Phylome 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1975
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1413.860

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