DRSC/TRiP Functional Genomics Resources

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Protein Alignment ASPP and PPP1R13B

DIOPT Version :9

Sequence 1:NP_788423.1 Gene:ASPP / 37422 FlyBaseID:FBgn0034606 Length:1069 Species:Drosophila melanogaster
Sequence 2:XP_011534895.1 Gene:PPP1R13B / 23368 HGNCID:14950 Length:1193 Species:Homo sapiens


Alignment Length:1198 Identity:358/1198 - (29%)
Similarity:517/1198 - (43%) Gaps:344/1198 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    46 SPT----RGVVVTSEPK-----LNVPS-------------RLTSAELRAMALRQQQQIDSQHQLL 88
            |||    :|...|.|.:     :|||.             .||.:||:.||.||||||::|.|:|
Human   153 SPTENSEQGGRQTQEQRTQRNVINVPGEKRTENGVGNPRVELTLSELQDMAARQQQQIENQQQML 217

  Fly    89 ATKEQRLRFLKSQEVRSAVASAEGERLRRLRERVEAQESKLRRLRALRGQVDLQKTYNVTLSNDL 153
            ..|||||.|||.||.|...:.:|.|:|::|:|||||||:||:::||:|||||..|..|..||.::
Human   218 VAKEQRLHFLKQQERRQQQSISENEKLQKLKERVEAQENKLKKIRAMRGQVDYSKIMNGNLSAEI 282

  Fly   154 DSIRALFSEKEKELSLAVAKVEALTRQLEELRRDRRCPVNILTAAGNGVGGQS----LPPQASRE 214
            :...|:|.||::|:..|:.:|:.|::|||:|::            |...|.||    |...|:.|
Human   283 ERFSAMFQEKKQEVQTAILRVDQLSQQLEDLKK------------GKLNGFQSYNGKLTGPAAVE 335

  Fly   215 LEKLRRELMYRNQLSLQQDARLHMQREALQQRQAELRSTDQRIYELQTRLQRKKQANTHHQQQQQ 279
            |::|.:||..||||:.:|:::|..|:|.|.:|..|:...|:||.||:.||..||           
Human   336 LKRLYQELQIRNQLNQEQNSKLQQQKELLNKRNMEVAMMDKRISELRERLYGKK----------- 389

  Fly   280 QQQQHQQQQHQQQHQQTTVQQQQQQQQQLHVQSAQLLAAAAAATAQQQQQHQQHQQQQQQQQQQS 344
                                             .||......::.|                   
Human   390 ---------------------------------IQLNRVNGTSSPQ------------------- 402

  Fly   345 ASNLGKHGGVAALKQQLLQKQVN-----------QLAAAAAAAAAGRARGNVAAVEPFIHTPQKS 398
             |.|...|.|||:...:......           |..:.|:.||.||::.:.       |:..:.
Human   403 -SPLSTSGRVAAVGPYIQVPSAGSFPVLGDPIKPQSLSIASNAAHGRSKSDG-------HSKPRV 459

  Fly   399 TITSTASYLSGGMKH------AAATANTNQQNQLIQDLTHVKLGQNSGFFAGSV-PVPVASSSCE 456
            |.:.|.|.|..|..:      |:...|.|..|       ...|.|||   :.|| ||.||.:..:
Human   460 TSSWTVSDLDVGPNYGSSRPSASPFVNPNDGN-------WPTLKQNS---SSSVKPVQVAGADWK 514

  Fly   457 SDESKLAKKLLAAPAKTEAELRKQAQTEAMDSTTHIYAEVGPKKRDREAAAAAAAAAAAAAAAAQ 521
                             :..:....:...:.|....::.:||.::                    
Human   515 -----------------DPSVEGSVKQGTVSSQPVPFSALGPTEK-------------------- 542

  Fly   522 AAAEAANQAATAAAASAISPPATANASKIPKS-------TTSSSSSASALISKLNQQATAKESQD 579
                      .......:.||......::|.|       |.....|.|:|  :..::.:......
Human   543 ----------PGIEIGKVPPPIPGVGKQLPPSYGTYPSPTPLGPGSTSSL--ERRKEGSLPRPSA 595

  Fly   580 QQQSQAKKNEISVTSETL---SERNTQQQLTV-----------HSMPLGAISKSVALAVSNASKP 630
            ...|:.:...:..|..|.   |.:..||:::|           .:.|.|.....:.|.|  |.:|
Human   596 GLPSRQRPTLLPATGSTPQPGSSQQIQQRISVPPSPTYPPAGPPAFPAGDSKPELPLTV--AIRP 658

  Fly   631 LQVQVSNVAVPPRKPISSVAPNSVSSGS---------SIPKMITYSPKV-NRVAPNVVMTDPRPA 685
            ......:....|||     .|.:|:|.|         :.||  .|.|.. :.:..:|.....:|.
Human   659 FLADKGSRPQSPRK-----GPQTVNSSSIYSMYLQQATPPK--NYQPAAHSALNKSVKAVYGKPV 716

  Fly   686 LPPKPSKMSP-----------TEQPSPVEANTSGSAGGAGSGA-ASASTANKTQTATFGLQSLNI 738
            ||...:..||           |.||.|...:|.......|..| |..||.....      :.|:.
Human   717 LPSGSTSPSPLPFLHGSLSTGTPQPQPPSESTEKEPEQDGPAAPADGSTVESLP------RPLSP 775

  Fly   739 NDNLPIKAKPLTIR--------KQPLFEQPR---LKSSQSSSNGQQKPPLLQLQNQRKS------ 786
            ....||...||..:        ::.|...||   .:||.:...|...|.:.:|..||.:      
Human   776 TKLTPIVHSPLRYQSDADLEALRRKLANAPRPLKKRSSITEPEGPGGPNIQKLLYQRFNTLAGGM 840

  Fly   787 ------EPSARQP------------------TENLPDTSP------QHSPSSESS-----ADETD 816
                  :||..|.                  .|.||...|      :.:|||:::     :.|.:
Human   841 EGTPFYQPSPSQDFMGTLADVDNGNTNANGNLEELPPAQPTAPLPAEPAPSSDANDNELPSPEPE 905

  Fly   817 RMVAPSITTSQQETSTSATSTTTTVTT-------------------------------------- 843
            .::.|..|....|.:....:...||.|                                      
Human   906 ELICPQTTHQTAEPAEDNNNNVATVPTTEQIPSPVAEAPSPGEEQVPPAPLPPASHPPATSTNKR 970

  Fly   844 SNIK----ERTGNGKPKLGRRVSFDPLALLLDASLEGELELVKKTAMQVANPSAANDEGITALHN 904
            :|:|    ||||:     |.||.|:|||||||||||||.:||::...:|.:||..||||||.|||
Human   971 TNLKKPNSERTGH-----GLRVRFNPLALLLDASLEGEFDLVQRIIYEVEDPSKPNDEGITPLHN 1030

  Fly   905 AICAGHIDIVKFLVEFGCDVNAQDSDGWTPLHCAASCNNLSMVKFLVESGACLFASTLSDHETPA 969
            |:||||..|||||::||.:|||.|||||||||||||||::.:.|.||||||.:||||:||.||.|
Human  1031 AVCAGHHHIVKFLLDFGVNVNAADSDGWTPLHCAASCNSVHLCKQLVESGAAIFASTISDIETAA 1095

  Fly   970 EKCEEDEEGFDGCSEYLYSIQEKLGILHNGDVYAVFSYEAQNGDELSFHVNEPLIVLRKGDDAEN 1034
            :||||.|||:..||::||.:|||||:::.|..||::.|||||.||||||..:.|.:||:.|::|.
Human  1096 DKCEEMEEGYIQCSQFLYGVQEKLGVMNKGVAYALWDYEAQNSDELSFHEGDALTILRRKDESET 1160

  Fly  1035 EWWWARNAAGEEGYVPRNLLGLYPRVPP 1062
            |||||| ....|||||:||||||||:.|
Human  1161 EWWWAR-LGDREGYVPKNLLGLYPRIKP 1187

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ASPPNP_788423.1 ANK 867..968 CDD:238125 69/100 (69%)
Ank_2 869..955 CDD:289560 58/85 (68%)
ANK repeat 869..895 CDD:293786 14/25 (56%)
ANK repeat 897..928 CDD:293786 22/30 (73%)
ANK repeat 930..955 CDD:293786 18/24 (75%)
SH3_ASPP 999..1056 CDD:212741 33/56 (59%)
PPP1R13BXP_011534895.1 DUF4200 <221..315 CDD:290574 46/93 (49%)
YscO 222..385 CDD:284686 72/174 (41%)
Prefoldin 276..386 CDD:298833 42/121 (35%)
Ten_N <857..>971 CDD:284015 14/113 (12%)
ANK 989..1112 CDD:238125 83/122 (68%)
Ank_2 995..1081 CDD:289560 58/85 (68%)
ANK repeat 995..1021 CDD:293786 14/25 (56%)
ANK repeat 1023..1054 CDD:293786 22/30 (73%)
ANK repeat 1056..1085 CDD:293786 20/28 (71%)
SH3_ASPP1 1125..1181 CDD:212887 33/56 (59%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165147690
Domainoid 1 1.000 198 1.000 Domainoid score I3071
eggNOG 1 0.900 - - E1_KOG0515
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 416 1.000 Inparanoid score I1826
Isobase 1 0.950 - 0 Normalized mean entropy S4925
OMA 1 1.010 - - QHG47177
OrthoDB 1 1.010 - - D1041229at2759
OrthoFinder 1 1.000 - - FOG0002975
OrthoInspector 1 1.000 - - otm42268
orthoMCL 1 0.900 - - OOG6_104019
Panther 1 1.100 - - LDO PTHR24131
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3074
SonicParanoid 1 1.000 - - X1975
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.840

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