back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ASPP and PPP1R13B

DIOPT Version :10

Sequence 1:	NP_788423.1	Gene:	ASPP / 37422	FlyBaseID:	FBgn0034606	Length:	1069	Species:	Drosophila melanogaster
Sequence 2:	XP_011534895.1	Gene:	PPP1R13B / 23368	HGNCID:	14950	Length:	1193	Species:	Homo sapiens

Alignment Length:	1198	Identity:	358/1198 - (29%)
Similarity:	517/1198 - (43%)	Gaps:	344/1198 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 SPT----RGVVVTSEPK-----LNVPS-------------RLTSAELRAMALRQQQQIDSQHQLL 88
            |||    :|...|.|.:     :|||.             .||.:||:.||.||||||::|.|:|
Human   153 SPTENSEQGGRQTQEQRTQRNVINVPGEKRTENGVGNPRVELTLSELQDMAARQQQQIENQQQML 217

  Fly    89 ATKEQRLRFLKSQEVRSAVASAEGERLRRLRERVEAQESKLRRLRALRGQVDLQKTYNVTLSNDL 153
            ..|||||.|||.||.|...:.:|.|:|::|:|||||||:||:::||:|||||..|..|..||.::
Human   218 VAKEQRLHFLKQQERRQQQSISENEKLQKLKERVEAQENKLKKIRAMRGQVDYSKIMNGNLSAEI 282

  Fly   154 DSIRALFSEKEKELSLAVAKVEALTRQLEELRRDRRCPVNILTAAGNGVGGQS----LPPQASRE 214
            :...|:|.||::|:..|:.:|:.|::|||:|::            |...|.||    |...|:.|
Human   283 ERFSAMFQEKKQEVQTAILRVDQLSQQLEDLKK------------GKLNGFQSYNGKLTGPAAVE 335

  Fly   215 LEKLRRELMYRNQLSLQQDARLHMQREALQQRQAELRSTDQRIYELQTRLQRKKQANTHHQQQQQ 279
            |::|.:||..||||:.:|:::|..|:|.|.:|..|:...|:||.||:.||..||
Human   336 LKRLYQELQIRNQLNQEQNSKLQQQKELLNKRNMEVAMMDKRISELRERLYGKK----------- 389

  Fly   280 QQQQHQQQQHQQQHQQTTVQQQQQQQQQLHVQSAQLLAAAAAATAQQQQQHQQHQQQQQQQQQQS 344
                                             .||......::.|
Human   390 ---------------------------------IQLNRVNGTSSPQ------------------- 402

  Fly   345 ASNLGKHGGVAALKQQLLQKQVN-----------QLAAAAAAAAAGRARGNVAAVEPFIHTPQKS 398
             |.|...|.|||:...:......           |..:.|:.||.||::.:.       |:..:.
Human   403 -SPLSTSGRVAAVGPYIQVPSAGSFPVLGDPIKPQSLSIASNAAHGRSKSDG-------HSKPRV 459

  Fly   399 TITSTASYLSGGMKH------AAATANTNQQNQLIQDLTHVKLGQNSGFFAGSV-PVPVASSSCE 456
            |.:.|.|.|..|..:      |:...|.|..|       ...|.|||   :.|| ||.||.:..:
Human   460 TSSWTVSDLDVGPNYGSSRPSASPFVNPNDGN-------WPTLKQNS---SSSVKPVQVAGADWK 514

  Fly   457 SDESKLAKKLLAAPAKTEAELRKQAQTEAMDSTTHIYAEVGPKKRDREAAAAAAAAAAAAAAAAQ 521
                             :..:....:...:.|....::.:||.::
Human   515 -----------------DPSVEGSVKQGTVSSQPVPFSALGPTEK-------------------- 542

  Fly   522 AAAEAANQAATAAAASAISPPATANASKIPKS-------TTSSSSSASALISKLNQQATAKESQD 579
                      .......:.||......::|.|       |.....|.|:|  :..::.:......
Human   543 ----------PGIEIGKVPPPIPGVGKQLPPSYGTYPSPTPLGPGSTSSL--ERRKEGSLPRPSA 595

  Fly   580 QQQSQAKKNEISVTSETL---SERNTQQQLTV-----------HSMPLGAISKSVALAVSNASKP 630
            ...|:.:...:..|..|.   |.:..||:::|           .:.|.|.....:.|.|  |.:|
Human   596 GLPSRQRPTLLPATGSTPQPGSSQQIQQRISVPPSPTYPPAGPPAFPAGDSKPELPLTV--AIRP 658

  Fly   631 LQVQVSNVAVPPRKPISSVAPNSVSSGS---------SIPKMITYSPKV-NRVAPNVVMTDPRPA 685
            ......:....|||     .|.:|:|.|         :.||  .|.|.. :.:..:|.....:|.
Human   659 FLADKGSRPQSPRK-----GPQTVNSSSIYSMYLQQATPPK--NYQPAAHSALNKSVKAVYGKPV 716

  Fly   686 LPPKPSKMSP-----------TEQPSPVEANTSGSAGGAGSGA-ASASTANKTQTATFGLQSLNI 738
            ||...:..||           |.||.|...:|.......|..| |..||.....      :.|:.
Human   717 LPSGSTSPSPLPFLHGSLSTGTPQPQPPSESTEKEPEQDGPAAPADGSTVESLP------RPLSP 775

  Fly   739 NDNLPIKAKPLTIR--------KQPLFEQPR---LKSSQSSSNGQQKPPLLQLQNQRKS------ 786
            ....||...||..:        ::.|...||   .:||.:...|...|.:.:|..||.:
Human   776 TKLTPIVHSPLRYQSDADLEALRRKLANAPRPLKKRSSITEPEGPGGPNIQKLLYQRFNTLAGGM 840

  Fly   787 ------EPSARQP------------------TENLPDTSP------QHSPSSESS-----ADETD 816
                  :||..|.                  .|.||...|      :.:|||:::     :.|.:
Human   841 EGTPFYQPSPSQDFMGTLADVDNGNTNANGNLEELPPAQPTAPLPAEPAPSSDANDNELPSPEPE 905

  Fly   817 RMVAPSITTSQQETSTSATSTTTTVTT-------------------------------------- 843
            .::.|..|....|.:....:...||.|
Human   906 ELICPQTTHQTAEPAEDNNNNVATVPTTEQIPSPVAEAPSPGEEQVPPAPLPPASHPPATSTNKR 970

  Fly   844 SNIK----ERTGNGKPKLGRRVSFDPLALLLDASLEGELELVKKTAMQVANPSAANDEGITALHN 904
            :|:|    ||||:     |.||.|:|||||||||||||.:||::...:|.:||..||||||.|||
Human   971 TNLKKPNSERTGH-----GLRVRFNPLALLLDASLEGEFDLVQRIIYEVEDPSKPNDEGITPLHN 1030

  Fly   905 AICAGHIDIVKFLVEFGCDVNAQDSDGWTPLHCAASCNNLSMVKFLVESGACLFASTLSDHETPA 969
            |:||||..|||||::||.:|||.|||||||||||||||::.:.|.||||||.:||||:||.||.|
Human  1031 AVCAGHHHIVKFLLDFGVNVNAADSDGWTPLHCAASCNSVHLCKQLVESGAAIFASTISDIETAA 1095

  Fly   970 EKCEEDEEGFDGCSEYLYSIQEKLGILHNGDVYAVFSYEAQNGDELSFHVNEPLIVLRKGDDAEN 1034
            :||||.|||:..||::||.:|||||:::.|..||::.|||||.||||||..:.|.:||:.|::|.
Human  1096 DKCEEMEEGYIQCSQFLYGVQEKLGVMNKGVAYALWDYEAQNSDELSFHEGDALTILRRKDESET 1160

  Fly  1035 EWWWARNAAGEEGYVPRNLLGLYPRVPP 1062
            |||||| ....|||||:||||||||:.|
Human  1161 EWWWAR-LGDREGYVPKNLLGLYPRIKP 1187

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.