DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ASPP and MYO16

DIOPT Version :9

Sequence 1:	NP_788423.1	Gene:	ASPP / 37422	FlyBaseID:	FBgn0034606	Length:	1069	Species:	Drosophila melanogaster
Sequence 2:	NP_001185879.1	Gene:	MYO16 / 23026	HGNCID:	29822	Length:	1880	Species:	Homo sapiens

Alignment Length:	185	Identity:	52/185 - (28%)
Similarity:	81/185 - (43%)	Gaps:	34/185 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   832 TSATSTTTTVTTSNIKERTGNGKPKLGRRVSFDPLALLLDASLEGELELVKKTAMQVANPSAAND 896
            |.::|...|....|..:.|...:.||.|     |:::|.|         ||.......|.:..||
Human   192 TESSSILLTYLDENGVDLTSLRQMKLQR-----PMSMLTD---------VKHFLSSGGNVNEKND 242

  Fly   897 EGITALHNAICAGHIDIVKFLVEFGCDVNAQDSDGWTPLHCAASCNNLSMVKFLVESGACLFAST 961
            ||:|.||.|..:|:.::|..::|.|.|:|..|...|||||.||.....::||.|:...|
Human   243 EGVTLLHMACASGYKEVVSLILEHGGDLNIVDDQYWTPLHLAAKYGQTNLVKLLLMHQA------ 301

  Fly   962 LSDHETPAEKCEEDEEGFDGCSEYLYSIQEKLGILHNGDVYAVFSYEAQNGDELS 1016
             :.|   ...|.|::......||:   |:|.|       :.|..::|.:..:.||
Human   302 -NPH---LVNCNEEKASDIAASEF---IEEML-------LKAEIAWEEKMKEPLS 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ASPP	NP_788423.1	ANK	867..968	CDD:238125	32/100 (32%)
		Ank_2	869..955	CDD:289560	30/85 (35%)
		ANK repeat	869..895	CDD:293786	5/25 (20%)
		ANK repeat	897..928	CDD:293786	12/30 (40%)
		ANK repeat	930..955	CDD:293786	10/24 (42%)
		SH3_ASPP	999..1056	CDD:212741	4/18 (22%)
MYO16	NP_001185879.1	ANKYR	81..332	CDD:223738	49/173 (28%)
		ANK repeat	86..112	CDD:293786
		ANK	89..190	CDD:238125
		ANK repeat	114..145	CDD:293786
		ANK	142..297	CDD:238125	38/118 (32%)
		ANK repeat	147..178	CDD:293786
		ANK repeat	180..210	CDD:293786	4/17 (24%)
		ANK repeat	243..274	CDD:293786	12/30 (40%)
		ANK repeat	276..307	CDD:293786	12/40 (30%)
		ANK repeat	309..335	CDD:293786	7/35 (20%)
		MYSc	426..1165	CDD:214580
		MYSc_Myo16	437..1155	CDD:276844
		NYAP_N	1253..1590	CDD:292079
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0515
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900