back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ASPP and Ppp1r13b

DIOPT Version :10

Sequence 1:	NP_788423.1	Gene:	ASPP / 37422	FlyBaseID:	FBgn0034606	Length:	1069	Species:	Drosophila melanogaster
Sequence 2:	XP_006515859.1	Gene:	Ppp1r13b / 21981	MGIID:	1336199	Length:	1122	Species:	Mus musculus

Alignment Length:	1170	Identity:	363/1170 - (31%)
Similarity:	521/1170 - (44%)	Gaps:	291/1170 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 SPT----RGVVVTSEPK-----LNVPS-------------RLTSAELRAMALRQQQQIDSQHQLL 88
            |||    :|...|.|.:     :|||.             .||.:||:.||.||||||::|.|:|
Mouse    85 SPTESSEQGARQTQEQRTQRSVVNVPGEKRTENGVGNPRVELTLSELQDMAARQQQQIENQQQML 149

  Fly    89 ATKEQRLRFLKSQEVRSAVASAEGERLRRLRERVEAQESKLRRLRALRGQVDLQKTYNVTLSNDL 153
            ..|||||.|||.||.|...:.:|.|:|::|:|||||||:||:::||:|||||..|..|..||.::
Mouse   150 VAKEQRLHFLKQQERRQQQSVSENEKLQKLKERVEAQENKLKKIRAMRGQVDYSKIMNGNLSAEI 214

  Fly   154 DSIRALFSEKEKELSLAVAKVEALTRQLEELRRDRRCPVNILTAAGNGVGGQS----LPPQASRE 214
            :...|:|.||::|:..|:.:|:.|::|||:|::            |...|.||    |...|:.|
Mouse   215 ERFSAMFQEKKQEVQTAILRVDQLSQQLEDLKK------------GKLNGFQSYNGRLTGPAAVE 267

  Fly   215 LEKLRRELMYRNQLSLQQDARLHMQREALQQRQAELRSTDQRIYELQTRLQRKKQANTHHQQQQQ 279
            |::|.:||..||||:.:|:::|..|:|.|.:|..|:...|:||.||:.||..||
Mouse   268 LKRLYQELQIRNQLNQEQNSKLQQQKELLNKRNMEVAMMDKRISELRERLYGKK----------- 321

  Fly   280 QQQQHQQQQHQQQHQQTTVQQQQQQQQQLHVQSAQLLAAAAAATAQQQQQHQQHQQQQQQQQQQS 344
                                             .||......::.|
Mouse   322 ---------------------------------IQLNRVNGTSSPQ------------------- 334

  Fly   345 ASNLGKHGGVAALKQQLLQKQVN-----------QLAAAAAAAAAGRARGNVAAVEPFIHTPQKS 398
             |.|...|.|||:...:......           |....|::||.||::.:.       ::..:.
Mouse   335 -SPLSTSGRVAAVGPYIQVPSTGGFPLPGDPVKPQSLTIASSAAHGRSKSDG-------YSRGRG 391

  Fly   399 TITSTASYLS-----GGMKHAAA-TANTNQQN--QLIQDLTHVKLGQNSGFF------------- 442
            |.|.|.|.|.     |..:|:|: .||:|..|  .|.|:...||..|.:|.:
Mouse   392 TSTWTVSDLDVRPHCGSSEHSASPLANSNDGNWPPLKQNSASVKSTQMTGDWKDSGMEGTLKQGA 456

  Fly   443 AGSVPVPVASSSCESDESKLAKKLLAAP--------------------------AKTEAELRKQA 481
            ..|.|:|:::...   ..||..::...|                          :.:..|.||:.
Mouse   457 ISSQPLPLSALGA---TEKLGIEIGKGPPPIPGVGKPLPPSYGTYPSSGPLGPGSTSSLERRKEG 518

  Fly   482 QTEAMDSTTHIYAEVGPKKRDREAAAAAAAAAAAAAAAAQAAAEAANQAATAAAASAISPPATAN 546
            ......:        ||..|.:.|....|:.|....::.|.      |...:...|...|||..
Mouse   519 SLPRPGA--------GPPSRQKPAPLPPASNAPQPGSSQQI------QQRISVPPSPTYPPAGP- 568

  Fly   547 ASKIPKSTTSSSSSASALISKLNQQATAKESQDQQQSQAKKNEISVTSETLSERNTQQ------- 604
                |...|........|...:......|.|:.|   ..:|...:|.|.::.....||
Mouse   569 ----PAFPTGDGKPELPLTVAIRPFLADKGSRPQ---SPRKGPQTVNSSSIYSMYLQQATPPKNY 626

  Fly   605 QLTVHSMPLGAISKSV------ALAVSNASKP-----LQVQVSNVAVPPRKPISSVAPNSVSSGS 658
            |...|    |.::|||      .:..|.::.|     |...:......|:.|..|........|.
Mouse   627 QPPAH----GTLNKSVKAVYGKPVLPSGSASPSPLPFLHGSLGTGTAQPQPPSDSAEKEPEQEGP 687

  Fly   659 SIPKMITYSPKVNRVAPNVVMTDPRPALPPK--PSKMSP----------------TEQPSPVEAN 705
            |:|.           ..:.|.:.|||..|.|  |...||                ...|.|::..
Mouse   688 SVPG-----------EGSTVESLPRPLSPTKLTPIVHSPLRYQSDADLEALRRKLANAPRPLKKR 741

  Fly   706 TS-GSAGGAGSGAASASTANKTQTATFGLQ-----------------------SLNINDNL--PI 744
            :| ....|.|..........:..|...|::                       :.|.|.||  |.
Mouse   742 SSITEPEGPGGPNIQKLLYQRFNTLAGGMEGTPFYQPSPSQDFVGTLADMDNGNTNANGNLDEPF 806

  Fly   745 KAKPLTIRKQPLFEQPRLKSSQSSSNGQQKPPLLQLQNQRKSEPSARQPTEN-------LPDTSP 802
            ..:|..    ||.|: ...||.::.|....|...:|...:.:..:| :|||:       :|.|..
Mouse   807 PPRPTA----PLPEE-LAPSSDANDNELPSPEPEELICPQTTHQTA-EPTEDNNNNVAPVPSTEQ 865

  Fly   803 QHSPSSESSADETDRMVAPSITTSQQETSTSATSTTTTVTTSNIKERTGNGKPKLGRRVSFDPLA 867
            ..||.:|:.::|.  .|.|:..:.......::.|..|.:...| .||||:     |.||.|:|||
Mouse   866 IPSPVAEAPSEED--QVPPAPLSPVIHPPAASASKRTNLKKPN-SERTGH-----GLRVRFNPLA 922

  Fly   868 LLLDASLEGELELVKKTAMQVANPSAANDEGITALHNAICAGHIDIVKFLVEFGCDVNAQDSDGW 932
            ||||||||||.:||::...:|.:||..||||||.||||:||||..|||||::||.:|||.|||||
Mouse   923 LLLDASLEGEFDLVQRIIYEVEDPSKPNDEGITPLHNAVCAGHHHIVKFLLDFGVNVNAADSDGW 987

  Fly   933 TPLHCAASCNNLSMVKFLVESGACLFASTLSDHETPAEKCEEDEEGFDGCSEYLYSIQEKLGILH 997
            ||||||||||::.:.|.||||||.:||||:||.||.|:||||.|||:..||::||.:|||||:::
Mouse   988 TPLHCAASCNSVHLCKQLVESGAAIFASTISDIETAADKCEEMEEGYIQCSQFLYGVQEKLGVMN 1052

  Fly   998 NGDVYAVFSYEAQNGDELSFHVNEPLIVLRKGDDAENEWWWARNAAGEEGYVPRNLLGLYPRVPP 1062
            .|.|||::.|||||.||||||..:.:.:||:.|:.|.|||||| ....|||||:||||||||:.|
Mouse  1053 KGTVYALWDYEAQNSDELSFHEGDAITILRRKDENETEWWWAR-LGDREGYVPKNLLGLYPRIKP 1116

Fly 1063 1062
Mouse 1117 1116

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.