Protein Alignment ASPP and Trp53bp2

DIOPT Version :10

• Sequence 1: NP_788423.1
• Gene: ASPP / 37422
• FlyBaseID: FBgn0034606
• Length: 1069
• Species: Drosophila melanogaster
• Sequence 2: NP_775554.2
• Gene: Trp53bp2 / 209456
• MGIID: 2138319
• Length: 1134
• Species: Mus musculus
• Alignment Length: 1167
• Identity: 363/1167 - (31%)
• Similarity: 533/1167 - (45%)
• Gaps: 256/1167 - (21%)

  Fly    23 PAHRASASSASSSTSSTASLAFVSPTRGVVVTSE----------PKLNVPSRLTSAELRAMALRQ 77
            |.:|...|...|...|.       ...||.|..|          |:|:    ||.|||:.||.||
Mouse    91 PPNRDIVSGPRSQDPSV-------KRNGVKVPGEHRRKENGVNSPRLD----LTLAELQEMASRQ 144

  Fly    78 QQQIDSQHQLLATKEQRLRFLKSQEVRSAVASAEGERLRRLRERVEAQESKLRRLRALRGQVDLQ 142
            ||||::|.|:||||||||:|||.|:.|....:||.|:|:||||..|:||:||:::|||:|.|:.:
Mouse   145 QQQIEAQQQMLATKEQRLKFLKQQDQRQQQQAAEQEKLKRLREIAESQEAKLKKVRALKGHVEQK 209

  Fly   143 KTYNVTLSNDLDSIRALFSEKEKELSLAVAKVEALTRQLEELRRDRRCPVNILTAAGNGVGGQSL 207
            :..|..|..:::.:.:||.:|::||.|||:|||.||||||.|:..|             :.|...
Mouse   210 RLSNGKLVEEIEQMNSLFQQKQRELVLAVSKVEELTRQLEMLKNGR-------------IDGHHD 261

  Fly   208 PPQASRELEKLRRELMYRNQLSLQQDARLHMQREALQQRQAELRSTDQRIYELQTRLQRKKQANT 272
            ...|..||::|.:||..||:|:.:|:|:|..|||.|.:|.:|:...|:|:.||:.||.:||.|
Mouse   262 NQSAVAELDRLYKELQLRNKLNQEQNAKLQQQRECLNKRNSEVAVMDKRVSELRDRLWKKKAA-- 324

  Fly   273 HHQQQQQQQQQHQQQQHQQQH--------------QQTTVQQQQQQQQ----------QLHVQSA 313
              .||::...........||.              |.:|:.:...:.:          .|.:|||
Mouse   325 --LQQKENLPVSPDGNLPQQAVSAPSRVAAVGPYIQSSTMPRMPSRPELLVKPALPDGSLLMQSA 387

  Fly   314 ------QLLAAAAAATAQQQQQHQQHQQQQQQQQQQSASNLGKHGGVAALKQQLLQKQVNQLAAA 372
                  |.|....:..|.|.:..:.|..........:               .||..|.:.:..:
Mouse   388 EGPMKIQTLPNMRSGAASQSKGSKAHPASPDWNPSNA---------------DLLPSQGSSVPQS 437

  Fly   373 AAAAAAGRARGNVAA------VEPFIHTPQKSTITSTASYLSGGMKHAAATANTNQQNQLIQDLT 431
            |..|......|.:|.      |.||   ....|:...|:..|.|         |.::||..:|:.
Mouse   438 AGTALDQVDDGEIAVREKEKKVRPF---SMFDTVDQCAAPPSFG---------TLRKNQSSEDIL 490

  Fly   432 HVKLGQNSGFFAGSVPVPVASSSCESDESKLAKKLLAAPAKTEAELRKQAQTEAMD-STTHIYAE 495
            ......|..  ...||.||.:.     ..::........|::.::::.....:.:. :.|.:.|:
Mouse   491 RDAQAVNKN--VAKVPPPVPTK-----PKQIHLPYFGQTAQSPSDMKPDGNAQQLPIAATSVGAK 548

  Fly   496 V---GPKKRDREAAAAAAAAAAAAAAAAQAAAEAANQAATAAAASAISPPATANASK------IP 551
            :   ||:.|      ...:..|.:....|..:.|:.|.:..|||..   |.|...||      ..
Mouse   549 LKPAGPQAR------MLLSPGAPSGGQDQVLSPASKQESPPAAAVR---PFTPQPSKDTFPPAFR 604

  Fly   552 KSTTSSSSSASALISKLNQQATAKE------------------------------SQDQQQ---- 582
            |..|.::||..::.::  |||..|.                              :|:.||
Mouse   605 KPQTVAASSIYSMYTQ--QQAPGKNFQQAVQSALTKTQPRGPHFSSVYGKPVIAAAQNPQQHPEN 667

  Fly   583 ----SQAKKNEISVTSETLSERNTQQQLTVHSMPLG-----------------AISKSVALAVSN 626
                ||.|.......:||:|..:...:......||.                 |..:::...:||
Mouse   668 IYSCSQGKPGSPEPETETVSSVHESHENERIPRPLSPTKLLPFLSNPYRNQSDADLEALRKKLSN 732

  Fly   627 ASKPLQVQVSNVAVP--PRKP-----------ISSVAPNSV-SSGSSIPKMITYSPKVNRVAPNV 677
            |.:||:.: |::..|  |..|           |:::...|| |..|..|..:|.:|:.:...||
Mouse   733 APRPLKKR-SSITEPEGPNGPNIQKLLYQRTTIAAMETISVPSHPSKSPGSVTVNPESSVEIPN- 795

  Fly   678 VMTDPRPALPPKPSKMSPTEQPSPVEANTSGSAGGAGSGAASASTANKTQTATFGLQSLNINDNL 742
                  |.|..:|.|...:..|.|:.....|||....|...:.|...:..:......|.|:.:|:
Mouse   796 ------PYLHVEPEKEVGSLVPEPLSPEDMGSASTENSDVPAPSAGLEYVSEGVTDSSTNLQNNV 854

  Fly   743 PIKAKPLTIRKQPLFEQPRLKSSQSSSNGQQKPPLLQLQNQRKSEPSARQPTENLPDTSPQHSPS 807
                                     .....:.|.||::.            .|..|...|...||
Mouse   855 -------------------------EETNPEAPHLLEVY------------LEEYPPYPPPPYPS 882

  Fly   808 SESSADETD--RMVAPSITTSQQETSTSATSTTTTVTTSNIKERTGNGKPKLGRRVSFDPLALLL 870
            .|....|.|  ||..|.||   .:.|......|      |:: :||:.:...|.||.|:||||||
Mouse   883 GEPEVSEEDSARMRPPEIT---GQVSLPPGKRT------NLR-KTGSERIAHGMRVKFNPLALLL 937

  Fly   871 DASLEGELELVKKTAMQVANPSAANDEGITALHNAICAGHIDIVKFLVEFGCDVNAQDSDGWTPL 935
            |:|||||.:||::...:|.:||..|||||||||||:||||.:||||||:||.:|||.||||||||
Mouse   938 DSSLEGEFDLVQRIIYEVDDPSLPNDEGITALHNAVCAGHTEIVKFLVQFGVNVNAADSDGWTPL 1002

  Fly   936 HCAASCNNLSMVKFLVESGACLFASTLSDHETPAEKCEEDEEGFDGCSEYLYSIQEKLGILHNGD 1000
            ||||||||:.:.||||||||.:||.|.||.:|.|:||||.|||:..||::||.:|||:||::.|.
Mouse  1003 HCAASCNNVQVCKFLVESGAAVFAMTYSDMQTAADKCEEMEEGYTQCSQFLYGVQEKMGIMNKGV 1067

  Fly  1001 VYAVFSYEAQNGDELSFHVNEPLIVLRKGDDAENEWWWARNAAGEEGYVPRNLLGLYPRVPP 1062
            :||::.||.|:.|||.....:.:.|:|:.|:.|.|||||| ...:||||||||||||||:.|
Mouse  1068 IYALWDYEPQHDDELLMKEGDCMTVIRREDEEEIEWWWAR-LNDKEGYVPRNLLGLYPRIKP 1128

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ASPP	NP_788423.1	COG4913	<123..>270	CDD:443941	58/146 (40%)
		ANKYR	<868..>955	CDD:440430	62/86 (72%)
		ANK repeat	869..895	CDD:293786	13/25 (52%)
		ANK repeat	897..928	CDD:293786	24/30 (80%)
		ANK repeat	930..955	CDD:293786	20/24 (83%)
		SH3_ASPP	999..1056	CDD:212741	28/56 (50%)
Trp53bp2	NP_775554.2	RA_ASPP2	10..89	CDD:340745
		SMC_prok_B	<155..>330	CDD:274008	82/191 (43%)
		PRK12323	<523..687	CDD:481241	33/174 (19%)
		ANK repeat	936..962	CDD:293786	13/25 (52%)
		ANKYR	<957..>1037	CDD:440430	58/79 (73%)
		ANK repeat	964..995	CDD:293786	24/30 (80%)
		ANK repeat	997..1026	CDD:293786	22/28 (79%)
		SH3	1066..1122	CDD:473055	28/56 (50%)