DRSC/TRiP Functional Genomics Resources

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Protein Alignment ASPP and Trp53bp2

DIOPT Version :9

Sequence 1:NP_788423.1 Gene:ASPP / 37422 FlyBaseID:FBgn0034606 Length:1069 Species:Drosophila melanogaster
Sequence 2:NP_775554.2 Gene:Trp53bp2 / 209456 MGIID:2138319 Length:1134 Species:Mus musculus


Alignment Length:1167 Identity:363/1167 - (31%)
Similarity:533/1167 - (45%) Gaps:256/1167 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 PAHRASASSASSSTSSTASLAFVSPTRGVVVTSE----------PKLNVPSRLTSAELRAMALRQ 77
            |.:|...|...|...|.       ...||.|..|          |:|:    ||.|||:.||.||
Mouse    91 PPNRDIVSGPRSQDPSV-------KRNGVKVPGEHRRKENGVNSPRLD----LTLAELQEMASRQ 144

  Fly    78 QQQIDSQHQLLATKEQRLRFLKSQEVRSAVASAEGERLRRLRERVEAQESKLRRLRALRGQVDLQ 142
            ||||::|.|:||||||||:|||.|:.|....:||.|:|:||||..|:||:||:::|||:|.|:.:
Mouse   145 QQQIEAQQQMLATKEQRLKFLKQQDQRQQQQAAEQEKLKRLREIAESQEAKLKKVRALKGHVEQK 209

  Fly   143 KTYNVTLSNDLDSIRALFSEKEKELSLAVAKVEALTRQLEELRRDRRCPVNILTAAGNGVGGQSL 207
            :..|..|..:::.:.:||.:|::||.|||:|||.||||||.|:..|             :.|...
Mouse   210 RLSNGKLVEEIEQMNSLFQQKQRELVLAVSKVEELTRQLEMLKNGR-------------IDGHHD 261

  Fly   208 PPQASRELEKLRRELMYRNQLSLQQDARLHMQREALQQRQAELRSTDQRIYELQTRLQRKKQANT 272
            ...|..||::|.:||..||:|:.:|:|:|..|||.|.:|.:|:...|:|:.||:.||.:||.|  
Mouse   262 NQSAVAELDRLYKELQLRNKLNQEQNAKLQQQRECLNKRNSEVAVMDKRVSELRDRLWKKKAA-- 324

  Fly   273 HHQQQQQQQQQHQQQQHQQQH--------------QQTTVQQQQQQQQ----------QLHVQSA 313
              .||::...........||.              |.:|:.:...:.:          .|.:|||
Mouse   325 --LQQKENLPVSPDGNLPQQAVSAPSRVAAVGPYIQSSTMPRMPSRPELLVKPALPDGSLLMQSA 387

  Fly   314 ------QLLAAAAAATAQQQQQHQQHQQQQQQQQQQSASNLGKHGGVAALKQQLLQKQVNQLAAA 372
                  |.|....:..|.|.:..:.|..........:               .||..|.:.:..:
Mouse   388 EGPMKIQTLPNMRSGAASQSKGSKAHPASPDWNPSNA---------------DLLPSQGSSVPQS 437

  Fly   373 AAAAAAGRARGNVAA------VEPFIHTPQKSTITSTASYLSGGMKHAAATANTNQQNQLIQDLT 431
            |..|......|.:|.      |.||   ....|:...|:..|.|         |.::||..:|:.
Mouse   438 AGTALDQVDDGEIAVREKEKKVRPF---SMFDTVDQCAAPPSFG---------TLRKNQSSEDIL 490

  Fly   432 HVKLGQNSGFFAGSVPVPVASSSCESDESKLAKKLLAAPAKTEAELRKQAQTEAMD-STTHIYAE 495
            ......|..  ...||.||.:.     ..::........|::.::::.....:.:. :.|.:.|:
Mouse   491 RDAQAVNKN--VAKVPPPVPTK-----PKQIHLPYFGQTAQSPSDMKPDGNAQQLPIAATSVGAK 548

  Fly   496 V---GPKKRDREAAAAAAAAAAAAAAAAQAAAEAANQAATAAAASAISPPATANASK------IP 551
            :   ||:.|      ...:..|.:....|..:.|:.|.:..|||..   |.|...||      ..
Mouse   549 LKPAGPQAR------MLLSPGAPSGGQDQVLSPASKQESPPAAAVR---PFTPQPSKDTFPPAFR 604

  Fly   552 KSTTSSSSSASALISKLNQQATAKE------------------------------SQDQQQ---- 582
            |..|.::||..::.::  |||..|.                              :|:.||    
Mouse   605 KPQTVAASSIYSMYTQ--QQAPGKNFQQAVQSALTKTQPRGPHFSSVYGKPVIAAAQNPQQHPEN 667

  Fly   583 ----SQAKKNEISVTSETLSERNTQQQLTVHSMPLG-----------------AISKSVALAVSN 626
                ||.|.......:||:|..:...:......||.                 |..:::...:||
Mouse   668 IYSCSQGKPGSPEPETETVSSVHESHENERIPRPLSPTKLLPFLSNPYRNQSDADLEALRKKLSN 732

  Fly   627 ASKPLQVQVSNVAVP--PRKP-----------ISSVAPNSV-SSGSSIPKMITYSPKVNRVAPNV 677
            |.:||:.: |::..|  |..|           |:::...|| |..|..|..:|.:|:.:...|| 
Mouse   733 APRPLKKR-SSITEPEGPNGPNIQKLLYQRTTIAAMETISVPSHPSKSPGSVTVNPESSVEIPN- 795

  Fly   678 VMTDPRPALPPKPSKMSPTEQPSPVEANTSGSAGGAGSGAASASTANKTQTATFGLQSLNINDNL 742
                  |.|..:|.|...:..|.|:.....|||....|...:.|...:..:......|.|:.:|:
Mouse   796 ------PYLHVEPEKEVGSLVPEPLSPEDMGSASTENSDVPAPSAGLEYVSEGVTDSSTNLQNNV 854

  Fly   743 PIKAKPLTIRKQPLFEQPRLKSSQSSSNGQQKPPLLQLQNQRKSEPSARQPTENLPDTSPQHSPS 807
                                     .....:.|.||::.            .|..|...|...||
Mouse   855 -------------------------EETNPEAPHLLEVY------------LEEYPPYPPPPYPS 882

  Fly   808 SESSADETD--RMVAPSITTSQQETSTSATSTTTTVTTSNIKERTGNGKPKLGRRVSFDPLALLL 870
            .|....|.|  ||..|.||   .:.|......|      |:: :||:.:...|.||.|:||||||
Mouse   883 GEPEVSEEDSARMRPPEIT---GQVSLPPGKRT------NLR-KTGSERIAHGMRVKFNPLALLL 937

  Fly   871 DASLEGELELVKKTAMQVANPSAANDEGITALHNAICAGHIDIVKFLVEFGCDVNAQDSDGWTPL 935
            |:|||||.:||::...:|.:||..|||||||||||:||||.:||||||:||.:|||.||||||||
Mouse   938 DSSLEGEFDLVQRIIYEVDDPSLPNDEGITALHNAVCAGHTEIVKFLVQFGVNVNAADSDGWTPL 1002

  Fly   936 HCAASCNNLSMVKFLVESGACLFASTLSDHETPAEKCEEDEEGFDGCSEYLYSIQEKLGILHNGD 1000
            ||||||||:.:.||||||||.:||.|.||.:|.|:||||.|||:..||::||.:|||:||::.|.
Mouse  1003 HCAASCNNVQVCKFLVESGAAVFAMTYSDMQTAADKCEEMEEGYTQCSQFLYGVQEKMGIMNKGV 1067

  Fly  1001 VYAVFSYEAQNGDELSFHVNEPLIVLRKGDDAENEWWWARNAAGEEGYVPRNLLGLYPRVPP 1062
            :||::.||.|:.|||.....:.:.|:|:.|:.|.|||||| ...:||||||||||||||:.|
Mouse  1068 IYALWDYEPQHDDELLMKEGDCMTVIRREDEEEIEWWWAR-LNDKEGYVPRNLLGLYPRIKP 1128

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ASPPNP_788423.1 ANK 867..968 CDD:238125 70/100 (70%)
Ank_2 869..955 CDD:289560 61/85 (72%)
ANK repeat 869..895 CDD:293786 13/25 (52%)
ANK repeat 897..928 CDD:293786 24/30 (80%)
ANK repeat 930..955 CDD:293786 20/24 (83%)
SH3_ASPP 999..1056 CDD:212741 28/56 (50%)
Trp53bp2NP_775554.2 UBQ 17..90 CDD:294102
Ank_2 936..1022 CDD:289560 61/85 (72%)
ANK repeat 936..962 CDD:293786 13/25 (52%)
ANK 942..1053 CDD:238125 74/110 (67%)
ANK repeat 964..995 CDD:293786 24/30 (80%)
ANK repeat 997..1026 CDD:293786 22/28 (79%)
SH3 1066..1122 CDD:302595 28/56 (50%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167837772
Domainoid 1 1.000 182 1.000 Domainoid score I3443
eggNOG 1 0.900 - - E1_KOG0515
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 436 1.000 Inparanoid score I1674
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG47177
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002975
OrthoInspector 1 1.000 - - otm44322
orthoMCL 1 0.900 - - OOG6_104019
Panther 1 1.100 - - O PTHR24131
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3074
SonicParanoid 1 1.000 - - X1975
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1312.880

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