DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ASPP and ape-1

DIOPT Version :9

Sequence 1:	NP_788423.1	Gene:	ASPP / 37422	FlyBaseID:	FBgn0034606	Length:	1069	Species:	Drosophila melanogaster
Sequence 2:	NP_001256353.1	Gene:	ape-1 / 179601	WormBaseID:	WBGene00000146	Length:	769	Species:	Caenorhabditis elegans

Alignment Length:	1075	Identity:	269/1075 - (25%)
Similarity:	398/1075 - (37%)	Gaps:	399/1075 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 SLMPAHRASASSASSSTSSTASLAFVSPTRGVVVTSEPKLNVPSRLTSAELRAMALRQQQQIDSQ 84
            |..|.:|.::|.||:....:::..|:|..:.:   |:|.:.|.::......:|::.:..||  :.
Worm    34 STAPIYRPTSSMASTMAHKSSTAPFISANQRM---SKPPVRVVAQPPPPHPQALSQQYHQQ--NP 93

  Fly    85 HQLLATKEQRLRFLKSQEVRSAVASAEGERLRRLRERVEAQESKLRRLRALRGQVDLQKTYNVTL 149
            ..:.:....|...:.:.:|:..:|:                            |:......|...
Worm    94 MMMYSAPNTRPHVIPTMQVQPTMAA----------------------------QIKRNNPVNAQF 130

  Fly   150 SNDLDSIRALFSEKEKELSLAVAKVEALTRQL----EELRRDRRCPVNILTAAGNGVGGQSLPPQ 210
            .|..:.| |.:..|.:.:.: |.:|.|:.||:    .||||
Worm   131 QNPSEMI-ADYGVKPQSVEM-VQRVRAVRRQVADEETELRR------------------------ 169

  Fly   211 ASRELEKLRRELMYRNQLSLQQDARLHMQREALQQRQAELRSTDQRIYELQTRLQRKKQANTHHQ 275
             .||||....:|..:|   ..::..|::|...|::.|.|||:...|...|          |.|.:
Worm   170 -LRELEHETAQLQNKN---YGRERELNVQGSMLKEAQLELRNASMRAQSL----------NKHLE 220

  Fly   276 QQQQQQQQHQQQQHQQQHQQTTVQQQQQQQQQLHVQSAQLLAAAAAATAQQQQQHQQHQQQQQQQ 340
            :..:::|                                   .||||...:|::.|||
Worm   221 EMYRRRQ-----------------------------------TAAAAALVEQRKMQQH------- 243

  Fly   341 QQQSASNLGKHGGVAALKQQLLQKQVNQLAAAAAAAAAGRARGNVAAVEPFIHTPQKSTITSTAS 405
                              |.||.:..||::.....    |.|   |:||||
Worm   244 ------------------QILLARAANQVSTQEVI----RPR---ASVEPF-------------- 269

  Fly   406 YLSGGMKHAAATANTNQQNQLIQDLTHVKLGQNSGFFAGSVPVPVASSSCESDESKLAKKLLAAP 470
                       ..|..||.|                     |.|....|.|..|.:
Worm   270 -----------QVNNTQQQQ---------------------PSPQMMKSEEFSEKR--------- 293

  Fly   471 AKTEAELRKQAQT-EAMDSTTHIYAEVGPKKRDREAAAAAAAAAAAAAAAAQAAAEAANQAATAA 534
                 :|..|..: :|:|
Worm   294 -----DLNGQTGSYDAID----------------------------------------------- 306

  Fly   535 AASAISPPATANASKIPKSTTSSSSSASALISKLNQQATAKESQDQQQSQAKKNEISVTSETLSE 599
                    .:.:..|||              ::.:..|..||:|.      |.:|:|..:.|...
Worm   307 --------GSGDHQKIP--------------TEPSYLAPCKENQQ------KYSELSKMASTDPH 343

  Fly   600 RNTQQQLTVHSMPLGAISKSVALAVSNASKPLQVQVSNVAVPPRKPISSVAPNSVSSGSSIPKMI 664
            .|       ||.|                                         .:|....|.:|
Worm   344 SN-------HSSP-----------------------------------------STSSQKAPTLI 360

  Fly   665 TYSPKVNRVAPNVVMTDPRPALPPKPSKMSPTEQPSPVEANTSGSAGGAGSGAASASTANKTQTA 729
            |:||               |:...|.:..:.|.....||..||
Worm   361 TFSP---------------PSFEQKINSSTMTRDSPFVERPTS---------------------- 388

  Fly   730 TFGLQSLNINDNLPIKAKPLTIRKQPLFEQPRLKSSQSSSNGQQKPPLLQ--LQNQRK------- 785
             || .||:.:.....|...:::|...|....|...:.|......:..::.  |..||:
Worm   389 -FG-DSLDESRLRSGKTDLVSLRSDSLKATKRRSWAASEGTSMSEAEMIHRLLDEQRRGRSHFIP 451

  Fly   786 ------SEPSA----RQPTENLPDTSPQHSPSSESSAD---ETDRMVAPSITTSQQETSTSATST 837
                  .||||    ....|.:...|.|.:.||:|:.:   .|::||..|.||::::.|:.:|.:
Worm   452 QLPTSQEEPSAITSETYAEEVVNSESKQVATSSDSTNNLELPTEQMVLGSDTTTEEDASSCSTRS 516

  Fly   838 TTTVTTS---NIKERTGNG---KP--KLGR-RVSFDPLALLLDASLEGELELVKKTAMQVANPSA 893
            .......   .|:.||..|   :|  |:.: |:.||||||||||:|||||:||:.:|.::.:.|.
Worm   517 DDGQNLEMEVAIERRTVKGILRRPNEKMNKGRIEFDPLALLLDAALEGELDLVRSSASKLTDVSQ 581

  Fly   894 ANDEGITALHNAICAGHIDIVKFLVEFGCDVNAQDSDGWTPLHCAASCNNLSMVKFLVESGACLF 958
            |||||||||||||||||.:||:||:|...||||||||||||||||||||||.||:.|||.|.|:.
Worm   582 ANDEGITALHNAICAGHYEIVRFLIENDADVNAQDSDGWTPLHCAASCNNLPMVRQLVEGGGCVL 646

  Fly   959 ASTLSDHETPAEKCEEDEEGFDGCSEYLYSIQEKLGILHNGDVYAVFSYEAQNGDELSFHVNEPL 1023
            ||||||.|||.|||||||:|:|||.:||.:.....|.::.|.|||.:.|||...|||||...:.|
Worm   647 ASTLSDMETPVEKCEEDEDGYDGCLKYLSAAHNSTGSINTGKVYAAYGYEAAFEDELSFDAGDEL 711

  Fly  1024 IVLRKGDDAENEWWWARNAAGEEGYVPRNLLGLYP 1058
            .|:.| |..:..||......||:|.|||..|.|||
Worm   712 TVIEK-DKVDKNWWTCEKNNGEKGQVPRTYLALYP 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ASPP	NP_788423.1	ANK	867..968	CDD:238125	73/100 (73%)
		Ank_2	869..955	CDD:289560	62/85 (73%)
		ANK repeat	869..895	CDD:293786	13/25 (52%)
		ANK repeat	897..928	CDD:293786	23/30 (77%)
		ANK repeat	930..955	CDD:293786	20/24 (83%)
		SH3_ASPP	999..1056	CDD:212741	25/56 (45%)
ape-1	NP_001256353.1	DUF2315	154..225	CDD:287233	24/108 (22%)
		Ank_4	<564..606	CDD:290365	27/41 (66%)
		ANK	<578..674	CDD:238125	72/95 (76%)
		ANK repeat	585..616	CDD:293786	23/30 (77%)
		Ank_4	588..639	CDD:290365	40/50 (80%)
		ANK repeat	618..642	CDD:293786	20/23 (87%)
		SH3	687..742	CDD:214620	24/55 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159678
Domainoid	1	1.000	64	1.000	Domainoid score	I6698
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	309	1.000	Inparanoid score	I1565
Isobase	1	0.950	-	0	Normalized mean entropy	S4925
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto17711
orthoMCL	1	0.900	-	-		OOG6_104019
Panther	1	1.100	-	-	LDO	PTHR24131
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3074
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.960