Protein Alignment ASPP and PPP1R13L

DIOPT Version :10

• Sequence 1: NP_788423.1
• Gene: ASPP / 37422
• FlyBaseID: FBgn0034606
• Length: 1069
• Species: Drosophila melanogaster
• Sequence 2: NP_006654.2
• Gene: PPP1R13L / 10848
• HGNCID: 18838
• Length: 828
• Species: Homo sapiens
• Alignment Length: 678
• Identity: 195/678 - (28%)
• Similarity: 275/678 - (40%)
• Gaps: 159/678 - (23%)

  Fly   493 YAEVGPKKRDREAAAAAAAAAAAAAAAAQAAAEAANQAATAAAASAISPPATA----NASKIPKS 553
            :.|.||..|             ..|.|..|.|.|...:...:..||.:||..|    ...:.|..
Human   197 FPERGPSPR-------------PPATAYDAPASAFGSSLLGSGGSAFAPPLRAQDDLTLRRRPPK 248

  Fly   554 TTSSSSSASALISKLNQQAT--------------------AKESQDQQQSQAKKNEISVT----- 593
            ..:.|....|...|.:|.|:                    .:.|.|......|.|..|.|
Human   249 AWNESDLDVAYEKKPSQTASYERLDVFARPASPSLQLLPWRESSLDGLGGTGKDNLTSATLPRNY 313

  Fly   594 --SETLSERNTQQQLTVHSMPLGAISKSVALAVSNASKPLQVQ-VSNVAVPPRKPISSVAP---- 651
              |...|:|.:.         .|:..:|:..|..:.:.|...| ||.:.:||..|....||
Human   314 KVSPLASDRRSD---------AGSYRRSLGSAGPSGTLPRSWQPVSRIPMPPSSPQPRGAPRQRP 369

  Fly   652 ----------NSVSSGSSIPKMITYSPKVNRVAPNVV----------MTDPRPALPPKPSKMSPT 696
                      |:.....:...|:..||...|..|..:          .:.|:|.|||:|.....|
Human   370 IPLSMIFKLQNAFWEHGASRAMLPGSPLFTRAPPPKLQPQPQPQPQPQSQPQPQLPPQPQTQPQT 434

  Fly   697 EQPSPVEANTSGSAGGAGSGAASASTANKTQTATFGLQSLNIN----DNLPIKAKPLT-IRKQP- 755
            ..|:|.....:...  ...|.....|..:.:....||.:..:.    |..|: |:||: .|.||
Human   435 PTPAPQHPQQTWPP--VNEGPPKPPTELEPEPEIEGLLTPVLEAGDVDEGPV-ARPLSPTRLQPA 496

  Fly   756 -----------------LFEQPR---LKSSQSSSNGQQKPPLLQLQNQR---------------- 784
                             |.|.||   .:.|...:.....||..:.|.|:
Human   497 LPPEAQSVPELEEVARVLAEIPRPLKRRGSMEQAPAVALPPTHKKQYQQIISRLFHRHGGPGPGG 561

  Fly   785 ----------KSEPSARQPTENLPDTSPQHSPSSESSADETDRMVAPSITTSQQETSTSATSTTT 839
                      .||..|..|....|...|..:||..|..::...|...|:....
Human   562 PEPELSPITEGSEARAGPPAPAPPAPIPPPAPSQSSPPEQPQSMEMRSVLRKA------------ 614

  Fly   840 TVTTSNIKERTGNGKPKLGRRVSFDPLALLLDASLEGELELVKKTAMQVANPSAANDEGITALHN 904
                         |.|:..||...:||.|||||:|.||||:|::...::.:||..|:||||||||
Human   615 -------------GSPRKARRARLNPLVLLLDAALTGELEVVQQAVKEMNDPSQPNEEGITALHN 666

  Fly   905 AICAGHIDIVKFLVEFGCDVNAQDSDGWTPLHCAASCNNLSMVKFLVESGACLFASTLSDHETPA 969
            |||..:..||.||:..|.:||:.||.||||||||||||:..:...||:.||.:||:||||..|..
Human   667 AICGANYSIVDFLITAGANVNSPDSHGWTPLHCAASCNDTVICMALVQHGAAIFATTLSDGATAF 731

  Fly   970 EKCEEDEEGFDGCSEYLYSIQEKLGILHNGDVYAVFSYEAQNGDELSFHVNEPLIVLRKGDDAEN 1034
            |||:...||:..|:.||..:::.:|::::|.|||::.|.|:.||||||...|.:.|||:....|.
Human   732 EKCDPYREGYADCATYLADVEQSMGLMNSGAVYALWDYSAEFGDELSFREGESVTVLRRDGPEET 796

  Fly  1035 EWWWARNAAGEEGYVPRNLLGLYPRVPP 1062
            :||||. ..|:|||||||..||:|||.|
Human   797 DWWWAA-LHGQEGYVPRNYFGLFPRVKP 823

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ASPP	NP_788423.1	COG4913	<123..>270	CDD:443941
		ANKYR	<868..>955	CDD:440430	48/86 (56%)
		ANK repeat	869..895	CDD:293786	12/25 (48%)
		ANK repeat	897..928	CDD:293786	18/30 (60%)
		ANK repeat	930..955	CDD:293786	14/24 (58%)
		SH3_ASPP	999..1056	CDD:212741	29/56 (52%)
PPP1R13L	NP_006654.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	45..267		19/82 (23%)
		PHA03247	<75..507	CDD:223021	68/334 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	286..371		21/93 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	393..506		25/115 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	520..619		18/123 (15%)
		ANKYR	<605..>730	CDD:440430	64/149 (43%)
		ANK repeat	631..657	CDD:293786	12/25 (48%)
		ANK 1	659..691		18/31 (58%)
		ANK repeat	659..690	CDD:293786	18/30 (60%)
		ANK 2	692..724		18/31 (58%)
		ANK repeat	692..721	CDD:293786	16/28 (57%)
		SH3_iASPP	761..817	CDD:212885	29/56 (52%)